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Bill Fulkerson

Viral and host factors related to the clinical outcome of COVID-19 | Nature - 0 views

www.nature.com/...s41586-020-2355-0

outcome viral factors clinical

shared by Bill Fulkerson on 27 May 20 - No Cached
  • Bill Fulkerson on 27 May 20
     
    In December 2019, the Coronavirus disease 2019 (COVID-19), caused by a novel coronavirus SARS-CoV-2, emerged in Wuhan, Hubei province, China1 and soon spread across the world. In this ongoing pandemic, public health concerns and the urgent need for effective therapeutic measures require a deep understanding of its epidemiology, transmissibility and pathogenesis. Here we analyzed the clinical, molecular and immunological data from 326 confirmed cases of COVID-19 in Shanghai. Genomic sequences of SARS-CoV-2 assembled from 112 quality samples together with sequences in the Global Initiative on Sharing All Influenza Data (GISAID) showed a stable evolution and suggested two major lineages with differential exposure history during the early phase of the outbreak in Wuhan. Nevertheless, they exhibited similar virulence and clinical outcomes. Lymphocytopenia, especially the reduced CD4+ and CD8+ T cell counts upon admission, was predictive of disease progression. High levels of IL-6 and IL-8 during treatment were observed in patients with severe or critical disease and correlated with decreased lymphocyte count. The determinants of disease severity seemed to stem mostly from host factors such as age, lymphocytopenia, and its associated cytokine storm, whereas viral genetic variation did not significantly affect the outcomes.
Steve Bosserman

Beyond Prisons, Mental Health Clinics: When Austerity Opens Cages, Where Do the Service... - 0 views

www.politicalresearch.org/...cages-where-do-the-services-go

policy change mental health neoliberalism research incarceration prisons political

shared by Steve Bosserman on 02 May 18 - No Cached
  • Today, states grapple with decarceration and deinstitutionalization, not necessarily because of an ethical recognition of the continuing harm of confinement and segregation, or because of an understanding of the intertwined histories of capitalism, white supremacy, ableism, and punishment in the United States, but because of a desire to curb public spending on social services. These include the very services that people need as alternatives to more oppressive edifices and as preventive measures to winding up in such places. While public neighborhood urban schools, public housing, and mental health clinics are shuttered, private companies and “not for profit” services partially fill the void.
  • Alternatives emerge when facilities shut their doors. Closures, as prison justice organizer Angela Davis suggests, provide an opportunity for not only a “radical imagining” of the kind of social landscape desperately needed—but also the moment to build it. As people move between different forms and scales of cages, and as patterns of surveillance and punishment morph, new forms of capture do emerge and yet resistance is also possible. The state often refuses to offer services in place of the ones that were shuttered, leaving the responsibility to the individual (or her family and the market). This is a moment to collectively demand, fund, and build public infrastructure that will move everyone closer towards a world that does not rely on segregation and confinement, or access to private capital, as its mode of dealing with structural inequities.
Steve Bosserman

Paying for Health Care With Trees: A Win-Win for Orangutans and Communities - 0 views

psmag.com/s-and-communities-ed76b7139a7b

basic needs conservation deforestration borneo

shared by Steve Bosserman on 04 Apr 17 - No Cached
  • Today, the clinic not only provides high-quality health care that is affordable to all, but actively rewards communities that reduce logging, or stop altogether, with further reductions on the cost of treatment. Forest guardians, recruited in every village, encourage others in their community to reduce logging. The guardians also monitor illegal activity and reforestation efforts, and offer training in organic farming techniques.
  • Today, the clinic not only provides high-quality health care that is affordable to all, but actively rewards communities that reduce logging, or stop altogether, with further reductions on the cost of treatment. Forest guardians, recruited in every village, encourage others in their community to reduce logging. The guardians also monitor illegal activity and reforestation efforts, and offer training in organic farming techniques.
Bill Fulkerson

Next-generation drug testing on chips - 0 views

medicalxpress.com/...ext-generation-drug-chips.html

testing chips

shared by Bill Fulkerson on 18 Jun 20 - No Cached
  • Bill Fulkerson on 18 Jun 20
     
    Researchers at Kyoto University's Institute for Integrated Cell-Material Sciences (iCeMS) in Japan have designed a small 'body-on-a-chip' device that can test the side effects of drugs s on human cells. The device solves some issues with current, similar microfluidic devices and offers promise for the next generation of pre-clinical drug tests.
Bill Fulkerson

Age-dependent effects in the transmission and control of COVID-19 epidemics | Nature Me... - 0 views

www.nature.com/...s41591-020-0962-9

transmission effects medicine coronavirus age

shared by Bill Fulkerson on 16 Jun 20 - No Cached
  • Bill Fulkerson on 16 Jun 20
     
    , we disentangle the relative contributions of three potential drivers of the observed distribution of clinical cases by age. We present a summary of the main findings, limitations and implications of
Bill Fulkerson

Case Series of Multisystem Inflammatory Syndrome in Adults Associated with SARS-CoV-2 I... - 0 views

www.cdc.gov/...mm6940e1.htm

united states

shared by Bill Fulkerson on 05 Oct 20 - No Cached
  • Bill Fulkerson on 05 Oct 20
     
    Clinical suspicion and indicated SARS-CoV-2 testing, including antibody testing, might be needed to recognize and treat adults with MIS-A. Further research is needed to understand the pathogenesis and long-term effects of this condition. Ultimately, the recognition of MIS-A reinforces the need for prevention efforts to limit spread of SARS-CoV-2. COVID-19
Steve Bosserman

Why we find change so difficult, according to neuroscience - 0 views

www.nbcnews.com/...ording-neuroscience-ncna934011

adaptation change neuroscience

shared by Steve Bosserman on 14 Nov 18 - No Cached
  • “Emotionally and cognitively and executively the brain has established a lot of pathways,” says Dr. Sanam Hafeez, a licensed clinical psychologist and neuropsychologist. “The more you do something the more ingrained it becomes in neural pathways, much like how a computer that stores the sites you visit — when you log onto your browser, they will pop up because you use them a lot. Change is an upheaval of many things and the brain has to work to fit it into an existing framework.”
  • “You absolutely can and should teach your brain to change,” says Hafeez, noting that keeping the brain agile has been shown to help delay aging. “I've done quite a bit of work on the aging process and slowing that down. It starts with changing the aversion to change.”
  • “Let’s say you’re a financial planer who takes up knitting,” says Hafeez. “That is doing something very different, where the brain truly has to adapt new neural pathways. Learning a new skill like this have been shown to ward off dementia, aging and cognitive decline because it regenerates cellular activity. Learn a new language in middle age. You tax your brain by shaking things up and it’s effective for your body in the way HIIT is for your body.”
  • ...1 more annotation...
  • “Most people won't try something new because they’re deathly afraid of failing,” notes Hafeez. “When you see that something is doable it makes you more receptive and brave. There's that emotional, therapeutic factor that is separate from the neural pathway factor. Over the years, we learn to succeed by viewing our previous failures and successes in a certain light and as we get older we lose sight of that. When you try a new thing it makes you more confident to try to do more new things.”
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