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Many biology courses are designed to develop student understanding and application of the scientific method, but few seriously examine the various ethical questions associated with scientific research. This interdisciplinary case study presents three experiments and asks not only if they are scientifically valid but whether they were ethically performed.  The experiments examine the psychology of love, a cause of breast cancer, and how the immune system functions in the presence of cancer. Based on their opinions of the validity and ethics of each experiment, students are asked to conclude which of the experiments were actually conducted by scientists and which are fictional. Students should already be familiar with the scientific method, but information on the Georgetown Mantra and Nuremberg Code.is included. The case could be modified for use in non-majors and majors classes.  The format of the case challenges students of any background to use information from both science and ethics to see how the differing approaches of scientist and ethicist can complement and strengthen each other.

Unprecedented multiple and extreme-level resistance is generated in mosquitoes found in the rice fields of Tiassalé in southern Côte d'Ivoire. A new study highlights the combination of stringently-replicated whole genome transcription profiling, in vivo transgenic gene expression and in vitro metabolism assays to identify and validate genes from the P450 detoxification enzyme superfamily which are highly expressed in the adult females from the area.

This case study introduces students to the true story of Caster Semenya, an outstanding female mid-distance runner from South Africa.  Caster won the 800 m race at the 2009 Track and Field World Championships when she was just 18. Since then, she has faced scrutiny about her sex and gender. Due to her high levels of endogenous testosterone, she was banned from running for almost a year by the track and field governing body, the IAAF. In this case study, students use information from news reports and Caster's appearance to determine the possible biological underpinnings likely responsible for her anatomy and physiology.  Students are also asked to consider if using circulating testosterone levels to determine if a female can race is a valid method of exclusion. This case asks students to think about how sex and gender are related, and pushes them to discuss societal implications of labeling both of these constructs as binary when in fact they are much better described as spectra.

This case study introduces students to the "Red Queen Hypothesis." The hypothesis states that when two species compete for a limited resource or exist in a predator-prey relationship, in order for the antagonists to remain in relative population equilibrium, there must be ongoing and reciprocal adaptation on each side. If one species fails to adapt, it may quickly face extinction. Students are introduced to the Red Queen Hypothesis through an excerpt from Lewis Carroll's novel, Through the Looking Glass, in which Alice meets the Red Queen. They then review experiments from the research literature to evaluate the validity of the hypothesis in extant populations.  Students culminate their learning by contrasting their knowledge of the Red Queen Hypothesis to Darwinian evolutionary theory based on a passage from On the Origin of Species.  Students then craft a letter to Darwin helping to explain his "wedge" theory, a notion he originally developed but removed from later iterations of his book due to a lack of experimental evidence. Originally developed for advanced high school biology students, the case also may be used in a college-level introductory course on evolutionary biology.