The CRISP solicitation seeks to fund projects likely to produce new knowledge that can contribute to making ICI services more effective, efficient, dependable, adaptable, resilient, safe, and secure, taking into account the human systems in which they are embedded. Successful proposals are expected to study multiple infrastructures focusing on them as interdependent systems that deliver services, enabling a new interdisciplinary paradigm in infrastructure research. To meet the interdisciplinary criterion, proposals must broadly integrate across engineering, computer, information and computational science, and the social, behavioral and economic sciences.

The CRISP solicitation seeks to fund projects likely to produce new knowledge that can contribute to making ICI services more effective, efficient, dependable, adaptable, resilient, safe, and secure, taking into account the human systems in which they are embedded. Successful proposals are expected to study multiple infrastructures focusing on them as interdependent systems that deliver services, enabling a new interdisciplinary paradigm in infrastructure research. To meet the interdisciplinary criterion, proposals must broadly integrate across engineering, computer, information and computational science, and the social, behavioral and economic sciences.

Effective solutions will bring together cyberinfrastructure expertise and domain researchers, to ensure that the resulting cyberinfrastructure address researchers' data needs. The activities should address the data challenges arising in a disciplinary or cross-disciplinary context. (Throughout this solicitation, 'community' refers to a group of researchers interested in solving one or more linked scientific questions, while 'domains' and 'disciplines' refer to areas of expertise or application.) The projects should stimulate data-driven scientific discoveries and innovations, and address broad community needs, nationally and internationally.

Effective solutions will bring together cyberinfrastructure expertise and domain researchers, to ensure that the resulting cyberinfrastructure address researchers' data needs. The activities should address the data challenges arising in a disciplinary or cross-disciplinary context. (Throughout this solicitation, 'community' refers to a group of researchers interested in solving one or more linked scientific questions, while 'domains' and 'disciplines' refer to areas of expertise or application.) The projects should stimulate data-driven scientific discoveries and innovations, and address broad community needs, nationally and internationally.

In recent years, somatic cells as therapeutic agents have provided new treatment approaches for a number of pathological conditions that were deemed untreatable, or difficult to treat. Several successful cell therapies using T cells have been demonstrated for cancer and autoimmune diseases, while stem cell therapies have given relief for heart disease and stroke. Hundreds of clinical trials are ongoing to examine efficacy of cell therapies for a variety of other diseases including diabetes, Alzheimer's, Parkinson's, and Crohn's disease. Production of therapeutic cells is currently expensive and, therefore, cost prohibitive for the large number of people who might benefit from these treatments. The overarching goal of this Advanced Biomanufacturing of Therapeutic Cells (ABTC) solicitation is to catalyze well-integrated interdisciplinary research to understand, design, and control cell manufacturing systems and processes that will enable reproducible, cost-effective, and high-quality production of cells with predictable performance for the identified therapeutic function.

In recent years, somatic cells as therapeutic agents have provided new treatment approaches for a number of pathological conditions that were deemed untreatable, or difficult to treat. Several successful cell therapies using T cells have been demonstrated for cancer and autoimmune diseases, while stem cell therapies have given relief for heart disease and stroke. Hundreds of clinical trials are ongoing to examine efficacy of cell therapies for a variety of other diseases including diabetes, Alzheimer's, Parkinson's, and Crohn's disease. Production of therapeutic cells is currently expensive and, therefore, cost prohibitive for the large number of people who might benefit from these treatments. The overarching goal of this Advanced Biomanufacturing of Therapeutic Cells (ABTC) solicitation is to catalyze well-integrated interdisciplinary research to understand, design, and control cell manufacturing systems and processes that will enable reproducible, cost-effective, and high-quality production of cells with predictable performance for the identified therapeutic function.

In 2010, NSF established the Science, Engineering, and Education for Sustainability (SEES)1 investment area to lay the research foundation for decision capabilities and technologies aimed at mitigating and adapting to environmental changes that threaten sustainability. Some SEES investments advanced a systems-based approach to understanding, predicting, and reacting to stress upon, and changes in, the linked natural, social, and built environments. In this context, the importance of understanding the interconnected and interdependent systems involving food, energy, and water (FEW) has emerged. The NSF aims to specifically focus on advancing knowledge of the nitrogen and phosphorus cycles; the production and use of fertilizers for food production; and the detection, separation, and reclamation/recycling of nitrogen- and phosphorus-containing species in and from complex aqueous environments.

In 2010, NSF established the Science, Engineering, and Education for Sustainability (SEES)1 investment area to lay the research foundation for decision capabilities and technologies aimed at mitigating and adapting to environmental changes that threaten sustainability. Some SEES investments advanced a systems-based approach to understanding, predicting, and reacting to stress upon, and changes in, the linked natural, social, and built environments. In this context, the importance of understanding the interconnected and interdependent systems involving food, energy, and water (FEW) has emerged. The NSF aims to specifically focus on advancing knowledge of the nitrogen and phosphorus cycles; the production and use of fertilizers for food production; and the detection, separation, and reclamation/recycling of nitrogen- and phosphorus-containing species in and from complex aqueous environments.

ecoTech Grants were created to combat the notion that students needed to choose between "the screen" or "the green" and to encourage educators and students to explore the role technology can play in designing and implementing solutions to some of our most pressing environmental challenges. We believe that technology can present innovative ways to address environmental challenges - and that when dealing with digital natives, we do ourselves a disservice by asking them to unplug.

ecoTech Grants were created to combat the notion that students needed to choose between "the screen" or "the green" and to encourage educators and students to explore the role technology can play in designing and implementing solutions to some of our most pressing environmental challenges. We believe that technology can present innovative ways to address environmental challenges - and that when dealing with digital natives, we do ourselves a disservice by asking them to unplug.

In FY 2017, NSF is continuing a program aligned with the Improving Undergraduate STEM Education (IUSE) framework: REvolutionizing engineering and computer science Departments. This funding opportunity enables engineering and computer science departments to lead the nation by successfully achieving significant sustainable changes necessary to overcome longstanding issues in their undergraduate programs and educate inclusive communities of engineering and computer science students prepared to solve 21st century challenges.

In FY 2017, NSF is continuing a program aligned with the Improving Undergraduate STEM Education (IUSE) framework: REvolutionizing engineering and computer science Departments. This funding opportunity enables engineering and computer science departments to lead the nation by successfully achieving significant sustainable changes necessary to overcome longstanding issues in their undergraduate programs and educate inclusive communities of engineering and computer science students prepared to solve 21st century challenges.

The Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET) will consider proposals for collaborative funding with the Electric Power Research Institute (EPRI), the Water Environment & Reuse Foundation (WE&RF) [formerly the Water Environment Research Foundation], and/or the Water Research Foundation (WRF). For a proposal to be considered for collaborative funding, the proposal must be submitted to the appropriate NSF-CBET program as an unsolicited proposal during the CBET unsolicited submission window, which is October 1, 2016 - October 20, 2016. The same dates will apply in future years. Proposals will be reviewed as part of the unsolicited program(s). Proposals must follow guidelines for the CBET program to which they are submitted. Proposals will be evaluated according to the NSF criteria of intellectual merit and broader impacts.

The Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET) will consider proposals for collaborative funding with the Electric Power Research Institute (EPRI), the Water Environment & Reuse Foundation (WE&RF) [formerly the Water Environment Research Foundation], and/or the Water Research Foundation (WRF). For a proposal to be considered for collaborative funding, the proposal must be submitted to the appropriate NSF-CBET program as an unsolicited proposal during the CBET unsolicited submission window, which is October 1, 2016 - October 20, 2016. The same dates will apply in future years. Proposals will be reviewed as part of the unsolicited program(s). Proposals must follow guidelines for the CBET program to which they are submitted. Proposals will be evaluated according to the NSF criteria of intellectual merit and broader impacts.

This funding opportunity announcement (FOA) invites applications for mentored career enhancement (K18) awards in research areas that are highly relevant to the NIH BRAIN Initiative. This career enhancement program will support development of research capability for the BRAIN Initiative, with specific emphasis on cross-training independent investigators in a substantively different area of neuroscience, neuroethics, or in a quantitative and physical discipline (e.g., physics, chemistry, engineering, computer science, mathematics); and vice versa, cross-training independent investigators trained in a quantitative or physical discipline proposing to gain in-depth training in a high-priority area of neuroscience. The research project conducted under this K18 should enhance the candidate's ability to significantly contribute to or lead projects that investigate questions central to the goals of the BRAIN Initiative. Eligible candidates are independent investigators at any faculty rank or level.

This funding opportunity announcement (FOA) invites applications for mentored career enhancement (K18) awards in research areas that are highly relevant to the NIH BRAIN Initiative. This career enhancement program will support development of research capability for the BRAIN Initiative, with specific emphasis on cross-training independent investigators in a substantively different area of neuroscience, neuroethics, or in a quantitative and physical discipline (e.g., physics, chemistry, engineering, computer science, mathematics); and vice versa, cross-training independent investigators trained in a quantitative or physical discipline proposing to gain in-depth training in a high-priority area of neuroscience. The research project conducted under this K18 should enhance the candidate's ability to significantly contribute to or lead projects that investigate questions central to the goals of the BRAIN Initiative. Eligible candidates are independent investigators at any faculty rank or level.

The CDS&E-MSS program accepts proposals that confront and embrace the host of mathematical and statistical challenges presented to the scientific and engineering communities by the ever-expanding role of computational modeling and simulation on the one hand, and the explosion in production of digital and observational data on the other. The goal of the program is to promote the creation and development of the next generation of mathematical and statistical theories and tools that will be essential for addressing such issues. To this end, the program will support fundamental research in mathematics and statistics whose primary emphasis will be on meeting the aforementioned computational and data-related challenges. This program is part of the wider Computational and Data-enabled Science and Engineering (CDS&E) enterprise in NSF that seeks to address this emerging discipline

The CDS&E-MSS program accepts proposals that confront and embrace the host of mathematical and statistical challenges presented to the scientific and engineering communities by the ever-expanding role of computational modeling and simulation on the one hand, and the explosion in production of digital and observational data on the other. The goal of the program is to promote the creation and development of the next generation of mathematical and statistical theories and tools that will be essential for addressing such issues. To this end, the program will support fundamental research in mathematics and statistics whose primary emphasis will be on meeting the aforementioned computational and data-related challenges. This program is part of the wider Computational and Data-enabled Science and Engineering (CDS&E) enterprise in NSF that seeks to address this emerging discipline

Critical infrastructures are the mainstay of our nation's economy, security and health. These infrastructures are interdependent. They are linked to individual preferences and community needs. For example, the electrical power system depends on the delivery of fuels to power generating stations through transportation services, the production of those fuels depends in turn on the use of electrical power, and those fuels are needed by the transportation services. Social networks, interactions, and policies can enable or hinder the successful creation of resilient complex adaptive systems. The goals of the Critical Resilient Interdependent Infrastructure Systems and Processes (CRISP) solicitation are to: (1) foster an interdisciplinary research community of engineers, computer and computational scientists and social and behavioral scientists, that creates new approaches and engineering solutions for the design and operation of infrastructures as processes and services; (2) enhance the understanding and design of interdependent critical infrastructure systems (ICIs) and processes that provide essential goods and services despite disruptions and failures from any cause, natural, technological, or malicious; (3) create the knowledge for innovation in ICIs so that they safely, securely, and effectively expand the range of goods and services they enable; and (4) improve the effectiveness and efficiency with which they deliver existing goods and services.

Critical infrastructures are the mainstay of our nation's economy, security and health. These infrastructures are interdependent. They are linked to individual preferences and community needs. For example, the electrical power system depends on the delivery of fuels to power generating stations through transportation services, the production of those fuels depends in turn on the use of electrical power, and those fuels are needed by the transportation services. Social networks, interactions, and policies can enable or hinder the successful creation of resilient complex adaptive systems. The goals of the Critical Resilient Interdependent Infrastructure Systems and Processes (CRISP) solicitation are to: (1) foster an interdisciplinary research community of engineers, computer and computational scientists and social and behavioral scientists, that creates new approaches and engineering solutions for the design and operation of infrastructures as processes and services; (2) enhance the understanding and design of interdependent critical infrastructure systems (ICIs) and processes that provide essential goods and services despite disruptions and failures from any cause, natural, technological, or malicious; (3) create the knowledge for innovation in ICIs so that they safely, securely, and effectively expand the range of goods and services they enable; and (4) improve the effectiveness and efficiency with which they deliver existing goods and services.

The National Science Foundation's Directorates for Engineering (ENG) and Computer and Information Science and Engineering (CISE) are coordinating efforts to identify bold new concepts to significantly improve the efficiency of radio spectrum utilization while addressing new challenges in energy efficiency and security, thus enabling spectrum access for all users and devices, and allowing traditionally underserved Americans to benefit from wireless-enabled goods and services. The SpecEES program solicitation (pronounced "SpecEase") seeks to fund innovative collaborative research that transcends the traditional boundaries of existing programs.

The National Science Foundation's Directorates for Engineering (ENG) and Computer and Information Science and Engineering (CISE) are coordinating efforts to identify bold new concepts to significantly improve the efficiency of radio spectrum utilization while addressing new challenges in energy efficiency and security, thus enabling spectrum access for all users and devices, and allowing traditionally underserved Americans to benefit from wireless-enabled goods and services. The SpecEES program solicitation (pronounced "SpecEase") seeks to fund innovative collaborative research that transcends the traditional boundaries of existing programs.

Transdisciplinary Research In Principles Of Data Science (TRIPODS) aims to bring together the statistics, mathematics, and theoretical computer science communities to develop the theoretical foundations of data science through integrated research and training activities. Phase I, described in this solicitation, will support the development of small collaborative Institutes. Phase II (to be described in an anticipated future solicitation, subject to availability of funds) will support a smaller number of larger Institutes, selected from the Phase I Institutes via a second competitive proposal process. All TRIPODS Institutes must involve significant and integral participation by all three of the aforementioned communities.

Transdisciplinary Research In Principles Of Data Science (TRIPODS) aims to bring together the statistics, mathematics, and theoretical computer science communities to develop the theoretical foundations of data science through integrated research and training activities. Phase I, described in this solicitation, will support the development of small collaborative Institutes. Phase II (to be described in an anticipated future solicitation, subject to availability of funds) will support a smaller number of larger Institutes, selected from the Phase I Institutes via a second competitive proposal process. All TRIPODS Institutes must involve significant and integral participation by all three of the aforementioned communities.

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative research proposals in the areas of physical sciences, engineering, materials, mathematics, biology, computing, informatics, social science, and manufacturing of interest to DARPA's Defense Sciences Office (DSO), Microsystems Technology Office (MTO), and Biological Technologies Office (BTO).

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative research proposals in the areas of physical sciences, engineering, materials, mathematics, biology, computing, informatics, social science, and manufacturing of interest to DARPA's Defense Sciences Office (DSO), Microsystems Technology Office (MTO), and Biological Technologies Office (BTO).

The Office of Science (SC) of the Department of Energy hereby announces its continuing interest in receiving grant applications for support of work in the following program areas: Advanced Scientific Computing Research, Basic Energy Sciences, Biological and Environmental Research, Fusion Energy Sciences, High Energy Physics, and Nuclear Physics.

The Office of Science (SC) of the Department of Energy hereby announces its continuing interest in receiving grant applications for support of work in the following program areas: Advanced Scientific Computing Research, Basic Energy Sciences, Biological and Environmental Research, Fusion Energy Sciences, High Energy Physics, and Nuclear Physics.

This FOA has two components, A and B. Component A: To support a 5-year multi-center research network of innovative, non-health system-based, natural experiments approaches to alter the diabetogenic characteristics of US communities. Priority areas include population-level approaches to the promotion of healthy eating and active living by evaluating the impact of environmental and policy interventions on population-level risk factors for diabetes. Component B: To fund a Central Coordinating Center (CCC) to provide organizational, logistic and communication support to enhance the efficiency, productivity, and impact of the Natural Experiments research centers that are funded as part of Component A.

This FOA has two components, A and B. Component A: To support a 5-year multi-center research network of innovative, non-health system-based, natural experiments approaches to alter the diabetogenic characteristics of US communities. Priority areas include population-level approaches to the promotion of healthy eating and active living by evaluating the impact of environmental and policy interventions on population-level risk factors for diabetes. Component B: To fund a Central Coordinating Center (CCC) to provide organizational, logistic and communication support to enhance the efficiency, productivity, and impact of the Natural Experiments research centers that are funded as part of Component A.

The Greenwall Foundation is soliciting Letters of Intent for its Greenwall Faculty Scholars Program in Bioethics, a career development award designed to enable junior faculty members to carry out innovative bioethics research. Each year, around three Greenwall Faculty Scholars are selected to receive 50 percent salary support for three years to enable them to develop their research program. The program supports research focused on resolving pressing ethical issues in clinical care, biomedical research, and public policy. Scholars and alumni attend twice-yearly meetings, where they present their work in progress, receive feedback and mentoring from the Faculty Scholars Program Committee and other scholars, and have the opportunity to develop collaborations with other researchers. The ongoing involvement of alumni with the program provides them ongoing opportunities for professional development and feedback and engages them in mentoring of younger scholars.

The Greenwall Foundation is soliciting Letters of Intent for its Greenwall Faculty Scholars Program in Bioethics, a career development award designed to enable junior faculty members to carry out innovative bioethics research. Each year, around three Greenwall Faculty Scholars are selected to receive 50 percent salary support for three years to enable them to develop their research program. The program supports research focused on resolving pressing ethical issues in clinical care, biomedical research, and public policy. Scholars and alumni attend twice-yearly meetings, where they present their work in progress, receive feedback and mentoring from the Faculty Scholars Program Committee and other scholars, and have the opportunity to develop collaborations with other researchers. The ongoing involvement of alumni with the program provides them ongoing opportunities for professional development and feedback and engages them in mentoring of younger scholars.

The purpose of this Funding Opportunity Announcement (FOA) is to encourage small businesses to address the technological needs of the Kidney Precision Medicine Project (KPMP). The KPMP will obtain and evaluate kidney biopsies from participants with acute kidney injury (AKI) and chronic kidney disease (CKD), create a kidney tissue atlas, define disease subgroups, and identify critical cells, pathways and targets for novel therapies. Proposed technologies are expected to improve the safety of the human kidney biopsy or enhance interrogation of human kidney tissue, thus ensuring that the kidney biopsy yields useful research or clinical information.

The purpose of this Funding Opportunity Announcement (FOA) is to encourage small businesses to address the technological needs of the Kidney Precision Medicine Project (KPMP). The KPMP will obtain and evaluate kidney biopsies from participants with acute kidney injury (AKI) and chronic kidney disease (CKD), create a kidney tissue atlas, define disease subgroups, and identify critical cells, pathways and targets for novel therapies. Proposed technologies are expected to improve the safety of the human kidney biopsy or enhance interrogation of human kidney tissue, thus ensuring that the kidney biopsy yields useful research or clinical information.

Understanding the dynamic activity of neural circuits is central to the NIH BRAIN Initiative.  This FOA seeks applications for proof-of-concept testing and development of new technologies and novel approaches for large scale recording and manipulation of neural activity to enable transformative understanding of dynamic signaling in the nervous system.  In particular, we seek exceptionally creative approaches to address major challenges associated with recording and manipulating neural activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain.  It is expected that the proposed research may be high-risk, but if successful could profoundly change the course of neuroscience research.

Understanding the dynamic activity of neural circuits is central to the NIH BRAIN Initiative.  This FOA seeks applications for proof-of-concept testing and development of new technologies and novel approaches for large scale recording and manipulation of neural activity to enable transformative understanding of dynamic signaling in the nervous system.  In particular, we seek exceptionally creative approaches to address major challenges associated with recording and manipulating neural activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain.  It is expected that the proposed research may be high-risk, but if successful could profoundly change the course of neuroscience research.

The Emerging Frontiers in Research and Innovation (EFRI) program of the NSF Directorate for Engineering (ENG) serves a critical role in helping ENG focus on important emerging areas in a timely manner. This solicitation is a funding opportunity for interdisciplinary teams of researchers to embark on rapidly advancing frontiers of fundamental engineering research. For this solicitation, we will consider proposals that aim to investigate emerging frontiers in the following two research areas: -Advancing Communication Quantum Information Research in Engineering (ACQUIRE) -New Light, EM (Electronic) and Acoustic Wave Propagation: Breaking Reciprocity and Time-Reversal Symmetry (NewLAW) EFRI seeks proposals with transformative ideas that represent an opportunity for a significant shift in fundamental engineering knowledge with a strong potential for long term impact on national needs or a grand challenge.The proposals must also meet the detailed requirements delineated in this solicitation.

The Emerging Frontiers in Research and Innovation (EFRI) program of the NSF Directorate for Engineering (ENG) serves a critical role in helping ENG focus on important emerging areas in a timely manner. This solicitation is a funding opportunity for interdisciplinary teams of researchers to embark on rapidly advancing frontiers of fundamental engineering research. For this solicitation, we will consider proposals that aim to investigate emerging frontiers in the following two research areas: -Advancing Communication Quantum Information Research in Engineering (ACQUIRE) -New Light, EM (Electronic) and Acoustic Wave Propagation: Breaking Reciprocity and Time-Reversal Symmetry (NewLAW) EFRI seeks proposals with transformative ideas that represent an opportunity for a significant shift in fundamental engineering knowledge with a strong potential for long term impact on national needs or a grand challenge.The proposals must also meet the detailed requirements delineated in this solicitation.

Funding Opportunity Announcement DE-FOA-0001616 The Department of Energy (DOE), National Energy Technology Laboratory (NETL), on behalf of the Office of Electricity Delivery and Energy Reliability (OE), is seeking applications under this Funding Opportunity Announcement (FOA), herein referred to as Announcement, to conduct research, development and demonstrations (RD&D). This RD&D, in the areas of low cost sensors and improved modeling using sensor data input, will lead to enhanced observability and controllability of power systems to support increased hosting capacity for distributed energy resources (DERs), including energy storage. Capturing the benefits commonly attributed to DERs and/or microgrids, as well as establishing new value propositions that could be enabled by these RD&D efforts is the focus of this FOA. New value propositions could include, but are not limited to, mitigating ancillary resource requirements and meeting the growing demand for reliable and resilient grid operations against outages under all-hazards conditions.

Funding Opportunity Announcement DE-FOA-0001616 The Department of Energy (DOE), National Energy Technology Laboratory (NETL), on behalf of the Office of Electricity Delivery and Energy Reliability (OE), is seeking applications under this Funding Opportunity Announcement (FOA), herein referred to as Announcement, to conduct research, development and demonstrations (RD&D). This RD&D, in the areas of low cost sensors and improved modeling using sensor data input, will lead to enhanced observability and controllability of power systems to support increased hosting capacity for distributed energy resources (DERs), including energy storage. Capturing the benefits commonly attributed to DERs and/or microgrids, as well as establishing new value propositions that could be enabled by these RD&D efforts is the focus of this FOA. New value propositions could include, but are not limited to, mitigating ancillary resource requirements and meeting the growing demand for reliable and resilient grid operations against outages under all-hazards conditions.