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Skeletal Muscle Atrophy: Link between Depression of Protein Synthesis and Increase in ... - 0 views

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    Eley, HL and Tisdale, MJ: Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham UK. January 2007
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    Skeletal Muscle Atrophy: Link between Depression of Protein Synthesis and Increase in Degradation -- Eley and Tisdale 282 (10): 7087 -- Journal of Biological Chemistry. Eley, HL and Tisdale, MJ: Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham UK. January 2007
avivajazz  jazzaviva

Science in the Open | Friendfeed for Scientists | What, Why, and How? - 0 views

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    friendfeed science medicine scientists doctors physicians researchers biomedicine biomedical socialmedia socialnetworking "social media" "social networking" medicine2.0 healthcare2.0 profession professional web2.0 lifestream lifestreams streaming streams
avivajazz  jazzaviva

A negative regulator of MAP kinase causes depressive behavior : Nature Medicine : Natur... - 0 views

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    New findings in rodents and human brain shed light on the mechanisms of major depressive disorder (MDD), uncovering over-expression of MKP-1 (mitogen-activated protein kinase [MAPK] phosphatase-1)...and identifying a new therapeutic target. MKP-1, also known as dual-specificity phosphatase-1 (DUSP1), is a member of a family of proteins that dephosphorylate both threonine and tyrosine residues and thereby serves as a key negative regulator of the MAPK cascade4, a major signaling pathway involved in neuronal plasticity, function and survival This study identifies MKP-1 as a key factor in MDD pathophysiology, and as a new target for therapeutic interventions.f Here we use whole-genome expression profiling of postmortem tissue and show significantly increased expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1, encoded by DUSP1, but hereafter called MKP-1) in the hippocampal subfields of subjects with MDD compared to matched controls. MKP-1, also known as dual-specificity phosphatase-1 (DUSP1), is a member of a family of proteins that dephosphorylate both threonine and tyrosine residues and thereby serves as a key negative regulator of the MAPK cascade4, a major signaling pathway involved in neuronal plasticity, function and survival. We tested the role of altered MKP-1 expression in rat and mouse models of depression and found that increased hippocampal MKP-1 expression, as a result of stress or viral-mediated gene transfer, causes depressive behaviors. Conversely, chronic antidepressant treatment normalizes stress-induced MKP-1 expression and behavior, and mice lacking MKP-1 are resilient to stress. These postmortem and preclinical studies identify MKP-1 as a key factor in MDD pathophysiology and as a new target for therapeutic interventions.
avivajazz  jazzaviva

What is the future of peer review? | Full Text | Vasc Health Risk Manag. 2007 February;... - 0 views

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    What is the future of peer review? Why is there fraud in science? Is plagiarism out of control? Why do scientists do bad things? Is it all a case of:"All that is necessary for the triumph of evil is that good men do nothing?"
avivajazz  jazzaviva

Neurogenesis in the adult brain: The association with stress and depression || Bio-Medi... - 0 views

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    Professor Fuchs from the Clinical Neurobiology Laboratory, German Primate Center in Goettingen, will present the latest findings on how brain cells can be adversely affected by stress and depression. He will explain how the adult brain is generating new cells and which impact these findings will have on the development of novel antidepressant drugs. Contact: Sonja Mak s.mak@update.europe.at 43-140-55734 European College of Neuropsychopharmacology Source:Eurekalert (2008)
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Stem Cell Breakthrough Removes Moral Quagmire | Scientists Revert Adult Skin Cells, Rep... - 0 views

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    clever scientists have found a way to create stem cells by reverting adult skin cells.
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