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The laboratory-based animal study found a link between greater susceptibility to obesity and diabetes, and whether one's ancestors have been undernourished for several generations, and was published on Friday in the journal Cell Metabolism.

This directed case study in PowerPoint format focusses on the London Underground Mosquito, Culex molestus, and its potential relationship to the common mosquito, Culex pipiens, in order to explore the topics of evolution, reproductive isolation, and speciation. As the story unfolds, the case mirrors the process of science. The students receive some initial data and observations collected by Byrne and Nichols in London. Based on these observations, the students then form a hypothesis and design an experiment. Finally, they receive more data collected by Becker et al. and draw conclusions.

PBL units for variety of topics

"I Heart Running" is a case study in which students diagnose the cause of exercise-induced tachycardia in an otherwise healthy, 27-year-old female. The patient, Sam, is a long-distance runner and realizes that her exercising heart rate reaches over 200 beats per minute. As the story of Sam's encounters with her physician develops, students are given results from multiple laboratory tests and detailed patient background information.  Students are guided through the material with a series of questions with the ultimate goal of determining the cause of the exercise-induced tachycardia that Sam experiences. The case study is based on actual laboratory results and was designed for students in an upper-level undergraduate Human Physiology course. In this activity students will learn about heart rate, cardiovascular physiology, and oxygen carrying capacity, and factors which influence these concepts, as they try to diagnose Sam.

Many biology courses are designed to develop student understanding and application of the scientific method, but few seriously examine the various ethical questions associated with scientific research. This interdisciplinary case study presents three experiments and asks not only if they are scientifically valid but whether they were ethically performed.  The experiments examine the psychology of love, a cause of breast cancer, and how the immune system functions in the presence of cancer. Based on their opinions of the validity and ethics of each experiment, students are asked to conclude which of the experiments were actually conducted by scientists and which are fictional. Students should already be familiar with the scientific method, but information on the Georgetown Mantra and Nuremberg Code.is included. The case could be modified for use in non-majors and majors classes.  The format of the case challenges students of any background to use information from both science and ethics to see how the differing approaches of scientist and ethicist can complement and strengthen each other.

If you were limited to choosing only three crops to sustainably farm in an arid, inhospitable environment, what would they be and how would you decide? This interrupted case study places students in the role of a proposed self-sufficient Martian colony that requires an optimized profile of food crops. After students form small groups, they discuss the factors that affect sustainability of a food supply, determine criteria for selection of crops to grow, and rank crops using these criteria. Lists of criteria and of foodstuffs are provided, but the case can easily be transformed into a problem-based learning (PBL) case by having students research and generate their own lists. The case includes questions that walk students through the selection process and require them to explain why they chose their criteria and how those criteria apply to their chosen foods. The case is designed for undergraduate students at the introductory level in courses in astronomy/astrobiology, food science/nutrition, agricultural engineering, or any discipline where sustainability is a key theme.

Current CRISPR-based screens often mutate the beginning of a gene, which sometimes results in the expression of a functional protein variant. To circumvent this problem, researchers at Cold Spring Harbor Laboratory (CSHL) designed CRISPR guide RNAs that would mutate the portion of a gene encoding a domain on the surface of the protein where a small molecule could bind to alter the protein's function. The team had previously identified such a binding pocket on the protein BRD4, and a small molecule inhibitor that binds in the pocket is an effective leukemia treatment.

WEDNESDAY, April 22, 2015 (HealthDay News) -- In a step toward personalized vaccines against cancer, scientists report they have developed an immune-system therapy that knocks out several types of aggressive tumors in mice. German researchers said the findings, reported April 22 in the journal Nature, could lead to a "blueprint" for developing tailored vaccines for a range of cancers. Such vaccines would be designed for individual patients, based on the specific genetic mutations in their tumors.

3:16 video To track commercial fishing activity around the world, SkyTruth, a small nonprofit based in Shepherdstown, West Virginia, has recently launched Global Fishing Watch in partnership with Google and Oceana. This prototype tool analyzes a satellite-collected feed of tracking data from ships' automatic identification systems-which vessels use to communicate their location to one another-to map movement over time and automatically determine which ships are engaged in fishing activity. Each vessel is pinpointed on a map outlining fishing laws around the globe. This map will be publicly available on theWeb, allowing anyone with an Internet connection to act as a watchdog and see when and where commercial fishing activity is occurring.

The Innovative Technology in Science Inquiry project engages students in STEM activities through the integrated use of technologies that include modeling, computational thinking, and real-time data acquisition. This comprehensive project will assist teachers in preparing diverse students for STEM careers by engaging them in exciting, inquiry-based science projects.

Cell Biology and Cancer-developed with the National Cancer Institute (NCI)-is a creative, inquiry-based instruction program, designed to promote active learning and stimulate student interest in medical topics. This curriculum supplement will: Deepen students' awareness of the importance of basic research to advances in medicine and health Foster students' abilities to think critically Help students understand the effects of scientific discoveries on their own lives Encourage students to take more responsibility for their own health

he National Agricultural Literacy Curriculum Matrix is an online, searchable, and standards-based curriculum map for K-12 teachers. The Matrix contextualizes national education standards in science, social studies, and nutrition education with relevant instructional resources linked to Common Core Standards. Search our instructional, classroom-ready resources now! After you find what you need, consider storing them in your personal binder - MyBinder!

This case study is used to teach undergraduate students about hydraulic fracturing (hydrofracking), a controversial method for extracting methane from shale. The controversy arises from claims that chemicals used in the fracking process and the methane itself find their way into drinking water and are also sometimes found at dangerous levels in the air. The case study begins in a college chemistry class where a student inquires about a news item he saw about residents setting their tap water on fire. The instructor uses this as an opportunity for the students to research hydrofracking and natural gas, and she then integrate these topics into their present study of isotopes. The class first examines what isotopes are by using a guided inquiry based activity. The students then learn how mass spectrometry, which uses the principles just learned about isotopes, is employed to determine the source of methane in contaminated wells. This case study is designed for freshman chemistry students and students in environmental studies.

Components of the immune system called antibodies are found in the liquid portion of blood and help protect the body from harm. Antibodies can also be used outside the body in a laboratory-based assay to help diagnose disease caused by malfunctions of the immune system or by infections.

Deep-sea mystery solved: astonishing larval transformation and extreme sexual dimorphism unite three fish families by Johnson, et al. (2009)* published in Biology Letters, Royal Society. The deep sea fishes at the heart of the investigation and this activity were historically classified into three families or clades based on the obvious morphological differences between the members of each group. 

This integrative case study is based on real events that the author experienced with her ten-year-old daughter. Although the names have been changed, all of the events (symptoms, diagnoses and treatments, types of healthcare professionals) are recorded exactly as they occurred. Both asthma and pneumonia are common in the United States (and globally). Many of the drugs described in the case study are frequently prescribed for a wide variety of ailments. The four "episodes" that constitute the case cover 1) a study of asthma triggers, incidence and treatment; 2) side effects and possible medication errors associated with steroids; 3) causes, diagnosis, treatment and prevention of community-acquired bacterial pneumonia; and 4) the mechanism of action of two different antibiotics. The "epilogue" explores a few larger themes related to healthcare and public health (e.g., continuity of care, drug resistance, asthma prevention programs). The case study could be used in an undergraduate, upper-level, infectious disease, microbiology, public health or physiology course or in a graduate-level health professions program.

The Path to Myozyme Beginning in the 1960s and fueled by the biotechnology revolution in 1980s, researchers at academic centers around the world initiated work to identify a treatment for Pompe - including therapies that could replace the missing GAA enzyme in patients. Based on these early efforts, from 1998-2002 Genzyme worked to advance promising research involving four different drug candidates to treat Pompe:

The Rare Disease Foundation is focussed on linking basic science and clinical practice to increase the efficiency of rare disease research. This model is called Translational Care. This model drives patient based, treatment focussed research projects from disease characterization to treatment with greater efficiency. By incorporating research, astute clinician observation and parental knowledge into the various stages of rare disease research we impact the speed of discovery and the way rare conditions are managed.

Different disciplines follow different versions of the inquiry process. Graphic comparing: problem solving, scientific method, writing process, computation, theater, and engineering design.

Here is a list of additional resources for Inquire High School. These inquiry resources include great links to Web sites, articles, videos, and much more that supports inquiry