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"ScienceDaily ( 2010) : For those who choose not to obtain anti-inflammatory resveratrol from grapes or wine, researchers have found that carvacrol, derived from six essential oils (thyme, clove, rose, eucalyptus, fennel, bergamot) can suppress inflammatory COX-2 enzyme activity in a similar manner to that of resveratrol.

Mice fed fish oil and curcumin showed a significantly reduced tumor volume, 25% (P < 0.04) and 43% (P < 0.005), respectively, and importantly, a combination of curcumin and fish oil diet showed > 72% (P < 0.0001) tumor volume reduction. Expression and activity of iNOS, COX-2, and 5-LOX are downregulated, and p21 is upregulated in tumor xenograft fed curcumin combined with fish oil diet when compared to individual diets. The preceding results evidence for the first time that curcumin combined with omega-3 fatty acids provide synergistic pancreatic tumor inhibitory properties. \n\nPrevention and treatment of pancreatic cancer by curcumin in combination with omega-3 fatty acids.\nSwamy MV, Citineni B, Patlolla JM, Mohammed A, Zhang Y, Rao CV. \nNutr Cancer. 2008;60 Suppl 1:81-9. \nPMID: 19003584

This study shows that by modulating the eicosanoid metabolism using a combination of n-3 fatty acids and cyclooxygenase-2 inhibitor, some of the signs and symptoms associated with a Systemic Immune-Metabolic Syndrome (SIMS) could be ameliorated.

J Ethnopharmacology. 65:13-19. 1997. Singh, S. Evaluation of anti-inflammatory activity of fatty acids of Ocimum sanctum fixed oil. Ind J Exp Biol. 35:380-383. || Int J Clin Pharm and Ther: 34(9): 406-409. 2001. Devi, U. Radioprotective, anticarcinogenic and antioxidant properties of the Indian Holy Basil, Ocimum sanctum (Tulsi). Ind J Exp Biol. 39:185-190. 1999. Singh, S. Evaluation of the gastric antiulcer activity of fixed oil of Ocimum sanctum (Holy Basil). "