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"What is art? What does art reveal about human nature? The trend these days is to approach such questions in the key of neuroscience. "Neuroaesthetics" is a term that has been coined to refer to the project of studying art using the methods of neuroscience. It would be fair to say that neuroaesthetics has become a hot field. It is not unusual for leading scientists and distinguished theorists of art to collaborate on papers that find their way into top scientific journals. Semir Zeki, a neuroscientist at University College London, likes to say that art is governed by the laws of the brain. It is brains, he says, that see art and it is brains that make art. Champions of the new brain-based approach to art sometimes think of themselves as fighting a battle with scholars in the humanities who may lack the courage (in the words of the art historian John Onians) to acknowledge the ways in which biology constrains cultural activity. Strikingly, it hasn't been much of a battle. Students of culture, like so many of us, seem all too glad to join in the general enthusiasm for neural approaches to just about everything."

"MID the squawks and pings of our digital devices, the old-fashioned virtues of reading novels can seem faded, even futile. But new support for the value of fiction is arriving from an unexpected quarter: neuroscience. Brain scans are revealing what happens in our heads when we read a detailed description, an evocative metaphor or an emotional exchange between characters. Stories, this research is showing, stimulate the brain and even change how we act in life. Researchers have long known that the "classical" language regions, like Broca's area and Wernicke's area, are involved in how the brain interprets written words. What scientists have come to realize in the last few years is that narratives activate many other parts of our brains as well, suggesting why the experience of reading can feel so alive. Words like "lavender," "cinnamon" and "soap," for example, elicit a response not only from the language-processing areas of our brains, but also those devoted to dealing with smells. In a 2006 study published in the journal NeuroImage, researchers in Spain asked participants to read words with strong odor associations, along with neutral words, while their brains were being scanned by a functional magnetic resonance imaging (fMRI) machine. When subjects looked at the Spanish words for "perfume" and "coffee," their primary olfactory cortex lit up; when they saw the words that mean "chair" and "key," this region remained dark. The way the brain handles metaphors has also received extensive study; some scientists have contended that figures of speech like "a rough day" are so familiar that they are treated simply as words and no more. Last month, however, a team of researchers from Emory University reported in Brain & Language that when subjects in their laboratory read a metaphor involving texture, the sensory cortex, responsible for perceiving texture through touch, became active. Metaphors like "The singer had a velvet vo

"Modern art is an explosion of colors, smooth lines, flat portraits - and it turns out, neuroscience. It also once triggered some strong psychology. A pot of paint has been flung in the face of the public," the criticCamille Mauclair, said in outrage over a Paris showing of the artist Henri Matisse's vibrant works. His condemnation today seems more colorful than the paintings themselves, many now hanging in museums all over the world. What was really going on at the turn of the last century to excite such controversy? Brain researchers have increasingly turned their eyes on artists, in an effort to enrich our understanding of how we see art and of the time when paintings could shake society. "When we look at a picture and feel rewarded, we know something is occurring in our brain," says neuroscientist and artist Bevil Conway of Wellesley (Mass.) College. Conway and other neuroscientists, such as Nobel Prize winner Eric Kandel, author of the just-released The Age of Insight: The Quest to Understand the Unconscious in Art, Mind, and Brain, represent the latest voices among brain researchers taking a look at art. "By closely examining artists' paintings and practices, we can discover hints to how the brain works, and achieve insight into the discoveries and inventions of artists and their impact on culture," Conway writes in the current Annals of the New York Academy of Sciences, looking at color in the paintings of Matisse , Paul Cezanne and Claude Monet . Public domain Montross Gallery 1915 exhibition catalogue image of 'Gold Fish' by Henri Matisse. Color depends on more than the wavelength of light reaching your eye. Five decades ago, brain researchers thought only the cone-shaped "photoreceptor" cells in the retina determined what colors we see. But we now know that starting from the retina and proceeding through at least five brain regions, our perception of color is shaped not so much by the redness of the paint used to hang an apple from a tree, but

"Stress in the Brain Anxiety has become a hot topic in education research, as educators and policymakers become increasingly focused on test performance and more-intensive curricula, and neuroscience has begun to provide a window into how the brain responds to anxiety. Anxieties and Stereotypes Researchers have found that the more anxious their female teachers were about math, the more likely girls-but not boys- were to endorse gender-related stereotypes about math ability. In turn, the girls who echoed those stereotypical beliefs were performing less well than other students in math by year's end. SOURCE: University of Chicago Anxiety can literally cut off the working memory needed to learn and solve problems, according to Dr. Judy Willis, a Santa Barbara, Calif.-based neurologist, former middle school teacher, and author of the 2010 book Learning to Love Math. When first taking in a problem, a student processes information through the amygdala, the brain's emotional center, which then prioritizes information going to the prefrontal cortex, the part responsible for the brain's working memory and critical thinking. During stress, there is more activity in the amygdala than the prefrontal cortex; even as minor a stressor as seeing a frowning face before answering a question can decrease a student's ability to remember and respond accurately. "When engaged in mathematical problem-solving, highly math-anxious individuals suffer from intrusive thoughts and ruminations," said Daniel Ansari, the principal investigator for the Numerical Cognition Laboratory at the University of Western Ontario, in London, Ontario. "This takes up some of their processing and working memory. It's very much as though individuals with math anxiety use up the brainpower they need for the problem" on worrying. Moreover, a series of experiments at the Mangels Lab of Cognitive Neuroscience of Memory and Attention at Baruch College at the City University of New York sugg

"You may think you decided to read this story -- but in fact, your brain made the decision long before you knew about it. In a study published Sunday in Nature Neuroscience, researchers using brain scanners could predict people's decisions seven seconds before the test subjects were even aware of making them. The decision studied -- whether to hit a button with one's left or right hand -- may not be representative of complicated choices that are more integrally tied to our sense of self-direction. Regardless, the findings raise profound questions about the nature of self and autonomy: How free is our will? Is conscious choice just an illusion? "Your decisions are strongly prepared by brain activity. By the time consciousness kicks in, most of the work has already been done," said study co-author John-Dylan Haynes, a Max Planck Institute neuroscientist. Haynes updated a classic experiment by the late Benjamin Libet, who showed that a brain region involved in coordinating motor activity fired a fraction of a second before test subjects chose to push a button. Later studies supported Libet's theory that subconscious activity preceded and determined conscious choice -- but none found such a vast gap between a decision and the experience of making it as Haynes' study has. In the seven seconds before Haynes' test subjects chose to push a button, activity shifted in their frontopolar cortex, a brain region associated with high-level planning. Soon afterwards, activity moved to the parietal cortex, a region of sensory integration. Haynes' team monitored these shifting neural patterns using a functional MRI machine. Taken together, the patterns consistently predicted whether test subjects eventually pushed a button with their left or right hand -- a choice that, to them, felt like the outcome of conscious deliberation. For those accustomed to thinking of themselves as having free will, the implications are far more unsettling than learning about the physiological basis

"Is free will an illusion? Some leading scientists think so. For instance, in 2002 the psychologist Daniel Wegner wrote, "It seems we are agents. It seems we cause what we do… It is sobering and ultimately accurate to call all this an illusion." More recently, the neuroscientist Patrick Haggard declared, "We certainly don't have free will. Not in the sense we think." And in June, the neuroscientist Sam Harris claimed, "You seem to be an agent acting of your own free will. The problem, however, is that this point of view cannot be reconciled with what we know about the human brain." Many neuroscientists are employing a flawed notion of free will. Such proclamations make the news; after all, if free will is dead, then moral and legal responsibility may be close behind. As the legal analyst Jeffrey Rosen wrote in The New York Times Magazine, "Since all behavior is caused by our brains, wouldn't this mean all behavior could potentially be excused? … The death of free will, or its exposure as a convenient illusion, some worry, could wreak havoc on our sense of moral and legal responsibility." Indeed, free will matters in part because it is a precondition for deserving blame for bad acts and deserving credit for achievements. It also turns out that simply exposing people to scientific claims that free will is an illusion can lead them to misbehave, for instance, cheating more or helping others less. [1] So, it matters whether these scientists are justified in concluding that free will is an illusion. "

"Scientists say they have found a way to activate the brain cells that trigger particular memories, according to research published today in the journal Science. Researchers at MIT employed optogenetics, a branch of science that uses light to stimulate molecules, to show that memories reside in specific brain cells, and that activating a tiny fraction of brain cells can revive the entire memory. The study was performed on mice, but the researchers say it is a powerful demonstration that memories are tangible and are physically stored in a particular part of the brain. "We demonstrate that behaviour based on high-level cognition, such as the expression of a specific memory, can be generated in a mammal by highly specific physical activation of a specific small subpopulation of brain cells, in this case by light," said Susumu Tonegawa, the Picower Professor of Biology and Neuroscience at MIT and lead author of the study. In the early 1900s, the Canadian neurosurgeon Wilder Penfield found that when he electrically stimulated certain neurons in the hippocampus area of the brain, his patients vividly recalled whole events. Until now, however, scientists have been unable to prove that the direct reactivation of the hippocampus was enough to cause memory recall."

"A technology that monitors electrical activity in the brain could help identify infants who will go on to develop autism, scientists say. The technology, known as electroencephalography, or EEG, is also providing hints about precisely how autism affects the brain and which therapies are likely to help children with autism spectrum disorders. "Right now, the earliest we can reliably identify a child is, say, three years of age," says Charles Nelson, a professor of pediatrics and neuroscience at Children's Hospital Boston and Harvard Medical School. "Our work is designed to see [if we] can we do that in early infancy, long before any signs or symptoms of autism are apparent in the child's behavior." If EEG lives up to its early promise, Nelson says, children with autism might start getting therapy before their first birthday. "

"A MOTHER sits in a playroom with her young son. The phone rings. When she picks it up, a researcher watching through a two-way mirror asks her to look into her son's eyes and ''show him, in the way that feels most natural for you, that you love him''. The mother is doing her best to connect, but this little boy won't return her gaze. He looks at her mouth, where the words are coming from, but it's as if he can't understand what she means. Advertisement: Story continues below Robert Thompson and Jon Venables killed UK toddler James Bulger. Robert Thompson and Jon Venables killed UK toddler James Bulger. Mark Dadds says some children literally cannot see the love in their mother's eyes. Professor Dadds, a parenting expert from the University of New South Wales, has just published results of his work in the British Journal of Psychiatry and the Journal of Child Psychiatry and Psychology that suggest the ability to make eye contact is vital in learning how to love other people. For the past five years, he has been working with children referred to his Sydney clinic for sustained rages, continual aggression, calculated violence and, occasionally, cruelty to animals. These are children with some of the worst behavioural problems, who score highly for ''callous, unemotional'' traits. In his studies in both Sydney and London, it was these children who did not meet their mother's gaze, even when told they were loved. People marvel at the resilience of children who overcome appalling family backgrounds to make good lives. We understand when childhood trauma sends a child off the rails. But we also have to accept that even good parents can have mean children - how else to explain families where only one child seems to be callous and unemotional, while the siblings are not? Dadds distinguishes between children who are emotionally ''hot'' - those who lash out at the world - and the much smaller subset of ''cold'' children - the ones who don't react emotionally, don't car

"rom heroin and cocaine to sex and lies, Tetris and the ponies, the spectrum of human addictions is vast. But for Dr. Nora D. Volkow, the neuroscientist in charge of the National Institute on Drug Abuse, they all boil down to pretty much the same thing. She must say it a dozen times a day: Addiction is all about the dopamine. The pleasure, pain and devilish problem of control are simply the detritus left by waves of this little molecule surging and retreating deep in the brain. A driven worker with a colorful family history and a bad chocolate problem of her own, Dr. Volkow (pronounced VOHL-kuv), 55, has devoted her career to studying this chemical tide. And now, eight years into her tenure at the institute, the pace of addiction research is accelerating, propelled by a nationwide emergency that has sent her agency, with a $1.09 billion budget, into crisis mode. The toll from soaring rates of prescription drug abuse, including both psychiatric medications and drugs for pain, has begun to dwarf that of the usual illegal culprits. Hospitalizations related to prescription drugs are up fivefold in the last decade, and overdose deaths up fourfold. More high school seniors report recreational use of tranquilizers or prescription narcotics, like OxyContin and Vicodin, than heroin and cocaine combined. The numbers have alarmed drug policy experts, their foreboding heightened by the realization that the usual regulatory tools may be relatively unhelpful in this new crisis. As Dr. Volkow said to a group of drug experts convened by the surgeon general last month to discuss the problem, "In the past, when we have addressed the issue of controlled substances, illicit or licit, we have been addressing drugs that we could remove from the earth and no one would suffer." But prescription drugs, she continued, have a double life: They are lifesaving yet every bit as dangerous as banned substances. "The challenges we face are much more complex," Dr. Volkow said, "becau

"MIT researchers have shown, for the first time ever, that memories are stored in specific brain cells. By triggering a small cluster of neurons, the researchers were able to force the subject to recall a specific memory. By removing these neurons, the subject would lose that memory. As you can imagine, the trick here is activating individual neurons, which are incredibly small and not really the kind of thing you can attach electrodes to. To do this, the researchers used optogenetics, a bleeding edge sphere of science that involves the genetic manipulation of cells so that they're sensitive to light. These modified cells are then triggered using lasers; you drill a hole through the subject's skull and point the laser at a small cluster of neurons. Now, just to temper your excitement, we should note that MIT's subjects in this case are mice - but it's very, very likely that the human brain functions in the same way. To perform this experiment, though, MIT had to breed genetically engineered mice with optogenetic neurons - and we're a long, long way off breeding humans with optogenetic brains. In the experiment, MIT gave mice an electric shock to create a fear memory in the hippocampus region of the brain (pictured above) - and then later, using laser light, activated the neurons where the memory was stored. The mice "quickly entered a defensive, immobile crouch," strongly suggesting the fear memory was being recalled."

"Researchers led by New York University neuroscientist Joseph LeDoux recently claimed to be the first scientists to erase a single memory. Working with rats, LeDoux's team first taught the animals to fear both a beep and a siren by giving them an electric shock every time either of the tones sounded. Then LeDoux gave half the rats the drug U0126, which is known to interfere with memory storage, and replayed the beep without electric shocks. A day later, when LeDoux played back both tones to the rats, the animals that hadn't been given the drug were still fearful of both sounds. But the rats that had been given the memory-blocking drug weren't afraid of the beep, which they had last heard while under the influence of U0126. advertisement | article continues below Click here! Exactly how U0126 exerts its amnesiac effect is unknown, but it may block the synthesis of proteins that help strengthen connections between neurons and establish memories. The opportunity for erasure occurs during the act of retrieving a memory because that's when the memory is being updated and stabilized again for long-term storage. "Only those memories that are activated are vulnerable," LeDoux says. Drugs like U0126 may someday help sufferers of traumatic memories. A small group of human studies have been done on a drug called propranolol, which blocks the action of stress neurotransmitters that help cement memories in the brain, but LeDoux's work shows the potential for greater precision. "You might be able to reduce the traumatic impact of memories in people with PTSD," says LeDoux. "The good news is you wouldn't be erasing their memory bank." "