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To advance this mission, the foundation will award grants of up to $5,000 in support of research on the elimination of ocular diseases causing vision loss and suffering in animals. Grant funds can support research supplies, materials, limited equipment, publication, and salaries for technical support personnel. Grants may not support the salary of the resident, salary of the faculty mentor, tuition, major equipment, or institutional indirect costs.

 The goal of this Funding Opportunity Announcement [FOA] is to support research that will define and validate a set(s) of molecular biomarkers and/or bio-signatures indicating the degree of loss of functional reserve, or of resilience of the host defense mechanisms, at different phases of HIV-1 pathogenesis in individuals with substance use disorders (SUDs). 

Despite centuries of discovery, most of our planet's biodiversity remains unknown. The scale of Earth's unknown diversity is especially troubling given the rapid and permanent loss of biodiversity across the globe. The goal of the Dimensions of Biodiversity campaign is to transform how we describe and understand the scope and role of life on Earth. This campaign promotes novel integrative approaches to fill the most substantial gaps in our understanding of the diversity of life on Earth. It takes a broad view of biodiversity, and focuses on the intersection of genetic, phylogenetic, and functional dimensions of biodiversity. Successful proposals must integrate these three dimensions to understand interactions among them. While this focus complements several core programs in the Biological Sciences Directorate at NSF, it differs by requiring that multiple dimensions of biodiversity be addressed simultaneously, in novel ways, to understand their synergistic roles in critical ecological and evolutionary processes, especially pertaining to the mechanisms driving the origin, maintenance, and functional roles of biodiversity.

Despite centuries of discovery, most of our planet's biodiversity remains unknown. The scale of Earth's unknown diversity is especially troubling given the rapid and permanent loss of biodiversity across the globe. The goal of the Dimensions of Biodiversity campaign is to transform how we describe and understand the scope and role of life on Earth. This campaign promotes novel integrative approaches to fill the most substantial gaps in our understanding of the diversity of life on Earth. It takes a broad view of biodiversity, and focuses on the intersection of genetic, phylogenetic, and functional dimensions of biodiversity. Successful proposals must integrate these three dimensions to understand interactions among them. While this focus complements several core programs in the Biological Sciences Directorate at NSF, it differs by requiring that multiple dimensions of biodiversity be addressed simultaneously, in novel ways, to understand their synergistic roles in critical ecological and evolutionary processes, especially pertaining to the mechanisms driving the origin, maintenance, and functional roles of biodiversity.

The aim of this RFP is to develop biomarkers for which there is a clear clinical need in Alzheimer's disease and related dementias. Specifically, this RFP focuses on: - developing novel PET ligands for clinical use - supporting novel CSF biomarkers - validating established MRI approaches in larger cohorts Novel biomarkers of neuroinflammation and synaptic integrity are considered high priority. Other target areas of interest include: - Neuronal loss - Vascular injury and blood-brain barrier integrity - Mitochondria and metabolic function - Protein misfolding/proteostasis - Oxidative stress - White matter changes - Other novel targets supported by compelling biological rationale and connection to disease The ADDF has limited interest in CSF measures of amyloid and tau.