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Tero Toivanen

Brain Stimulant: Brain Chip to Restore Functioning from Damage - 1 views

  • The ReNaChip project is developing electronic biomimetic technology that could serve to replace damaged or missing brain tissue. This is basically neuromorphic engineering that seeks to mimic how neurons function. In the future this may be useful for people who have had injuries due to stroke or other illnesses.
  • The objective of this project is to develop a full biohybrid rehabilitation and substitution methodology; replacing the aged cerebellar brain circuit with a biomimetic chip bidirectionally interfaced to the inputs and outputs of the system. Information processing will interface with the cerebellum to actuate a normal, real-time functional behavioural recovery, providing a proof-of-concept test for the functional rehabilitation of more complex neuronal systems.
  • A sophisticated exocortex could potentially allow a two way communication between the external apparatus and the mind. The contraption could essentially scale up the amount of neurons in your brain by an artificial means. Most likely it would be used to improved the disabled first, with other applications being more speculative possibilities.
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    The ReNaChip project is developing electronic biomimetic technology that could serve to replace damaged or missing brain tissue. This is basically neuromorphic engineering that seeks to mimic how neurons function. In the future this may be useful for people who have had injuries due to stroke or other illnesses.
Tero Toivanen

Does Vitamin D Improve Brain Function?: Scientific American - 0 views

  • And although vitamin D is well known for promoting bone health and regulating vital calcium levels—hence its addition to milk—it does more than that. Scientists have now linked this fat-soluble nutrient’s hormonelike activity to a number of functions throughout the body, including the workings of the brain.
  • We know there are receptors for vitamin D throughout the central nervous system and in the hippocampus
  • We also know vitamin D activates and deactivates enzymes in the brain and the cerebrospinal fluid that are involved in neurotransmitter synthesis and nerve growth.
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  • In addition, animal and laboratory studies suggest vitamin D protects neurons and reduces inflammation.
  • The scientists found that the lower the subjects’ vitamin D levels, the more negatively impacted was their perform­ance on a battery of mental tests. Compared with people with optimum vitamin D levels, those in the lowest quartile were more than twice as likely to be cognitively impaired.
  • The data show that those people with lower vitamin D levels exhibited slower information-processing speed. This correlation was particularly strong among men older than 60 years.
  • Although we now know that low levels of vitamin D are associated with cognitive impairment, we do not know if high or optimum levels will lessen cognitive losses. It is also unclear if giving vitamin D to those who lack it will help them regain some of these high-level functions.
  • So how much is enough vitamin D? Experts say 1,000 to 2,000 IU daily—about the amount your body will synthesize from 15 to 30 minutes of sun exposure two to three times a week—is the ideal range for almost all healthy adults. Keep in mind, however, that skin color, where you live and how much skin you have exposed all affect how much vitamin D you can produce.
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    And although vitamin D is well known for promoting bone health and regulating vital calcium levels-hence its addition to milk-it does more than that. Scientists have now linked this fat-soluble nutrient's hormonelike activity to a number of functions throughout the body, including the workings of the brain.
Tero Toivanen

Brain Function Cerebellum and Brain Stem - 0 views

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    A Guide to Brain Anatomy, Function and Symptoms: serebellum, midbrain, pons and medulla oblongata.
Tero Toivanen

AK's Rambling Thoughts: Nerve Cells and Glial Cells: Redefining the Foundation of Intel... - 0 views

  • Glia are generally divided into two broad classes, microglia and macroglia. Microglia are part of the immune system, specialized macrophages, and probably don't participate in information handling. Macroglia are present in both the peripheral and central nervous systems, in different types.
  • Traditionally, there were four types of glia in the CNS: astrocytes, oligodendrocytes, ependymal cells, and radial glia. Of these, the one type that's most important to the developing revolution in our ideas are those cells called astrocytes.2 It turns out that there are at least two types of cell (at least) subsumed under this name.24, 25, 31, 32 One, which retains the name of astrocyte, takes up neurotransmitters released by neurons (and glial cells), aids in osmoregulation,10 controls circulation in the brain,1, 31 and generally appears to provide support for the neurons and other types of glia.
  • Although both NG2-glia and astrocytes extend processes to nodes of Ranvier in white matter ([refs]) and synapses in grey matter, their geometric relationship to these neuronal elements is different. Thus, although astrocytes and NG2-glia bear a superficial resemblance, they are distinguished by their different process arborizations. This will reflect fundamental differences in the way these two glial cell populations interact with other elements in the neural network.
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  • Both types of glia are closely integrated with the nervous system, receiving information from action potentials via synapses22 (which, only a few years ago were thought to be limited to neurons), and returning control of neuron activity through release of neurotransmitters and other modulators. Both, then, demonstrate the potential for considerable intelligent activity, contributing to the overall intelligence of the brain.
  • Astrocytes probably (IMO) are limited, or mostly so, to maintaining the supplies of energy and necessary metabolites. They receive action potentials,3, 6 which allows them to closely and quickly monitor general activity and increase circulation in response, even before the neurons and NG2-glia have reduced their supply of ATP.21 They appear to be linked in a network among themselves,2, 5 allowing them to communicate their needs without interfering with the higher-level calculations of the brain.
  • NG2-glia appear to have several functions, but one of the most exciting things about them is that they seem to be able to fire action potentials.33 Their cell membranes, like those of the dendrites of neurons, have all the necessary channels and receptors to perform real-time electrical calculations in the same way as neural dendrites. They have also demonstrated the ability to learn through long term potentiation.
  • Dividing NG2-glia also retain the ability to fire action potentials, as well as receiving synaptic inputs from neurons.23 Presumably, they continue to perform their full function, including retaining any elements of long term potentiation or depression contained in their synapses.
  • Oligodendrocytes are responsible for the insulation of the axons, wrapping around approximately 1 mm of each of up to 50 axons within their reach, and forming the myelin sheath.
  • Although the precise type of neuron formed by maturing cells hasn't been determined, the very fact that cells of this type can change into neurons is very important. We actually don't know whether the cells that do this maturation are the same as those that perform neuron-like activities, there appear to be two separate types of NG2-glia, spiking and non-spiking.26 It may very well be that the "spiking" type have actually differentiated, while the "non-spiking" type may be doing the maturing. Of course, very few differentiated cell types remain capable of division, as even the "spiking" type do.
  • What's important about both dendrites and NG2-glia isn't so much their ability to propagate action potentials, as that their entire cell membranes are capable of "intelligent" manipulation of the voltage across it.
  • While there are many ion channels involved in controlling the voltage across the cell membrane, the only type we really need to worry about for action potentials is voltage-gated sodium channels. These are channels that sometimes allow sodium ions to pass through the cell membrane, which they will do because the concentration of sodium ions outside the cell is very much higher than inside. When and how much they open depends, among other things, on the voltage across the membrane.
  • A normal neuron will have a voltage of around -60 to -80mV (millivolts), in a direction that tends to push the sodium ions (which are positive) into the cell (the same direction as the concentration is pushing). When the voltage falls to around -55mV, the primary type of gate will open for a millisecond or so, after which it will close and rest for several milliseconds. It won't be able to open again until the voltage is somewhere between -55 and around -10mV. Meanwhile, the sodium current has caused the voltage to swing past zero to around +20mV.
  • When one part of the cell membrane is "depolarized" in this fashion, the voltage near it is also depressed. Thus, if the voltage is at zero at one point, it might be at -20mV 10 microns (μm) away, and -40mV 20μm away, and -60mV 30μm, and so on. Notice that somewhere between 20μm and 30μm, it has passed the threshold for the ion channels, which means that they are open, allowing a current that drives the voltage further down. This will produce a wave of voltage drop along the membrane, which is what the action potential is.
  • After the action potential has passed, and the gates have closed (see above), the voltage is recovered by diffusion of ions towards and away from the membrane, the opening of other gates (primarily potassium), and a set of pumps that push the ions back to their resting state. These pumps are mostly powered by the sodium gradient, except for the sodium/potassium pump that maintains it, which is powered by ATP.
  • the vast majority of calculation that goes into human intelligence takes place at the level of the network of dendrites and NG2-glia, with the whole system of axons, dendrites, and action potentials only carrying a tiny subset of the total information over long distances. This is especially important considering that the human brain has a much higher proportion of glial matter than our relatives.
  • This, in turn, suggests that our overall approach to understanding the brain has been far too axon centric, there needs to be a shift to a more membrane-centric approach to understanding how the brain creates intelligence.
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    Our traditional idea of how the brain works is based on the neuron: it fires action potentials, which travel along the axon and, when the reach the synapses, the receiving neuron performs a calculation that results in the decision when (or whether) to fire its own action potential. Thus, the brain, from a thinking point of view, is viewed as a network of neurons each performing its own calculation. This view, which I'm going to call the axon-centric view, is simplistic in many ways, and two recent papers add to it, pointing up the ways in which the glial cells of the brain participate in ongoing calculation as well as performing their more traditional support functions.
Tero Toivanen

» Brain Plasticity: How learning changes your brain   « Brain Fitness Revolut... - 0 views

  • A surprising consequence of neuroplasticity is that the brain activity associated with a given function can move to a different location as a consequence of normal experience, brain damage or recovery.
  • The brain compensates for damage by reorganizing and forming new connections between intact neurons. In order to reconnect, the neurons need to be stimulated through activity.
  • Research has shown that in fact the brain never stops changing through learning. Plasticity IS the capacity of the brain to change with learning. Changes associated with learning occur mostly at the level of the connections between neurons. New connections can form and the internal structure of the existing synapses can change.
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  • It looks like learning a second language is possible through functional changes in the brain: the left inferior parietal cortex is larger in bilingual brains than in monolingual brains.
  • Did you know that when you become an expert in a specific domain, the areas in your brain that deal with this type of skill will grow?
  • For instance, London taxi drivers have a larger hippocampus (in the posterior region) than London bus drivers (Maguire, Woollett, & Spiers, 2006)…. Why is that? It is because this region of the hippocampus is specialized in acquiring and using complex spatial information in order to navigate efficiently. Taxi drivers have to navigate around London whereas bus drivers follow a limited set of routes.
  • Plastic changes also occur in musicians brains compared to non-musicians.
  • They found that gray matter (cortex) volume was highest in professional musicians, intermediate in amateur musicians, and lowest in non-musicians in several brain areas involved in playing music: motor regions, anterior superior parietal areas and inferior temporal areas.
  • Medical students’ brains showed learning-induced changes in regions of the parietal cortex as well as in the posterior hippocampus. These regions of the brains are known to be involved in memory retrieval and learning.
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    A surprising consequence of neuroplasticity is that the brain activity associated with a given function can move to a different location as a consequence of normal experience, brain damage or recovery.
David McGavock

Scientific Understanding of Consciousness - 0 views

  • During the past 20 years or so, biological sciences have advanced to the point that scientists have begun researching biological mechanisms of brain function and suggesting some reasonably well-founded hypotheses for consciousness. Leading the way in these pioneering efforts, in my judgment, have been:   Gerald Edelman with his hypothesis of the Dynamic Core, Antonio Damasio with his concepts of  Protoself, Core Self, Autobiographical Self, Core Consciousness and Extended Consciousness, Joseph LeDoux and his emphasis on the intricacies of synapses and the emotional brain,
  • Rudolfo Llinás and his researches into ~40 Hz oscillations and synchronization, György Buzsáki with his discussion and exploration of neural mechanisms related to oscillation and synchronization in the neocortex and hippocampus for perception and memory, Joaquín Fuster, the world’s preeminent expert on the frontal lobes, and his concept of the "perception-action cycle," Susan Greenfield's notion of "neuronal gestalts" as a way of conceptualizing a highly variable aggregation of neurons that is temporarily recruited around a triggering epicenter. I use the neuronal gestalts idea in my way of visualizing the functionality of the dynamic core of the thalamocortical system, Eric Kandel who has explored short-term and long-term memory,
  • The late Francis Crick with his collaborator Christof Koch who have pursued the neural correlate of consciousness (NCC), Michael Gazzaniga with the concept of the left hemisphere ‘interpreter’ unifying consciousness experience, Edmund Rolls and Gustavo Deco with their mathematical models of brain function using information theory approaches for biologically plausible neurodynamical modeling of cognitive phenomena corroborated by brain imaging studies, David LaBerge with his discussion of the thalamocortical circuit and attention, Alan Baddeley who continues to refine his model for working memory, Philosopher John Searle who endorses the idea that consciousness is an emergent property of neural networks.
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    "My objective in this website has been to bring together salient features of these assorted interpretations by science experts into a synthesis of my own understanding of consciousness. I consider these statements and interpretations to be a framework on which to build a fuller understanding as further data, concepts and insights develop from ongoing research."
Tero Toivanen

YouTube - Early Split Brain Research Gazzaniga - 0 views

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    Left Brain - Right Brain functions
Tero Toivanen

Selective aphasia in a brain damaged bilingual patient : Neurophilosophy - 0 views

  • A unique case study published in the open access journal Behavioral and Brain Functions sheds some light on this matter. The study, by Raphiq Ibrahim, a neurologist at the University of Haifa, describes a bilingual Arabic-Hebrew speaker who incurred brain damage following a viral infection. Consequently, the patient experienced severe deficits in Hebrew but not in Arabic. The findings support the view that specific components of a first and second language are represented by different substrates in the brain.
  • A native Arabic speaker, he learned Hebrew at an early age (4th grade) and later used it competently both professionally and academically.
  • A CT scan showed that he had suffered a massive hemorrhage in the left temporal lobe, which was compressing the tissue on both sides of the central sulcus, the prominent gfissure which separates the frontal and parietal lobes.
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  • A craniotomy was performed to relieve the pressure, and afterwards another scan showed moderate hemorrhage and herpes encephalitis in the left temporal lobe, and another hemorrhage beneath the outer membrane (the dura) lying over the right frontal lobe.
  • During his 2 month stay there, he developed epileptic seizures which originated in the left temporal lobe, and amnestic aphasia (an inability to name objects or to recognize their written or spoken names). 
  • After the rehabilitation period, a series of linguistic tests was administered to determine the extent of his speech deficits. M.H. exhibited deficits in both languages, but the most severe deficits were seen only in Hebrew. In this language he had a severe difficulty in recalling words and names, so that his speech was non-fluent and interrupted by frequent pauses. He had difficulty understanding others' spoken Hebrew, and also had great difficulty reading and writing Hebrew. In Arabic, his native language, all of these abilities were affected only mildy.
  • The results support a neurolinguistic model in which the brain of bilinguals contains a semantic system (which represents word meanings) which is common to both languages and which is connected to independent lexical systems (which encode the vocabulary of each language). The findings further suggest that the second language (in this case, Hebrew) is represented by an independent subsystem which does not represent the first language (Arabic) and is more succeptible to brain damage.
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    A unique case study published in the open access journal Behavioral and Brain Functions sheds some light on this matter. The study, by Raphiq Ibrahim, a neurologist at the University of Haifa, describes a bilingual Arabic-Hebrew speaker who incurred brain damage following a viral infection. Consequently, the patient experienced severe deficits in Hebrew but not in Arabic. The findings support the view that specific components of a first and second language are represented by different substrates in the brain.
Tero Toivanen

Memory Improved 20% by Nature Walk « PsyBlog - 0 views

  • Marc G. Berman and colleagues at the University of Michigan wanted to test the effect of a walk’s scenery on cognitive function (Berman, Jonides & Kaplan, 2008; PDF).
  • In the first of two studies participants were given a 35 minute task involving repeating loads of random numbers back to the experimenter, but in reverse order.
  • The results showed that people’s performance on the test improved by almost 20% after wandering amongst the trees. By comparison those subjected to a busy street did not reliably improve on the test.
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  • In the second study participants weren’t even allowed to leave the lab but instead some stared at pictures of natural scenes while others looked at urban environments. The improvements weren’t quite as impressive as the first study, but, once again, the trees and fields beat the roads and lampposts.
  • These results replicated a previous study by Berto (2005) who found that just viewing pictures of natural scenes had a restorative effect on cognitive function.
  • So just as we might have predicted nature is a kind of natural cognitive enhancer, helping our brain let off steam so it can cruise back up to full functioning.
  • When our minds need refreshing and if natural scenery is accessible, we should take the opportunity. If not then just looking at pictures of nature is a reasonable second best.
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    New study finds that short-term memory is improved 20% by walking in nature, or even just by looking at an image of a natural scene.
Tero Toivanen

Wired 14.02: Buddha on the Brain - 0 views

  • Davidson's research created a stir among brain scientists when his results suggested that, in the course of meditating for tens of thousands of hours, the monks had actually altered the structure and function of their brains.
  • Lutz asked Ricard to meditate on "unconditional loving-kindness and compassion." He immediately noticed powerful gamma activity - brain waves oscillating at roughly 40 cycles per second -�indicating intensely focused thought. Gamma waves are usually weak and difficult to see. Those emanating from Ricard were easily visible, even in the raw EEG output. Moreover, oscillations from various parts of the cortex were synchronized - a phenomenon that sometimes occurs in patients under anesthesia.
  • In the traditional view, the brain becomes frozen with the onset of adulthood, after which few new connections form. In the past 20 years, though, scientists have discovered that intensive training can make a difference. For instance, the portion of the brain that corresponds to a string musician's fingering hand grows larger than the part that governs the bow hand - even in musicians who start playing as adults. Davidson's work suggested this potential might extend to emotional centers
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  • The researchers had never seen anything like it. Worried that something might be wrong with their equipment or methods, they brought in more monks, as well as a control group of college students inexperienced in meditation. The monks produced gamma waves that were 30 times as strong as the students'. In addition, larger areas of the meditators' brains were active, particularly in the left prefrontal cortex, the part of the brain responsible for positive emotions.
  • But Davidson saw something more. The monks had responded to the request to meditate on compassion by generating remarkable brain waves. Perhaps these signals indicated that the meditators had attained an intensely compassionate state of mind. If so, then maybe compassion could be exercised like a muscle; with the right training, people could bulk up their empathy. And if meditation could enhance the brain's ability to produce "attention and affective processes" - emotions, in the technical language of Davidson's study - it might also be used to modify maladaptive emotional responses like depression.
  • Davidson and his team published their findings in the Proceedings of the National Academy of Sciences in November 2004. The research made The Wall Street Journal, and Davidson instantly became a celebrity scientist.
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    Davidson's research created a stir among brain scientists when his results suggested that, in the course of meditating for tens of thousands of hours, the monks had actually altered the structure and function of their brains
Tero Toivanen

New Light On Nature Of Broca's Area: Rare Procedure Documents How Human Brain Computes ... - 0 views

  • The study – which provides a picture of language processing in the brain with unprecedented clarity – will be published in the October 16 issue of the journal Science.
  • "Two central mysteries of human brain function are addressed in this study: one, the way in which higher cognitive processes such as language are implemented in the brain and, two, the nature of what is perhaps the best-known region of the cerebral cortex, called Broca's area," said first author Ned T. Sahin, PhD, post-doctoral fellow in the UCSD Department of Radiology and Harvard University Department of Psychology.
  • The study demonstrates that a small piece of the brain can compute three different things at different times – within a quarter of a second – and shows that Broca's area doesn't just do one thing when processing language.
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  • The procedure, called Intra-Cranial Electrophysiology (ICE), allowed the researchers to resolve brain activity related to language with spatial accuracy down to the millimeter and temporal accuracy down to the millisecond.
  • "We showed that distinct linguistic processes are computed within small regions of Broca's area, separated in time and partially overlapping in space," said Sahin. Specifically, the researchers found patterns of neuronal activity indicating lexical, grammatical and articulatory computations at roughly 200, 320 and 450 milliseconds after the target word was presented. These patterns were identical across nouns and verbs and consistent across patients.
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    "Two central mysteries of human brain function are addressed in this study: one, the way in which higher cognitive processes such as language are implemented in the brain and, two, the nature of what is perhaps the best-known region of the cerebral cortex, called Broca's area," said first author Ned T. Sahin, PhD, post-doctoral fellow in the UCSD Department of Radiology and Harvard University Department of Psychology.
Tero Toivanen

VS Ramachandran: The neurons that shaped civilization - YouTube - 0 views

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    "Neuroscientist Vilayanur Ramachandran outlines the fascinating functions of mirror neurons. Only recently discovered, these neurons allow us to learn complex social behaviors, some of which formed the foundations of human civilization as we know it."
Tero Toivanen

YouTube - Split brain behavioral experiments - 0 views

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    Left and right hemisphere's functions.
Tero Toivanen

Left Brain and Right Brain | Boost Your IQ - 0 views

  • The left brain follows a completely different “way” and process of thinking from the right brain. The left brain sees things in an analytical, objective and logical manner. The right brain on the other hand is more symbol and metaphorically orientated.
  • In order to develop a particular brain, it is therefore necessary to focus on doing things which complement its attributes. For example, if I were to develop my left brain, i would embark on logical analysis and maths. If I were to exercise my right brain, i would indulge in art work.
  • do you see the dancer turning clockwise or anti-clockwise? If clockwise, then you use more of the right side of the brain and vice versa.
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    do you see the dancer turning clockwise or anti-clockwise?
Tero Toivanen

Music and Intelligence | Boost Your IQ - 0 views

  • Studies indicate that early exposure to musical training helps a child’s brain reach its potential by generating neural connections utilized in abstract reasoning.
  • The reasoning skills required for a test in spatial reasoning are the same ones children use when they listen to music. Children use these reasoning skills to order the notes in their brain to form the melodies. Also, some concepts of math must be understood in order to understand music. Experts speculate that listening to music exercises the same parts of the brain that handle mathematics, logic, and higher level reasoning.
  • In 1997 a study involving three groups of preschoolers was conducted to determine the effect of music versus computer training on early childhood development.
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  • The group that received the piano/keyboard training scored 34% higher on tests measuring spatial-temporal ability than either of the other two groups. These results suggest that music enhances certain higher brain functions, particularly abstract reasoning skills, required in math and science.
  • The use of music in training four and five year old children yielded the highest improvement in the ability to name body parts.
  • Although the three experimental groups displayed an increase in their ability to name body parts the music group exhibited the highest degree of improvement.
  • First grade students received extensive Kodaly training for seven months.
  • At the end of seven months the experimental group had higher reading scores than the control group, which did not receive any special treatment. Not only did the seven month instruction increase reading scores, but continued musical training proved to be beneficial. The experimental group continued to show higher reading scores with continued training.
  • Students who were involved in arts education achieved higher SAT scores. The longer students were involved in arts education, the higher the increase in SAT scores. This study also correlated arts education with higher scores in standardized tests, reading, English, history, citizenship, and geography.
  • The results indicated that students with a relatively lower socioeconomic status, that were exposed to arts education, had an advantage over those students without any arts education which was proportionally equal to the students with a relatively higher socioeconomic status and exposure to arts education.
  • Music exposure affects older students as well. Three groups of college students were exposed to either Mozart’s Sonata for Two Pianos, K448, a relaxation tape, or silence. The group exposed to the Mozart piece was the only group to achieve an increase on the spatial IQ test. Further studies revealed that neither dance music nor taped short stories produced an increase in spatial IQ similar to the Mozart piece. The increase in spatial IQ appears to be related to some unique aspects of the Mozart piece rather than music in general.
  • Music may not only be related to intelligence by its stimulation of the brain, but it may also increase intelligence by the type of attitudes, interests, and discipline it fosters in children.
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    Studies indicate that early exposure to musical training helps a child's brain reach its potential by generating neural connections utilized in abstract reasoning.
Tero Toivanen

YouTube - Cognitive Neuroscience of Mindfulness Meditation - 0 views

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    Speaker: Philippe Goldin. Mindfulness meditation, one type of meditation technique, has been shown to enhance emotional awareness and psychological flexibility as well as induce well-being and emotional balance. Scientists have also begun to examine how meditation may influence brain functions.
Tero Toivanen

Interactive Movie - How the human brain works - New Scientist - 0 views

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    Interactive image of brain and it's functions.
Tero Toivanen

Google-syötteenlukija (463) - 2 views

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    Results provide direct evidence for functional changes of the adult hippocampus in humans related to musical training.
Tero Toivanen

Use It or Lose It: The Principles of Brain Plasticity - 3 views

  • You probably haven't realizd it, but as you acquire an ability – for example, the ability to read – you have actually created a system in the brain that does not exist, that's not in place, in the non-reader. It [the ability; the brain system that controls the ability] actually evolves in you as it has been acquired through experience or learning.
  • "There are some very useful exercises at www.BrainHQ.com that are free, and using them can give a person a better understanding of how exercising your brain can drive it in a rejuvenating direction. Using exercises at BrainHQ, most people, of any age, can drive sharp improvements in brain speed and accuracy, and thereby rewire the brain so that it again represents information in detail," he says.
  • Children operating in the 10th to 20th percentile of academic performance are commonly able to improve their scores to the middle or average level with 20-30 hours of intensive computer-based training. "That's a big difference for the child," he says. "It carries most children who are near the bottom of the class, on the average, to be somewhere in the middle or above average in the class. And that gives struggling children a chance to really succeed and in many cases excel in school."
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  • Careful controlled studies in seniors have also been reported in scientific journals. After 40 hours of computer-based training, the average improvement in cognitive performance across the board was 14 years. On average, if you were 70 years old when you underwent the training after 40 hours of brain training, your cognitive abilities operated like that of a 56-year old. Equally strong or even greater effects were seen in 40 to 50 year olds using the program. Individuals who worked on the BrainHQ exercises at home did just as well as those who completed training in a clinic or research center.
  • Ideally, it would be wise to invest at least 20 minutes a day. But no more than five to seven minutes is to be spent on a specific task. When you spend longer amounts of time on a task, the benefits weaken. According to Dr. Merzenich, the primary benefits occur in the first five or six minutes of the task.
  • Find ways to engage yourself in new learning
  • "When it matters to you, you are going to drive changes in your brain," he explains. "That's something always to keep in mind. If what you're doing seems senseless, meaningless, if it does not matter to you, then you're gaining less from it."
  • Get 15-30 minutes of physical exercise each day,
  • Spend about five minutes every day working on the refinement of a specific, small domain of your physical body.
  • You can typically improve yourself to the highest practical or possible level in anywhere between five to a dozen brief sessions of seven or eight minutes each. Again, having a sense of purpose is crucial.
  • Stay socially engaged.
  • Practice "mindfulness,"
  • Foods have an immense impact on your brain, and eating whole foods as described in my nutrition plan will best support your mental and physical health.
  • The medical literature is also showing that coconut oil can be of particular benefit for brain health, and anecdotal evidence suggests it could be very beneficial in the treatment of Alzheimer's disease.
  • Optimize your vitamin D levels
  • Take a high-quality animal-based omega-3 fat.
  • Avoid processed foods and sugars, especially fructose
  • Avoid grains
  • Avoid artificial sweeteners
  • Avoid soy
  • Men who ate tofu at least twice weekly had more cognitive impairment, compared with those who rarely or never ate the soybean curd, and their cognitive test results were about equivalent to what they would have been if they were five years older than their current age.
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    "It was once thought that any brain function lost was irretrievable. Today, research into what's referred to as "brain plasticity" has proven that this is not the case. On the contrary, your brain continues to make new neurons throughout life in response to mental activity."
Tero Toivanen

Phasic Firing Of Dopamine Neurons Is Key To Brain's Prediction Of Rewards - 0 views

  • Our research findings provide a direct functional link between the bursting activity of midbrain dopamine neurons and behavior. The research has significant applications for the improvement of health, because the dopamine neurons we are studying are the same neurons that become inactivated during Parkinson's Disease and with the consumption of psychostimulants such as cocaine and amphetamine
  • Midbrain dopamine neurons fire in two characteristic modes, tonic and phasic, which are thought to modulate distinct aspects of behavior. When an unexpected reward is presented to an individual, midbrain dopamine neurons fire high frequency bursts of electrical activity. Those bursts of activity allow us to learn to associate the reward with cues in our environment, which may predict similar rewards in the future.
  • When researchers placed the mice in reward-based situations, they found that the mice without the NMDA receptor in their dopaminergic neurons could not learn tasks that required them to associate sensory cues with reward. Those same mice, however, were able to learn tasks that did not involve an association with rewards.
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