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"Acousticians have been designing concert halls for more than a century, but Dr. Kyriakakis does something different. He shapes the sound of music to conform to the space in which it is played. The goal is what Dr. Kyriakakis calls the "ground truth" - to replicate the original in every respect. "We remove the room," he said, "so the ground truth can be delivered." Dr. Kyriakakis, an electrical engineer at U.S.C. and the founder and chief technical officer of Audyssey Laboratories, a Los Angeles-based audio firm, could not achieve his results without modern sound filters and digital microprocessors. But the basis of his technique is rooted in the science of psychoacoustics, the study of sound perception by the human auditory system. "It's about the human ear and the human brain, and understanding how the human ear perceives sound," Dr. Kyriakakis said. Psychoacoustics has become an invaluable tool in designing hearing aids and cochlear implants, and in the study of hearing generally. "Psychoacoustics is fundamental," said Andrew J. Oxenham, a psychologist and hearing expert at the University of Minnesota. "You need to know how the normally functioning auditory system works - how sound relates to human perception." "

"On a hot summer day 15 years ago in Parma, Italy, a monkey sat in a special laboratory chair waiting for researchers to return from lunch. Thin wires had been implanted in the region of its brain involved in planning and carrying out movements. Every time the monkey grasped and moved an object, some cells in that brain region would fire, and a monitor would register a sound: brrrrrip, brrrrrip, brrrrrip. A graduate student entered the lab with an ice cream cone in his hand. The monkey stared at him. Then, something amazing happened: when the student raised the cone to his lips, the monitor sounded - brrrrrip, brrrrrip, brrrrrip - even though the monkey had not moved but had simply observed the student grasping the cone and moving it to his mouth. The researchers, led by Giacomo Rizzolatti, a neuroscientist at the University of Parma, had earlier noticed the same strange phenomenon with peanuts. The same brain cells fired when the monkey watched humans or other monkeys bring peanuts to their mouths as when the monkey itself brought a peanut to its mouth. Later, the scientists found cells that fired when the monkey broke open a peanut or heard someone break a peanut. The same thing happened with bananas, raisins and all kinds of other objects. "It took us several years to believe what we were seeing," Dr. Rizzolatti said in a recent interview. The monkey brain contains a special class of cells, called mirror neurons, that fire when the animal sees or hears an action and when the animal carries out the same action on its own. But if the findings, published in 1996, surprised most scientists, recent research has left them flabbergasted. Humans, it turns out, have mirror neurons that are far smarter, more flexible and more highly evolved than any of those found in monkeys, a fact that scientists say reflects the evolution of humans' sophisticated social abilities. The human brain has multiple mirror neuron systems that specialize in carrying out and understanding

"Researchers led by New York University neuroscientist Joseph LeDoux recently claimed to be the first scientists to erase a single memory. Working with rats, LeDoux's team first taught the animals to fear both a beep and a siren by giving them an electric shock every time either of the tones sounded. Then LeDoux gave half the rats the drug U0126, which is known to interfere with memory storage, and replayed the beep without electric shocks. A day later, when LeDoux played back both tones to the rats, the animals that hadn't been given the drug were still fearful of both sounds. But the rats that had been given the memory-blocking drug weren't afraid of the beep, which they had last heard while under the influence of U0126. advertisement | article continues below Click here! Exactly how U0126 exerts its amnesiac effect is unknown, but it may block the synthesis of proteins that help strengthen connections between neurons and establish memories. The opportunity for erasure occurs during the act of retrieving a memory because that's when the memory is being updated and stabilized again for long-term storage. "Only those memories that are activated are vulnerable," LeDoux says. Drugs like U0126 may someday help sufferers of traumatic memories. A small group of human studies have been done on a drug called propranolol, which blocks the action of stress neurotransmitters that help cement memories in the brain, but LeDoux's work shows the potential for greater precision. "You might be able to reduce the traumatic impact of memories in people with PTSD," says LeDoux. "The good news is you wouldn't be erasing their memory bank." "

"Science all but confirms that humans are hard-wired to respond to music. Studies also suggest that someday music may even help patients heal from Parkinson's disease or a stroke. In The Power of Music, Elena Mannes explores how music affects different groups of people and how it could play a role in health care. Mannes tracked the human relationship with music over the course of a life span. She tells NPR's Neal Conan that studies show that infants prefer "consonant intervals, the smooth-sounding ones that sound nice to our Western ears in a chord, as opposed to a jarring combination of notes." In fact, Mannes says the cries of babies just a few weeks old were found to contain some of the basic intervals common to Western music. She also says scientists have found that music stimulates more parts of the brain than any other human function. That's why she sees so much potential in music's power to change the brain and affect the way it works. Mannes says music also has the potential to help people with neurological deficits. "A stroke patient who has lost verbal function - those verbal functions may be stimulated by music," she says. One technique, known as melodic intonation therapy, uses music to coax portions of the brain into taking over for those that are damaged. In some cases, it can help patients regain their ability to speak. And because of how we associate music with memories, Mannes says such techniques could also be helpful for Alzheimer's patients. Less recently, archaeologists have discovered ancient flutes - one of which is presumed to be the oldest musical instrument in the world - that play a scale similar to the modern Western scale. "And remarkably," Mannes says, "this flute, when played, produces these amazingly pure tones." It's a significant discovery because it adds to the argument that musical ability and interest were present early in human history."

"Jerome Kagan's "Aha!" moment came with Baby 19. It was 1989, and Kagan, a professor of psychology at Harvard, had just begun a major longitudinal study of temperament and its effects. Temperament is a complex, multilayered thing, and for the sake of clarity, Kagan was tracking it along a single dimension: whether babies were easily upset when exposed to new things. He chose this characteristic both because it could be measured and because it seemed to explain much of normal human variation. He suspected, extrapolating from a study he had just completed on toddlers, that the most edgy infants were more likely to grow up to be inhibited, shy and anxious. Eager to take a peek at the early results, he grabbed the videotapes of the first babies in the study, looking for the irritable behavior he would later call high-reactive. Enlarge This Image Mickey Duzyj Related Letters: The Anxious Mind (October 18, 2009) Health Guide: Anxiety Enlarge This Image Mickey Duzyj Enlarge This Image Mickey Duzyj Enlarge This Image Mickey Duzyj Enlarge This Image Mickey Duzyj Readers' Comments Readers shared their thoughts on this article. Read All Comments (191) » No high-reactors among the first 18. They gazed calmly at things that were unfamiliar. But the 19th baby was different. She was distressed by novelty - new sounds, new voices, new toys, new smells - and showed it by flailing her legs, arching her back and crying. Here was what Kagan was looking for but was not sure he would find: a baby who essentially fell apart when exposed to anything new. Baby 19 grew up true to her temperament. This past summer, Kagan showed me a video of her from 2004, when she was 15. We sat in a screening room in Harvard's William James Hall - a building named, coincidentally, for the 19th-century psychologist who described his own struggles with anxiety as "a horrible dread at the pit of my stomach ... a sense of the insecurity of life." Kagan is elfin and spry, ba

"Virtually nobody has memories from very early childhood - but it's not because we don't retain information as young children. Rather, it may be because at that age, our brains don't yet function in a way that bundles information into the complex neural patterns that we know as memories. It's clear that young children do remember facts in the moment - such as who their parents are, or that one must say "please" before mom will give you candy. This is called "semantic memory." Until sometime between the ages two and four, however, children lack "episodic memory" -- memory regarding the details of a specific event. Such memories are stored in several parts of the brain's surface, or "cortex." For example, memory of sound is processed in the auditory cortexes, on the sides of the brain, while visual memory is managed by the visual cortex, at the back. A region of the brain called the hippocampus ties all the scattered pieces together. "

"What if you could predict a hit? It's a music industry dream (or nightmare depending on how you look at it.) New research from Emory University suggests that the answers might lie in our brains. Dr. Gregory Berns and his team have discovered that teens have tell-tale brain responses when listening to hit songs, and that could help predict a song's commercial success. He explains to Jim and Greg that the discovery was an accident. After conducting MRI studies on teens listening to MySpace music, he noted that one of the tracks, One Republic's "Apologize" became an American Idol hit years later. Strong activity in two brain regions could predict hits about 1/3 of the time. Weak activity was even better at predicting non-hits. And brain responses in those regions were better predictors of song success than whether the participants said they liked or disliked any given song. Jim and Greg aren't teens, but wonder if their work could be made easier with MRI technology. "

"Maybe such a crisis is in order. It isn't just that as these machines get more powerful they do more jobs once done only by people, from financial analysis to secretarial work to world-class chess playing. It's that, in the process, they seem to underscore the generally dispiriting drift of scientific inquiry. First Copernicus said we're not the center of the universe. Then Darwin said we're just protozoans with a long list of add-ons--mere "survival machines," as modern Darwinians put it. And machines don't have souls, right? Certainly Deep Blue hasn't mentioned having one. The better these seemingly soulless machines get at doing things people do, the more plausible it seems that we could be soulless machines too. But however logical this downbeat argument may sound, it doesn't appear to be prevailing among scholars who ponder such issues for a living. That isn't to say philosophers are suddenly resurrecting the idea of a distinct, immaterial soul that governs the body for a lifetime and then drifts off to its reward. They're philosophers, not theologians. When talking about some conceivably nonphysical property of human beings, they talk not about "souls" but about "consciousness" and "mind." The point is simply that as the information age advances and computers get brainier, philosophers are taking the ethereal existence of mind, of consciousness, more seriously, not less. And one result is to leave the theologically inclined more room for spiritual speculation."

"As neurologists, psychologists and biologists have zeroed in more and more precisely on the physical causes of mental disorders, they have found themselves addressing a much deeper mystery, a set of interrelated conundrums probably as old as humanity: What, precisely, is the mind, the elusive entity where intelligence, decision making, perception, awareness and sense of self reside? Where is it located? How does it work? Does it arise from purely physical processes-pulses of electricity zapping from brain cell to brain cell, helped along their way by myriad complex chemicals? Or is it something beyond the merely physical-something ethereal that might be close to the spiritual concept of the soul? Great thinkers have had no shortage of ideas on the subject. Plato was convinced that the mind must be located inside the head, because the head is shaped more or less like a sphere, his idea of the highest geometrical form. Aristotle insisted that the mind was in the heart. His reasoning: warmth implies vitality; the blood is warm; the heart pumps the blood. By the Middle Ages, though, pretty much everyone agreed that the mind arose from the brain -- but still had no clear idea how it arose. Finally, in the 17th century, the French philosopher Rena Descartes declared that the mind, while it might live in the brain, was a nonmaterial thing, entirely separate from the physical tissues found inside the head. Furthermore, said Descartes in one of history's most memorable sound bites, "Cogito, ergo sum" (I think, therefore I am). His point: consciousness is the only sure evidence that we actually exist. Until just a few years ago, unraveling the relationship of mind and brain was beyond the realm of observation and experimentation. But science has finally begun to catch up with philosophy. Using sensitive electrodes inserted deep into the gray matter of test animals, researchers have watched vision as it percolates inward from the eye's retina to the inner brain. Powerful te

Once, experts feared that young children exposed to more than one language would suffer "language confusion," which might delay their speech development. Today, parents often are urged to capitalize on that early knack for acquiring language. Upscale schools market themselves with promises of deep immersion in Spanish - or Mandarin - for everyone, starting in kindergarten or even before. Yet while many parents recognize the utility of a second language, families bringing up children in non-English-speaking households, or trying to juggle two languages at home, are often desperate for information. And while the study of bilingual development has refuted those early fears about confusion and delay, there aren't many research-based guidelines about the very early years and the best strategies for producing a happily bilingual child. But there is more and more research to draw on, reaching back to infancy and even to the womb. As the relatively new science of bilingualism pushes back to the origins of speech and language, scientists are teasing out the earliest differences between brains exposed to one language and brains exposed to two. Researchers have found ways to analyze infant behavior - where babies turn their gazes, how long they pay attention - to help figure out infant perceptions of sounds and words and languages, of what is familiar and what is unfamiliar to them. Now, analyzing the neurologic activity of babies' brains as they hear language, and then comparing those early responses with the words that those children learn as they get older, is helping explain not just how the early brain listens to language, but how listening shapes the early brain. Recently, researchers at the University of Washington used measures of electrical brain responses to compare so-called monolingual infants, from homes in which one language was spoken, to bilingual infants exposed to two languages. Of course, since the subjects of the study, adorable in their

"It is unusual for the subtitle of a book to undersell it, but Steven Pinker's "Better Angels of Our Nature" tells us much more than why violence has declined. Pinker, a professor of psychology at Harvard who first became widely known as the author of "The Language Instinct," addresses some of the biggest questions we can ask: Are human beings essentially good or bad? Has the past century witnessed moral progress or a moral collapse? Do we have grounds for being optimistic about the future?"