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The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this NCI R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nation's biomedical, behavioral and clinical research needs. To accomplish the stated over-arching goal, this FOA will support creative educational activities with a primary focus on Research Experiences. Applications are encouraged that propose innovative, state-of-the-art programs that address the cause, diagnosis, prevention, or treatment of cancer, rehabilitation from cancer, or the continuing care of cancer patients and the families of cancer patients.

The National Institute of General Medical Sciences (NIGMS) of the NIH invites applications for renewal of eligible Centers of Biomedical Research Excellence (COBRE) grants. The objective of the COBRE initiative is to strengthen an institution's biomedical research infrastructure through the establishment of a thematic, multi-disciplinary center and to enhance the ability of investigators to compete independently for National Institutes of Health (NIH) individual research grants or other external peer-reviewed support. COBRE awards are supported through the Institutional Development Award (IDeA) Program, which aims to foster health-related research by increasing the competitiveness of investigators at institutions located in IDeA states.

The National Institute of General Medical Sciences (NIGMS) invites applications for Centers of Biomedical Research Excellence (COBRE) from investigators at biomedical research institutions that award doctoral degrees in the health sciences or sciences related to health or at independent biomedical research institutes with ongoing biomedical research programs funded by the NIH or other federal agencies within Institutional Development Award (IDeA) eligible states. The objectives of the COBRE initiative is to strengthen an institution's biomedical research infrastructure through the establishment of a thematic multi-disciplinary center and to enhance the ability of investigators to compete independently for complementary National Institutes of Health (NIH) individual research grants or other external peer-reviewed support. COBRE awards are supported through the IDeA Program, which aims to foster health-related research by increasing the competitiveness of investigators at institutions located in states with historically low aggregate success rates for grant awards from the NIH.

The purpose of this Funding Opportunity Announcement (FOA) is to support the development of infrastructure and other resources required for the conduct of Clinical and Translational Research (CTR) in IDeA-eligible states. IDeA-CTR Centers are expected to provide added value to the biomedical research efforts in the participating institutions through support of activities that cannot easily be provided through standard research grant awards. The proposed activities will provide the infrastructure and resources that will enhance the competitiveness of the investigators to obtain additional funding for clinical and translational research. Applicants must establish a statewide network of collaborating and partnering institutions/organizations. Other institutions/organizations outside the state may be included if forming a network of wider reach. Since only one award will be made per IDeA-eligible state, only one application should be submitted per state.

Genomic Science program supports basic research aimed at identifying the foundational principles that drive biological systems. These principles govern the translation of the genetic code into integrated networks of proteins, enzymes, regulatory elements, and metabolite pools that are the functional processes of organisms including microbes and multispecies communities relevant to DOE missions in energy and the environment. To address the DOE mission in sustainable Bioenergy development, the Genomic Science program brings omics-driven tools of modern systems biology to bear on the challenges associated with microbial production of advanced Biofuels and Bioproducts.Developing an increased understanding of how biological systems function and translating that knowledge to enhance the production capabilities of microbes and plants forms the basis of DOE's mission in sustainable Bioenergy. To harness the biosynthetic processing power of the microbial world for advanced Biofuels and Bioproducts production, an expanded set of platform organisms with appropriate metabolic capabilities and stress tolerance characteristics with a suite of modification tools will need to be developed. To foster this development, the DOE-BER Genomic Science program supports research aimed at understanding the principles that govern the functional properties of bioenergy relevant organisms at the genomic scale.

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this NICHD R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nation's biomedical, behavioral and clinical research needs. To accomplish the stated over-arching goal, this FOA will support creative educational activities with a primary focus on Courses for Skills Development, which are encouraged to include hands-on research experiences. This FOA encourages applications to develop and conduct short-term research education programs to improve the knowledge and research skills of biomedical and behavioral scientists conducting research in areas relevant to the mission of NICHD, including reproductive, developmental, behavioral, social, and rehabilitative processes that determine the health and well-being of newborns, infants, children, adults, families, and populations.

The purpose of this Funding Opportunity Announcement (FOA) is to accelerate the adoption and validation of molecular/cellular/imaging markers and assays for cancer detection, diagnosis, prognosis, monitoring, and prediction of response or resistance to treatment, as well as markers for cancer prevention and control. This FOA also includes the validation of pharmacodynamic markers and markers of toxicity. Applicants to this FOA must have an assay(s) whose performance has been analytically validated in specimens similar to those for the intended clinical use of the assay(s) and marker(s). As chemotherapies and/or radiation therapies are increasingly combined with immunotherapies to enhance durability of anti-cancer responses, multiple assays for measuring multiple markers, including immune markers, can be developed and validated simultaneously.

The goal of the RCN program is to advance a field or create new directions in research or education by supporting groups of investigators to communicate and coordinate their research, training, and educational activities across disciplinary, organizational, geographic, and international boundaries. The RCN-UBE program originated as a unique RCN track to "catalyze positive changes in biology undergraduate education" (NSF 08-035) and is now supported by the collaborative efforts of the Directorate for Biological Sciences (BIO) and the Directorate for Education and Human Resources (EHR). It has been responsive to the national movement to revolutionize undergraduate learning and teaching in the biological sciences as described in the "Vision and Change in Undergraduate Biology Education" report. The RCN-UBE program seeks to improve undergraduate biology in different areas by leveraging the power of a collaborative network. The theme or focus of an RCN-UBE proposal can be on any topic likely to advance the goal of enhancing undergraduate biology education. Collectively, the program has contributed to developing and disseminating educational research resources and modules, to forging of new collaborations, and to sharing of best practices and ideas for scalability and sustainability of activities.  These efforts have involved a large cadre of faculty, students, and other stakeholders. Proposed networking activities directed to the RCN-UBE program should focus on a theme to give coherence to the collaboration.

NSF INCLUDES (Inclusion across the Nation of Communities of Learners of Underrepresented Discoverers in Engineering and Science) is a comprehensive national initiative designed to enhance U.S. leadership in science, technology, engineering, and mathematics (STEM) discoveries and innovations by focusing on broadening participation in these fields at scale. The vision of NSF INCLUDES is to catalyze the STEM enterprise to collaboratively work for inclusive change, which will result in a STEM workforce that reflects the population of the Nation. The initiative is developing a National Network composed of NSF INCLUDES Design and Development Launch Pilots, NSF INCLUDES Alliances, an NSF INCLUDES Coordination Hub, NSF-funded broadening participation projects, other relevant NSF-funded projects, scholars engaged in broadening participation research, and other organizations that support the development of talent from all sectors of society to build an inclusive STEM workforce.

TheMacrosystems Biology and NEON-Enabled Science (MSB-NES): Research on Biological Systems at Regional to Continental Scalesprogram will support quantitative, interdisciplinary, systems-oriented research on biosphere processes and their complex interactions with climate, land use, and changes in species distributionatregional to continental scales as well as training activities to broaden participation of researchers in Macrosystems Biology and NEON-EnabledScience. Proposers are encouraged to use NEON resources, and proposals for substantive and innovative NEON-enabled research will be prioritized for funding.Substantive NEON-enabled projects rely on data and/or samples collected by NEON, co-locate research activities at NEON sites, and/or develop tools that will explicitly enhance the processing, use, and/or analysis of NEON data or collections within the context of Macrosystems Biology research questions.

I-Corps@Ohio is a statewide program developed to assist faculty, staff and students from Ohio universities, colleges and community colleges in validating the market potential of technologies and launching startup companies. I-Corps@Ohio is modeled after the National Science Foundation's (NSF) successful I-Corps (Innovation Corps) program, which has been proven to increase innovation, entrepreneurship, and industry collaboration. The I-Corps@Ohio program incorporates lean launch, customer discovery and business model innovation methodologies to assess technologies, enhance the business acumen of research faculty and students and expand their entrepreneurial network relationships. Two cohort tracks are offered in Science & Engineering and Medtech, with each designed to offer both common and subject matter specific content. The long-term objective of I-Corps@Ohio is to systematically build a steady and predictable pipeline of  high-quality, high-growth startups from technology developed at the State's colleges, universities, and research institutions, that contribute to economic development in Ohio.

This Funding Opportunity Announcement (FOA) solicits grant applications proposing exploratory research projects focused on the early-stage development of highly innovative technologies that improve the quality of the samples used for cancer research or clinical care. This includes new capabilities to address issues related to pre-analytical degradation of targeted analytes during the collection, processing, handling, and/or storage of cancer-relevant biospecimens. The overall goal is to support the development of highly innovative technologies capable of maximizing or otherwise interrogating the quality and utility of biological samples used for downstream analyses. This FOA will support the development of tools, devices, instrumentation, and associated methods to preserve or protect sample integrity, or establish verification criteria for quality assessment/quality control and handling under diverse conditions. These technologies are expected to accelerate and/or enhance research in cancer biology, early detection and screening, clinical diagnosis, treatment, epidemiology, or address issues associated with cancer health disparities, by reducing pre-analytical variations that affect biospecimen sample quality. This funding opportunity is part of a broader NCI-sponsored Innovative Molecular Analysis Technologies (IMAT) Program.

This Funding Opportunity Announcement (FOA) solicits grant applications proposing exploratory research projects focused on further development and validation of emerging technologies that improve the quality of the samples used for cancer research or clinical care. This includes the ability to address issues related to pre-analytical degradation of targeted analytes during the collection, processing, handling, and/or storage of cancer-relevant biospecimens. The overall goal is to support the development of highly innovative technologies capable of maximizing or otherwise interrogating the quality and utility of biological samples used for downstream analyses. FOA Emphasis. The FOA utilizes the R33 mechanism which is suitable for projects where proof-of-principle of the proposed technology or methodology has been demonstrated and supportive preliminary data are available. Proposed projects should offer new tools, devices, instrumentation, and associated methods to preserve or protect sample integrity, or establish verification criteria for quality assessment/quality control and handling under diverse conditions. These technologies are expected to accelerate and/or enhance research in cancer biology, early detection, and screening, clinical diagnosis, treatment, epidemiology, or address issues associated with cancer health disparities, by reducing pre-analytical variations that affect biospecimen sample quality.

This Funding Opportunity Announcement (FOA) solicits grant applications proposing exploratory research projects focused on further development and validation of emerging technologies offering novel capabilities for targeting, probing, or assessing molecular and cellular features of cancer biology for basic or clinical cancer research. Well-suited applications must offer the potential to accelerate and/or enhance research in the areas of cancer biology, early detection and screening, clinical diagnosis, treatment, control, epidemiology, and/or address issues associated with cancer health disparities. Technologies proposed for development may be intended to have widespread applicability but must be focused on improving molecular and/or cellular characterizations of cancer. FOA Emphasis. This FOA utilizes the R33 mechanism and is suitable for projects, which have overcome major feasibility gaps for the technology or methodology as demonstrated with supportive preliminary data but still require further development and rigorous validation to encourage adoption by the research community. Proposed projects should offer the potential to produce a molecular or cellular analysis capability with a major impact in a broad area of cancer-relevant research.

This Funding Opportunity Announcement (FOA) solicits grant applications proposing exploratory research projects focused on the inception and early-stage development of highly innovative, molecular and/or cellular analysis technologies with transformative potential. The emphasis of this FOA is on supporting the development of novel capabilities involving a high degree of technical innovation for targeting, probing, or assessing molecular and cellular features of cancer biology. Well-suited applications must offer the potential to accelerate and/or enhance research in the areas of cancer biology, early detection, and screening, clinical diagnosis, treatment, control, epidemiology, and/or cancer health disparities. Technologies proposed for development may be intended to have widespread applicability but must focus on improving molecular and/or cellular characterizations of cancer. Applications involving an existing technology not yet demonstrated for the proposed cancer-relevant application(s) are also within the scope of this FOA but must involve additional technical modifications and development to allow for the proposed cancer-relevant context of use or some significant question of feasibility exists for achieving the proposed aims. If the research focus for the application involves an existing technology, a clear description of the feasibility risk justifying the use of the R21 mechanism must be included in the application.  Applicants are encouraged to reach out to the Scientific/Research Contact below with any questions.

This Funding Opportunity Announcement (FOA) solicits grant applications proposing exploratory research projects focused on early-stage development of highly innovative technologies that improve the quality of the samples used for cancer research or clinical care. This includes new capabilities to address issues related to pre-analytical degradation of targeted analytes during the collection, processing, handling, and/or storage of cancer-relevant biospecimens. The emphasis of this FOA is to support the development of highly innovative technologies capable of maximizing or otherwise interrogating the quality and utility of biological samples used for downstream analyses. This FOA will support the development of tools, devices, instrumentation, and associated methods to preserve or protect sample integrity, or establish verification criteria for quality assessment/quality control and handling under diverse conditions. These technologies are expected to accelerate and/or enhance research in cancer biology, early detection, screening, clinical diagnosis, treatment, epidemiology, or address issues in cancer health disparities, by reducing pre-analytical variations that affect biospecimen sample quality.

Purpose The purpose of this FOA is to support a network to enhance collaborations across NIA's 6 centers programs. These collaborations are intended to leverage NIA's substantial investments by fostering and sustaining the development of novel interdisciplinary efforts in aging research. This opportunity will provide resources to build additional infrastructure and establish specific collaborative activities that could include, but are not limited to, information and data exchange, meetings and conferences, pilot studies, research opportunities for early investigators, visiting scholar programs, dissemination, and other collaborative efforts. The successful awardee will involve all 6 centers programs. Background The National Institute on Aging supports 6 research centers programs: Alzheimer's Disease Centers Claude D. Pepper Older Americans Independence Centers (OAICs) Nathan Shock Centers of Excellence in the Basic Biology of Aging Resource Centers for Minority Aging Research (RCMARs) Edward R. Roybal Centers for Translation Research in the Behavioral and Social Sciences of Aging Centers on the Demography and Economics of Aging These programs, comprised of over 80 individual centers across the US, are highly productive hubs of research activity that are advancing the science of aging in their individual areas of focus. As advances in one area have the potential to address obstacles to progress in another area, numerous opportunities exist for collaborations across different centers programs. However, these opportunities have been realized to only a limited degree to date.

The NIH Research Education Program (R25) supports research educational activities that complement other formal training programs in the mission areas of the NIH Institutes and Centers. The over-arching goals of the NIH R25 program are to: (1) complement and/or enhance the training of a workforce to meet the nation's biomedical, behavioral and clinical research needs; (2) encourage individuals from diverse backgrounds, including those from groups underrepresented in the biomedical and behavioral sciences, to pursue further studies or careers in research; (3) help recruit individuals with specific specialty or disciplinary backgrounds to research careers in biomedical, behavioral and clinical sciences; and (4) foster a better understanding of biomedical, behavioral and clinical research and its implications. The over-arching goal of this R25 program is to support educational activities that encourage individuals from diverse backgrounds, including those from groups underrepresented in the biomedical and behavioral sciences, to pursue further studies or careers in research. To accomplish the stated overarching goal, this FOA will support creative educational activities with a primary focus on: Research Experiences: For example, to provide hands-on exposure to research, to prepare participants for graduate school admissions, successful completion of a research-focused doctoral degree, and careers in the biomedical research workforce. Courses for Skills Development: For example, to provide advanced courses in a specific discipline, research technique or research area, and/or courses or workshops to develop scholarly potential to prepare participants for graduate school admissions, successful completion of a research-focused doctoral degree, and careers in the biomedical research workforce

Genome-wide association studies (GWAS) identify statistical relationships between common single nucleotide variants (SNVs) across the genome and a trait of interest. Due to the correlated nature of nearby SNVs (i.e., linkage disequilibrium), GWAS implicate regions of the genome (loci) and do not necessarily pinpoint the causal variant(s), gene(s), isoform(s) or proximate molecular mechanism(s) underlying the trait association. Greater than 90% of genome-wide significant variants associated with traits fall within non-coding regions of the genome. A minority of these variants will be the actual causal variants and a majority will not affect the nearest genes. Moreover, functional annotation of the non-coding genome is still incomplete; the target genes of many genomic regulatory elements such as enhancers remain unknown. This presents a major challenge to mapping variants onto genes and genes onto traits. Thus, an immediate barrier to translating genetic associations into causal disease mechanisms is the uncertain relationship between statistically identified genetic variants and the resultant molecular changes influencing, directly or indirectly, a trait.

The purpose of this Funding Opportunity Announcement (FOA) is to support multidisciplinary research projects that examine the relative biological effectiveness (RBE) of high linear energy transfer (high LET) radiation on cell and tissue targets. The overall goal of the research is to establish a firm scientific basis for RBE models of high LET radiation and determine potential benefits in cancer treatment. A meritorious application is expected to be well-balanced in terms of interdisciplinary science that spans approaches in both radiation biology and radiation physics research. Priorities for this FOA are on 1) Applications with potential to enhance the understanding of mechanisms related to high LET effects in both cancer and normal tissues; and 2) Characterization of high LET effects that have potential to inform treatment strategies for cancers resistant to conventional radiation or other combined modality treatments.