AbstractNormal subjects
and patients with adult-onset diabetes received 10 gm. of aspirin in four days.
On the fourth day, the fasting serum glucose and the glucose response to oral
glucose were decreased in both groups. These changes were associated with
increased levels of serum insulin and pancreatic glucagon, although the glucagon
responses to oral glucose were unchanged. In the diabetic patients, aspirin
therapy was followed by a decreased glucose response to I.V. glucose and by the
appearance of an early insulin peak, which could not be demonstrated before
treatment. Aspirin did not affect the I.V. glucose tolerance in normal subjects,
although it did enhance the early insulin peak. A decrease in the fasting levels
of free fatty acids was noted in both groups, whereas the fasting level of
triglycerides decreased only in the diabetic patients. Cholesterolemia did not
change in either group. A few preliminary observations indicate that, in normal
subjects, ibuprofen and ketoprofen, two other presumed prostaglandin inhibitors,
did not affect fasting glycemia, glucose tolerance, or the insulin response to
glucose. No changes were noted after the administration of placebo.
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11-08-2010 #2
trinitarian3n1
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That's a
hefty dose of aspirin.
John
C.A clean house is the sign of a broken computer.Last HgbA1c - 5.5%
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11-08-2010 #3
MCS
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Yes it
is, 650mg 4 times a day. I wonder if they did that to make sure they had a
response and if there is a break point of some lower dose. I am on 325 once a
day now. Been that high in the past for other things, lots of ringing in the
ears when you get that high of a dose.
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11-08-2010 #4
furball64801
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