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MiamiOH OARS

The Role of Epitranscriptomics in Development and Disease (R01 - Clinical Trial Not All... - 0 views

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    The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications from the scientific community to support outstanding research in the area of epitranscriptomics, i.e., the chemical modifications of RNA. Evidence is accumulating that RNA modifications regulate the function of both coding and noncoding RNAs, suggesting that these modifications are involved in both development, and in health and disease. Yet the extent and types of these RNA modifications as well as their roles in particular biological processes remain either poorly understood or not known. The goal of the FOA is to promote research into the role of RNA chemical modifications in the initiation and progression of various developmental processes and disease states and conditions relevant to the scientific mission of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Cancer Institute (NCI), and the National Eye Institute (NEI).
MiamiOH OARS

The Role of Epitranscriptomics in Development and Disease (R21 - Clinical Trial Not All... - 0 views

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    The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications from the scientific community to support outstanding research in the area of epitranscriptomics, i.e., the chemical modifications of RNA. Evidence is accumulating that RNA modifications regulate the function of both coding and noncoding RNAs, suggesting that these modifications are involved in both development, and in health and disease. Yet the extent and types of these RNA modifications as well as their roles in particular biological processes remain either poorly understood or not known. The goal of the FOA is to promote research into the role of RNA chemical modifications in the initiation and progression of various developmental processes and disease states and conditions relevant to the scientific mission of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
MiamiOH OARS

Immune Mechanisms at the Maternal-Fetal Interface (R01 Clinical Trial Optional) - 0 views

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    This initiative will support research to determine the roles and interactions of immune cells at the maternal-fetal interface throughout pregnancy, including mechanisms of responses to vaccination and infection that protect the fetus and that may influence fetal immune system development.
MiamiOH OARS

Data Management and Coordinating Center (DMCC) for Rare Diseases Clinical Research Netw... - 0 views

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    This Funding Opportunity Announcement (FOA) is to invite applications for new applications for the Data Management and Coordinating Center (DMCC) for the Rare Diseases Clinical Research Network (RDCRN). Each consortium within the RDCRN is intended to advance the diagnosis, management, and treatment of rare diseases. The DMCC will facilitate and support the activities of each Rare Diseases Clinical Research Consortium (RDCRC) along with trans-network activities that broadly facilitate the advancement of rare disease research via four Cores; 1) Administrative; 2) Data Management; 3) Clinical Research and; 4) Engagement and Dissemination.
MiamiOH OARS

PA-18-816: Better Defining Growth Medium to Improve Reproducibility of Cell Culture (ST... - 0 views

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    Fetal bovine serum (FBS) is the most widely used growth supplement for cell culture because it cost-effectively supports the survival and growth of many cell lines. Although serum is an effective growth promotor, it is highly variable in its composition, activity, and physiological effects on cells. This variability introduces inconsistencies into cell culture research. This Funding Opportunity Announcement (FOA) will support STTR projects to develop novel, reliable, and cost-effective tools that will make it easier for researchers to standardize or replace serum in cell culture. Also listed under R43/44
MiamiOH OARS

Defense Sciences Office (DSO) Office-Wide - Federal Business Opportunities: Opportunities - 0 views

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    The mission of the Defense Advanced Research Projects Agency (DARPA) Defense Sciences Office (DSO) is to identify and pursue high-risk, high-payoff research initiatives across a broad spectrum of science and engineering disciplines and to transform these initiatives into disruptive technologies for U.S. national security. In support of this mission, the DSO Office-wide BAA invites proposers to submit innovative basic or applied research concepts that address one or more of the following technical domains:
MiamiOH OARS

Large Animal Testing Centers for Evaluation of Somatic Cell Genome Editing Tools (U42 -... - 0 views

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    The purpose of this Funding Opportunity Announcement (FOA) is to support large animal Testing Centers to evaluate in vivo genome editing technologies developed by other investigators in the Somatic Cell Genome Editing Program (SCGE). Testing Centers will use either pigs or non-human primates, including wild-type animals, as well as reporter animals developed by RFA-RM-18-013. The Testing Centers will work collaboratively with investigators funded under RM-18-016 and RFA-RM-18-017 to assess efficacy and safety of in vivo genome editing and delivery technologies. Centers will breed, archive and maintain cohorts of well characterized and genotyped large animals, establish methods and protocols for the evaluation of the delivery systems and editing tools, conduct testing and provide results to the Dissemination and Coordination Center of the SCGE. Such activities will accelerate the translation of genome editing technologies into treatments for human diseases.
MiamiOH OARS

Research Interests of the Air Force Office of Scientific Research - 0 views

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    AFOSR plans, coordinates, and executes the Air Force Research Laboratory's (AFRL) basic research program in response to technical guidance from AFRL and requirements of the Air Force. Additionally, the office fosters, supports, and conducts research within Air Force, university, and industry laboratories; and ensures transition of research results to support U.S. Air Force needs. The focus of AFOSR is on research areas that offer significant and comprehensive benefits to our national war fighting and peacekeeping capabilities. These areas are organized and managed in two scientific Departments: Engineering and Information Science (RTA) and Physical and Biological Sciences (RTB). The research activities managed within each Department are summarized in this section.
MiamiOH OARS

RFA-AI-18-006: Sustained Release Innovation for HIV (SRI) (R61/R33 Clinical Trial Optio... - 0 views

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    The purpose of this Funding Opportunity Announcement (FOA) is to stimulate the development of new and innovative sustained/extended release drugs and drug delivery systems (DDS) that can achieve extended durations (months to years) of HIV prevention in at-risk individuals. This FOA requires an industry partner, milestones linked to Go/No-Go decisions and year 5 funding requires submission of a pre-IND application to the FDA.
MiamiOH OARS

PAR-18-827: Minor Use Minor Species Development of Drugs (R01) - 0 views

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    This Funding Opportunity Announcement (FOA) is issued by the Food and Drug Administration (FDA), Center for Veterinary Medicine (CVM), and solicits Research Project (R01) grant applications from institutions or organizations that propose to develop, or support the development of new animal drugs intended for minor use in major species or for use in minor species.
MiamiOH OARS

Oxalosis & Hyperoxaluria Foundation » Grants & Funding - 0 views

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    The Oxalosis and Hyperoxaluria Foundation was established in 1989 to promote research to find a cure for oxalosis, primary hyperoxaluria, and related stone diseases and improve the care and treatment of those they affect. To date, the foundation has provided more than $10 million for PH-related education, awareness, and research programs.
MiamiOH OARS

RFA-DK-18-009: Gastrointestinal Mechanisms Contributing to HIV Pathogenesis (R01 Clinic... - 0 views

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    This Funding Opportunity Announcement (FOA) seeks to bring together investigators with complementary expertise in HIV and in gastrointestinal mucosal pathobiology to dissect fundamental processes within the gastrointestinal tract that impact infection, persistence, and comorbidities. This multidisciplinary approach should lead to comprehensive, in-depth mechanistic analyses and advance progress toward alleviating comorbidities that afflict people living with HIV and toward developing a cure.
MiamiOH OARS

Biomechanics and Mechanobiology - 0 views

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    The BMMB program supports fundamental research in biomechanics and mechanobiology. The program emphasizes multiscale mechanics approaches that integrate across molecular, cell, tissue and organ domains in the study of organisms. Projects may include theoretical, computational, and experimental approaches. An important concern is the influence of in vivo mechanical forces on cell and matrix biology in the histomorphogenesis, maintenance, regeneration and aging of tissues. The program also is interested in efforts to translate recent mechanobiological discoveries into engineering science. The program encourages the consideration of diverse living tissues as smart materials that are self-designing.
MiamiOH OARS

Gastrointestinal Mechanisms Contributing to HIV Pathogenesis (R01 Clinical Trial Not Al... - 0 views

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    This Funding Opportunity Announcement (FOA) seeks to bring together investigators with complementary expertise in HIV and in gastrointestinal mucosal pathobiology to dissect fundamental processes within the gastrointestinal tract that impact HIV infection, persistence, and comorbidities. This multidisciplinary approach should lead to comprehensive, in-depth mechanistic analyses and advance progress toward alleviating comorbidities that afflict people living with HIV and toward developing a cure.
MiamiOH OARS

DoD Duchenne Muscular Dystrophy, Investigator-Initiated Research Award - 0 views

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    The DMDRP Investigator-Initiated Research Award (IIRA) supports translational research that will accelerate the movement of promising ideas in Duchenne research into clinical applications. Translational research may be defined as an integration of basic science and clinical observations with the specific goal of developing new therapies. The ultimate goal of translational research is to move a concept or observation forward into clinical application. However, Principal Investigators (PIs) should not view translational research as a one-way continuum from bench to bedside. The research plan should involve a reciprocal flow of ideas and information between basic and clinical science. Within this continuum, the IIRA supports later-stage translational research projects, including early-phase, proof-of-principle clinical trials and correlative studies to better inform development of drugs, devices, and other interventions. Research projects may also include preclinical studies utilizing animal models, human subjects, or human anatomical substances.
MiamiOH OARS

Sustained Release Innovation for HIV (SRI) (R61/R33 Clinical Trial Optional) - 0 views

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    The purpose of this Funding Opportunity Announcement (FOA) is to stimulate the development of new and innovative sustained/extended release drugs and drug delivery systems (DDS) that can achieve extended durations (months to years) of HIV prevention in at-risk individuals. This FOA requires an industry partner, milestones linked to Go/No Go decisions and year 5 funding requires communication with/ pre-IND submission to the FDA.
MiamiOH OARS

DoD Epilepsy, Idea Development Award - 0 views

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    he intent of the FY18 ERP IDA is to solicit research to understand the magnitude and underlying mechanisms of PTE related to the ERP's mission (see Section II.A, Program Description). The FY18 ERP IDA offers two levels of funding. Funding Level I is intended to support high-risk or high-gain applications with Principal Investigators (PIs) at or above the level of a postdoctoral fellow (or equivalent), but below the level of Assistant Professor (or equivalent). Note that organizations submitting Funding Level I applications will be required to verify their eligibility for this award. Funding Level II is intended to support a more mature, hypothesis-driven research project. For an FY18 ERP IDA Funding Level II application, the PI must be an independent investigator at or above the level of Assistant Professor (or equivalent). While not required, applications to either Funding Level I or II should provide relevant preliminary data. Preliminary data for either Funding Level may come from the PI's published work, pilot data, or from peer-reviewed literature. The requested budget level should be appropriate for the scope of research proposed.
    Research proposed to either the Epidemiology or Longitudinal Studies Focus Area, described below, will require the development of an Epidemiological/Longitudinal Studies Research Statement.
MiamiOH OARS

DoD Lupus, Impact Award - 0 views

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    The LRP Impact Award encourages applications that support the full spectrum of research projects or ideas that specifically focus on scientific and clinical lupus issues, which, if successfully addressed, have the potential to make a major impact in lupus research. Applications should include a well-formulated, testable hypothesis based on strong scientific rationale that is established through inferential reasoning and/or critical review and analysis of the literature. Inclusion of preliminary data is encouraged.
MiamiOH OARS

RFA-MH-19-200: Rare Genetic Syndromes as a Window into the Genetic Architecture of Ment... - 0 views

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    This initiative will foster collaborative and coordinated efforts to characterize the underlying genetic architecture of diverse neuropsychiatric phenotypes within and across rare genetic disorders and identify the shared genetic risk across rare and idiopathic neuropsychiatric disorders. Projects from multi-disciplinary teams will utilize genome-wide data to comprehensively assess the contribution of genetic variation to the variable expressivity and incomplete penetrance of neuropsychiatric phenotypes across rare genetic disorders. Projects are encouraged to leverage existing resources, cohorts, and collaborative networks with established infrastructure for consistent and high-quality phenotypic data collection and genomic data generation. Projects should seek to enhance the quality of the phenotypic data available for rare genetic disorders by developing or applying phenotyping methodologies that create a pipeline for standardizing assessments and that cut across rare genetic disorders and across developmental time points. Under this initiative, investigators will form a network to facilitate data sharing and harmonization of clinical and genetic data across different studies within the network, as well as accelerate characterization of genotype to phenotype relationships across rare genetic disorders. This network will also generate a resource of bio-samples, as well as phenotypic and genetic data for broader dissemination to the scientific community.
MiamiOH OARS

RFA-MH-19-201: Rare Genetic Syndromes as a Window into the Genetic Architecture of Ment... - 0 views

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    Projects from multi-disciplinary teams will utilize genome-wide data to comprehensively assess the contribution of genetic variation to the variable expressivity and incomplete penetrance of neuropsychiatric phenotypes across rare genetic disorders. Projects are encouraged to leverage existing resources, cohorts, and collaborative networks with established infrastructure for consistent and high-quality phenotypic data collection and genomic data generation. Projects should seek to enhance the quality of the phenotypic data available for rare genetic disorders by developing or applying phenotyping methodologies that create a pipeline for standardizing assessments and that cut across rare genetic disorders and across developmental time points. Under this initiative, investigators will form a network to facilitate data sharing and harmonization of clinical and genetic data across different studies within the network, as well as accelerate characterization of genotype to phenotype relationships across rare genetic disorders. This network will also generate a resource of bio-samples, as well as phenotypic and genetic data for broader dissemination to the scientific community.   
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