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Eley, HL and Tisdale, MJ: Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham UK. January 2007

Skeletal Muscle Atrophy: Link between Depression of Protein Synthesis and Increase in Degradation -- Eley and Tisdale 282 (10): 7087 -- Journal of Biological Chemistry. Eley, HL and Tisdale, MJ: Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham UK. January 2007

Commercial site, but still has some worthwhile introductory information and links; good for creating handouts for clients and patients...

Resveratol, found in red wine (etc.) stimulates the SIRT1 gene, which is linked to extended health + lifespan in rodents. Sitris was able to replicate those results in humans. The resveratol formula stimulates the same gene that 'calorie-restricted' diets do. Sitris also found it reduces blood glucose in diabetic patients...But small trial, short duration...

their site? the site of a fine electronica team? totally trippy. ingenious. like much of their music.

Study provides the first evidence of a direct relationship between the depression of protein synthesis in skeletal muscle by PIF and Ang II, through activation of PKR, and eIF2{alpha} phosphorylation, and the enhanced degradation of the myofibrillar protein myosin, through activation of NF-{kappa}B resulting in an increased expression and activity of the ubiquitin-proteasome proteolytic pathway. This suggests that agents that target PKR may be effective in the treatment of muscle atrophy in cancer cachexia or other wasting conditions.