Plasma selenium, manganese superoxide dismutase, and intermediate- or high-risk prostate cancer.
Chan JM, Oh WK, Xie W, Regan MM, Stampfer MJ, King IB, Abe M, Kantoff PW.
J Clin Oncol. 2009 Aug 1;27(22):3577-83. Epub 2009 Jun 15.
PMID: 19528373
DOI: 10.1200/JCO.2008.18.8938
Conclusion: These data suggest that the relationship between circulating selenium levels at diagnosis and prognostic risk of prostate cancer is modified by SOD2 genotype and indicate caution against broad use of selenium supplementation for men with prostate cancer.
High prevalence of vitamin D deficiency despite supplementation in premenopausal women with breast cancer undergoing adjuvant chemotherapy.
Crew KD, Shane E, Cremers S, McMahon DJ, Irani D, Hershman DL.
J Clin Oncol. 2009 May 1;27(13):2151-6. Epub 2009 Apr 6.
PMID: 19349547
DOI: 10.1200/JCO.2008.19.6162
Conclusion Vitamin D deficiency is highly prevalent in women with breast cancer. The current recommended dietary allowance of vitamin D is too low to increase serum 25-OHD greater than 30 ng/mL. Optimal dosing for bone health and, possibly, improved survival has yet to be determined.
Prognostic effects of 25-hydroxyvitamin D levels in early breast cancer.
Goodwin PJ, Ennis M, Pritchard KI, Koo J, Hood N.
J Clin Oncol. 2009 Aug 10;27(23):3757-63. Epub 2009 May 18.
PMID: 19451439
DOI: 10.1200/JCO.2008.20.0725
Conclusion Vitamin D deficiency may be associated with poor outcomes in breast cancer.
Circulating 25-hydroxyvitamin d levels and survival in patients with colorectal cancer.
Ng K, Meyerhardt JA, Wu K, Feskanich D, Hollis BW, Giovannucci EL, Fuchs CS.
J Clin Oncol. 2008 Jun 20;26(18):2984-91.
PMID: 18565885
DOI: 10.1200/JCO.2007.15.1027
Conclusion Among patients with colorectal cancer, higher prediagnosis plasma 25(OH)D levels were associated with a significant improvement in overall survival. Further study of the vitamin D pathway and its influence on colorectal carcinogenesis and cancer progression is warranted.
Caution regarding 25-hydroxyvitamin D monitoring in women with breast cancer.
Chlebowski RT.
J Clin Oncol. 2009 Aug 20;27(24):e72-3; author reply e74. Epub 2009 Jul 20.
PMID: 1962047