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Land use change-for example, the conversion of natural habitats to agricultural or urban ecosystems-is widely recognized to influence the risk and emergence of zoonotic disease in humans1,2. However, whether such changes in risk are underpinned by predictable ecological changes remains unclear. It has been suggested that habitat disturbance might cause predictable changes in the local diversity and taxonomic composition of potential reservoir hosts, owing to systematic, trait-mediated differences in species resilience to human pressures3,4. Here we analyse 6,801 ecological assemblages and 376 host species worldwide, controlling for research effort, and show that land use has global and systematic effects on local zoonotic host communities. Known wildlife hosts of human-shared pathogens and parasites overall comprise a greater proportion of local species richness (18-72% higher) and total abundance (21-144% higher) in sites under substantial human use (secondary, agricultural and urban ecosystems) compared with nearby undisturbed habitats. The magnitude of this effect varies taxonomically and is strongest for rodent, bat and passerine bird zoonotic host species, which may be one factor that underpins the global importance of these taxa as zoonotic reservoirs. We further show that mammal species that harbour more pathogens overall (either human-shared or non-human-shared) are more likely to occur in human-managed ecosystems, suggesting that these trends may be mediated by ecological or life-history traits that influence both host status and tolerance to human disturbance5,6. Our results suggest that global changes in the mode and the intensity of land use are creating expanding hazardous interfaces between people, livestock and wildlife reservoirs of zoonotic disease.

Numerous different microorganisms play an important role in the health and fitness, including humans, through their interactions with their host organism. The ability to enter into functional communication with the host also characterizes the archaea. They are basically known for their many special properties. Representatives of this group of microorganisms can also exist as so-called extremophiles under extraordinary living conditions, such as very high temperatures, high salt concentrations or in acidic environments.

In December 2019, the Coronavirus disease 2019 (COVID-19), caused by a novel coronavirus SARS-CoV-2, emerged in Wuhan, Hubei province, China1 and soon spread across the world. In this ongoing pandemic, public health concerns and the urgent need for effective therapeutic measures require a deep understanding of its epidemiology, transmissibility and pathogenesis. Here we analyzed the clinical, molecular and immunological data from 326 confirmed cases of COVID-19 in Shanghai. Genomic sequences of SARS-CoV-2 assembled from 112 quality samples together with sequences in the Global Initiative on Sharing All Influenza Data (GISAID) showed a stable evolution and suggested two major lineages with differential exposure history during the early phase of the outbreak in Wuhan. Nevertheless, they exhibited similar virulence and clinical outcomes. Lymphocytopenia, especially the reduced CD4+ and CD8+ T cell counts upon admission, was predictive of disease progression. High levels of IL-6 and IL-8 during treatment were observed in patients with severe or critical disease and correlated with decreased lymphocyte count. The determinants of disease severity seemed to stem mostly from host factors such as age, lymphocytopenia, and its associated cytokine storm, whereas viral genetic variation did not significantly affect the outcomes.

The emergence of three lethal coronaviruses in <20 years and the urgency of the COVID-19 pandemic have prompted efforts to develop new therapeutic strategies, including by repurposing existing agents. After performing a comparative analysis of the three pathogenic human coronaviruses severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1), SARS-CoV-2, and Middle East respiratory syndrome coronavirus (MERS-CoV), we identified shared biology and host-directed drug targets to prioritize therapeutics with potential for rapid deployment against current and future coronavirus outbreaks.

Given time, biology will advance to the point where things can be done that cannot be defined right now, such as changing the way people think; changing their allegiance; diseases which cannot be cured or treated or prevented; a Pandora's box," he told The Current's guest host Gillian Findlay.

Dr. Arnott added: "Our research shows for the first time how microplastics are disrupting and causing behavioral changes among the hermit crab population. These crabs are an important part of the ecosystem, responsible for 'cleaning up' the sea through eating up decomposed sea-life and bacteria. By providing a hard, mobile surface, hermit crabs are also walking wildlife gardens. They host over 100 invertebrate species-far more than live snails or non-living substrates. Additionally, commercially valuable species prey on hermit crabs, such as cod, ling, and wolf-fish. With these findings of effects on animal behavior, the microplastic pollution crisis is therefore threatening biodiversity more than is currently recognised so it is vital that we act now to tackle this issue before it becomes too late."

A large team of researchers working with Google Inc. and affiliated with a host of institutions in the U.S., one in Germany and one in the Netherlands has implemented a quantum approximate optimization algorithm (QAOA) on a 53-qubit noisy intermediate-scale quantum (NISQ) device. In their paper published in the journal Nature Physics,, the group describes their method of studying the performance of their QAOA on Google's Sycamore superconducting 53-qubit quantum processor and what they learned from it. Boaz Barak with Harvard University has published a News & Views piece on the work done by the team in the same journal issue.

Human networks are not random. We connect to others who're like us in some way; social scientists call this homophily. A point of similarity might be something as fundamental to our identity as gender, religion, ethnicity, age, values, or beliefs. Or it could be, and often is, socioeconomic status. Or geographic-say, a neighborhood, city, or region where you grew up. Or an enthusiasm-football, a popular video game, or a breed of dog. When we meet someone at a party, we quickly try to find out if our networks connect in some way. Where are you from? What do you do? How do you know the host? Homophily is a human universal and an essential piece of our mental equipment for sustaining cooperation.

"One social solution that could be introduced is Universal Basic Income-a guaranteed income that is given to all individuals regardless of employment status or economic situation. It is a system that is already being debated, as a host of experts in various industries are pushing for it. In fact, it is already being tested in Finland and other nations. Thus, in the near future, we can analyze its results and, if positive, rework our economic and social structures to accommodate it."