Group items tagged

As stated in the Strategy for American Leadership in Advanced Manufacturing, worldwide competition in manufacturing has been dominated in recent decades by the maturation, commoditization, and widespread application of computation in production equipment and logistics, effectively leveling the global technological playing field and putting a premium on low wages and incremental technical improvements.[1] The next generation of technological competition in manufacturing will be dictated by inventions of new materials, chemicals, devices, systems, processes, machines, design and work methods, social structures and business practices. Fundamental research will be required in robotics, artificial intelligence, biotechnology, materials science, sustainability, education and public policy, and workforce development to take the lead in this global competition. The research supported under this solicitation will enhance U.S. leadership in manufacturing far into the future by providing new capabilities for established companies and entrepreneurs, improving our health and quality of life, and reducing the impact of manufacturing industries on the environment.

Asstated intheStrategy for American Leadership in Advanced Manufacturing,worldwide competition in manufacturing has been dominated in recent decades by the maturation, commoditization, and widespread application of computation in production equipment and logistics, effectively leveling the global technological playing field and putting a premium on low wages and incremental technical improvements.[1] The next generation of technological competition in manufacturing will be dictated by inventions of new materials, chemicals, devices, systems, processes, machines, design and work methods, social structures and business practices. Fundamental research will be required in robotics, artificial intelligence, biotechnology, materials science, sustainability, education and public policy, and workforce development to take the lead in this global competition. The research supported under this solicitationwillenhance U.S. leadership in manufacturing far into the future by providing new capabilitiesfor established companies andentrepreneurs,improving ourhealth and quality of life,andreducingthe impact of manufacturing industries on the environment.

CBER seeks to support the application of novel technologies for advanced manufacturing of complex biologic products, and innovative analytical approaches to improve product manufacturing and quality through active research.

CBER seeks to support the application of novel technologies for advanced manufacturing of complex biologic products, and innovative analytical approaches to improve product manufacturing and quality through active research.

The purpose of this Funding Opportunity Announcement (FOA) is to encourage biomedical, behavioral, and social science research that will inform the development and evaluation of regulations on tobacco product manufacturing, distribution, and marketing.  Research projects must address the research priorities related to the regulatory authority of the Food and Drug Administration (FDA) Center for Tobacco Products (CTP) as mandated by the Family Smoking Prevention and Tobacco Control Act (FSPTCA), Public Law 111-31. The awards under this FOA will be administered by NIH using designated funds from the FDA CTP for tobacco regulatory science. Research results from this FOA are expected to generate findings and data that are directly relevant to inform the FDA's regulation of the manufacture, distribution, and marketing of tobacco products to protect public health.  

The purpose of this Funding Opportunity Announcement (FOA) is to encourage biomedical, behavioral, and social science research that will inform the development and evaluation of regulations on tobacco product manufacturing, distribution, and marketing.  Research projects must address the research priorities related to the regulatory authority of the Food and Drug Administration (FDA) Center for Tobacco Products (CTP) as mandated by the Family Smoking Prevention and Tobacco Control Act (FSPTCA), Public Law 111-31. The awards under this FOA will be administered by NIH using designated funds from the FDA CTP for tobacco regulatory science. Research results from this FOA are expected to generate findings and data that are directly relevant to inform the FDA's regulation of the manufacture, distribution, and marketing of tobacco products to protect public health.  

The purpose of this Funding Opportunity Announcement (FOA) is to encourage biomedical, behavioral, and social science research that will inform the development and evaluation of regulations on tobacco product manufacturing, distribution, and marketing.  Research projects must address the research priorities related to the regulatory authority of the Food and Drug Administration (FDA) Center for Tobacco Products (CTP) as mandated by the Family Smoking Prevention and Tobacco Control Act (FSPTCA), Public Law 111-31. The awards under this FOA will be administered by NIH using designated funds from the FDA CTP for tobacco regulatory science. Research results from this FOA are expected to generate findings and data that are directly relevant to inform the FDA's regulation of the manufacture, distribution, and marketing of tobacco products to protect public health.  

The Biotechnology and Biochemical Engineering (BBE) program supports fundamental engineering research that advances the understanding of cellular andbiomolecular processes in engineering biology and eventually leads to the development of enabling technology for advanced manufacturing and/or applications in support of the biopharmaceutical, biotechnology, and bioenergy industries, or with applications in health or the environment. A quantitative treatment of biological and engineering problems of biological processes is considered vital to successful research projects in the BBE program. Fundamental to many research projects in this area is the understanding of how biomolecules, cells and cell populations interact in their environment, and how those molecular level interactions lead to changes in structure, function, phenotype, and/or behavior. The program encourages highly innovative and potentially transformative engineering research leading to novel bioprocessing and manufacturing approaches, and proposals that address emerging research areas and technologies that effectively integrate knowledge and practices from different disciplines while incorporating ongoing research into educational activities. 

The National Institute on Drug Abuse (NIDA) intends to solicit proposals from offerors having the capability to perform the following tasks: (1) cultivate and harvest, process, analyze, store, and distribute cannabis (marijuana) for research, (2) extract cannabis to produce pure and standardized (current Good Manufacturing Practices (cGMP)-grade) cannabis extracts containing varying concentrations of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), (3) isolate cGMP and research grade THC, CBD, and other cannabinoids, (4) periodically analyze cannabis extracts, and isolated cannabinoids for authenticity, purity and stability, (5) develop new methods for growing cannabis plants containing high THC, low CBD; high CBD, low THC; and equal strength of CBD and THC, (6) manufacture, analyze, determine stability, store, and supply marijuana cigarettes, and (7) supply cannabis, cannabis extract, other phyto-cannabinoids, and marijuana cigarettes to research investigators and/or to the NIDA Drug Supply program upon NIDA authorization.

This Program encourages research on processes and production systems based on computation, modeling and simulation, use of process metrology, sensing, monitoring, and control, and assessment of product (nanomaterial, nanostructure, nanodevice or nanosystem) quality and performance. The Program seeks to explore transformative approaches to nanomanufacturing, including but not limited to: micro-reactor and micro-fluidics enabled nanosynthesis, bio-inspired nanomanufacturing, manufacturing by nanomachines, additive nanomanufacturing, hierarchical nanostructure assembly, continuous high-rate nanofabrication such as roll-to-roll processing or massively-parallel large-area processing, and modular manufacturing platforms for nanosystems. 

NineSigma, representing a multi-billion-dollar medical instruments manufacturer, is looking for development partners to realize next-generation balloon catheters. The main development object involves balloon parts that act as components for balloon catheters. The client seeks technology that resolves the challenges of pressure resistance, flexibility, etc., and that is applicable to the field of medical instruments. The client also widely welcomes materials, structural designs, manufacturing methods, etc., that are used in other fields.

The intended outcome of this cooperative agreement is to advance the goal of a national food safety system by supporting and enhancing state food laboratories tasked with investigation of foodborne disease outbreaks in activities including: 1. Ensuring microbiological and chemical food analyses performed on behalf of the State manufactured food regulatory programs are conducted within the scope of an International Organization for Standardization (ISO)/ International Electrotechnical Commission (IEC) 17025 accredited laboratory; 2. Strengthening the collaboration between the laboratories and State manufactured food regulatory programs; 3. Increasing the number of State samples collected and analyzed for surveillance purposes annually; 4. Developing a stronger international rapid surveillance system for pathogen traceback through the GenomeTrakr network using a minimum set of metadata fields for all food and environmental isolates; and 5. Providing additional support to the State food laboratories through an outside association to offer trainings, workshops, and educational resources to both awardees under this cooperative agreement and to unfunded laboratories seeking ISO/IEC 17025 accreditation.

The Nano-Bio Manufacturing Consortium is expected to grow the US-centric innovation ecosystem that will risk reduce material supply (including nanomaterials & biomaterials), processing techniques, and flexible/stretchable device concepts by demonstrating component- and system-level functionality relevant to human-integrated technologies, such as airman-performance monitoring (APM) and augmentation (APA) systems. This public-private partnership should build upon the foundation of research & development excellence that has been established within NBMC since its 2013 inception. It is envisioned that technology development will require teaming between academia and industry in partnership with government researchers as well as with appropriate members of the regulatory and operational DoD communities. A balance between enabling component- and systems-level prototype development is expected to be realized through end-technologies between TRL 3 and TRL 6. It is expected that during the completion of certain NBMC projects, lab and/or field demonstrations will be conducted in partnership with relevant DoD partners to ensure that members of military human performance and/or aeromedical communities can assess the utility of developments and provide iterative feedback with respect to critical path issues.

This Funding Opportunity Announcement (FOA) supports the optimization of potential therapeutic Biotechnology Products and Biologics (e.g., peptides, proteins, oligonucleotides, gene and cell therapies) for disorders identified under the NINDS mission. This track supports the further characterization and optimization of therapeutic lead(s) that showed promise as a potential therapeutic agent as evidenced by convincing animal proof-of-concept studies. Therefore, at the end of this funding period, successful projects will have delivered and optimized therapeutic candidate with demonstrated bioactivity, stability, manufacturability, bioavailability, in vivo efficacy and should be eligible for entry into the CREATE Bio Development track. The CREATE Bio Development track is a later stage program focused on the development of optimized therapeutic candidates through Investigational New Drug (IND)-enabling studies and submission of an IND package to the Food and Drug Administration (FDA). This Funding Opportunity Announcement (FOA) supports the optimization of potential therapeutic Biotechnology Products and Biologics (e.g., peptides, proteins, oligonucleotides, gene and cell therapies) for disorders identified under the NINDS mission. This track supports the further characterization and optimization of therapeutic lead(s) that showed promise as a potential therapeutic agent as evidenced by convincing animal proof-of-concept studies. Therefore, at the end of this funding period, successful projects will have delivered and optimized therapeutic candidate with demonstrated bioactivity, stability, manufacturability, bioavailability, in vivo efficacy and should be eligible for entry into the CREATE Bio Development track. The CREATE Bio Development track is a later stage program focused on the development of optimized therapeutic candidates through Investigational New Drug (IND)-enabling studies and submission of an IND package to the Food and Drug Administration (FDA).

JDRF is launching an initiative to accelerate the development of "open-protocol" automated insulin delivery (artificial pancreas) systems. JDRF is soliciting proposals from insulin pump manufacturers and continuous glucose monitor (CGM) manufacturers that will enable seamless, secure connectivity with other devices (e.g., by using Bluetooth technology). JDRF remains committed to supporting the traditional, proprietary commercial development of artificial pancreas systems; in parallel, JDRF will launch efforts in the United States and globally to partner with regulators and legal experts to establish predictable approval pathways for systems that allow for secure, open-protocol-based control through commercially developed devices and software

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative research proposals in the areas of physical sciences, engineering, materials, mathematics, biology, computing, informatics, social science, and manufacturing of interest to DARPA's Defense Sciences Office (DSO), Microsystems Technology Office (MTO), and Biological Technologies Office (BTO).

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative research proposals in the areas of physical sciences, engineering, materials, mathematics, biology, computing, informatics, social science, and manufacturing of interest to DARPA's Defense Sciences Office (DSO), Microsystems Technology Office (MTO), and Biological Technologies Office (BTO).

The goal of the Particulate and Multiphase Processes (PMP) program is to support fundamental research on physico-chemical phenomena that govern particulate and multiphase systems, including flow of suspensions, drops and bubbles, granular and granular-fluid flows, behavior of micro- and nanostructured fluids, and self-assembly/directed-assembly processes that involve particulates.  The program encourages transformative research to improve our basic understanding of particulate and multiphase processes with emphasis on research that demonstrates how particle-scale phenomena affect the behavior and dynamics of larger-scale systems.  Although proposed research should focus on fundamentals, a clear vision is required that anticipates how results could benefit important applications in advanced manufacturing, energy harvesting, transport in biological systems, biotechnology, or environmental sustainability.  Collaborative and interdisciplinary proposals are encouraged, especially those that involve a combination of experiment with theory or modeling.  Proposals whose main focus is on the synthesis of particles are not encouraged.

The goal of the Particulate and Multiphase Processes (PMP) program is to support fundamental research on physico-chemical phenomena that govern particulate and multiphase systems, including flow of suspensions, drops and bubbles, granular and granular-fluid flows, behavior of micro- and nanostructured fluids, and self-assembly/directed-assembly processes that involve particulates.  The program encourages transformative research to improve our basic understanding of particulate and multiphase processes with emphasis on research that demonstrates how particle-scale phenomena affect the behavior and dynamics of larger-scale systems.  Although proposed research should focus on fundamentals, a clear vision is required that anticipates how results could benefit important applications in advanced manufacturing, energy harvesting, transport in biological systems, biotechnology, or environmental sustainability.  Collaborative and interdisciplinary proposals are encouraged, especially those that involve a combination of experiment with theory or modeling.  Proposals whose main focus is on the synthesis of particles are not encouraged.

The Biotechnology and Biochemical Engineering (BBE) program supports fundamental engineering research that advances the understanding of cellular and biomolecular processes in engineering biology and eventually leads to the development of enabling technology for advanced manufacturing and/or applications in support of the biopharmaceutical, biotechnology, and bioenergy industries, or with applications in health or the environment.  A quantitative treatment of biological and engineering problems of biological processes is considered vital to successful research projects in the BBE program.

The Biotechnology and Biochemical Engineering (BBE) program supports fundamental engineering research that advances the understanding of cellular and biomolecular processes in engineering biology and eventually leads to the development of enabling technology for advanced manufacturing and/or applications in support of the biopharmaceutical, biotechnology, and bioenergy industries, or with applications in health or the environment.  A quantitative treatment of biological and engineering problems of biological processes is considered vital to successful research projects in the BBE program. 

The goal of the Particulate and Multiphase Processes (PMP) program is to support fundamental research on physico-chemical phenomena that govern particulate and multiphase systems, including flow of suspensions, drops and bubbles, granular and granular-fluid flows, behavior of micro- and nanostructured fluids, and self-assembly/directed-assembly processes that involve particulates.  The program encourages transformative research to improve our basic understanding of particulate and multiphase processes with emphasis on research that demonstrates how particle-scale phenomena affect the behavior and dynamics of larger-scale systems.  Although proposed research should focus on fundamentals, a clear vision is required that anticipates how results could benefit important applications in advanced manufacturing, energy harvesting, transport in biological systems, biotechnology, or environmental sustainability.  Collaborative and interdisciplinary proposals are encouraged, especially those that involve a combination of experiment with theory or modeling.

The goal of the Particulate and Multiphase Processes (PMP) program is to support fundamental research on physico-chemical phenomena that govern particulate and multiphase systems, including flow of suspensions, drops and bubbles, granular and granular-fluid flows, behavior of micro- and nanostructured fluids, and self-assembly/directed-assembly processes that involve particulates.  The program encourages transformative research to improve our basic understanding of particulate and multiphase processes with emphasis on research that demonstrates how particle-scale phenomena affect the behavior and dynamics of larger-scale systems.  Although proposed research should focus on fundamentals, a clear vision is required that anticipates how results could benefit important applications in advanced manufacturing, energy harvesting, transport in biological systems, biotechnology, or environmental sustainability.  Collaborative and interdisciplinary proposals are encouraged, especially those that involve a combination of experiment with theory or modeling.

This challenge focuses on innovations in vaccine manufacturing platforms designed to lower production cost for vaccines that target diseases of great global burden and that are among the most costly to produce with current technologies. The vaccines should target one of the following diseases: human papillomavirus vaccine; inactivated poliovirus vaccine; measles-rubella vaccine; pentavalent vaccine (diphtheria, tetanus, whole-cell pertussis, hepatitis B, Hib); pneumococcal vaccine; or rotavirus vaccine. The target production cost of ≤ $0.15 per dose should represent the fully-loaded cost, which ensures that all relevant costs are accounted for.