Topical pine tar: History, properties and use as a treatment for common skin conditions... - 0 views
www.ncbi.nlm.nih.gov/...PMC5434829
pine-tar non-cancerous treatment HSR2023 environmental coal-tar trees wood
shared by katherine-medina on 28 Jul 23
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Pine tar is thought to exert its effect by reducing DNA synthesis and mitotic activity, which promotes a return to normal keratinisation. In addition, pine tar has been shown to be antipruritic, anti‐inflammatory, antibacterial and antifungal
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Topical pine tar has been available over‐the‐counter in Australia since 1953. Today, it is available in various formulations including a gel, lotion, oil, soap‐free bar and solution containing up to 2.3% w/w pine tar
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There are two kinds of wood tars; made either from trees with a high content of resin (pine and juniper), or from hardwood trees (birch and beech).3 Pine tar (also known as tar, alquitrán vegetal, pix liquida, stockholm tar (in commerce), wood tar, brea de pino, brea vegetal, goudron végétal, nadelholzteer, pix abietinarum, pix pini and pyroleum pini
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There are two kinds of wood tars; made either from trees with a high content of resin (pine and juniper), or from hardwood trees (birch and beech).3 Pine tar (also known as tar, alquitrán vegetal, pix liquida, stockholm tar (in commerce), wood tar, brea de pino, brea vegetal, goudron végétal, nadelholzteer, pix abietinarum, pix pini and pyroleum pini
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is obtained by high temperature carbonisation of pine wood from various trees of the family Pinaceae in anoxic conditions (dry distillation or destructive distillation)
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is obtained by high temperature carbonisation of pine wood from various trees of the family Pinaceae in anoxic conditions (dry distillation or destructive distillation)
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empyreumatic
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empyreumatic
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Although pine tar has been used for the treatment of various skin diseases for thousands of years, its mechanism of action is poorly understood and has been extrapolated from studies performed using coal tar.
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Why is it hard to understand the mechanisms behind how pine tar works?
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This promotes a return to normal keratinisation, which is important in skin diseases such as psoriasis
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carcinogenic
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antipruritic
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antipruritic
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Fractionation of pine tar has revealed that the components responsible for its bacteriostatic properties are the resin acids,14 and that acetovanillone, 1,1′,3,3′‐tetraoxo‐2,2′‐bicyclopentyl and its 4‐methyl derivative,
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Fractionation of pine tar has revealed that the components responsible for its bacteriostatic properties are the resin acids,14 and that acetovanillone, 1,1′,3,3′‐tetraoxo‐2,2′‐bicyclopentyl and its 4‐methyl derivative,
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as well as another unknown compound,
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If they know that there is another component that is responsible for how pine tar works, why haven't they found it yet?
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as well as another unknown compound,
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proliferation
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Sensitivity to pine tar.18 Pre‐existing folliculitis or severe acne are also possible contraindications.19
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In terms of pharmacokinetics, it has been observed by infrared spectroscopy that pine tar is detectable in the skin 1 h following the topical application of 12% pine tar to the skin, but was undetectable in the skin after 8 h
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Thus it can reasonably be assumed that pine tar lacks significant carcinogenic activity.23 Further, pine tar used in the manufacture of topical pine tar products available in Australia today has been found not to be carcinogenic by the Ames test (unpublished data, Ego Pharmaceuticals), and is not classified as a carcinogen
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Thus it can reasonably be assumed that pine tar lacks significant carcinogenic activity.23 Further, pine tar used in the manufacture of topical pine tar products available in Australia today has been found not to be carcinogenic by the Ames test (unpublished data, Ego Pharmaceuticals), and is not classified as a carcinogen
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Despite the extensive use of medicinal tars, particularly in psoriasis patients, there is no epidemiological evidence that topical tar products, including pine tar, cause cutaneous or internal cancer
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Despite the extensive use of medicinal tars, particularly in psoriasis patients, there is no epidemiological evidence that topical tar products, including pine tar, cause cutaneous or internal cancer
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Hypersensitivity reactions for tars are rare, but wood tars are more likely to cause sensitisation than coal tar
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Hypersensitivity reactions for tars are rare, but wood tars are more likely to cause sensitisation than coal tar
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It is important to note that the number of positive reactions for wood tars was not significantly greater than those for other common allergens.
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It is important to note that the number of positive reactions for wood tars was not significantly greater than those for other common allergens.
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generally a mixture of pine, juniper, birch and beech tars, and therefore the exact tar eliciting the positive reaction is not known.
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Furthermore, there have been only five cases of adverse events for pine tar reported to the Therapeutic Goods Administration of Australia since records began in 1971, which included pruritus, rash and dermatitis.
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Of the 21 patients 19 preferred the pine tar baths due to the attractive green colour and smell
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pityrosporum
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Both pine tar and glucocorticosteroid treatments had an almost equally inhibiting effect on the various cellular constituents of allergic inflammation including the influx of T‐cells, eosinophils, and CD1+, RFD1+, IFN‐γ+, and IL‐4+ cells,
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Both pine tar and glucocorticosteroid treatments had an almost equally inhibiting effect on the various cellular constituents of allergic inflammation including the influx of T‐cells, eosinophils, and CD1+, RFD1+, IFN‐γ+, and IL‐4+ cells,
