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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection platforms currently report qualitative results. However, technology based on RT-PCR allows for calculation of viral load, which is associated with transmission risk and disease severity in other viral illnesses.1 Viral load in COVID-19 might correlate with infectivity, disease phenotype, morbidity, and mortality. To date, no studies have assessed the association between viral load and mortality in a large patient cohort.2, 3, 4 To our knowledge, we are the first to report on SARS-CoV-2 viral load at diagnosis as an independent predictor of mortality in a large hospitalised cohort (n=1145).

"How the 'emotional contagion' of memes makes them the internet's moral conscience By Allie Volpe Aug 27, 2018, 11:30am EDT Illustration by Alex Castro & Keegan Larwin SHARE Newly single, Jason Donahoe was perusing Tinder for the first time since it started integrating users' Instagram feeds. Suddenly, he had an idea: follow the Instagram accounts of some of the women he'd been interested in but didn't match with on the dating service. A few days later, he considered taking it a step further and direct messaging one of the women on Instagram. After all, the new interface of the dating app seemed to encourage users to explore other areas of potential matches' online lives, so why not take the initiative to reach out? Before he had a chance, however, he came across the profile of another woman whose Tinder photo spread featured a meme with Parks and Recreation character Jean-Ralphio Saperstein (Ben Schwartz) leaning into the face of Ben Wyatt (Adam Scott) with the caption: hey I saw you on Tinder but we didn't match so I found your Instagram you're so beautiful you don't need to wear all that makeup ahah I bet you get a lot of creepy dm's but I'm not like all those other guys message me back beautiful btw what's your snap "I was like, 'Oh shit, wow,'" Donahoe says. Seeing his potential jerk move laid out so plainly as a neatly generalized joke, he saw it in a new light. "I knew a) to be aware of that, and b) to cut that shit out … It prompted self-reflection on my part." THE MOST SUCCESSFUL MEMES STRIKE A CULTURAL CHORD AND CAN GUIDE AND EVEN INFLUENCE BEHAVIOR Donahoe says memes have resonated with him particularly when they depict a "worse, extreme version" of himself. For Donahoe, the most successful memes are more than just jokes. They "strike a societal, cultural chord" and can be a potent cocktail for self-reflection as tools that can guide and even influence behavior. In the months leading up to the 2016 US

In December 2019, the Coronavirus disease 2019 (COVID-19), caused by a novel coronavirus SARS-CoV-2, emerged in Wuhan, Hubei province, China1 and soon spread across the world. In this ongoing pandemic, public health concerns and the urgent need for effective therapeutic measures require a deep understanding of its epidemiology, transmissibility and pathogenesis. Here we analyzed the clinical, molecular and immunological data from 326 confirmed cases of COVID-19 in Shanghai. Genomic sequences of SARS-CoV-2 assembled from 112 quality samples together with sequences in the Global Initiative on Sharing All Influenza Data (GISAID) showed a stable evolution and suggested two major lineages with differential exposure history during the early phase of the outbreak in Wuhan. Nevertheless, they exhibited similar virulence and clinical outcomes. Lymphocytopenia, especially the reduced CD4+ and CD8+ T cell counts upon admission, was predictive of disease progression. High levels of IL-6 and IL-8 during treatment were observed in patients with severe or critical disease and correlated with decreased lymphocyte count. The determinants of disease severity seemed to stem mostly from host factors such as age, lymphocytopenia, and its associated cytokine storm, whereas viral genetic variation did not significantly affect the outcomes.

There's rarely time to write about every cool science-y story that comes our way. So this year, we're once again running a special Twelve Days of Christmas series of posts, highlighting one science story that fell through the cracks in 2020, each day from December 25 through January 5. Today: the structure of folklore can help explain how unrelated facts and false information connect into a compelling narrative framework that can then go viral as a conspiracy theory.

People the world over have acquired a passing familiarity with epidemic models, critical threshold values for transmission (R0), comorbidities, and exponential growth. But these insights into the pandemic are like Harrison's H1-3; they focus on a few elements of the problem. The pandemic is every bit as much a problem of the non-linear dynamics of markets, the cognitive biases of decision-makers, the collective dynamics of groups, and the coevolution of biological species - humans, mammalian food sources, and viral agents.

While scientists still don't fully understand the diverse nature of RNA molecules, it is believed that the proteins binding to them, called RNA-binding proteins, are associated with many types of disease formation. Research led by biomedical scientists from City University of Hong Kong (CityU) has led to a novel detection method, called CARPID, to identify binding proteins of specific RNAs in living cells. It is expected that the innovation can be applied in various types of cell research, from identifying biomarkers of cancer diagnosis to detecting potential drug targets for treating viral diseases.

Aerosol transmission of viruses must be acknowledged as a key factor leading to the spread of infectious respiratory diseases. Evidence suggests that SARS-CoV-2 is silently spreading in aerosols exhaled by highly contagious infected individuals with no symptoms. Owing to their smaller size, aerosols may lead to higher severity of COVID-19 because virus-containing aerosols penetrate more deeply into the lungs (10). It is essential that control measures be introduced to reduce aerosol transmission. A multidisciplinary approach is needed to address a wide range of factors that lead to the production and airborne transmission of respiratory viruses, including the minimum virus titer required to cause COVID-19; viral load emitted as a function of droplet size before, during, and after infection; viability of the virus indoors and outdoors; mechanisms of transmission; airborne concentrations; and spatial patterns. More studies of the filtering efficiency of different types of masks are also needed. COVID-19 has inspired research that is already leading to a better understanding of the importance of airborne transmission of respiratory disease.

Viral immunologists say that results so far have been predictable - here's why that's good news.