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"Acousticians have been designing concert halls for more than a century, but Dr. Kyriakakis does something different. He shapes the sound of music to conform to the space in which it is played. The goal is what Dr. Kyriakakis calls the "ground truth" - to replicate the original in every respect. "We remove the room," he said, "so the ground truth can be delivered." Dr. Kyriakakis, an electrical engineer at U.S.C. and the founder and chief technical officer of Audyssey Laboratories, a Los Angeles-based audio firm, could not achieve his results without modern sound filters and digital microprocessors. But the basis of his technique is rooted in the science of psychoacoustics, the study of sound perception by the human auditory system. "It's about the human ear and the human brain, and understanding how the human ear perceives sound," Dr. Kyriakakis said. Psychoacoustics has become an invaluable tool in designing hearing aids and cochlear implants, and in the study of hearing generally. "Psychoacoustics is fundamental," said Andrew J. Oxenham, a psychologist and hearing expert at the University of Minnesota. "You need to know how the normally functioning auditory system works - how sound relates to human perception." "

"Jerome Kagan's "Aha!" moment came with Baby 19. It was 1989, and Kagan, a professor of psychology at Harvard, had just begun a major longitudinal study of temperament and its effects. Temperament is a complex, multilayered thing, and for the sake of clarity, Kagan was tracking it along a single dimension: whether babies were easily upset when exposed to new things. He chose this characteristic both because it could be measured and because it seemed to explain much of normal human variation. He suspected, extrapolating from a study he had just completed on toddlers, that the most edgy infants were more likely to grow up to be inhibited, shy and anxious. Eager to take a peek at the early results, he grabbed the videotapes of the first babies in the study, looking for the irritable behavior he would later call high-reactive. Enlarge This Image Mickey Duzyj Related Letters: The Anxious Mind (October 18, 2009) Health Guide: Anxiety Enlarge This Image Mickey Duzyj Enlarge This Image Mickey Duzyj Enlarge This Image Mickey Duzyj Enlarge This Image Mickey Duzyj Readers' Comments Readers shared their thoughts on this article. Read All Comments (191) » No high-reactors among the first 18. They gazed calmly at things that were unfamiliar. But the 19th baby was different. She was distressed by novelty - new sounds, new voices, new toys, new smells - and showed it by flailing her legs, arching her back and crying. Here was what Kagan was looking for but was not sure he would find: a baby who essentially fell apart when exposed to anything new. Baby 19 grew up true to her temperament. This past summer, Kagan showed me a video of her from 2004, when she was 15. We sat in a screening room in Harvard's William James Hall - a building named, coincidentally, for the 19th-century psychologist who described his own struggles with anxiety as "a horrible dread at the pit of my stomach ... a sense of the insecurity of life." Kagan is elfin and spry, ba

"Science all but confirms that humans are hard-wired to respond to music. Studies also suggest that someday music may even help patients heal from Parkinson's disease or a stroke. In The Power of Music, Elena Mannes explores how music affects different groups of people and how it could play a role in health care. Mannes tracked the human relationship with music over the course of a life span. She tells NPR's Neal Conan that studies show that infants prefer "consonant intervals, the smooth-sounding ones that sound nice to our Western ears in a chord, as opposed to a jarring combination of notes." In fact, Mannes says the cries of babies just a few weeks old were found to contain some of the basic intervals common to Western music. She also says scientists have found that music stimulates more parts of the brain than any other human function. That's why she sees so much potential in music's power to change the brain and affect the way it works. Mannes says music also has the potential to help people with neurological deficits. "A stroke patient who has lost verbal function - those verbal functions may be stimulated by music," she says. One technique, known as melodic intonation therapy, uses music to coax portions of the brain into taking over for those that are damaged. In some cases, it can help patients regain their ability to speak. And because of how we associate music with memories, Mannes says such techniques could also be helpful for Alzheimer's patients. Less recently, archaeologists have discovered ancient flutes - one of which is presumed to be the oldest musical instrument in the world - that play a scale similar to the modern Western scale. "And remarkably," Mannes says, "this flute, when played, produces these amazingly pure tones." It's a significant discovery because it adds to the argument that musical ability and interest were present early in human history."