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The emergence of three lethal coronaviruses in <20 years and the urgency of the COVID-19 pandemic have prompted efforts to develop new therapeutic strategies, including by repurposing existing agents. After performing a comparative analysis of the three pathogenic human coronaviruses severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1), SARS-CoV-2, and Middle East respiratory syndrome coronavirus (MERS-CoV), we identified shared biology and host-directed drug targets to prioritize therapeutics with potential for rapid deployment against current and future coronavirus outbreaks.

Younger generations are blamed for the pandemic's spread, but also face the brunt of the transmission risk that comes with keeping the economy going. 6 MINUTE READ BY REBECCA RENNER PUBLISHED SEPTEMBER 17, 2020 WHEN PARAMEDICS RUSHED the pregnant Honduran woman into the emergency room, 28-year-old Chuan-Jay Jeffrey Chen stood ready to receive her. It was April, and the pandemic had already taken over his final year as an emergency medicine resident. Of all the coronavirus patients surging into Massachusetts General Hospital in Boston, this 32-year-old patient remains Chen's most memorable. The woman was so short of breath she could barely speak, so Chen would need to intubate her-a tricky procedure that requires precision as well as speed. Every moment without oxygen causes a patient's chances of survival to decline; pregnancy further complicates the scenario by making airways swollen, causing blood pressure to drop more quickly. As Chen set to work and talked her through the steps in Spanish, he also tried to calm his own nerves. "I knew I had very little margin for error," says Chen. The woman's husband had been barred from entering the building because of coronavirus restrictionsgen-z

But the concept of developing a vaccine at "warp speed" makes many people uncomfortable. In a May survey, 49 percent of the Americans polled said they plan to get a coronavirus vaccine when one is available, 20 percent do not, and 31 percent indicated that they were not sure. The World Health Organization considers "vaccine hesitancy" a major threat to global health, and poor uptake would jeopardize the impact of a coronavirus vaccine.

Among the many uncertainties that remain about Covid-19 is how the human immune system responds to infection and what that means for the spread of the disease. Immunity after any infection can range from lifelong and complete to nearly nonexistent. So far, however, only the first glimmers of data are available about immunity to SARS-CoV-2, the coronavirus that causes Covid-19.

When you mix science and politics, you get politics. With the coronavirus, the United States has proved politics hasn't worked. If we are to fully reopen both the economy and schools safely - which can be done - we have to return to science.coronovirus

The coronavirus offers an opening to change the world for the better, not least by undoing decades of neoliberalization to give vital professions in health care and education the appreciation they deserve. Unfortunately, as detailed in Naomi Klein's 'The Shock Doctrine', crises also offer ample opportunity for the established order to realize ambitions which are inconceivable in normal times. The global political economy before the outbreak of corona was defined by the rise of a global billionaire class, tech platforms, and illiberal(izing) nationalist politics, having jointly propelled a novel wave of (geo) political-economic restructuring which I have called neo-illiberalism. What will be the effects of coronavirus on this new status quo?

At the beginning of the pandemic, the coronavirus looked to be another respiratory illness. But the virus has turned out to affect not just the lungs, but the kidneys, the heart and the circulatory system - even, somehow, our senses of smell and taste.

Converging lines of evidence indicate that SARS-CoV-2, the coronavirus responsible for the COVID-19 pandemic, can pass from person to person in tiny droplets called aerosols that waft through the air and accumulate over time. After months of debate about whether people can transmit the virus through exhaled air, there is growing concern among scientists about this transmission route.

In December 2019, the Coronavirus disease 2019 (COVID-19), caused by a novel coronavirus SARS-CoV-2, emerged in Wuhan, Hubei province, China1 and soon spread across the world. In this ongoing pandemic, public health concerns and the urgent need for effective therapeutic measures require a deep understanding of its epidemiology, transmissibility and pathogenesis. Here we analyzed the clinical, molecular and immunological data from 326 confirmed cases of COVID-19 in Shanghai. Genomic sequences of SARS-CoV-2 assembled from 112 quality samples together with sequences in the Global Initiative on Sharing All Influenza Data (GISAID) showed a stable evolution and suggested two major lineages with differential exposure history during the early phase of the outbreak in Wuhan. Nevertheless, they exhibited similar virulence and clinical outcomes. Lymphocytopenia, especially the reduced CD4+ and CD8+ T cell counts upon admission, was predictive of disease progression. High levels of IL-6 and IL-8 during treatment were observed in patients with severe or critical disease and correlated with decreased lymphocyte count. The determinants of disease severity seemed to stem mostly from host factors such as age, lymphocytopenia, and its associated cytokine storm, whereas viral genetic variation did not significantly affect the outcomes.