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"Acousticians have been designing concert halls for more than a century, but Dr. Kyriakakis does something different. He shapes the sound of music to conform to the space in which it is played. The goal is what Dr. Kyriakakis calls the "ground truth" - to replicate the original in every respect. "We remove the room," he said, "so the ground truth can be delivered." Dr. Kyriakakis, an electrical engineer at U.S.C. and the founder and chief technical officer of Audyssey Laboratories, a Los Angeles-based audio firm, could not achieve his results without modern sound filters and digital microprocessors. But the basis of his technique is rooted in the science of psychoacoustics, the study of sound perception by the human auditory system. "It's about the human ear and the human brain, and understanding how the human ear perceives sound," Dr. Kyriakakis said. Psychoacoustics has become an invaluable tool in designing hearing aids and cochlear implants, and in the study of hearing generally. "Psychoacoustics is fundamental," said Andrew J. Oxenham, a psychologist and hearing expert at the University of Minnesota. "You need to know how the normally functioning auditory system works - how sound relates to human perception." "

"A few months ago, a construction worker named Wesley Autrey leapt in front of a moving subway train in New York City to save a stranger who had just collapsed onto the tracks. Five days later, the New York Times speculated that this act of apparent altruism-"I just saw someone who needed help," Autrey said-might be explained by a bunch of cells thought to exist in the human brain, called mirror neurons. The idea that these particular cells might underlie a fundamental human impulse reflects the emergence of a new scientific myth. Like a traditional myth, it captures intuitions about the human condition through vivid metaphors. This isn't the first time that popular science has merged with the popular imagination. In the 1960s, for example, pioneering work on "split-brain" patients revealed real functional differences between the two cerebral hemispheres-an idea that quickly became a metaphor for ancient intuitions about reason and passion. Advertisement Mirror neurons have become the "left brain/right brain" of the 21st century. The idea that these cells could make a hero out of Wesley Autrey began with a genuine and important discovery about the brains of macaque monkeys. In the late 1980s and early 1990s, neuroscientists found a population of cells that fired whenever a monkey prepared to act but also when it watched another animal act. They called these cells "mirror neurons." It didn't take long for scientists and science writers to speculate that mirror neurons might serve as the physiological basis for a wide range of social behaviors, from altruism to art appreciation. Headlines like "Cells That Read Minds" or "How Brain's 'Mirrors' Aid Our Social Understanding" tapped into our intuitions about connectedness. Maybe this cell, with its mellifluous name, gives us our special capacity to understand one another-to care, to learn, and to communicate. Could mirror neurons be responsible for human language, culture, empathy, and morality? "

"Science all but confirms that humans are hard-wired to respond to music. Studies also suggest that someday music may even help patients heal from Parkinson's disease or a stroke. In The Power of Music, Elena Mannes explores how music affects different groups of people and how it could play a role in health care. Mannes tracked the human relationship with music over the course of a life span. She tells NPR's Neal Conan that studies show that infants prefer "consonant intervals, the smooth-sounding ones that sound nice to our Western ears in a chord, as opposed to a jarring combination of notes." In fact, Mannes says the cries of babies just a few weeks old were found to contain some of the basic intervals common to Western music. She also says scientists have found that music stimulates more parts of the brain than any other human function. That's why she sees so much potential in music's power to change the brain and affect the way it works. Mannes says music also has the potential to help people with neurological deficits. "A stroke patient who has lost verbal function - those verbal functions may be stimulated by music," she says. One technique, known as melodic intonation therapy, uses music to coax portions of the brain into taking over for those that are damaged. In some cases, it can help patients regain their ability to speak. And because of how we associate music with memories, Mannes says such techniques could also be helpful for Alzheimer's patients. Less recently, archaeologists have discovered ancient flutes - one of which is presumed to be the oldest musical instrument in the world - that play a scale similar to the modern Western scale. "And remarkably," Mannes says, "this flute, when played, produces these amazingly pure tones." It's a significant discovery because it adds to the argument that musical ability and interest were present early in human history."

"On a hot summer day 15 years ago in Parma, Italy, a monkey sat in a special laboratory chair waiting for researchers to return from lunch. Thin wires had been implanted in the region of its brain involved in planning and carrying out movements. Every time the monkey grasped and moved an object, some cells in that brain region would fire, and a monitor would register a sound: brrrrrip, brrrrrip, brrrrrip. A graduate student entered the lab with an ice cream cone in his hand. The monkey stared at him. Then, something amazing happened: when the student raised the cone to his lips, the monitor sounded - brrrrrip, brrrrrip, brrrrrip - even though the monkey had not moved but had simply observed the student grasping the cone and moving it to his mouth. The researchers, led by Giacomo Rizzolatti, a neuroscientist at the University of Parma, had earlier noticed the same strange phenomenon with peanuts. The same brain cells fired when the monkey watched humans or other monkeys bring peanuts to their mouths as when the monkey itself brought a peanut to its mouth. Later, the scientists found cells that fired when the monkey broke open a peanut or heard someone break a peanut. The same thing happened with bananas, raisins and all kinds of other objects. "It took us several years to believe what we were seeing," Dr. Rizzolatti said in a recent interview. The monkey brain contains a special class of cells, called mirror neurons, that fire when the animal sees or hears an action and when the animal carries out the same action on its own. But if the findings, published in 1996, surprised most scientists, recent research has left them flabbergasted. Humans, it turns out, have mirror neurons that are far smarter, more flexible and more highly evolved than any of those found in monkeys, a fact that scientists say reflects the evolution of humans' sophisticated social abilities. The human brain has multiple mirror neuron systems that specialize in carrying out and understanding

"ACCORDING to Joseph Henrich and his colleagues at the University of British Columbia, most undergraduates are WEIRD. Those who teach them might well agree. But Dr Henrich did not intend the term as an insult when he popularised it in a paper published in Behavioral and Brain Sciences in 2010. Instead, he was proposing an acronym: Western, Educated, Industrialised, Rich and Democratic. One reason these things matter is that undergraduates are also psychology's laboratory rats. Incentivised by rewards, in the form of money or course credits, they will do the human equivalents of running mazes and pressing the levers in Skinner boxes until the cows come home. Which is both a blessing and a problem. It is a blessing because it provides psychologists with an endless supply of willing subjects. And it is a problem because those subjects are WEIRD, and thus not representative of humanity as a whole. Indeed, as Dr Henrich found from his analysis of leading psychology journals, a random American undergraduate is about 4,000 times more likely than an average human being to be the subject of such a study. Drawing general conclusions about the behaviour of Homo sapiens from the results of these studies is risky. This state of affairs, though, may be coming to an end. The main reasons undergraduates have been favoured in the past are that they are cheap, and easy for academics to recruit. But a new source of supply is now emerging: crowdsourcing."

We humans are such complex beasts. Why is it that we can be so wonderful and yet so awful, eccentric and prosaic, enigmatic and obvious, witty and dull, and all of these at once? All in the Mind, presented by Natasha Mitchell, is Radio National's weekly foray into all things mental - a program about the mind, brain and behaviour. From dreaming to depression, addiction to artificial intelligence, consciousness to coma, psychoanalysis to psychopathy, free will to forgetting - All in the Mind explores the human condition through the mind's eye. Our mental machinery remains one of the greatest mysteries of this or any other age, performing for us the most incredible feats of perception, cognition and coordination. Scientists, theologians, philosophers and armchair psychologists alike have long debated its form and function. And yet, the mind, in all its madness and brilliance, continues to elude us. All in the Mind brings together unexpected voices, themes and ideas and engages with both leading thinkers and personal stories. Psychology and human behaviour are only part of the equation. The program's scope is considerably broader and explores themes in science, religion, health, philosophy, education, history and pop culture, with the mind as the key focus.

"The research, reported online in the journal Legal and Criminological Psychology, could lead to new tools for diagnosis and treatment, and perhaps have applications in law enforcement. "Our paper is the first to show that you can use automated tools to detect the distinct speech patterns of psychopaths," says Jeff Hancock, professor of communication at Cornell University. This can be valuable to clinical psychologists, because the approach to treatment of psychopaths can be very different. Straight from the Source Read the original study DOI: 10.1111/j.2044-8333.2011.02025.x Researchers compared stories told by 14 imprisoned psychopathic male murderers with those of 38 convicted murderers who were not diagnosed as psychopathic. Each subject was asked to describe his crime in detail; the stories were taped, transcribed, and subjected to computer analysis. A psychopath, as described by psychologists, is emotionally flat, lacks empathy for the feelings of others, and is free of remorse. Psychopaths behave as if the world is to be used for their benefit, and they employ deception and feigned emotion to manipulate others. The words of the experimental subjects matched these descriptions. Psychopaths used more conjunctions like "because," "since" or "so that," implying that the crime "had to be done" to obtain a particular goal. They used twice as many words relating to physical needs, such as food, sex, or money, while non-psychopaths used more words about social needs, including family, religion, and spirituality. Psychopaths are predators and their stories often include details of what they had to eat on the day of their crime, writes co-author Michael Woodworth, associate professor of psychology at the University of British Columbia. Psychopaths were more likely to use the past tense, suggesting a detachment from their crimes-and tended to be less fluent in their speech, using more "ums" and "uhs." Researchers speculate that the

"As neurologists, psychologists and biologists have zeroed in more and more precisely on the physical causes of mental disorders, they have found themselves addressing a much deeper mystery, a set of interrelated conundrums probably as old as humanity: What, precisely, is the mind, the elusive entity where intelligence, decision making, perception, awareness and sense of self reside? Where is it located? How does it work? Does it arise from purely physical processes-pulses of electricity zapping from brain cell to brain cell, helped along their way by myriad complex chemicals? Or is it something beyond the merely physical-something ethereal that might be close to the spiritual concept of the soul? Great thinkers have had no shortage of ideas on the subject. Plato was convinced that the mind must be located inside the head, because the head is shaped more or less like a sphere, his idea of the highest geometrical form. Aristotle insisted that the mind was in the heart. His reasoning: warmth implies vitality; the blood is warm; the heart pumps the blood. By the Middle Ages, though, pretty much everyone agreed that the mind arose from the brain -- but still had no clear idea how it arose. Finally, in the 17th century, the French philosopher Rena Descartes declared that the mind, while it might live in the brain, was a nonmaterial thing, entirely separate from the physical tissues found inside the head. Furthermore, said Descartes in one of history's most memorable sound bites, "Cogito, ergo sum" (I think, therefore I am). His point: consciousness is the only sure evidence that we actually exist. Until just a few years ago, unraveling the relationship of mind and brain was beyond the realm of observation and experimentation. But science has finally begun to catch up with philosophy. Using sensitive electrodes inserted deep into the gray matter of test animals, researchers have watched vision as it percolates inward from the eye's retina to the inner brain. Powerful te

"MIT researchers have shown, for the first time ever, that memories are stored in specific brain cells. By triggering a small cluster of neurons, the researchers were able to force the subject to recall a specific memory. By removing these neurons, the subject would lose that memory. As you can imagine, the trick here is activating individual neurons, which are incredibly small and not really the kind of thing you can attach electrodes to. To do this, the researchers used optogenetics, a bleeding edge sphere of science that involves the genetic manipulation of cells so that they're sensitive to light. These modified cells are then triggered using lasers; you drill a hole through the subject's skull and point the laser at a small cluster of neurons. Now, just to temper your excitement, we should note that MIT's subjects in this case are mice - but it's very, very likely that the human brain functions in the same way. To perform this experiment, though, MIT had to breed genetically engineered mice with optogenetic neurons - and we're a long, long way off breeding humans with optogenetic brains. In the experiment, MIT gave mice an electric shock to create a fear memory in the hippocampus region of the brain (pictured above) - and then later, using laser light, activated the neurons where the memory was stored. The mice "quickly entered a defensive, immobile crouch," strongly suggesting the fear memory was being recalled."

"Daniel Kahneman spent part of his childhood in Nazi-occupied Paris. Like the other Jews, he had to wear a Star of David on the outside of his clothing. One evening, when he was about 7 years old, he stayed late at a friend's house, past the 6 p.m. curfew. The intellectual, cultural and scientific findings that land on the columnist's desk nearly every day. He turned his sweater inside out to hide the star and tried to sneak home. A German SS trooper approached him on the street, picked him up and gave him a long, emotional hug. The soldier displayed a photo of his own son, spoke passionately about how much he missed him and gave Kahneman some money as a sentimental present. The whole time Kahneman was terrified that the SS trooper might notice the yellow star peeking out from inside his sweater. Kahneman finally made it home, convinced that people are complicated and bizarre. He went on to become one of the world's most influential psychologists and to win the Nobel in economic science. Kahneman doesn't actually tell that childhood story in his forthcoming book. "Thinking, Fast and Slow" is an intellectual memoir, not a personal one. The book is, nonetheless, sure to be a major intellectual event (look for an excerpt in The Times Magazine this Sunday) because it superbly encapsulates Kahneman's research, and the vast tide of work that has been sparked by it. I'd like to use this column not to summarize the book but to describe why I think Kahneman and his research partner, the late Amos Tversky, will be remembered hundreds of years from now, and how their work helped instigate a cultural shift that is already producing astounding results. Before Kahneman and Tversky, people who thought about social problems and human behavior tended to assume that we are mostly rational agents. They assumed that people have control over the most important parts of their own thinking. They assumed that people are basically sensible utility-maximizers and that w

"Humans are storytelling machines. We don't passively perceive the world - we tell stories about it, translating the helter-skelter of events into tidy narratives. This is often a helpful habit, helping us make sense of mistakes, consider counterfactuals and extract a sense of meaning from the randomness of life. But our love of stories comes with a serious side-effect: like all good narrators, we tend to forsake the facts when they interfere with the plot. We're so addicted to the anecdote that we let the truth slip away until, eventually, those stories we tell again and again become exercises in pure fiction. Just the other day I learned that one of my cherished childhood tales - the time my older brother put hot peppers in my Chinese food while I was in the bathroom, thus scorching my young tongue - actually happened to my little sister. I'd stolen her trauma. The reason we're such consummate bullshitters is simple: we bullshit for each other. We tweak our stories so that they become better stories. We bend the facts so that the facts appeal to the group. Because we are social animals, our memory of the past is constantly being revised to fit social pressures. The power of this phenomenon was demonstrated in a new Science paper by Micah Edelson, Tali Sharot, Raymond Dolan and Yadin Dudai. The neuroscientists were interested in how the opinion of other people can alter our personal memories, even over a relatively short period of time. The experiment itself was straightforward. A few dozen people watched an eyewitness style documentary about a police arrest in groups of five. Three days later, the subjects returned to the lab and completed a memory test about the documentary. Four days after that, they were brought back once again and asked a variety of questions about the short movie while inside a brain scanner. This time, though, the subjects were given a "lifeline": they were shown the answers given by other people in their film-viewing g

Samuel Beckett, born in a suburb of Dublin in 1906, was a native English speaker. However, in 1946 Beckett decided that he would begin writing exclusively in French. After composing the first draft in his second language, he would then translate these words back into English. This difficult constraint - forcing himself to consciously unpack his own sentences - led to a burst of genius, as many of Beckett's most famous works (Malloy, Malone Dies, Waiting for Godot, etc.) were written during this period. When asked why he wrote first in French, Beckett said it made it easier for him to "write without style." Beckett would later expand on these comments, noting that his use of French prevented him from slipping into his usual writerly habits, those crutches of style that snuck into his English prose. Instead of relying on the first word that leapt into consciousness - that most automatic of associations - he was forced by his second language to reflect on what he actually wanted to express. His diction became more intentional. There's now some neat experimental proof of this Beckettian strategy. In a recent paper published in Psychological Science, a team of psychologists led by Boaz Keysar at the University of Chicago found that forcing people to rely on a second language systematically reduced human biases, allowing the subjects to escape from the usual blind spots of cognition. In a sense, they were better able to think without style. The paper is a tour de force of cross-cultural comparison, as the scientists conducted six experiments on three continents (n > 600) in five different languages: English, Korean, French, Spanish and Japanese. Although all subjects were proficient in their second language, they were not "balanced bilingual." The experiments themselves relied on classic paradigms borrowed from prospect theory, in which people are asked to make decisions under varying conditions of uncertainty and risk. For instance, native English

Once, experts feared that young children exposed to more than one language would suffer "language confusion," which might delay their speech development. Today, parents often are urged to capitalize on that early knack for acquiring language. Upscale schools market themselves with promises of deep immersion in Spanish - or Mandarin - for everyone, starting in kindergarten or even before. Yet while many parents recognize the utility of a second language, families bringing up children in non-English-speaking households, or trying to juggle two languages at home, are often desperate for information. And while the study of bilingual development has refuted those early fears about confusion and delay, there aren't many research-based guidelines about the very early years and the best strategies for producing a happily bilingual child. But there is more and more research to draw on, reaching back to infancy and even to the womb. As the relatively new science of bilingualism pushes back to the origins of speech and language, scientists are teasing out the earliest differences between brains exposed to one language and brains exposed to two. Researchers have found ways to analyze infant behavior - where babies turn their gazes, how long they pay attention - to help figure out infant perceptions of sounds and words and languages, of what is familiar and what is unfamiliar to them. Now, analyzing the neurologic activity of babies' brains as they hear language, and then comparing those early responses with the words that those children learn as they get older, is helping explain not just how the early brain listens to language, but how listening shapes the early brain. Recently, researchers at the University of Washington used measures of electrical brain responses to compare so-called monolingual infants, from homes in which one language was spoken, to bilingual infants exposed to two languages. Of course, since the subjects of the study, adorable in their

"rom heroin and cocaine to sex and lies, Tetris and the ponies, the spectrum of human addictions is vast. But for Dr. Nora D. Volkow, the neuroscientist in charge of the National Institute on Drug Abuse, they all boil down to pretty much the same thing. She must say it a dozen times a day: Addiction is all about the dopamine. The pleasure, pain and devilish problem of control are simply the detritus left by waves of this little molecule surging and retreating deep in the brain. A driven worker with a colorful family history and a bad chocolate problem of her own, Dr. Volkow (pronounced VOHL-kuv), 55, has devoted her career to studying this chemical tide. And now, eight years into her tenure at the institute, the pace of addiction research is accelerating, propelled by a nationwide emergency that has sent her agency, with a $1.09 billion budget, into crisis mode. The toll from soaring rates of prescription drug abuse, including both psychiatric medications and drugs for pain, has begun to dwarf that of the usual illegal culprits. Hospitalizations related to prescription drugs are up fivefold in the last decade, and overdose deaths up fourfold. More high school seniors report recreational use of tranquilizers or prescription narcotics, like OxyContin and Vicodin, than heroin and cocaine combined. The numbers have alarmed drug policy experts, their foreboding heightened by the realization that the usual regulatory tools may be relatively unhelpful in this new crisis. As Dr. Volkow said to a group of drug experts convened by the surgeon general last month to discuss the problem, "In the past, when we have addressed the issue of controlled substances, illicit or licit, we have been addressing drugs that we could remove from the earth and no one would suffer." But prescription drugs, she continued, have a double life: They are lifesaving yet every bit as dangerous as banned substances. "The challenges we face are much more complex," Dr. Volkow said, "becau

"One day last summer, Anne and her husband, Miguel, took their 9-year-old son, Michael, to a Florida elementary school for the first day of what the family chose to call "summer camp." For years, Anne and Miguel have struggled to understand their eldest son, an elegant boy with high-planed cheeks, wide eyes and curly light brown hair, whose periodic rages alternate with moments of chilly detachment. Michael's eight-week program was, in reality, a highly structured psychological study - less summer camp than camp of last resort. Michael's problems started, according to his mother, around age 3, shortly after his brother Allan was born. At the time, she said, Michael was mostly just acting "like a brat," but his behavior soon escalated to throwing tantrums during which he would scream and shriek inconsolably. These weren't ordinary toddler's fits. "It wasn't, 'I'm tired' or 'I'm frustrated' - the normal things kids do," Anne remembered. "His behavior was really out there. And it would happen for hours and hours each day, no matter what we did." For several years, Michael screamed every time his parents told him to put on his shoes or perform other ordinary tasks, like retrieving one of his toys from the living room. "Going somewhere, staying somewhere - anything would set him off," Miguel said. These furies lasted well beyond toddlerhood. At 8, Michael would still fly into a rage when Anne or Miguel tried to get him ready for school, punching the wall and kicking holes in the door. Left unwatched, he would cut up his trousers with scissors or methodically pull his hair out. He would also vent his anger by slamming the toilet seat down again and again until it broke. When Anne and Miguel first took Michael to see a therapist, he was given a diagnosis of "firstborn syndrome": acting out because he resented his new sibling. While both parents acknowledged that Michael was deeply hostile to the new baby, sibling rivalr

"FOR a brief, heady period in the history of autism spectrum diagnosis, in the late '90s, I had Asperger syndrome. There's an educational video from that time, called "Understanding Asperger's," in which I appear. I am the affected 20-year-old in the wannabe-hipster vintage polo shirt talking about how keen his understanding of literature is and how misunderstood he was in fifth grade. The film was a research project directed by my mother, a psychology professor and Asperger specialist, and another expert in her department. It presents me as a young man living a full, meaningful life, despite his mental abnormality. "Understanding Asperger's" was no act of fraud. Both my mother and her colleague believed I met the diagnostic criteria laid out in the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. The manual, still the authoritative text for American therapists, hospitals and insurers, listed the symptoms exhibited by people with Asperger disorder, and, when I was 17, I was judged to fit the bill. I exhibited a "qualified impairment in social interaction," specifically "failure to develop peer relationships appropriate to developmental level" (I had few friends) and a "lack of spontaneous seeking to share enjoyment, interests, or achievements with other people" (I spent a lot of time by myself in my room reading novels and listening to music, and when I did hang out with other kids I often tried to speak like an E. M. Forster narrator, annoying them). I exhibited an "encompassing preoccupation with one or more stereotyped and restricted patterns of interest that is abnormal either in intensity or focus" (I memorized poems and spent a lot of time playing the guitar and writing terrible poems and novels). The general idea with a psychological diagnosis is that it applies when the tendencies involved inhibit a person's ability to experience a happy, normal life. And in my c