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Deprescribing, the cessation of long-term therapy under clinician supervision, is a fundamental technique of geriatric practice and palliative medicine to address inappropriate medication use and/or polypharmacy common among older adults with multimorbidity. Important research gaps remain whose resolution may improve approaches to deprescribing and may improve health outcomes by optimizing the goal-directed care of older adults with multiple chronic conditions. This FOA is intended to support a collaborative network to advance scientific research into techniques and outcomes of deprescribing medications for prevention and treatment of older adults with multiple chronic conditions. This network should address the scientific, safety, ethical, and logistical challenges of deprescribing trials and may incorporate focused attention to other relevant and well-justified topics, such as the risks and benefits of target medications, or alternative approaches that may substitute for the deprescribed drugs. This FOA will support the establishment and initial operations of a network over the 5-year grant period including development of collaborations, resources, and infrastructure.

This Funding Opportunity Announcement (FOA) encourages applicants to develop innovative research applications on prescription drug abuse, including research to examine the factors contributing to prescription drug abuse; to characterize the adverse medical, mental health and social consequences associated with prescription drug abuse; and to develop effective prevention and service delivery approaches and behavioral and pharmacological treatments. Applications to address these issues are encouraged across a broad range of methodological approaches including basic science, clinical, epidemiological, and health services research to define the extent of the problem of prescription drug abuse, to characterize this problem in terms of classes of drugs abused and combinations of drug types, etiology of abuse, and populations most affected (including analyses by age group, race/ethnicity, gender, and psychiatric symptomatology). Studies on individual- and patient-level factors, prescriber factors, and/or health system factors are encouraged, as are studies on all classes of prescription drugs with high abuse liability, including analgesics, stimulants, sedative/hypnotics and anxiolytics. Researchers are further encouraged to study the relationship between the prescription medication, the indication for which the medication was prescribed (e.g., pain, sleep disorder, anxiety disorder, obesity), and the environmental and individual factors contributing to abuse.

The Communities Building Healthier Environments for a Stronger Nation Initiative ('Communities Initiative') intends to demonstrate the effectiveness of community-based networks in improving health outcomes among racial and ethnic minority and/or other disadvantaged populations. This program seeks to improve health outcomes through the establishment of integrated networks that collaboratively employ evidence-based disease management and preventive health activities; build the capacity of communities to address social determinants and barriers to healthcare access; and increase access to and utilization of preventive health care, medical treatment, and supportive services. The Communities Initiative specifically targets the unmet healthcare and supportive service needs of racial and ethnic minority populations at highest risk for poorer health outcomes. Health services provided under the Communities Initiative will not be denied to any person based on race, color, or national origin. Populations at highest risk include, but are not limited to, individuals who are newly diagnosed and lack a medical home; individuals who experience difficulty in adhering to a prescribed medical treatment plan; individuals with a chronic disease that is not well managed; and individuals that are unstably housed. Specific health areas to be addressed by the Communities Initiative include asthma, cardiovascular disease, diabetes, HIV/AIDS, Hepatitis B or C, obesity/overweight, and mental disorders. Community health programs are required to address social determinants of health, and improve coordination of health, social, and supportive services to significantly improve health outcomes among minority and/or disadvantaged communities. Applicants must choose two but no more than three chronic conditions

With support from the Gordon and Betty Moore Foundation, researchers from the Johns Hopkins School of Nursing (JHSON), Duke University Margolis Center for Health Policy, University of Michigan Medical School and the Society for Medical Decision Making (SMDM) have partnered to catalyze innovative COVID-19 decision models for rapid uptake and impact. The COVID Decision Modeling Initiative (CDMI) will support the development of decision models to inform the urgent needs of decision makers responding to the Covid-19 pandemic. CDMI has several specific goals to facilitate responsive decision modeling research: Determine key priorities and critical questions where decision modeling can support better decisions and outcomes during the COVID-19 pandemic Implement grant making program to fund 6-10 projects with rapid impact potential Leverage Society for Medical Decision Making (SMDM) repository of models and network of decision modelers addressing COVID-19 To optimize success of decision modeling projects funded for rapid impact, the research team will coordinate efforts from their institutions along with the SMDM COVID-19 Modeling Special Committee to provide connectivity between decision makers and decision modelers and disseminate the combined CDMI results to the public at large. Johns Hopkins University will administer 6-10 agreements to recipients for decision modeling projects with anticipated impact within 4-6 months from start date.

Competitive applications will focus on studies that achieve one or more of the following goals: - Characterize disease progression for people with Parkinson's - Evaluate the utility of different instruments and/or instrument sub-items in measuring burden of disease, especially in individuals within the first two (2) years of Parkinson's diagnosis - Identify the role of pharmacological, medical device and/or non-medical interventions on managing Parkinson's symptoms and long-term health outcomes - Predict the future health status of participants without Parkinson's based on disease risk variables and model their likelihood of developing Parkinson's - Determine elements of disease experience that drive patient preference and risk tolerance - Explore the factors that affect volunteer compliance and completeness of participation in an online study - Determine how economic factors, patient-physician communication and lifestyle factors influence medical treatment and long-term health outcomes in people with Parkinson's - Analyst's choice: Researchers can submit their own analysis topics based on available Fox Insight data especially as it relates to longitudinal analyses

CMF works to improve health care outcomes through grant funding of: * Programs and initiatives that improve patient safety and quality of care through education and training of health care professionals or through systems changes and improvements; * Pilot programs that are designed to reduce medical errors; and * Development and implementation of checklists and other tools to improve disease management and transitions in care. The 2021 focus area is fragmentation across care settings. Breakdowns in care from a fragmented healthcare system can lead to readmissions, missed diagnoses, medication errors, delayed treatment, duplicative testing and procedures, and reduction in quality of care leading to general patient and provider dissatisfaction. Healthcare organizations must collaborate with each other and decide how to transfer information about patients they share. For example, health information technology can help providers share information about their patients. Organizations must devise strategies to "close the loop" and ensure that providers are aware of and address actionable patient information, such as test results.

The Department of Defense Peer Reviewed Orthopaedic Research Program (PRORP) is administered by the US Army Medical Research and Materiel Command (USAMRMC) through the Office of the Congressionally Directed Medical Research Programs (CDMRP). Congressional funds for the FY13 PRORP have not yet been appropriated, and this document is not to be construed as an obligation by the Government; there is no guarantee of funding for the program. However, the PRORP anticipates releasing program announcements in February 2013, and the information provided in this pre-announcement is intended to allow investigators time to plan and develop applications. Focus Areas: The FY13 PRORP plans to solicit research applications that address the following focus areas, which are subject to change. Information on the final focus areas and the award mechanisms to which they correspond will be included in the program announcements when they are posted

BARDA encourages the advanced research, development and acquisition of medical countermeasures such as vaccines, therapeutics, and diagnostics, as well as innovative approaches to meet the threat of Chemical, Biological, Radiological and Nuclear (CBRN) agents in support of the preparedness mission and priorities of the HHS Public Health Emergency Medical Countermeasures Enterprise (PHEMCE) articulated in the 2014 PHEMCE Implementation Plan for CBRN Threats. 

NineSigma, representing a multi-billion-dollar medical instruments manufacturer, is looking for development partners to realize next-generation balloon catheters. The main development object involves balloon parts that act as components for balloon catheters. The client seeks technology that resolves the challenges of pressure resistance, flexibility, etc., and that is applicable to the field of medical instruments. The client also widely welcomes materials, structural designs, manufacturing methods, etc., that are used in other fields.

The purpose of this Funding Opportunity Announcement (FOA) is to invite cooperative agreement applications for research that advances promising compounds through the drug development pipeline for the treatment of Alcohol Use Disorder (AUD). NIAAA is seeking applications for medications development research projects from both for-profit and not-for-profit entities, including academic institutions, pharmaceutical and biotechnology companies, private and public foundations, small businesses not eligible for the SBIR/STTR program and single entities able to demonstrate significant resource commitment to the proposed project. A resource commitment from a single entity could, for example, consist of salary support for key personnel or production and formulation of clinical trial material. The aim of this FOA is to move candidate compounds through Investigational New Drug (IND) requirements, Phase 1 human safety, tolerability, and dosing studies, and Phase 2 human laboratory and proof-of-concept trials. Within these phases of drug development, each proposed project should have a defined entry and exit point.  Finally, this FOA will support animal studies to prove efficacy if the candidate compound is patentable and has a plausible path to commercialization.  Applicants are strongly encouraged to contact the NIAAA Division of Medications Development Staff prior to submitting to this FOA. 

The purpose of this Funding Opportunity Announcement (FOA) is to support a national network of research centers for development of effective and comprehensive medical countermeasures applicable to all subsets of the civilian population in the event of radiological or nuclear emergencies. Applications are sought that propose multidisciplinary basic and translational research to support the development of new medical products that will assess, diagnose, mitigate and/or treat the short-, delayed- and long-term consequences of radiation exposure during and following a radiation public health emergency (e.g. a radiological/nuclear terrorist incident or accident). The goals of this FOA are to: 1) develop new techniques and devices to measure radiation exposure in the human body; 2) follow biomarkers of tissue damage and recovery; and 3) further develop existing (e.g. products in clinical use) as well as novel therapies to minimize tissue damage, hasten tissue recovery, restore normal physiological function, and improve survival.

Founded in 2009 by two sisters from Brooklyn, the Tell Every Amazing Lady (T.E.A.L.) About Ovarian Cancer Louisa M. McGregor Ovarian Cancer Foundation works to drive medical research, provide survivor support, and promote public awareness and education of the signs, symptoms, and risk factors of ovarian cancer. To that end, the foundation is accepting applications for its 2019 Medical Research Program. Through the program, grants of up to $40,000 will be awarded to investigators working to advance research on ovarian cancer. To be eligible, applicants must be affiliated with a nonprofit institution in the United States.

This is the renewal of a Funding Opportunity Announcement (FOA), issued by NICHD, NINDS, NIBIB, NIDCD, and NINR, National Institutes of Health, to invite grant applications from institutions/organizations that propose to build a research infrastructure center to promote external collaboration with the medical rehabilitation community. The aim of this FOA is to create a national network of research centers that provide access to collateral expertise in biomedical, behavioral, engineering, and/or psychosocial fields that are particularly relevant to medical rehabilitation research and the needs of people with chronic physical disabilities. Specifically, the NIH is interested in addressing gaps in the rehabilitation research portfolio and is particularly interested in the following high-priority areas: pediatric rehabilitation; personalized medicine approaches; family, caregiver, and community support; implementation and dissemination research; clinical trial design and combinatorial therapies; strategies to explore and validate combination therapies; and, technology to track real-world outcomes.

With this solicitation, NIJ seeks proposals to strengthen the medical examiner/coroner (ME/C) system in the United States. Through this program, NIJ will support grants in two focus areas by: (1) Supporting forensic pathology fellowships; and (2) Providing resources necessary for medical examiner and coroner offices to achieve accreditation. Statutory Authority: Any awards under this solicitation would be made under statutory authority provided by a full-year appropriations act for FY 2018. As of the writing of this solicitation, the Department of Justice is operating under a short-term "Continuing Resolution"; no full-year appropriation for the Department has been enacted for FY 2018.

The Harold Amos Medical Faculty Development Program was established by the Robert Wood Johnson Foundation to increase the number of faculty from historically disadvantaged backgrounds who can achieve senior rank in academic medicine and dentistry and who will encourage the development of future physicians and dentists from similar backgrounds. The program defines the term "historically disadvantaged" to mean the challenges facing individuals because of their race, ethnicity, socioeconomic status, or similar factors. In 2018, the program will award up to ten four-year postdoctoral research. Recipients will receive an annual stipend of up to $75,000 each, complemented by a $30,000 annual grant toward support of research activities.

The Substance Abuse and Mental Health Services Administration (SAMHSA), Center for Substance Abuse Treatment (CSAT), is accepting applications for fiscal year (FY) 2018 Targeted Capacity Expansion: Medication Assisted Treatment - Prescription Drug and Opioid Addiction (Short Title: MAT-PDOA) grants. The purpose of this program is to expand/enhance access to medication-assisted treatment (MAT) services for persons with an opioid use disorder (OUD) seeking or receiving MAT. This program's focus is on funding organizations and tribes/tribal organizations within states identified as having the highest rates of primary treatment admissions for heroin and opioids per capita and includes those states with the most dramatic increases for heroin and opioids, based on SAMHSA's 2015 Treatment Episode Data Set (TEDS). The desired outcomes include: 1) an increase in the number of individuals with OUD receiving MAT 3) a decrease in illicit opioid drug use and prescription opioid misuse at six-month follow-up.

HRSA is pleased to provide this funding opportunity announcement (FOA) for the Targeted Issues Demonstration Projects.  Support is available from the Division of Child, Adolescent, and Family Health (DCAFH), part of the Maternal and Child Health Bureau (MCHB) of the Health Resources and Services Administration (HRSA) in the U.S. Department of Health and Human Services (HHS).  Please read the entire FOA carefully before completing the application. The Emergency Medical Services for Children (EMSC) program works to ensure that critically ill and injured children receive optimal pediatric emergency care.  This FOA for the Targeted Issues grants is intended to invite applications that will improve the care provided by Emergency Medical Services (EMS) providers for critically ill and injured children.  Applicants should address specific needs in the field of prehospital pediatric emergency care that transcend State boundaries.

HIV+ alcohol users remain an underserved group at high risk for medication non-adherence and rapid disease progression, medication toxicities, organ failure, and poor viremic control leading to increased risk of transmission and premature death. It has been estimated that the effective implementation of alcohol interventions for HIV+ individuals may reduce the rates of new infections by nearly 20% and extend life by up to 15 years in some at-risk and patient populations respectively. This new initiative seeks to advance knowledge of the effective implementation and comparative effectiveness of alcohol-focused interventions among HIV+ individuals. Multiple factors need to be investigated, including potentially important patient and provider characteristics, and the organizational, financial, and structural factors that facilitate or inhibit the delivery of evidence-based services for HIV+ individuals with a range of alcohol use disorders. The overall goal is to inform clinical decision-making that will enhance treatment outcomes and reduce harms associated with interventions for HIV+ individuals with alcohol use disorders. This solicitation is divided into two parts, one or both of which an applicant may choose to address. These parts include: 1) comparative effectiveness research focused on understanding factors related to patient engagement in appropriate alcohol and HIV care and retention in treatment; and 2) modeling and testing alternative approaches to the implementation of effective interventions to reduce HIV disease transmission and progression. This announcement addresses the need to further develop patient- centered approaches for making informed health care decisions and to improve research on health care delivery and outcomes.

HIV+ alcohol users remain an underserved group at high risk for medication non-adherence and rapid disease progression, medication toxicities, organ failure, and poor viremic control leading to increased risk of transmission and premature death. It has been estimated that the effective implementation of alcohol interventions for HIV+ individuals may reduce the rates of new infections by nearly 20% and extend life by up to 15 years in some at-risk and patient populations respectively. This new initiative seeks to advance knowledge of the effective implementation and comparative effectiveness of alcohol-focused interventions among HIV+ individuals. Multiple factors need to be investigated, including potentially important patient and provider characteristics, and the organizational, financial, and structural factors that facilitate or inhibit the delivery of evidence-based services for HIV+ individuals with a range of alcohol use disorders. The overall goal is to inform clinical decision-making that will enhance treatment outcomes and reduce harms associated with interventions for HIV+ individuals with alcohol use disorders. This solicitation is divided into two parts, one or both of which an applicant may choose to address. These parts include: 1) comparative effectiveness research focused on understanding factors related to patient engagement in appropriate alcohol and HIV care and retention in treatment; and 2) modeling and testing alternative approaches to the implementation of effective interventions to reduce HIV disease transmission and progression. This announcement addresses the need to further develop patient- centered approaches for making informed health care decisions and to improve research on health care delivery and outcomes.

Malawi faces chronic shortages, skill mix imbalances, and uneven geographical distribution of professionally qualified health workers such as medical doctors, clinical officers, nurse midwives, and allied health professionals. The purpose of this Funding Opportunity Announcement (FOA) is to provide technical assistance (TA) to the Government of Malawi in support of the national HIV response through the secondment of technical assistance (Technical assistants recruited and posted to requesting institutions to continue support to the HIV program (TA positions for Care and Treatment, Logistics and Supply Chain, Monitoring and Evaluation)) to the Ministry of Health (MOH) and other organizations, implementation of a fellowship program to develop technical and leadership capacity for HIV program management, provision of technical assistance to regulatory bodies (Medical Council of Malawi, Nurses and Midwives Council of Malawi and Pharmacy Medicines and Poisons Board), and improvement of the quality of in-service and pre-service education for critical health worker cadres in collaboration with Ministry of Health and training institutions under the University of Malawi and the Christian Health Association of Malawi (CHAM). Key outcomes of this program include the development and dissemination of technical guidelines, teaching materials, and tools for curricula strengthening. Teaching sites will be appropriately equipped and staffed. Capacity gaps in national programs will be addressed through the recruitment and deployment of technical assistants & fellows. In addition, the roles of regulatory bodies in education will be strengthened through the provision of technical assistance