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The NIEHS and partnering Institutes and Centers are establishing an infrastructure, the Human Health Exposure Analysis Resource (HHEAR) as a continuation of the Children's Health Exposure Analysis Resource (CHEAR). The goal of this consortium is to provide the research community access to laboratory and statistical analyses to add or expand the inclusion of environmental exposures in their research and to make that data publicly available as a means to improve our knowledge of the comprehensive effects of environmental exposures on human health throughout the life course. This FOA solicits Laboratories (Lab Hubs) that can provide comprehensive measurement of the exposome using untargeted approaches (such as metabolomics using libraries enriched for environmental exposure biomarkers) for biological samples derived from extant or ongoing human health studies in the NIH extramural research community. Each Hub will incorporate an administrative core and a developmental core to improve the ability of untargeted platform to detect a wide range of environmental exposures and endogenous changes in response to environmental influences in a variety of biological matrices.

This Funding Opportunity Announcement invites applications for a U24 Telomere Research Network/Collaboratory. This U24 will coordinate activities of a telomere length (TL) methods comparison study involving multiple labs supported under U01 awards made in response to FOA (RFA-AG-19-023) to address the need for cross-validation between protocols and samples for establishing best practices for population-based TL research. The U24 will serve as the central resource for the organization of meetings and other activities of this coordinated program, including support for the methods study, dissemination of its results and resultant recommendations. It will also develop and foster an extended Telomere Research Network (TRN) connecting the broader field through a flexible range of activities that will advance an interdisciplinary research agenda on telomeres and activities directly associated with TL maintenance as sentinels of environmental exposures, psychosocial stress, and disease susceptibility.

GSK is seeking rapid, point of care analytical tests for gene therapy products that can go from sample to result within 2 hours   Tests should work with human cells at a concentration of 1x106 - 1x108 cells per mL in growth media. They should characterize / quantify the populations of cell immunophenotypes in the sample.   Lab tests are welcome. GSK would be especially interested in analytical techniques that could be carried out at or close to the patient's bedside.

This Funding Opportunity Announcement invites applications for a U24 Telomere Research Network/Collaboratory. This U24 will coordinate activities of a telomere length (TL) methods comparison study involving multiple labs supported under U01 awards made in response to FOA (RFA-AG-19-023) to address the need for cross-validation between protocols and samples for establishing best practices for population-based TL research. The U24 will serve as the central resource for the organization of meetings and other activities of this coordinated program, including support for the methods study, dissemination of its results, and resultant recommendations. It will also develop and foster an extended Telomere Research Network (TRN) connecting the broader field through a flexible range of activities that will advance an interdisciplinary research agenda on telomeres and activities directly associated with TL maintenance as sentinels of environmental exposures, psychosocial stress, and disease susceptibility. 

The Infrastructure Capacity for Biology (ICB) supports the development, expansion, or improvement of infrastructure that will enable fundamental research within the biological sciences. Infrastructure supported under thissolicitation may include cyberinfrastructure, instrumentation, biological collections, living stocks, field stations, marine labs, or other resources that are shared and openly accessible. Proposals submitted to the ICB solicitation must make a compelling case that the proposed infrastructure will advance or transform research in areas of science that are supported by the Directorate for Biological Sciences (BIO) at the National Science Foundation. While other programs in the Division of Biological Infrastructure (DBI) focus on innovative research leading to new infrastructure or sustained operation of mature infrastructure, thissolicitation focuses on supporting projects that seek to deliver, enable access to, or substantially improve infrastructure that will advance the capacity oftoday's scientific community to conduct leading edge research. The impacts of the activities funded by awards made through this solicitation will be reflected not just in the quality of their products, but by the novel and transformative science outcomes that will be achieved by the users of these resources. Infrastructure projects that will advance any field of research supported by the Directorate for Biological Sciences are eligible for support under this program. Please refer to the individual program descriptions for detailed guidance on what is supported through this solicitation:

The Divisions of Chemical, Bioengineering and Environmental Transport (CBET) and Civil, Mechanical, and Manufacturing Infrastructure (CMMI) in the Engineering Directorate of the National Science Foundation (NSF) are partnering with The Center for the Advancement of Science in Space (CASIS) to solicit research projects in the general fields of tissue engineering and mechanobiology that can utilize the International Space Station (ISS) National Lab to conduct research that will benefit life on Earth. U.S. entities including academic investigators, non-profit independent research laboratories and academic-commercial teams are eligible to apply.

The Nano-Bio Manufacturing Consortium is expected to grow the US-centric innovation ecosystem that will risk reduce material supply (including nanomaterials & biomaterials), processing techniques, and flexible/stretchable device concepts by demonstrating component- and system-level functionality relevant to human-integrated technologies, such as airman-performance monitoring (APM) and augmentation (APA) systems. This public-private partnership should build upon the foundation of research & development excellence that has been established within NBMC since its 2013 inception. It is envisioned that technology development will require teaming between academia and industry in partnership with government researchers as well as with appropriate members of the regulatory and operational DoD communities. A balance between enabling component- and systems-level prototype development is expected to be realized through end-technologies between TRL 3 and TRL 6. It is expected that during the completion of certain NBMC projects, lab and/or field demonstrations will be conducted in partnership with relevant DoD partners to ensure that members of military human performance and/or aeromedical communities can assess the utility of developments and provide iterative feedback with respect to critical path issues.

The purpose of the administrative supplement is to provide support for NIH-funded investigators to participate in an entrepreneurship training course, the Concept to Clinic: Commercializing Innovation (C3i) Program. The C3i Program is designed to provide medical device innovators with the specialized business frameworks and essential tools for successful translation of biomedical technologies from the lab (concept) to the market (clinic). Through this program, the NIH fosters the development and commercialization of early-stage biomedical technologies by engaging investigators who are interested in better understanding the value of their innovation in addressing an unmet market need. The curriculum and customized mentoring provided by the C3i Program are intended to guide investigators as they assess the commercial viability and potential business opportunity for their innovation. Prospective applicants are strongly encouraged to contact NIH Scientific/Research staff for more information about the program before applying.

The purpose of the administrative supplement is to provide support for NIH-funded investigators to participate in an entrepreneurship training course, the Concept to Clinic: Commercializing Innovation (C3i) Program. The C3i Program is designed to provide medical device innovators with the specialized business frameworks and essential tools for successful translation of biomedical technologies from the lab (concept) to the market (clinic). Through this program, the NIH fosters the development and commercialization of early-stage biomedical technologies by engaging investigators who are interested in better understanding the value of their innovation in addressing an unmet market need. The curriculum and customized mentoring provided by the C3i Program are intended to guide investigators as they assess the commercial viability and potential business opportunity for their innovation. Prospective applicants are strongly encouraged to contact NIH Scientific/Research staff for more information about the program before applying.

The DOE Isotope Program (IP), managed by SC Nuclear Physics (NP), hereby announces its interest in receiving applications for Research and Development (R&D) on novel methods to produce or improve production radioactive or enriched stable isotopes needed for a wide variety of research and applications. This announcement is administered under the NP Isotope Development & Production for Research and Applications (IDPRA) Sub-Program. The proposed R&D should generate data relevant to isotope production or lead to new and innovative technologies, or improvements to existing technologies to foster enhanced production of isotopes. Successful proposals will clearly describe how the outcome of the proposed work would support and enhance the production of isotopes used for research and applications in medicine, homeland security, the physical sciences, biological and geological sciences, energy, industry, etc. Applications incorporating effective ways to train personnel with essential knowledge and skills related to the production, processing, purification, and distribution of enriched stable and radioactive isotopes are strongly encouraged. A companion Program Announcement to DOE National Laboratories (LAB-1896) will be posted on the SC Grants and Contracts web site at: https://science.energy.gov/grants. Applications submitted to this FOA will be evaluated by peer review competitively with those submitted to the Laboratory companion announcement.

The purpose of this funding opportunity announcement (FOA) is to support non-commercial lab-to-user dissemination of novel, reliable imaging and bioengineering technologies of high interest to NIBIB, including biomedical devices, software, methods and imaging agents. Technologies proposed for dissemination should have been prototyped and validated and have demonstrated potential for high value to the research community but for which dissemination via commercialization is not a viable pathway. Projects should focus on transforming functioning prototypes into reliable tools and delivering them to end users. Related activities may include, but are not limited to, quality control, scale-up production, user training, and minor technical improvements.

This funding opportunity announcement (FOA) seeks to develop and nurture a national innovation ecosystem that builds upon biomedical research to develop technologies, products and services that benefit society. Toward meeting this objective, the I- Corps program is being offered. The I-Corps at NIH program is focused on educating researchers and technologists on how to translate technologies from the lab into the marketplace. Under this FOA, participating NIH and CDC Institutes and Centers will provide administrative supplement awards to two cohorts of currently-funded SBIR and STTR Phase I grantees to support entrepreneurial training under the I-Corps at NIH Program. The program is designed to provide three-member project teams with access to instruction and mentoring in order to accelerate the translation of technologies currently being developed with NIH and CDC SBIR and STTR funding. It is anticipated that outcomes for the I-Corps teams participating in this program will include significantly refined commercialization plans and well-informed pivots in their overall commercialization strategies. Prospective applicants are strongly encouraged to contact NIH or CDC Scientific/Research staff for more information about the program before applying.

The Department of Biomedical Informatics hosts an annual internship program each summer which provides high school, undergraduate, and graduate students opportunities to pursue research projects in the field of biomedical informatics under the guidance of research and operational staff and renowned faculty mentors in the Department of Biomedical Informatics. Participants learn useful tools and technologies used in biomedical and clinical research and attend weekly seminars to learn more about the various fields and interdisciplinary interactions biomedical informatics facilitates. Interns also gain very useful presentation abilities through regular lab and programmatic presentation opportunities, including an end-of-program poster session. Many students who have participated in this program have gone on to pursue doctoral degrees in biomedicine, biomedical informatics, computer science, and electrical engineering or to complete degrees in medicine and nursing. All student internship positions in the Department of Biomedical Informatics have the potential to be either paid or unpaid, depending on student experience levels and faculty preference. Most positions have the ability to turn into full student employment opportunities, and/or count for course credit (depending on performance) during the school year.

) multiplex biosensing platforms that exceed the performance of current state-of-the-art devices; 2) novel transduction principles, mechanisms and sensor designs suitable for measurement in practical matrix and sample-preparation-free approaches, including error-free detection of pathogens and toxins in food matrices, waterborne pathogens, parasites, toxins, biomarkers in body fluids, neuron chemicals, and others that improve human condition; 3) biosensors that enable measurement of biomolecular interactions in their native states, transmembrane transport, intracellular transport and reactions, and other biological phenomena; 4) biosensing performance optimization for specific health applications such as point-of-care testing and personalized health monitoring; and 5) miniaturization of biosensors for lab-on-a-chip and cell/organ-on-a-chip applications to enable measurement of biological properties and functions of cell/tissues in vitro. The Biosensors Program does not encourage proposals addressing surface functionalization and modulation of bio-recognition molecules, development of basic chemical mechanisms for biosensing applications, circuit design for signal processing and amplification, computational modeling, and microfluidics for sample separation and filtration.

Through its Shaffer Grants program, the foundation will award one-year, $50,000 grants in support of innovative clinical, epidemiological, and laboratory research projects. Grant awards do not support equipment purchases exceeding $12,000, salaries for principal investigators and co-investigators, projects with overt commercial applications, lab supplies, or indirect costs.

Through its Shaffer Grants program, the foundation will award one-year, $50,000 grants in support of innovative, high-impact clinical, epidemiological, and laboratory research projects aimed at finding better ways to care for people with glaucoma. The grants do not support equipment exceeding $12,000, salaries for principal investigators and co-investigators, projects with overt commercial applications, lab supplies, and indirect costs.

Each ACT Fellowship will provide up to $220,000 for up to thirty-three months in support of a systematic and sustained course of study in an empirical science such as physics, psychology, biology, genetics, cognitive science, neuroscience, or sociology. Acceptable courses of study might include a plan to audit undergraduate and graduate-level courses, a plan to spend time in residence at a research lab, or a plan to earn a degree in an empirical science. This iteration of the program also will permit applicants to request that up to one year of the ACT Fellowship be used to support a small-scale pilot scientific research project that improves or enhances the capacity, skill, and talent of the fellow to investigate the above-described Big Questions. Fellows may undertake their study at their home institution or another institution. All fellows must have a faculty mentor in their cross-training discipline.

Ethical and Responsible Research (ER2) funds research projects that identify (1) factors that are effective in the formation of ethical STEM researchers and (2) approaches to developing those factors in all STEM fields that NSF supports. ER2 solicits proposals for research that explores the following: "What constitutes responsible conduct for research (RCR), and which cultural and institutional contexts promote ethical STEM research and practice and why?" Do certain labs have a "culture of academic integrity?" What practices contribute to the establishment and maintenance of ethical cultures and how can these practices be transferred, extended to, and integrated into other research and learning settings?" Factors one might consider include: honor codes, professional ethics codes and licensing requirements, an ethic of service and/or service learning, life-long learning requirements, curricula or memberships in organizations (e.g. Engineers without Borders) that stress responsible conduct for research, institutions that serve under-represented groups, institutions where academic and research integrity are cultivated at multiple levels, institutions that cultivate ethics across the curriculum, or programs that promote group work, or do not grade. Successful proposals typically have a comparative dimension, either between or within institutional settings that differ along these or among other factors, and they specify plans for developing interventions that promote the effectiveness of identified factors.

The Maximizing Investigators' Research Award (MIRA) under this FOA is a grant to provide support for a program of research in an early stage investigator's laboratory that falls within the mission of NIGMS. For the purpose of this FOA, a program of research is a collection of projects in the investigator's lab that are relevant to the mission of NIGMS. The goal of MIRA is to increase the efficiency and efficacy of NIGMS funding. It is anticipated that this FOA will: Enable investigators to apply earlier in their independent research careers, allowing them to secure grant funding that will launch and sustain successful research careers. Enhance investigators' ability to move into research areas that are distinct from those of their postdoctoral mentors, which could lead to new scientific discoveries. Increase the stability of funding for NIGMS-supported investigators, which could enhance their ability to take on ambitious scientific projects and approach problems more creatively. Increase flexibility for investigators to follow important new research directions as opportunities arise, rather than being bound to specific aims proposed in advance of the studies. More widely distribute funding among the nation's highly talented and promising investigators to increase overall scientific productivity and the chances for important breakthroughs. Reduce the time spent by researchers writing and reviewing grant applications, allowing them to spend more time conducting research. Enable investigators to devote more time and energy to mentoring trainees in a more stable research environment.

The National Institute of Biomedical Imaging and Bioengineering (NIBIB) and VentureWell hold the Design by Biomedical Undergraduate Teams (DEBUT) Challenge which recognizes undergraduate excellence in biomedical innovation. DEBUT will award a total of $100K to undergraduate student teams working on innovative solutions to unmet health and clinical problems. Revised Criteria for 2020 In light of the social distancing measures that kept most students from entering labs this year, we are modifying our criteria to acknowledge teams that had excellent ideas for healthcare innovations but could not build and/or test/debug a prototype. We also want to reward teams who were able to achieve a working prototype. For 2020, each team will receive an ideation score and a prototype score and the team's final score will be the higher of the two.