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The National Institutes of Health (NIH) Office of the Associate Director for Data Science (ADDS) announces a collaboration with the Wellcome Trust (WT) and the Howard Hughes Medical Institute (HHMI) to launch the ``Open Science Prize'' (the ``Challenge'') to encourage and support the prototyping and development of services, tools and/or platforms that enable open content--including publications, datasets, code and other research outputs--to be discovered, accessed and re-used in ways that will advance research, spark innovation, and generate new societal benefits. The Challenge is necessary to accelerate the field of ``open'' biomedical research beyond what current funding mechanisms can achieve.

The Office of Energy Efficiency and Renewable Energy (EERE), within the U.S. Department of Energy (DOE), invests in high-risk, high-value research, development and deployment in energy efficiency and renewable energy technologies. EERE, through the Building Technologies Office (BTO) seeks to develop technologies, techniques, and tools for making buildings more energy efficient, productive, and affordable. BTO's strategic goal is to significantly improve the energy efficiency of new and existing buildings to reduce national energy demand and allow the nation to work toward greater energy independence and a cleaner environment. This Funding Opportunity Announcement (FOA) is targeted specifically at research to increase energy savings and reduce consumer bills through improved compliance with building energy codes. The first and largest topic area for this FOA is to develop and test a methodology for identifying the commercial energy code requirements that can provide the maximum cost-effective energy and cost savings through increased compliance. The methodology will be tested in selected building types and climate zones. Quantifying those savings will create the foundations of a business case for private investors, particularly utilities, to fund programs aimed at increasing compliance. The empirical data to support such an investment does not currently exist.

The purpose of the NOAA Research to Operations (R2O) Initiative is to expand and accelerate critical weather forecasting research to operations to address growing service demands and increase the accuracy of weather forecasts. This will be achieved through: (1) accelerated development and implementation of improved global weather prediction models, and inclusion of the coupling of atmosphere, ocean, wave, land surface and ice system components; (2) improved data assimilation techniques; (3) nested regional prediction capabilities; (4) improved hurricane and tropical cyclone modeling techniques; (5) improved ensemble techniques; (6) post-processing forecast tools and techniques; and (7) improved software architecture and system engineering.

The Paralyzed Veterans of America Education Foundation helps develop tools that share spinal cord injury and disease (SCI/D) knowledge and improve the lives of those with SCI/D. The sponsor provides support for demonstration projects that improve the identification, selection, and use of assistive devices by people with SCI/D.

The Division of Materials Research (DMR), the Division of Mathematical Sciences (DMS), the Division of Electrical, Communications and Cyber Systems (ECCS), and the Office of Advanced Cyberinfrastructure (OAC) seek to rapidly accelerate quantum materials design, synthesis, characterization, and translation of fundamental materials engineering and information research for quantum devices, systems, and networks. The new program of Enabling Quantum Leap: Convergent Accelerated Discovery Foundries for Quantum Materials Science, Engineering, and Information (Q-AMASE-i) aims to support these goals by establishing Foundries with mid-scale infrastructure for rapid prototyping and development of quantum materials and devices. The new materials, devices, tools and methods developed by Q-AMASE-i will be shared with the science and engineering communities through a Foundry-operated network. Technology transfer of Foundry activities will be enabled by close cooperation with industrial partners.

The Office ofAdvanced Cyberinfrastructure (OAC) supports translational research and education activities in all aspects of advanced cyberinfrastructure (CI) that lead to deployable, scalable, and sustainable systems capable of transforming science and engineering research. Advanced CI includes the spectrum of computational, data, software, networking, and security resources, tools, and services, along with the computational and data skills and expertise, that individually and collectively can transform science and engineering. OAC supports advanced CI research to address new CI frontiers for discovery leading to major innovations, and supports the development and deployment processes, as well as expert services, necessary for realizing the research CI that is critical to the advancement of all areas of science and engineering research and education. OAC research investments are characterized by their translational nature, i.e., building on basic research results and spanning the design to practice stages. They are further characterized by one or more of the following key attributes: multi-disciplinary, extreme-scale, driven by science and engineering research, end-to-end, and deployable as robust research CI. Areas of translational research supported by OAC include systems architecture and middleware for extreme-scale systems, scalable algorithms and applications, and the advanced CI ecosystem. Principal investigators (PIs) are strongly encouraged to contact an OAC cognizant program director listed in this solicitation with a 1-page project summary for further guidance. For foundational computer and information science and engineering research, PIs are referred to the core research programs of the Computer and Communication Foundations (CCF), Computer and Network Systems (CNS), and Information and Intelligent Systems (IIS) divisions of CISE. Proposers are invited to submit proposals in one project class, which is defined as follows:

The Office of Advanced Cyberinfrastructure (OAC) supports translational research and education activities in all aspects of advanced cyberinfrastructure (CI) that lead to deployable, scalable, and sustainable systems capable of transforming science and engineering research. Advanced CI includes the spectrum of computational, data, software, networking, and security resources, tools, and services, along with the computational and data skills and expertise, that individually and collectively can transform science and engineering. OAC supports advanced CI research to address new CI frontiers for discovery leading to major innovations, and supports the development and deployment processes, as well as expert services, necessary for realizing the research CI that is critical to the advancement of all areas of science and engineering research and education.

NHGRI invites applications for research developing comparative approaches that can be used to understand genome structure and function and the relationship between genomic features and phenotypes. This program supports studies that enable the use of a diverse array of species to advance our ability to understand basic biological processes related to human health and disease, as well as studies that develop novel analytical tools and resources for the comparative genomics research community.

The overall goal of the Three Dimensional Monolithic System-on-a-Chip (3DSoC) program is to develop 3D monolithic technology that will enable > 50X improvement in SOC digital performance at power. 3DSOC aims to drive research in process, design tools, and new compute architectures for future designs while utilizing U.S. fabrication capabilities. The goal of the Foundations Required for Novel Compute (FRANC) program is to define the foundations required for assessing and establishing the proof of principle for beyond von Neumann compute architectures. FRANC will seek to demonstrate prototypes that quantify the benefits of such new computing architectures.

The Solar Energy Technologies Office (SETO), in the Office of Energy Efficiency and Renewable Energy (EERE) of the U.S. Department of Energy (DOE), is requesting input on integrated data and analysis needs across the solar value chain to inform near to mid-term plans for the development of information based network planning, real time optimization, and bankability tools in the context of the SunShot 2030 goals. SETO aims to better understand the information-related problems and questions that exist for key stakeholders, including manufacturers, project developers, financiers, engineering procurement and construction businesses, state and local jurisdictions, researchers, analysts, and others supporting the technological advancement and wide scale adoption of solar technology. All submissions must be submitted via solaranalysis@ee.doe.gov.

The Home Depot Foundation is accepting applications from nonprofit organizations using volunteers to address the physical needs of their communities. Through its Community Impact Grants program, the foundation will award grants of up to $5,000 (in the form of Home Depot gift cards that can be used to purchase tools, materials, and services) for projects aimed at repairing, modifying, weatherizing, or otherwise improving low-income and/or transitional housing or community facilities. Priority will be given to programs that use volunteers to serve veterans with home-improvement needs. Only IRS-registered 501(c)(3) nonprofit organizations and tax-exempt public service agencies (e.g., police/fire departments) in the United States are eligible to apply. In addition, grants must support work completed by community volunteers in the U.S., and projects must be completed within six months following notification that the grant has been awarded.

The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is aimed at revolutionizing neuroscience through development and application of innovative technologies to map neural circuits, monitor and modulate their activity, and understand how they contribute to thoughts, sensations, emotions and behavior. NIH has issued a variety of Funding Opportunity Announcements (FOAs) that will support projects that apply technologies to understand neural circuit function in the context of specific circuits, resulting in a diverse portfolio of research into the fundamental biology of nervous system function. The purpose of this announcement is to notify the research community that NIH welcomes BRAIN Initiative applications targeting central nervous system nociceptive and pain circuits, as appropriate to the goals and requirements of specific BRAIN Initiative FOAs. Pain conditions represent an important public health problem and NIH continues to support research into pain pathologies through normal Institute and Center appropriations. However, pain and nociception are also components of normal nervous system function, and the BRAIN Initiative is committed to understanding pain circuits along with brain circuits underlying other sensory, motor, cognitive and emotional functions. It is expected that the unique opportunities of the BRAIN Initiative will enable production of detailed maps of pain circuits, and the adoption of powerful new tools for monitoring and modulating pain circuit activity, leading to significant advances in the understanding of pain and nociception. For a list of past and open BRAIN Initiative FOAs, see https://braininitiative.nih.gov/funding/.

NHGRI invites applications for research developing comparative approaches that can be used to understand genome structure and function and the relationship between genomic features and phenotypes. This program supports studies that enable the use of a diverse array of species to advance our ability to understand basic biological processes related to human health and disease, as well as studies that develop novel analytical tools and resources for the comparative genomics research community.

AR is an immersive technology which combines virtual computer-generated information with the real environment in the real-time performance, enhancing the user's perception of reality and enriching the provided information content. Such information can assist project managers and engineers with the delivery and accuracy of their construction projects, safer and in a timely manner resulting in greater efficiency. With the capability of navigating through all phases of a construction project, managers would be able to catch any errors or mistakes before they present themselves or change and augment the design and construction details. They may also be able to use these tools for training or project outreach. Considering its benefits and success in the entertainment and video game industries, leveraging AR could be the next big development in construction management of highway infrastructure assets.

The Federal Highway Administration (FHWA) hereby requests applications for assistance to result in the award of a Cooperative Agreement (Agreement), entitled "Development and Deployment of Innovative Asphalt Pavement Technologies." The purpose of this proposed Agreement is to stimulate, facilitate, and expedite the deployment and rapid adoption of new and innovative technology relating to the design, production, testing, control, construction, and investigation of asphalt pavements. The proposed project is a cooperative effort between the FHWA and the Recipient to improve the quality and performance of asphalt pavements. Products shall include developing marketing/implementation plans, engaging subject matter experts to aid in conducting forensic investigations pertaining to deployment and in the refinement of specifications and practices, developing web-based training tools, marketing of case studies, data analysis, market analysis, specification tracking, compilation of findings, and supporting stakeholder engagement. This effort will leverage the unique technology capabilities and facilities of the Recipient with FHWA's mission.

The purpose of this Funding Opportunity Announcement (FOA) is to invite Cooperative Agreement (U01) applications for the development of enabling informatics technologies to improve the acquisition, management, analysis, and dissemination of data and knowledge across the cancer research continuum including cancer biology, cancer treatment and diagnosis, cancer prevention, cancer control and epidemiology, and/or cancer health disparities. As a component of the NCI's Informatics Technology for Cancer Research (ITCR) Program, this FOA focuses on early-stage development from prototyping to hardening and adaptation. Early-stage development is defined for the purpose of this FOA as the initial development or the significant modification of existing tools for new applications. The central mission of ITCR is to promote research-driven informatics technology across the development lifecycle to address priority needs in cancer research. In order to be successful, proposed development plans must have a clear rationale on why the proposed technology is needed and how it will benefit the cancer research field.

The National Science Foundation (NSF) and The Boeing Company are supporting a new initiative, managed and administered by NSF through its EHR Core Research (ECR) program, to accelerate training in critical skill areas for the Nation's engineering and advanced manufacturing workforce. The EHR Core Research: Production Engineering Education and Research (ECR: PEER) initiative supports foundational research arising from the design, development, and deployment of creative online curricula that provide learners at various levels with skills in five focal areas: model-based systems engineering, software engineering, mechatronics, data science, and artificial intelligence. ECR: PEER invites proposals to design, develop, deploy, and study the effectiveness of online courses in any one of these focal areas using the theories and tools of the learning sciences. Proposals for these ECR: PEER Course, Curriculum, and Evaluation projects may request a maximum of $2,000,000 support for a duration of up to three years. Additionally, ECR: PEER welcomes proposals to convene experts in the academic, for-profit, and non-profit sectors to imagine the future of production engineering education for one of the five focal areas. Proposals for these ECR: PEER Workforce Development Workshops may request a maximum of $100,000 support for a duration of up to one year.

The purpose of this funding opportunity announcement (FOA) is to support non-commercial lab-to-user dissemination of novel, reliable imaging and bioengineering technologies, including devices, software, methods, chemical agents, etc. Proposed technologies should have been prototyped, validated, and are potentially highly impactful to the research community. However, their beyond-the-lab dissemination via commercialization or industry partnership is not anticipated. Projects should focus on transforming functioning prototypes to usable tools and delivering them to end users for high-quality research in a reliable manner. Related activities may include, but are not limited to, quality control, scale-up production, user training, and technical improvements that are within the scope of the prototyped technology and limited to applying proven techniques or existing resources. Projects that involve clinical trials, commercialization, academic-industry partnership, or service using existing equipment are not responsive to this FOA.

The National Science Foundation (NSF) seeks to further develop and nurture a national innovation ecosystem that builds upon fundamental research to guide the output of scientific discoveries closer to the development of technologies, products, processes and services that benefit society. The goal of the program is to dramatically reduce the period of time necessary to bring a promising idea from its inception to widespread implementation. Through this solicitation, NSF is seeking to expand and sustain the network of Innovation Corps (I-CorpsTM) (hereinafter I-Corps) Nodes that work cooperatively to support the development of innovations that will benefit society. NSF plans to build upon the established National Innovation Network (consisting of I-Corps Nodes and Sites) to further support the needs for innovation research, education and training. The interconnected nodes of the network are expected to be diverse in research areas, resources, tools, programs, capabilities, and geographic locations - providing the network with the flexibility to grow or reconfigure as needs arise.

The CDS&E-MSS program accepts proposals that confront and embrace the host of mathematical and statistical challenges presented to the scientific and engineering communities by the ever-expanding role of computational modeling and simulation on the one hand, and the explosion in production of digital and observational data on the other. The goal of the program is to promote the creation and development of the next generation of mathematical and statistical theories and tools that will be essential for addressing such issues. To this end, the program will support fundamental research in mathematics and statistics whose primary emphasis will be on meeting the aforementioned computational and data-related challenges. This program is part of the wider Computational and Data-enabled Science and Engineering (CDS&E) enterprise in NSF that seeks to address this emerging discipline. The research supported by the CDS&E-MSS program will aim to advance mathematics or statistics in a significant way and will address computational or big-data challenges.