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JAMA Network | Archives of General Psychiatry | Dehydroepiandrosterone Monotherapy in M... - 0 views

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    "Dehydroepiandrosterone Monotherapy in Midlife-Onset Major and Minor Depression"
avivajazz  jazzaviva

Psychiatry Weekly: Treatment Options in Treatment-Resistant Depression - 0 views

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    Treatment Options in Treatment-Resistant Depression, by Jennifer Gotto, MD, and Mark H. Rapaport, MD
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PsychiatryOnline | APA Practice Guidelines | Guideline Watch: Practice Guideline for th... - 0 views

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    "The American Psychiatric Association (APA) practice guidelines are developed by expert work groups using an explicit methodology that includes rigorous review of available evidence, broad peer review of iterative drafts, and formal approval by the APA"
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A negative regulator of MAP kinase causes depressive behavior : Nature Medicine : Natur... - 0 views

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    New findings in rodents and human brain shed light on the mechanisms of major depressive disorder (MDD), uncovering over-expression of MKP-1 (mitogen-activated protein kinase [MAPK] phosphatase-1)...and identifying a new therapeutic target. MKP-1, also known as dual-specificity phosphatase-1 (DUSP1), is a member of a family of proteins that dephosphorylate both threonine and tyrosine residues and thereby serves as a key negative regulator of the MAPK cascade4, a major signaling pathway involved in neuronal plasticity, function and survival This study identifies MKP-1 as a key factor in MDD pathophysiology, and as a new target for therapeutic interventions.f Here we use whole-genome expression profiling of postmortem tissue and show significantly increased expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1, encoded by DUSP1, but hereafter called MKP-1) in the hippocampal subfields of subjects with MDD compared to matched controls. MKP-1, also known as dual-specificity phosphatase-1 (DUSP1), is a member of a family of proteins that dephosphorylate both threonine and tyrosine residues and thereby serves as a key negative regulator of the MAPK cascade4, a major signaling pathway involved in neuronal plasticity, function and survival. We tested the role of altered MKP-1 expression in rat and mouse models of depression and found that increased hippocampal MKP-1 expression, as a result of stress or viral-mediated gene transfer, causes depressive behaviors. Conversely, chronic antidepressant treatment normalizes stress-induced MKP-1 expression and behavior, and mice lacking MKP-1 are resilient to stress. These postmortem and preclinical studies identify MKP-1 as a key factor in MDD pathophysiology and as a new target for therapeutic interventions.
avivajazz  jazzaviva

Antidepressant Medicines - A Guide for Adults With Depression - AHRQ Effective Health C... - 0 views

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    Available forms: PDF, Download Audio, Listen to Audio Stream
avivajazz  jazzaviva

JAMA -- Abstract: Antidepressant Drug Effects and Depression Severity: A Patient-Level ... - 0 views

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    Antidepressants, despite their popularity, are no more effective than sugar pills for most people with mild or moderate depression. For severe depression, they're somewhat more effective, but far from a cure.
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