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Nonsurgical Treatment Options for Basal Cell Carcinoma | Review Article | Journal of Sk... - 0 views

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    Journal of Skin CancerVolume 2011 (2011), Article ID 571734, 6 pagesdoi:10.1155/2011/571734 © 2011 Mary H. Lien and Vernon K. Sondak.
avivajazz  jazzaviva

Management of superficial basal cell carcinoma: focus on imiquimod - 0 views

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    There is reasonable evidence that the use of imiquimod for small (<2 cm) superficial BCC that occur other than on the face provides outcomes only marginally less satisfactory than surgery. There would be a place for imiquimod in treating patients with frequent multiple primary lesions when access to surgery is difficult or where clinical judgment may be influenced by patient factors as reported in some of the studies, eg, where patients may have contraindications to surgery.  It was noted that if recurrences occurred in this study they mostly occurred during the first 9 months after the end of treatment. The initial response was therefore predictive of long-term outcome so these authors recommend and encourage continued monitoring of skin lesions.
avivajazz  jazzaviva

Meta-analysis of prospective cohort studies evaluating the association of saturated fat... - 0 views

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    Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease.\nSiri--Tirino, et al.; \nAm J Clin Nutrition; 2010 Jan 13. \nPMID: 20071648\ndoi:10.3945/ajcn.2009.27725\n\nConclusions: A meta-analysis of prospective epidemiologic studies showed that there is NO significant evidence that dietary saturated fat is associated with increased risk for CHD or CVD. More data are needed to elucidate whether CVD risks are likely to be influenced by the specific nutrients used to replace saturated fat
avivajazz  jazzaviva

Recurrence rate of superficial basal cell carcinoma following treatment with imiquimod ... - 0 views

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    Recurrence rate of superficial basal cell carcinoma following treatment with imiquimod 5% cream: conclusion of a 5-year long-term follow-up study in Europe. by Harald Gollnick
avivajazz  jazzaviva

Treatment of Cutaneous Tumors with Topical 5% Imiquimod Cream | Alessi SS, et al | CLIN... - 0 views

    • avivajazz  jazzaviva
       
      For patients without comorbidities, our study revealed good cure rates for superficial BCC and superficial/nodular BCC (88% and 85%, respectively). Nodular and aggressive BCC and Bowen's disease exhibited lower cure rates (50%, 50%, and 57%, respectively). I
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    For patients without comorbidities, our study revealed good cure rates for superficial BCC and superficial/nodular BCC (88% and 85%, respectively). Nodular and aggressive BCC and Bowen's disease exhibited lower cure rates (50%, 50%, and 57%, respectively). I
avivajazz  jazzaviva

Two-year interim results from a 5-year study evalu... [Australas J Dermatol. 2006] - Pu... - 0 views

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    The proportion of subjects who were clinically clear at the 2-year follow-up visit was estimated to be 82.0%. Imiquimod was tolerated when applied daily, with erythema reported for all subjects participating in the study. The recurrence rate observed suggests that once daily dosing and 5x/week dosing yield similar clearance rates, but daily dosing increases local skin reactions.
avivajazz  jazzaviva

Use of 5% imiquimod cream in the treatment of facial basal cell carcinoma: A 3-year re... - 0 views

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    PDF, Free full text article... We found that 5% imiquimod cream is aneffective treatment option for superficial and nodularbasal cell carcinomas, giving a clearance rate of89.5% at an average of 39 months of follow up.   Dr Yin Vun, Siller Medical, 9th Floor, SilvertonPlace, 101 Wickham Terrace, Brisbane, Qld 4000, Australia.
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Two-year interim results from a 5-year study evaluating clinical recurrence o... - 0 views

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    The proportion of subjects who were clinically clear at the 2-year follow-up visit was estimated to be 82.0%. Imiquimod was tolerated when applied daily, with erythema reported for all subjects participating in the study. The recurrence rate observed suggests that once daily dosing and 5×/week dosing yield similar clearance rates, but daily dosing increases local skin reactions.
avivajazz  jazzaviva

New Study: Vitamin D3 + Cancer Prevention - 0 views

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    Study "determines" that intake of vitamin D3 and calcium would prevent 58,000 new cases of breast cancer and 49,000 new cases of colorectal cancer annually in the U.S. and Canada. [FIND STUDY, VERIFY]
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DHEA - Will DHEA Improve Your Well Being and Sexuality - 0 views

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    "According to a small German study published in the New England Journal of Medicine (NEJM), researchers found that DHEA improved sexuality and well-being in 24 women diagnosed with adrenal insufficiency. The double-blind study found that women who took 50 mg of DHEA daily reported significant increases in how often they thought about sex, how interested they were in sexual activity, and their levels of both mental and physical sexual satisfaction. These women also reported improvement in mental health issues such as obsessive-compulsive traits, depression, anxiety, and other psychological conditions. The most significant improvements were seen four months after treatment began. "
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Natural Standard Herbal Pharmacotherapy: An Evidence-Based Approach - 0 views

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    Natural Standard Herbal Pharmacotherapy: An Evidence-Based Approach is now available for purchase. The book provides practical guidance on the use of herbal therapies for medical conditions. This reference tool will be an essential part of herbal pharmacy core curricula for all healthcare disciplines. Chapters are organized by medical condition and present supportive evidence, including potential mechanisms of action and dosing, for selected herbal therapies. The chapters also include integrative therapy plans to help clinicians quickly assess patient needs and create cohesive treatment plans. In addition, adjunct therapies, including herbs, supplements and modalities, that are commonly used in combination with primary treatments are discussed. Case studies, which summarize efficacy, safety, dosing and interactions for high-utilization products, help prepare healthcare providers for patient counseling in clinical practice. Review questions, similar to those on national board exams, allow readers to evaluate their learning and identify areas for further study. The book also includes several appendices, which provide information about lab values as well as the safety, interactions and pharmacokinetics of select herbs.
avivajazz  jazzaviva

A negative regulator of MAP kinase causes depressive behavior : Nature Medicine : Natur... - 0 views

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    New findings in rodents and human brain shed light on the mechanisms of major depressive disorder (MDD), uncovering over-expression of MKP-1 (mitogen-activated protein kinase [MAPK] phosphatase-1)...and identifying a new therapeutic target. MKP-1, also known as dual-specificity phosphatase-1 (DUSP1), is a member of a family of proteins that dephosphorylate both threonine and tyrosine residues and thereby serves as a key negative regulator of the MAPK cascade4, a major signaling pathway involved in neuronal plasticity, function and survival This study identifies MKP-1 as a key factor in MDD pathophysiology, and as a new target for therapeutic interventions.f Here we use whole-genome expression profiling of postmortem tissue and show significantly increased expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1, encoded by DUSP1, but hereafter called MKP-1) in the hippocampal subfields of subjects with MDD compared to matched controls. MKP-1, also known as dual-specificity phosphatase-1 (DUSP1), is a member of a family of proteins that dephosphorylate both threonine and tyrosine residues and thereby serves as a key negative regulator of the MAPK cascade4, a major signaling pathway involved in neuronal plasticity, function and survival. We tested the role of altered MKP-1 expression in rat and mouse models of depression and found that increased hippocampal MKP-1 expression, as a result of stress or viral-mediated gene transfer, causes depressive behaviors. Conversely, chronic antidepressant treatment normalizes stress-induced MKP-1 expression and behavior, and mice lacking MKP-1 are resilient to stress. These postmortem and preclinical studies identify MKP-1 as a key factor in MDD pathophysiology and as a new target for therapeutic interventions.
avivajazz  jazzaviva

Management of superficial basal cell carcinoma: fo... [Clin Cosmet Investig Dermatol. 2... - 0 views

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    To date one long-term study indicates a treatment success rate of 78%-81% and that initial response is a predictor of long-term outcome. Recurrences tend to occur within the first year after treatment. Future research will compare this preparation to the gold standard treatment for superficial BCC - surgical excision.
avivajazz  jazzaviva

Treatment of Cutaneous Tumors with Topical 5% Imiquimod Cream - 0 views

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    For patients without comorbidities, our study revealed good cure rates for superficial BCC and superficial/nodular BCC (88% and 85%, respectively). Nodular and aggressive BCC and Bowen's disease exhibited lower cure rates (50%, 50%, and 57%, respectively). I
avivajazz  jazzaviva

Cardiovascular Disease (CVD) and Mortality: Treatment Studies - 0 views

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    PubMed abstracts and citations of landmark studies concerning PUFAs, omega-3 fatty acids, vitamine E, fish oils, and guidelines from the American Heart Association.
avivajazz  jazzaviva

Vitamin D3 + Cancer Prevention | VIDEO - 0 views

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    Study "determines" that intake of vitamin D3 and calcium would prevent 58,000 new cases of breast cancer and 49,000 new cases of colorectal cancer annually in the U.S. and Canada. [FIND STUDY, VERIFY]
avivajazz  jazzaviva

Effects of Pomegranate Juice Consumption on Myocardial Perfusion in Patients with Coron... - 0 views

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    © 2005 Elsevier (Am J Cardiol 2005;96:810-814). After 3 months, the extent of stress-induced ischemia decreased in the pomegranate group but increased in the control group. This benefit was observed without changes in cardiac medications, blood sugar, hemoglobin A1c, weight, or blood pressure in either group. In conclusion, daily consumption of pomegranate juice may improve stress-induced myocardial ischemia in patients who have CHD. (Small sample; further study warranted with quantitative coronary arteriography + intravascular ultrasound.)
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Recurrence rate of superficial basal cell carcinoma following successful treatment with... - 0 views

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    The initial sBCC clearance rate was 90% (12-week post treatment), whereas the proportion of subjects who were clinically clear at 2 years (current time point) was estimated to be 79.4%. 
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Efficacy of topical 5% imiquimod cream for the tre... [Arch Dermatol. 2002] - PubMed re... - 0 views

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    Topical 5% imiquimod cream is well tolerated and most effective in treating nodular BCC when applied once daily for 7 days per week for either 12 or 6 weeks.
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