Medicine & Healthcare

Impotence or erectile dysfunction is one of the most commonly experienced sexual problems amongst men.One of the most effective and popular prescription medications used by men for treating erectile dysfunction is Cialis. This pill is also known as 'the weekend pill' as its effectiveness lasts for up to 36 hours after taking the pill.

The frequency with which scientists fabricate and falsify data, or commit other forms of scientific misconduct is a matter of controversy... Misconduct was reported more frequently by medical/pharmacological researchers than others...This metareview is a conservative estimate of the true prevalence of scientific misconduct.

Daily intake of fruit and vegetables was associated with a lower risk of coronary heart disease when combined with a high dairy fat consumption...but not when combined with a low dairy fat consumption. Sara Holmberg, Anders Thelin and Eva-Lena Stiernström. Int. J. Environ. Res. Public Health 2009, 6, 2626-2638.

WikiProject Pharmacology coordinates the development of Wikipedia articles relating to drugs and pharmacology. Of interest to authors and editors of pharmacology articles.

Downloadable slideshows from this November 2007 conference. For report PDFs: (1) http://is.gd/3AoNu (2) http://is.gd/3AoXG

Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease.\nSiri--Tirino, et al.; \nAm J Clin Nutrition; 2010 Jan 13. \nPMID: 20071648\ndoi:10.3945/ajcn.2009.27725\n\nConclusions: A meta-analysis of prospective epidemiologic studies showed that there is NO significant evidence that dietary saturated fat is associated with increased risk for CHD or CVD. More data are needed to elucidate whether CVD risks are likely to be influenced by the specific nutrients used to replace saturated fat

"Lancet 2010: There is a U-shaped relationship between glycated hemoglobin (HbA1c) levels and mortality in people with diabetes, say researchers, meaning that intensive glucose-lowering therapy could be as harmful as uncontrolled hyperglycemia.\n\nWriting in The Lancet, Craig Currie and team (Cardiff University, UK) conclude that if their findings are confirmed, then diabetes guidelines may need to be revised to include a lower as well as an upper HbA1c threshold.\n\nCurrie's team used the UK General Practice Research Database from November 1986 to November 2008 to obtain data on two cohorts of patients aged 50 years and older with Type 2 diabetes.\n\nThe patients comprised 27,965 individuals whose treatment had been intensified from oral monotherapy to combination therapy with oral blood-glucose lowering agents, and 20,005 who had changed to insulin-containing regimens."

Treatment Options in Treatment-Resistant Depression, by Jennifer Gotto, MD, and Mark H. Rapaport, MD

Study "determines" that intake of vitamin D3 and calcium would prevent 58,000 new cases of breast cancer and 49,000 new cases of colorectal cancer annually in the U.S. and Canada. [FIND STUDY, VERIFY]

"ScienceDaily ( 2010) : For those who choose not to obtain anti-inflammatory resveratrol from grapes or wine, researchers have found that carvacrol, derived from six essential oils (thyme, clove, rose, eucalyptus, fennel, bergamot) can suppress inflammatory COX-2 enzyme activity in a similar manner to that of resveratrol.

Vitamin D, nervous system and aging.\nP. Tuohimaa, T. Keisala, A. Minasyan, J. Cachat and A. Kalueff. .\nPsychoneuroendocrinology, Volume 34, Supplement 1, December 2009, Pages S278-S286\n NEUROACTIVE STEROIDS: EFFECTS and MECHANISMS ofACTION\n \n\nReview of vitamin D3, its active metabolites, and their functioning in the central nervous system (CNS), especially in relation to nervous system pathologies and aging. The vitamin D3 endocrine system consists of 3 active calcipherol hormones: calcidiol (25OHD3), 1α-calcitriol (1α,25(OH)2D3) and 24-calcitriol (24,25(OH)2D3). The impact of the calcipherol hormone system on aging, health and disease is discussed. Low serum calcidiol concentrations are associated with an increased risk of several chronic diseases including osteoporosis, cancer, diabetes, autoimmune disorders, hypertension, atherosclerosis, and muscle weakness ~ all of which can be considered aging-related diseases. The relationship of many of these diseases and aging-related changes in physiology show a U-shaped response curve to serum calcidiol concentrations. Clinical data suggest that vitamin D3 insufficiency is associated with an increased risk of several CNS diseases, including multiple sclerosis, Alzheimers, Parkinsons, seasonal affective disorder (SAD), and schizophrenia. In line with this, recent animal and human studies suggest that vitamin D insufficiency is associated with abnormal development and functioning of the CNS. * Overall, imbalances in the calcipherol system appear to cause abnormal function, including premature aging, of the CNS. *

Blue Cross / Blue Shield in many states are under the Wellpoint umbrella. 

Antidepressants, despite their popularity, are no more effective than sugar pills for most people with mild or moderate depression. For severe depression, they're somewhat more effective, but far from a cure.

Available forms: PDF, Download Audio, Listen to Audio Stream

their site? the site of a fine electronica team? totally trippy. ingenious. like much of their music.

New findings in rodents and human brain shed light on the mechanisms of major depressive disorder (MDD), uncovering over-expression of MKP-1 (mitogen-activated protein kinase [MAPK] phosphatase-1)...and identifying a new therapeutic target. MKP-1, also known as dual-specificity phosphatase-1 (DUSP1), is a member of a family of proteins that dephosphorylate both threonine and tyrosine residues and thereby serves as a key negative regulator of the MAPK cascade4, a major signaling pathway involved in neuronal plasticity, function and survival This study identifies MKP-1 as a key factor in MDD pathophysiology, and as a new target for therapeutic interventions.f Here we use whole-genome expression profiling of postmortem tissue and show significantly increased expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1, encoded by DUSP1, but hereafter called MKP-1) in the hippocampal subfields of subjects with MDD compared to matched controls. MKP-1, also known as dual-specificity phosphatase-1 (DUSP1), is a member of a family of proteins that dephosphorylate both threonine and tyrosine residues and thereby serves as a key negative regulator of the MAPK cascade4, a major signaling pathway involved in neuronal plasticity, function and survival. We tested the role of altered MKP-1 expression in rat and mouse models of depression and found that increased hippocampal MKP-1 expression, as a result of stress or viral-mediated gene transfer, causes depressive behaviors. Conversely, chronic antidepressant treatment normalizes stress-induced MKP-1 expression and behavior, and mice lacking MKP-1 are resilient to stress. These postmortem and preclinical studies identify MKP-1 as a key factor in MDD pathophysiology and as a new target for therapeutic interventions.

Study "determines" that intake of vitamin D3 and calcium would prevent 58,000 new cases of breast cancer and 49,000 new cases of colorectal cancer annually in the U.S. and Canada. [FIND STUDY, VERIFY]

J Ethnopharmacology. 65:13-19. 1997. Singh, S. Evaluation of anti-inflammatory activity of fatty acids of Ocimum sanctum fixed oil. Ind J Exp Biol. 35:380-383. || Int J Clin Pharm and Ther: 34(9): 406-409. 2001. Devi, U. Radioprotective, anticarcinogenic and antioxidant properties of the Indian Holy Basil, Ocimum sanctum (Tulsi). Ind J Exp Biol. 39:185-190. 1999. Singh, S. Evaluation of the gastric antiulcer activity of fixed oil of Ocimum sanctum (Holy Basil). "

Wayne Shorter 4tet / Sanctuary / Philharmonie, Köln 2008 // Danilo Perez-piano, John Patitucci-bass, Brian Blade-drums VIDEO: http://tr.im/DHhO