Vitamin d and its role in cancer and immunity: a prescription for sunlight.
Mullin GE, Dobs A.
Nutr Clin Pract. 2007 Jun;22(3):305-22. Review.
PMID: 17507731
(free full text PDF available)
Vitamin D's days of obscurity seem pretty much over. Once just an afterthought to most people-relegated to the sides of milk cartons and the pages of medical texts-it's now on the cusp of becoming a full-fledged disease prevention star. Although vitamin D has long been known as an important factor in bone health, a quickly growing body of evidence now shows that it may also help lower the risk of cancer, heart disease, and even premature death.[1], [2] Not surprisingly, scientists and the public have started to take note, particularly of vitamin D's potential to protect against cancer
Addition of milk prevents vascular protective effects of tea.
Lorenz M, Jochmann N, von Krosigk A, Martus P, Baumann G, Stangl K, Stangl V.
Eur Heart J. 2007 Jan;28(2):219-23. Epub 2007 Jan 9.
PMID: 17213230
doi:10.1093/eurheartj/ehl442
In conclusion, milk may counteract the favourable health effects of tea on vascular function. The finding that the tea-induced improvement of vascular function in humans is completely attenuated after addition of milk may have broad implications on the mode of tea preparation and consumption. In addition, it indicates that caution is warranted in the design of studies involving nutritional flavonoids.
Exposure to diesel exhaust induces changes in EEG in human volunteers.
Crüts B, van Etten L, Törnqvist H, Blomberg A, Sandström T, Mills NL, Borm PJ.
Part Fibre Toxicol. 2008 Mar 11;5:4.
PMID: 18334019
doi:10.1186/1743-8977-5-4
Safety evaluation of topical applications of ethanol on the skin and inside the oral cavity.
Lachenmeier DW.
J Occup Med Toxicol. 2008 Nov 13;3:26.
PMID: 19014531
doi:10.1186/1745-6673-3-26
On the epidemiology of influenza.
Cannell JJ, Zasloff M, Garland CF, Scragg R, Giovannucci E.
Virol J. 2008 Feb 25;5:29. Review.
PMID: 18298852
doi:10.1186/1743-422X-5-29
Pomegranate juice: a heart-healthy fruit juice.
Basu A, Penugonda K.
Nutr Rev. 2009 Jan;67(1):49-56.
PMID: 19146506
DOI: 10.1111/j.1753-4887.2008.00133.x
The effects of whole mushrooms during inflammation.\nYu S, Weaver V, Martin K, Cantorna MT.\nBMC Immunol. 2009 Feb 20;10:12.\nPMID: 19232107 \ndoi:10.1186/1471-2172-10-12\n
The beverage maté: a risk factor for cancer of the head and neck.
Goldenberg D, Golz A, Joachims HZ.
Head Neck. 2003 Jul;25(7):595-601. Review.
PMID: 12808663
DOI: 10.1002/hed.10288
Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease.
Kidd P.
Altern Med Rev. 2003 Aug;8(3):223-46. Review.
PMID: 12946237
Th1 pathways typically produce activation of cytotoxic T
lymphocytes (Tc), NK cells, macrophages, and monocytes, all of
which can attack cancer cells and generally defend against tumors.
55 IFN-gamma and other Th1 cytokines are typically lower in
advanced cancer patients, while the Th2 marker IL-4 can be higher
or unchanged.56 Nodules of non-small cell lung cancer freshly
removed from patients expressed a marked imbalance toward Th2, as
did biopsy samples from basal cell carcinoma.57 In prostate cancer
patients IL-2 was low (Th1) and IL-10 high.58 IL-10 is a confirmed
Th1-suppressive cytokine, and heightened IL-10 is a common factor
in cancer.55
IL-10 has a variety of suppressive effects that include inhibiting
Th1 cytokine production, down-regulating APC and NK cell function,
and lowering overall T-cell proliferation.57 Especially under the
influence of IL-4 (Th2), tumor cells apparently up-regulate IL-10
that suppresses nearby killer cells. Tumor-derived IL-10 has been
documented in lymphoma, ovarian carcinoma, melanoma, neuroblastoma,
and renal cell and colon carcinoma.57 IL-12 is another cytokine
that can be up-regulated by Th1 activity and inhibited by Th2.59 A
low IL-12/IL-10 ratio was found in cervical cancer patients.55
Recent clinical studies suggest elevated IL-10 is predictive of a
poor prognosis. 57 With both IL-4 and IL-10 being proven inhibitors
of Th1 and promoters of Th2 activity, the recognized capability of
cancerous tissue to suppress immunity is readily rationalized.
Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women's Health Study.
Merlino LA, Curtis J, Mikuls TR, Cerhan JR, Criswell LA, Saag KG; Iowa Women's Health Study.
Arthritis Rheum. 2004 Jan;50(1):72-7.
PMID: 14730601
DOI: 10.1002/art.11434
CONCLUSION: Greater intake of vitamin D may be associated with a lower risk of RA in older women, although this finding is hypothesis generating.
Beneficial effects of a Paleolithic diet on cardiovascular risk factors in type 2 diabetes: a randomized cross-over pilot study.
onsson T, Granfeldt Y, Ahren B, Branell UC, Palsson G, Hansson A, Soderstrom M, Lindeberg S.
Cardiovasc Diabetol. 2009 Jul 16;8(1):35. [Epub ahead of print]
PMID: 19604407
doi:10.1186/1475-2840-8-35
Frankincense oil derived from Boswellia carteri induces tumor cell specific cytotoxicity.
Frank MB, Yang Q, Osban J, Azzarello JT, Saban MR, Saban R, Ashley RA, Welter JC, Fung KM, Lin HK.
BMC Complement Altern Med. 2009 Mar 18;9(1):6. [Epub ahead of print]
PMID: 19296830
doi:10.1186/1472-6882-9-6
Enriched eggs as a source of N-3 polyunsaturated fatty acids for humans.
Lewis NM, Seburg S, Flanagan NL.
Poult Sci. 2000 Jul;79(7):971-4. Review.
PMID: 10901195
Plasma triglycerides (TG) are decreased by addition of n-3 PUFA-enriched eggs to the diet. N-3 PUFA may influence LDL particle size, causing a shift toward a less atherogenic particle. Blood platelet aggregation is significantly decreased in participants consuming n-3 PUFA-enriched eggs. Overall results of studies to date demonstrate positive effects and no negative effects from consumption of n-3-enriched eggs. Three n-3 PUFA-enriched eggs provide approximately the same amount of n-3 PUFA as one meal with fish. It is recommended that n-3 PUFA-enriched eggs be used as one source of n-3 PUFA to increase individual consumption to meet the current Canadian recommendations