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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection platforms currently report qualitative results. However, technology based on RT-PCR allows for calculation of viral load, which is associated with transmission risk and disease severity in other viral illnesses.1 Viral load in COVID-19 might correlate with infectivity, disease phenotype, morbidity, and mortality. To date, no studies have assessed the association between viral load and mortality in a large patient cohort.2, 3, 4 To our knowledge, we are the first to report on SARS-CoV-2 viral load at diagnosis as an independent predictor of mortality in a large hospitalised cohort (n=1145).

The common challenge of covid-19 has produced very different outcomes around the world, leading to many questions about the determinants of national performance and shortcomings in global performance. Problems of reporting and standards do not make precise comparisons easy, but few would disagree that the roughly 1400 deaths reported by South Korea, Thailand, and Vietnam together represent far better results than the roughly 700 000 deaths reported by Brazil, the United Kingdom, and the United States.1 Adjusting these figures for population-the first group has about a third of the citizens of the second group-does not explain why covid-19 mortality differs by a factor of nearly 500. Neither typical proxy measures such as gross national income per capita nor national rankings on the 2019 Global Health Security Index have any meaningful association with performance on covid-19.2

High levels of gambling are associated with a 37% increase in mortality, according to a new study, which reveals that the top 1% of gamblers surveyed spent 58% of their income and one in ten are spending 8% on the habit. Published today [4 Feb] in Nature Human Behavior, the study led by Dr. Naomi Muggleton, of Oxford's Department of Social Policy and Intervention, highlights the financial damage, negative lifestyles and health of gamblers, who can move from 'social' to high-level gambling in months.