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Land use change-for example, the conversion of natural habitats to agricultural or urban ecosystems-is widely recognized to influence the risk and emergence of zoonotic disease in humans1,2. However, whether such changes in risk are underpinned by predictable ecological changes remains unclear. It has been suggested that habitat disturbance might cause predictable changes in the local diversity and taxonomic composition of potential reservoir hosts, owing to systematic, trait-mediated differences in species resilience to human pressures3,4. Here we analyse 6,801 ecological assemblages and 376 host species worldwide, controlling for research effort, and show that land use has global and systematic effects on local zoonotic host communities. Known wildlife hosts of human-shared pathogens and parasites overall comprise a greater proportion of local species richness (18-72% higher) and total abundance (21-144% higher) in sites under substantial human use (secondary, agricultural and urban ecosystems) compared with nearby undisturbed habitats. The magnitude of this effect varies taxonomically and is strongest for rodent, bat and passerine bird zoonotic host species, which may be one factor that underpins the global importance of these taxa as zoonotic reservoirs. We further show that mammal species that harbour more pathogens overall (either human-shared or non-human-shared) are more likely to occur in human-managed ecosystems, suggesting that these trends may be mediated by ecological or life-history traits that influence both host status and tolerance to human disturbance5,6. Our results suggest that global changes in the mode and the intensity of land use are creating expanding hazardous interfaces between people, livestock and wildlife reservoirs of zoonotic disease.

A sweeping effort to map a hospital's microorganisms has found that infectious pathogens hide in a place that's all about cleaning: the sink. Niranjan Nagarajan at the Genome Institute of Singapore and his colleagues sampled bacteria from bed rails, sinks and other sites in a Singapore hospital. Microbes that tend to grow in slimy 'biofilms' and cause hospital-acquired infections were prevalent on sink traps and faucet aerators, whereas skin-dwelling bacteria were abundant on objects, such as door knobs and bed rails, that are often touched. Frequently touched sites harboured multidrug-resistant microbes such as methicillin-resistant Staphylococcus aureus, which might persist in the hospital environment for more than eight years, the team suggested.

Aside from filtering, warming, and humidifying the air you breathe, the nose is your first line of defense against allergens and pathogens. The mucus and cilia inside are designed to block these outside invaders from going farther down the respiratory tract and making you sick. And NO, which is what the sinuses release when you breathe through your nose, is a vasodilator, meaning it relaxes the blood vessels and lowers blood pressure.

Flowering strips-pollinator-friendly rows of plants that increase foraging habitat for bees-can help offset pollinator decline but may also bring risks of higher pathogen infection rates for pollinators foraging in those strips.

The emergence of three lethal coronaviruses in <20 years and the urgency of the COVID-19 pandemic have prompted efforts to develop new therapeutic strategies, including by repurposing existing agents. After performing a comparative analysis of the three pathogenic human coronaviruses severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1), SARS-CoV-2, and Middle East respiratory syndrome coronavirus (MERS-CoV), we identified shared biology and host-directed drug targets to prioritize therapeutics with potential for rapid deployment against current and future coronavirus outbreaks.

Researchers from The Institute for Integrative Systems Biology have discovered a new gene family of antimicrobial peptides (small proteins) -the Blattellicins- in a German cockroach (Blattella germanica). The study, published in the journal Scientific Reports, may help to understand how these insects can live in unsanitary environments and defend themselves against the fungal and bacterial pathogens they encounter via the beneficial symbiotic organisms that they harbor.