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This PowerPoint-driven, flipped case study begins with a short video about a woman suffering from cystic fibrosis (CF) in the 1970s, a friend of the lead author's, whom she met in college and who died in her twenties. Hooked by this personal story, students then delve into the genetics and biology of cystic fibrosis as they learn about the difference between dominant and recessive genes, make Punnett squares that depict various types of inheritance, distinguish between probability and actual numbers, differentiate types of mutations, and learn about the opportunistic infections that CF patients often succumb to.  Students conclude the case by watching two additional videos on chest compression machines and the contemporary life expectancy of patients with CF.  In addition to the scientific content presented in the case, it is hoped that students will empathize with, and be motivated by, the young people presented in the videos as they struggle with a very real, incurable disease deeply rooted in genetics.

This case study is designed to help students learn about the ecosystem services of Earth (Biosphere 1) by examining the challenges faced by the designers who tried to replicate its components in Biosphere 2. In 1991, four men and four women entered Biosphere 2, a man-made closed ecological system in Arizona, to see if eight biospherians could be sustained by this miniature version of Biosphere 1. The project succeeded in producing most of the food needed, but required additional oxygen before the end of the two-year experiment. After an introduction to Biosphere 2, students learn about the four main types of ecosystem services and discuss how Biosphere 2 might provide these services. At the end of the case, students calculate their own ecological footprint, demonstrating how humans are overreaching the ecosystem services of Biosphere 1, just as the biospherians could not be sustained by the ecosystem services included in Biosphere 2. The case is suitable for an introductory undergraduate course in biology, ecology, or environmental science.

This directed case study was developed in order to present genomic data to students, allow them to interpret the impact of genetic variations on phenotype, and to explore precision medicine. Students are introduced to "Josie," a college sophomore who decides to have her genome sequenced after learning about genome-wide association studies (GWAS) in class. As students work  through the case, they learn about the different technologies that can be used in GWAS studies and interpret Josie's results for a subset of genetic markers that affect a range of traits from pharmacogenetics to disease risk alleles and non-pathogenic traits. Students are confronted with ethical issues such as duty to inform, actionable results, and variants of unknown significance (VUS). Students are also asked to reflect on their feelings about getting genomic testing for themselves. An optional activity for advanced students (included in the teaching notes) involves using the Gene database at NCBI to explore variants of the CYP2C9 gene. The case study is appropriate for use in undergraduate genetics or molecular biology classrooms.

This case study was written for an introductory course for biology majors who are first learning about embryonic development. The case is composed of several parts and involves a storyline about a team of researchers who find frogs and eggs in bamboo plants during a field study. Students consider what these observations mean, learn basics about the stages of animal embryonic development, and make connections to phylogeny and natural selection. Students then apply their understanding of animal embryonic stage development to the chemical atrazine in the environment by examining data from several experiments. As a concluding activity students write a letter to an agency or newspaper of their choosing stating their opinion surrounding the use of atrazine in the environment. The case proceeds in a progressive disclosure format and involves a combination of class discussion, small group work, and homework. Because the case focuses on very basic animal embryonic development, it would also be a great start to a developmental biology course or an embryology course.

n this interrupted case study, students learn about the influence of early fetal nutritional conditions on the expression of genes related to metabolism and growth. Beginning with the true event of a food and fuel embargo that led to famine in the western Netherlands toward the end of World War II, students learn about the historical background of the Dutch Hunger Winter and its social impact. Using real data from the study conducted by Heijmans and coauthors (2008), students then compare the methylation level of a specific gene between individuals conceived during the famine and their unaffected siblings, and how changes in the expression of this metabolically important gene may impact the risk of developing type 2 diabetes. Supported by other studies on mice and in humans, students conclude that in utero events may impact the health of individuals later in life through epigenetic mechanisms. The case is ideally suited for a molecular or cell biology course, but is also appropriate for an introductory biology course in which students have an understanding of descriptive statistics, interpretation of statistical test results, eukaryotic gene structure, and regulation of gene expression.

Extensive lessons from hands on inquiry lab at University of Rochester, developed/written with research funds.

In this "clicker case," students learn about sex determination, meiosis, and chromosomal "crossing over" through the story of Santhi Soundararajan, an athlete from Kathakkurichi, India, who was stripped of a medal at the 2006 Asian Games after failing to pass a sex test. The case is called a clicker case because it combines the use of student personal response systems (clickers) with case teaching methods and formats. The case itself is a PowerPoint presentation (~2 MB) shown in class that is punctuated by questions students respond to using their clickers. It can be adapted for use without these technologies. Developed for an introductory biology class for both majors and non-majors, the case could also be used in an anatomy and physiology course or an endocrinology course.

In this "clicker case," students learn about sex determination, meiosis, and chromosomal "crossing over" through the story of Santhi Soundararajan, an athlete from Kathakkurichi, India, who was stripped of a medal at the 2006 Asian Games after failing to pass a sex test. The case is called a clicker case because it combines the use of student personal response systems (clickers) with case teaching methods and formats. The case itself is a PowerPoint presentation (~2 MB) shown in class that is punctuated by questions students respond to using their clickers. It can be adapted for use without these technologies. Developed for an introductory biology class for both majors and non-majors, the case could also be used in an anatomy and physiology course or an endocrinology course.

Hyper-IgM syndrome is an X-linked genetic disorder more commonly affecting males than females. It is caused by the lack of heavy chain class-switching from IgM to other isotypes. Patients with hyper-IgM syndrome are susceptible to a variety of infections as demonstrated in this medical case study. Students are presented patient information, symptoms and a diagnosis that must be interpreted. The case was written for use with the team-based learning (TBL) format involving groups of 4-5 students per group, but it could also be completed as an individual project. The case is targeted to premedical/allied health advanced students and is appropriate for any immunology course at the undergraduate or graduate level in a biomedical science program, or health-related professional courses such as advanced physiology, pathophysiology, microbiology, or histology and cytology.

This interrupted case study tells the story of Miles, a freshman in college, who volunteers to help with the composting program on campus. Miles is excited about composting but his mother is hesitant to try it at home. Miles learns about the key ingredients for successful composting and his mother eventually begins to see its value. This case is presented in four parts, and can be used with or without the PowerPoint presentation and associated clicker questions (see Supplemental Materials). First, students are asked to analyze waste that they generate at home and identify any material that is compostable. Next, students explore the science of composting. Finally, students explore the topic of human manure to consider composting to the extreme. The case was designed for an environmental science course for non-majors; no prerequisite knowledge is assumed.

This interrupted case is based on a genome wide association study (GWAS) that identified the genetic variation causing some inhabitants of the Solomon Islands to have blond hair. The case illustrates the connection between genotype and phenotype, and an application of Hardy-Weinberg equilibrium. The narrative focusses on John and his new roommate, Peter, from the Solomon Islands who happens to have dark skin and blond hair. Using thought-provoking questions students learn about the genetics and the biochemistry of the hair color trait and how a single genetic variation can influence phenotype. Is migration or mutation involved?  Upon completion of the activity students will know the source of the genetic variation that causes the blond hair phenomenon in the Solomon Islands and if it has any European origins. The case was written for an upper-level genetics course, but could also be adapted for introductory biology or for a genetics course for non-majors. An optional PowerPoint presentation with clicker questions is available for download from within the Answer Key.

This clicker case study follows a dialogue between two college students, Lucy and Dan, as they discover how alternative splicing of mRNA molecules can allow a single gene to code for multiple proteins. Dan is participating in a clinical trial for a drug that may treat his migraines by inhibiting calcitonin gene-related peptide, and Lucy is working in a summer research lab that studies the protein calcitonin. They soon realize that the two proteins are both encoded by the same gene, and through their questioning and dialogue they come to understand the phenomenon of alternative splicing. They also learn about other steps of mRNA processing and about monoclonal antibodies. This case was designed to be taught in a flipped classroom, but could easily be adapted for a more traditional classroom setting if content covered in the pre-class videos is covered during the case study instead. It was designed for an introductory-level molecular biology course, but could be adapted for higher levels by including more information about the physiology and regulatory mechanisms involved.

This case study was developed to teach students the importance of understanding the behavior of wildlife, explore the difficulty in making management decisions when the public is invested in a species, and to help students develop critical thinking and public speaking skills. Students learn about the conservation status and behavior of the black rhinoceros by reading a primary literature article and answering a series of questions. They then listen to a Radiolab podcast that explores the moral dilemma of whether it is ethically appropriate to shoot an endangered rhinoceros if the purpose is to raise conservation funds. Students are assigned one of five positions and write essays to prepare for a town hall style debate in which they examine the pros and cons of such a decision. The Radiolab podcast is based on real events, and is also representative of many ethical dilemmas that wildlife managers regularly face. This case study is appropriate for several upper division biology courses.

This case study focuses on the relationship between evolution and plasticity using a hands-on, inquiry-based approach. Students view examples from the literature that illustrate the difference between nature and nurture, or the relative contributions of genes and the environment in shaping phenotypes. Using the Trinidadian guppy system as an example, students learn about seminal work in the field in addition to exploring quantitative genetic techniques used to partition phenotypic variance between genes (G) and the environment (E). They use real data from one of the publications cited in the case to graph reaction norms illustrating GxE interactions at the family and population level. The inquiry-based approach means that students are introduced to new concepts in a stepwise fashion, and asked to develop and build their understanding using causal, explanatory evidence. The case concludes with an exercise in which students apply their knowledge to a real conservation problem in Trinidad and Tobago, where guppies are native. This case would be appropriate for an upper level biology, genetics, or evolution course.

This case study is based on the 2014 Ebola epidemic that spread to multiple highly populated countries in West Africa, making it the largest and most devastating outbreak in the history of the virus. The storyline, inspired by a compilation of factual information, unfolds through a fictional narrative wherein students play the role of an infectious disease specialist in training to learn about the techniques used in the detection, diagnosis, and management of Ebola virus outbreaks. The story is presented as an interrupted "clicker case" that combines problem-based case teaching methods with simulated biological laboratory inquiry through the use of Case It, a free molecular biology software, along with the NCBI's online bioinformatics tools and databases. Students work in groups to collaboratively explore various biological and social aspects of this infectious disease outbreak. This case was developed for senior students at the secondary level and can be modified for use in an introductory biology, microbiology, or epidemiology course at the undergraduate level.

This case study follows a young cystic fibrosis (CF) patient named Lucas. Through Lucas's story and interactions between his parents and pediatrician, students learn about the scientific background and basis of CF. By reviewing email correspondence between Lucas's parents and various doctors, students gain an overview of CF research. CF has become a model disease in certain undergraduate biology classrooms due to its relatively clear mechanism and genetic basis. This case asks students to come up with their own ideas to improve on an existing line of research - gene therapy - in treating CF. During the process, students will gain a better appreciation of the innovative nature of science and develop research skills such as finding, understanding and analyzing primary literature. The activity was originally designed for first- and second-year students as part of an extracurricular case competition, but may be used for any undergraduate biology level. The case assumes basic (high school level) knowledge of genetics, biochemistry, cell biology and physiology.

Nanotechnology Center for Learning and Teaching (NCLT) is conceived to train a nano science and technology literate workforce that can solve global problems by implementing a three-pronged strategy: 1. Publish integrated STEM instructional modules with nano-based applications; 2. Offer professional training through workshops, lectures and seminars; 3. Develop a network of multi-sector nano education communities.

"I Heart Running" is a case study in which students diagnose the cause of exercise-induced tachycardia in an otherwise healthy, 27-year-old female. The patient, Sam, is a long-distance runner and realizes that her exercising heart rate reaches over 200 beats per minute. As the story of Sam's encounters with her physician develops, students are given results from multiple laboratory tests and detailed patient background information.  Students are guided through the material with a series of questions with the ultimate goal of determining the cause of the exercise-induced tachycardia that Sam experiences. The case study is based on actual laboratory results and was designed for students in an upper-level undergraduate Human Physiology course. In this activity students will learn about heart rate, cardiovascular physiology, and oxygen carrying capacity, and factors which influence these concepts, as they try to diagnose Sam.

If you were limited to choosing only three crops to sustainably farm in an arid, inhospitable environment, what would they be and how would you decide? This interrupted case study places students in the role of a proposed self-sufficient Martian colony that requires an optimized profile of food crops. After students form small groups, they discuss the factors that affect sustainability of a food supply, determine criteria for selection of crops to grow, and rank crops using these criteria. Lists of criteria and of foodstuffs are provided, but the case can easily be transformed into a problem-based learning (PBL) case by having students research and generate their own lists. The case includes questions that walk students through the selection process and require them to explain why they chose their criteria and how those criteria apply to their chosen foods. The case is designed for undergraduate students at the introductory level in courses in astronomy/astrobiology, food science/nutrition, agricultural engineering, or any discipline where sustainability is a key theme.

This interrupted case study explores the role of cytoskeletal structures on human health, specifically on respiratory function, sperm motility, and female fertility. It follows the story of a couple struggling to conceive a child and the doctors working to help them. Students are presented with clinical histories, narrative elements, documentary-style videos, and microscopic evidence in order to determine the cause of the couple's infertility. Along the way, they learn about the three types of cytoskeletal elements and the roles these play in cellular biology and human physiology. The use of videos makes it suitable for the "flipped classroom," allowing students to prepare outside the classroom for the case study, which they then complete in class. An original video by the author on the structure and function of microtubules, microfilaments, and intermediate filaments is included. The case was developed for an introductory level general biology course and could be delivered during a unit on the cell structure and function. The case could also be used in a cell biology course.

 Students must consider the role of rumen bacteria and how genetic modification may alter the potential of these bacteria. The case engages students in learning basic principles of bacterial genetics and biotechnology as they consider how microbes and microbial processes impact the environment. The case could also be used in an introductory genetics or biotechnology course.