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"Nothing is more morbidly intriguing, more chillingly compelling than an account of a malfunctioning mind, as medical writers have learned to their great profit. The victims of mental disease or brain damage are fascinating, not simply as exhibits in a neurological sideshow but also as stark demonstrations of how fragile reality can be. Most people agree, within limits, on the objective character of the world around them. Yet while the victims of mental disorders are certainly conscious and aware, their worlds are profoundly different from those of most of us. What can it possibly feel like, we wonder, to live without emotion, to be crippled without realizing it, to re-experience an event from the distant past complete with the fears that originally surrounded it? As neurologists, psychologists and biologists have zeroed in more and more precisely on the physical causes of mental disorders, they have found themselves addressing a much deeper mystery, a set of interrelated conundrums probably as old as humanity: What, precisely, is the mind, the elusive entity where intelligence, decision making, perception, awareness and sense of self reside? Where is it located? How does it work? Does it arise from purely physical processes-pulses of electricity zapping from brain cell to brain cell, helped along their way by myriad complex chemicals? Or is it something beyond the merely physical-something ethereal that might be close to the spiritual concept of the soul?"

"As neurologists, psychologists and biologists have zeroed in more and more precisely on the physical causes of mental disorders, they have found themselves addressing a much deeper mystery, a set of interrelated conundrums probably as old as humanity: What, precisely, is the mind, the elusive entity where intelligence, decision making, perception, awareness and sense of self reside? Where is it located? How does it work? Does it arise from purely physical processes-pulses of electricity zapping from brain cell to brain cell, helped along their way by myriad complex chemicals? Or is it something beyond the merely physical-something ethereal that might be close to the spiritual concept of the soul? Great thinkers have had no shortage of ideas on the subject. Plato was convinced that the mind must be located inside the head, because the head is shaped more or less like a sphere, his idea of the highest geometrical form. Aristotle insisted that the mind was in the heart. His reasoning: warmth implies vitality; the blood is warm; the heart pumps the blood. By the Middle Ages, though, pretty much everyone agreed that the mind arose from the brain -- but still had no clear idea how it arose. Finally, in the 17th century, the French philosopher Rena Descartes declared that the mind, while it might live in the brain, was a nonmaterial thing, entirely separate from the physical tissues found inside the head. Furthermore, said Descartes in one of history's most memorable sound bites, "Cogito, ergo sum" (I think, therefore I am). His point: consciousness is the only sure evidence that we actually exist. Until just a few years ago, unraveling the relationship of mind and brain was beyond the realm of observation and experimentation. But science has finally begun to catch up with philosophy. Using sensitive electrodes inserted deep into the gray matter of test animals, researchers have watched vision as it percolates inward from the eye's retina to the inner brain. Powerful te