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The OPORP Orthotics and Prosthetics Outcomes Research Award (OPORA) is being offered for the first time in FY14. It is intended to support research that evaluates the comparative effectiveness of and functional outcomes associated with prosthetic and orthotic clinical interventions and/or other rehabilitation interventions for Service Members and Veterans who have undergone limb salvage or limb amputation. The goal is to improve our understanding of and ultimately advance the implementation of the most effective prescriptions for prosthetic and orthotic devices, treatment, rehabilitation, and secondary health effect prevention options for patients, clinicians, other caregivers, and policymakers. Proposed projects should be designed to provide outcomes data regarding orthotic and prosthetic devices, and/or related clinical interventions and must include the anticipated effect on patient care metrics. Collaboration with military researchers and clinicians is encouraged, as are joint Department of Defense (DoD)-VA studies, including longitudinal outcome studies. Studies are sought that: * Compare different patient care approaches. * Include patient-centric outcome assessments. * Have the potential to generate new knowledge that can be developed into new clinical practice guidelines, and/or new prescription algorithms for prosthetic and orthotic devices. * Have the potential to develop new technology for improved prosthetic and orthotic devices, therefore improving patient outcomes. * Provide information on quality of life, reintegration, and/or return to duty/return to work as it pertains to those patients who use a prosthetic or orthotic device due to limb trauma. All applications must demonstrate direct relevance to Service Members and Veterans with traumatic extremity injury and/or amputation using prosthetics and orthotic devices. Examples of studies that are appropriate for submission to the FY14 OPORA include, but are not limited to, examination of the

It is estimated that more than 30 million Americans over the age of 12 years have hearing loss in both ears and an estimated 48 million have hearing loss in at least one ear. The most recent data from the Department of Veterans Affairs (VA) indicates that there are 1.1 million Veterans with Service-connected disability due to hearing loss. The HRRP will fund innovative research that has the potential to maximize operational performance, medical readiness, and quality of life for Service members, Veterans, and others living with significant auditory system injuries.

The mission of the Hearing Health Foundation is to prevent and cure hearing loss and tinnitus through groundbreaking research and promote hearing health. HHF envisions a world where people can enjoy life without hearing loss and tinnitus. To advance this mission, the foundation has issued a Call for Applications for its 2018 Emerging Research Grants program for projects designed to explore new avenues in specified topic areas of hearing and balance science. For the 2018 ERG cycle, grants of up to $30,000 will be awarded for research in seven priority areas, including general hearing health, central auditory processing disorders, hearing loss in children, hyperacusis, Ménière's disease, tinnitus, and Usher's syndrome.

The consequences of climate variability and change are becoming more immediate and profound than previously anticipated. Over recent decades, the world has witnessed the onset of prolonged droughts on several continents, increased frequency of floods, loss of agricultural and forest productivity, degraded ocean and permafrost ecosystems, global sea level rise and the rapid retreat of ice sheets and glaciers, loss of arctic sea ice, and changes in ocean currents. These important impacts highlight that climate variability and change can have significant effects on decadal and shorter time scales, with significant consequences for plant, animal, human, and physical systems. The EaSM funding opportunity enables interagency cooperation on one of the most pressing problems of the millennium: climate change and??how it is likely to affect our world. It allows the partner agencies -- National Science Foundation (NSF) and??U.S. Department of Agriculture (USDA) -- to combine resources to identify and fund the most meritorious and highest-impact projects that support their respective missions, while??avoiding duplication of effort and fostering collaboration between agencies and the investigators they support.This interdisciplinary scientific challenge calls for the development and application of next-generation Earth System Models that include coupled and interactive representations of such??components as ocean and atmospheric currents, agricultural working lands and forests,?? biogeochemistry, atmospheric chemistry,?? the water cycle and land ice.?? This solicitation seeks to attract scientists from the disciplines of geosciences, agricultural sciences, mathematics and statistics. Successful proposals will develop intellectual excitement in the participating disciplinary communities and engage diverse interdisciplinary teams with sufficient breadth to achieve the scientific objectives. 

The over-arching goal of this NIDCD R25 program is to support educational activities that foster a better understanding of biomedical research and its implications in the areas of auditory and vestibular research. The complexity of auditory and vestibular biology processes provide our hearing and balance function. Interruption of these processes may occur from a variety of factors, including genetic, environmental and pathogenic agents, and often results in the loss of hearing and balance function. While loss or impairment of these functions are most often non-life-threatening, the disruption to quality of life is substantial. Since August of 2007, the National Institute on Deafness and Other Communication Disorders (NIDCD) (http://www.nidcd.nih.gov/) has supported a special topics course in auditory and vestibular biology. The two to three week course, Biology of the Inner Ear, has been held at the Marine Biological Laboratory in Woods Hole, MA, and has brought together outstanding faculty to provide hands-on instruction to participants. It is the continued intent of the NIDCD to foster the advancement of research methodologies and technologies to improve, hasten and implement new treatments for these disorders and impairments. It is based on this template of excellence that the NIDCD invites R25 applications for support of a special topics course in the auditory and vestibular sciences. The purpose of this five-year initiative is to support three courses to be offered each in years 2021, 2023, and 2025. This will allow for a sustained specialized topics course that provides lecture and hands-on research exposure to the auditory and vestibular sciences. The target audience envisioned for this course consists of advanced graduate students, post-doctoral fellows and established early stage research investigators.

The goal of this FOA is to advance research on the underlying basis for the transfer (or transposition) of aging phenotypes observed between young and old rodents and discovered through heterochronic parabiosis. Examples of transposed phenotypes include reversal of cardiac hypertrophy, partial restoration of cognitive function, improved vascularization, and repair of skeletal muscle after cryo-injury (anti-geronic transposition), or as accelerated loss of cognitive function and neurogenesis (pro-geronic transposition). Other transposed phenotypes, as revealed solely through heterochronic parabiosis, may also be reported in the literature. There are also reports of candidate factors found in circulation that might be causally related to the transposition of these aging phenotypes; these are termed "circulating geronic factors" for purposes of this FOA. To date, these are proteins and peptides that pass between the young and old mice joined by parabiosis, due to anastomosis of their circulatory systems. Based on these novel findings and this novel experimental paradigm, the specific objective of this FOA is to test whether these candidate geronic factors are necessary for the transposition of aging phenotypes. The focus is on phenotypes transposed in heterochronic parabiosis and the candidate factors which are present and functional at physiological concentrations in circulation.

The goal of this FOA is to advance research on the underlying basis for the transfer (or transposition) of aging phenotypes observed between young and old rodents and discovered through heterochronic parabiosis. Examples of transposed phenotypes include reversal of cardiac hypertrophy, partial restoration of cognitive function, improved vascularization, and repair of skeletal muscle after cryo-injury (anti-geronic transposition), or as accelerated loss of cognitive function and neurogenesis (pro-geronic transposition). Other transposed phenotypes, as revealed solely through heterochronic parabiosis, may also be reported in the literature. There are also reports of candidate factors found in circulation that might be causally related to the transposition of these aging phenotypes; these are termed "circulating geronic factors" for purposes of this FOA. To date, these are proteins and peptides that pass between the young and old mice joined by parabiosis, due to anastomosis of their circulatory systems. Based on these novel findings and this novel experimental paradigm, the specific objective of this FOA is to test whether these candidate geronic factors are necessary for the transposition of aging phenotypes. The focus is on phenotypes transposed in heterochronic parabiosis and the candidate factors which are present and functional at physiological concentrations in circulation.

To advance this mission, the foundation awards grants of up to $5,000 in support of research on the elimination of ocular diseases causing vision loss and suffering in animals. Grant awards support the purchase of research supplies, materials, equipment (limited);, publication costs; and salary for technical support. Grant awards do not support the salary of the resident, the salary of the faculty mentor, tuition costs, major equipment purchases, or institutional indirect costs.

The purpose of this Funding Opportunity Announcement (FOA) is to support studies which utilize emerging genomic technologies to identify variants which predict risk for pregnancy loss in subsequent pregnancies beyond standard karyotype approaches.

JDRF, the world's leading non-profit organization with the mission to cure type 1 diabetes (T1D), invites applications from research investigators having interest and expertise to support the discovery and advancement of biomarkers of pancreatic beta cell stress and health correlating with early beta-cell loss.

JDRF, the world's leading non-profit organization with the mission to cure type 1 diabetes (T1D),  invites applications from research investigators having interest and expertise to support the discovery  and advancement of biomarkers of pancreatic beta cell stress and health correlating with early betacell loss. 

The Instrument Development for Biological Research (IDBR) Program supports the development, production, and distribution of novel instrumentation that addresses demonstrated needs in biological research in areas supported by NSF Biology programs (see http://www.nsf.gov/bio). These systems would benefit a broad user community through mass distribution of the technology. Interdisciplinary collaborations are strongly encouraged, as are partnerships with U.S. industries that can facilitate knowledge transfer, commercialization and broad utilization in the research community. The program accepts two types of proposals:Type A - Innovation: Proposals for the development of novel instrumentation that provides new research capabilities or, where appropriate, that significantly improves current technologies by at least an order of magnitude in fundamental aspects such as accuracy, precision, resolution, throughput, flexibility, breadth of application, costs of construction or operation, or user-friendliness.Type B - Bridging: Proposals for transforming ‘one of a kind' prototypes or high-end instruments into devices that are broadly available and utilizable without loss of capacity. If appropriate, PIs should seek SBIR/STTR Program, or similar support mechanism for implementation of broad distribution following an IDBR award.

The National Institute of Allergy and Infectious Diseases (NIAID) solicits applications from single institutions and consortia of institutions to participate in the Nonhuman Primate Transplantation Tolerance Cooperative Study Group (NHPCSG) program. The NHPCSG is a multi-center, cooperative program for research on nonhuman primate (NHP) models of kidney, pancreatic islet, heart, and lung transplantation. The goals of the NHPCSG are to evaluate the preclinical safety and efficacy of existing and newly developed immune tolerance induction regimens and to elucidate the underlying mechanisms of the induction, maintenance, and/or loss of tolerance in these models. The long-range goal of this program is to develop and evaluate immune tolerance induction regimens that will result in enhanced long-term graft survival in clinical transplantation.

The National Institute on Deafness and Other Communication Disorders (NIDCD) invites applications to renew an ongoing NIDCD-supported cooperative agreement, the Conservation of Hearing Study (CHEARS).This study will allow continued assessment of preventable risk factors for hearing loss in two large, ongoing, longitudinal cohort studies, the Nurses' Health Studies I and II. 

Despite centuries of discovery, most of our planet's biodiversity remains unknown. The scale of the unknown diversity on Earth is especially troubling given the rapid and permanent loss of biodiversity across the globe. The goal of the Dimensions of Biodiversity campaign is to transform, by 2020, how we describe and understand the scope and role of life on Earth. This campaign promotes novel integrative approaches to fill the most substantial gaps in our understanding of the diversity of life on Earth. 

NineSigma, representing a Global Biotechnology Company, invites proposals for technologies to purify monoclonal antibodies or other proteins whose instability results in significant losses when using Protein A affinity chromatography.

The goals of this funding opportunity announcement are to support science that will ultimately help: 1) Improve the ability to identify who is at risk for sub-optimal weight loss, weight regain, and short- or long-term adverse metabolic/physiologic or behavioral outcomes based on behavioral or psychological characteristics and 2) Inform the development of new treatment approaches to be used pre and/or post-surgery to minimize risks and improve outcomes or allow for more tailored patient and procedure selection.

Despite centuries of discovery, most of our planet's biodiversity remains unknown. The scale of Earth's unknown diversity is especially troubling given the rapid and permanent loss of biodiversity across the globe. The goal of the Dimensions of Biodiversity campaign is to transform how we describe and understand the scope and role of life on Earth. This campaign promotes novel integrative approaches to fill the most substantial gaps in our understanding of the diversity of life on Earth. It takes a broad view of biodiversity, and focuses on the intersection of genetic, phylogenetic, and functional dimensions of biodiversity. Successful proposals must integrate these three dimensions to understand interactions among them. While this focus complements several core programs in BIO, it differs by requiring that multiple dimensions of biodiversity be addressed simultaneously, in novel ways, to understand their synergistic roles in critical ecological and evolutionary processes, especially pertaining

The National Institute on Aging (NIA) solicits research projects that would advance our understanding of how protein homeostasis (proteostasis) in peripheral tissues affects brain aging, leading to the development of Alzheimers Disease (AD). Much research on AD has focused on the accumulation of aberrant protein aggregates in the brain, and in particular amyloid and Tau. Formation of aggregates due to mutations encoded in the APP gene or due to hyperphosphorylation, respectively, have been linked to familial AD. The etiology of the more common, sporadic form of AD, is less certain, although aging is considered a major risk for development of the disease. It is known that proteostasis is less efficiently maintained in all tissues with aging, and this may indicate a link between proteostasis in the periphery and the appearance of aging-related diseases and conditions, including the decline in cognitive function, as well as dementia and AD. Therefore, testing for a role of aging-related loss of peripheral proteostasis in the development of AD is the focus of this FOA.

This FOA will support national facility based case management activities implemented through associations of persons living with HIV (PLHIV). Activities include peer support for HIV treatment adherence, preventing and minimizing loss-to-follow-up and improving retention in care, and facilitating linkage of all HIV patients and others affected by HIV to comprehensive HIV services. The FOA will support planning, program and financial management; coordination and collaboration with partners and stakeholders; capacity building at different levels; training and deployment of case managers and adherence supporters to high load HIV care and treatment facilities. The awardee will conduct supportive supervision, mentoring, monitoring and evaluation of case management activities, and will maintain an updated inventory of available services in the catchment area of respective health facilities. These activities will minimize patient attrition, optimize adherence and improve patient outcomes.

The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications from the scientific community to support outstanding research in the area of trophoblast differentiation and function in relation to fertility and pregnancy, including the role of the immune system. It is anticipated that fundamental knowledge gained by this research will act as a solid foundation to hasten treatments for a number of placental-based pregnancy disorders, such as implantation failure, frequent pregnancy loss, preeclampsia, fetal growth restriction, and preterm birth.