Skip to main content

Home/ Health Now/ Group items tagged Mechanism

Rss Feed Group items tagged

Matti Narkia

Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of actio... - 0 views

  •  
    Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives. Volvert ML, Seyen S, Piette M, Evrard B, Gangolf M, Plumier JC, Bettendorff L. BMC Pharmacol. 2008 Jun 12;8:10. PMID: 18549472 doi:10.1186/1471-2210-8-10 Conclusion Our results show that, though benfotiamine strongly increases thiamine levels in blood and liver, it has no significant effect in the brain. This would explain why beneficial effects of benfotiamine have only been observed in peripheral tissues, while sulbutiamine, a lipid-soluble thiamine disulfide derivative, that increases thiamine derivatives in the brain as well as in cultured cells, acts as a central nervous system drug. We propose that benfotiamine only penetrates the cells after dephosphorylation by intestinal alkaline phosphatases. It then enters the bloodstream as S-benzoylthiamine that is converted to thiamine in erythrocytes and in the liver. Benfotiamine, an S-acyl derivative practically insoluble in organic solvents, should therefore be differentiated from truly lipid-soluble thiamine disulfide derivatives (allithiamine and the synthetic sulbutiamine and fursultiamine) with a different mechanism of absorption and different pharmacological properties.
Matti Narkia

Vitamin D and Vitamin K Team Up to Lower CVD Risk - Part I - 0 views

  •  
    Strong correlations have been noted between cardiovascular diseases and low bone density / osteoporosis-connections so strong that the presence of one type of pathology is considered a likely predictor of the other. This potentially causal relationship has led to the hypothesis that these conditions share core mechanisms. Recent advances in our understanding of the complimentary roles played by vitamin D3 and vitamin K2 in vascular and bone health provide support for this hypothesis, along with insight into key metabolic dysfunctions underlying cardiovascular disease and osteoporosis. Part I of this review summarizes current research linking vitamin D deficiency to cardiovascular disease, the physiological mechanisms underlying vitamin D's cardiovascular effects, and leading vitamin D researchers' recommendations for significantly higher supplemental doses of the pro-hormone. Part II reviews the vitamin K connection to cardiovascular disease; the ways in which vitamin D and vitamin K pair up to prevent inflammation, vascular calcification and osteoporosis; and the necessity of providing vitamin K along with vitamin D to preclude adverse effects associated with hypervitaminosis D, which include vascular and other soft tissue calcification.
Dr. John Bureau DC

Vitamin C Stops the Growth of Some Cancerous Tumors in Mice - 0 views

  • (NaturalNews) 30 years ago the famous Nobel laureate Linus Pauling said that vitamin C supplements can prevent cancer, a highly controversial statement at the time. Now a team of Johns Hopkins scientists have shown that vitamin C stops the growth of some tumors in mice.The StudyThe study was lead by Chi Dang, M.D., Ph.D., professor of medicine and oncology and Johns Hopkins Family Professor in Oncology Research. Their work is detailed in Cancer Cell, Volume 12, Issue 3, 230-238, 11 September, 2007. They found that the antioxidants' actual role may be to destabilize a tumor's ability to grow under conditions where there isn't enough oxygen to feed it. The conventional belief is that vitamin C helps prevent cancer growth by grabbing up volatile oxygen free radical molecules and preventing the damage they do to our DNA. "The potential anticancer benefits of antioxidants have been the driving force for many clinical and preclinical studies," Says Dang. "By uncovering the mechanism behind antioxidants, we are now better suited to maximize their therapeutic use."
  •  
    (NaturalNews) 30 years ago the famous Nobel laureate Linus Pauling said that vitamin C supplements can prevent cancer, a highly controversial statement at the time. Now a team of Johns Hopkins scientists have shown that vitamin C stops the growth of some tumors in mice. The Study The study was lead by Chi Dang, M.D., Ph.D., professor of medicine and oncology and Johns Hopkins Family Professor in Oncology Research. Their work is detailed in Cancer Cell, Volume 12, Issue 3, 230-238, 11 September, 2007. They found that the antioxidants' actual role may be to destabilize a tumor's ability to grow under conditions where there isn't enough oxygen to feed it. The conventional belief is that vitamin C helps prevent cancer growth by grabbing up volatile oxygen free radical molecules and preventing the damage they do to our DNA. "The potential anticancer benefits of antioxidants have been the driving force for many clinical and preclinical studies," Says Dang. "By uncovering the mechanism behind antioxidants, we are now better suited to maximize their therapeutic use."
Matti Narkia

The Pathobiology of Diabetic Complications - Diabetes - 0 views

  •  
    The pathobiology of diabetic complications: a unifying mechanism. Brownlee M. Diabetes. 2005 Jun;54(6):1615-25. PMID: 15919781 doi: 10.2337/diabetes.54.6.1615
Matti Narkia

Vitamin D and Vitamin K Team Up to Lower CVD Risk - Part II - 0 views

  •  
    Strong correlations have been noted between cardiovascular diseases and low bone density / osteoporosis-connections so strong that the presence of one is considered a likely predictor of the other. This relationship has led to the hypothesis that these conditions share core pathophysiological mechanisms. Recent advances in our understanding of the complimentary roles played by vitamin D3 and vitamin K2 in vascular and bone health provide support for this hypothesis, along with insight into key metabolic dysfunctions underlying cardiovascular disease and osteoporosis. Part II, The Vitamin K Connection to Cardiovascular Health, reviews the ways in which vitamin K regulates calcium utlization, preventing vascular and soft tissue calcification while complimenting the bone-building actions of vitamin D, and also discusses vitamin K safety and dosage issues, and the necessity of providing vitamin K and vitamin A along with vitamin D to preclude adverse effects associated with hypervitaminosis D.
Matti Narkia

YouTube - Vitamin D and Cancer Prevention - 0 views

  •  
    YouTube - Vitamin D and Cancer Prevention. A presentation by Dr. Cedric Garland.
Matti Narkia

Development Of Liver Cancer Prevented By Long-Term L-Carnitine Supplementation - 0 views

  •  
    Authors of the study reported that carnitine deficiency is a risk factor and should be viewed as a mechanism in hepatic carcinogenesis, and that long-term L-carnitine supplementation prevents the development of liver cancer. Therefore, carnitine supplementation alone or in combination with other natural chemopreventive compounds could be used to prevent, slow or reverse the occurrence of liver cance
Matti Narkia

WHFoods: How to prepare broccoli to retain its nutritional value. - 0 views

  •  
    Did you know that cutting the florets into smaller pieces and the stems into thin slices and letting them sit for 5 to 6 minutes before cooking will enhance their cancer protective properties? Cutting broccoli into smaller pieces breaks the cells and activates an enzyme called myrosinase. The myrosinase converts some of the sulfur-containing chemicals found in broccoli (call glucosinolates) into other sulfur containing chemicals (called isothiocyanates) which research has shown to contain cancer preventive properties not found in the glucosinolates . Studies have actually pinpointed specific mechanisms, like changes in cellular genetic processes, which are involved in increasing cancer protection.
Matti Narkia

Omega fatty acid balance can alter immunity and gene expression - 0 views

  •  
    Floyd Chilton and colleagues wanted to examine whether theses fatty acids might have other effects, and developed a dietary intervention strategy in which 27 healthy humans were fed a controlled diet mimicking the w6/w3 ratios of early humans over 5 weeks. They then looked at the gene levels of immune signals and cytokines (protein immune messengers), that impact autoimmunity and allergy in blood cells and found that many key signaling genes that promote inflammation were markedly reduced compared to a normal diet, including a signaling gene for a protein called PI3K, a critical early step in autoimmune and allergic inflammation responses. This study demonstrates, for the first time in humans, that large changes in gene expression are likely an important mechanism by which these omega fatty acids exert their potent clinical effects
Matti Narkia

Vitamin D and multiple sclerosis. - Wiley InterScience - J Cell Biochem. 2008 Oct 1 - 0 views

  •  
    Vitamin D and multiple sclerosis. Raghuwanshi A, Joshi SS, Christakos S. J Cell Biochem. 2008 Oct 1;105(2):338-43. Review. PMID: 18655192
Matti Narkia

Vitamin D and cancer Ali MM, Vaidya V - J Can Res Ther 2007 Oct-Dec - 0 views

  •  
    Vitamin D and cancer. Ali MM, Vaidya V. J Cancer Res Ther. 2007 Oct-Dec;3(4):225-30. Review. PMID: 18270398 DOI: 10.4103/0973-1482.38998
1 - 12 of 12
Showing 20 items per page