Cerebral Palsy

Magnesium is neuroprotective in neonatal animal models of acquired hypoxic-ischemic and/or inflammatory cerebral lesions. It is associated with a significant reduction of perinatal death and cerebral palsy in some observational studies.The objective of the study is to assess if prenatal magnesium sulfate given to women at risk of preterm birth before 33 week's gestation is neuroprotective

Study is to determine whether nerve growth factor (cerebrolysin®) therapy will improve the psychomotor outcome in infants with moderate and severe hypoxic ischemic encephalopathy.

PRIMARY OBJECTIVE of study is to determine whether cerebral outcome is improved if infants born between 24 0/7 and 31 6/7 gestational weeks at birth receive erythropoietin in high dose in the first three days after birth. SECONDARY OBJECTIVES To determine whether early administration of EPO alters the incidence of complications typically associated with preterm birth, i.e. mortality, septicaemia, necrotising enterocolitis, bronchopulmonary dysplasia (oxygen dependency at 36 weeks postmenstrual age), retinopathy, intracranial haemorrhage, white matter disease (periventricular leucomalacia), growth failure, cerebral palsy and handicap at 5 years.

The American Academy of Neurology AAN is an international professional association of more than 22,000 neurologists.

The National Science Foundation (NSF) is an independent federal agency to promote the progress of science; to advance the national health, prosperity, and welfare; to secure the national defense…Funding source for approximately 20 percent of all federally supported basic research conducted by America's colleges and universities.

Study to investigate motor learning through remapping of dance movements into low dimensions using virtual reality environment in children with cerebral palsy

Proposed study is to improve the efficacy of BWSTT in children with cerebral palsy (CP) using a novel robotic therapy that applies controlled force to the leg during the swing phase of gait.

Study to promote research in the area of cerebral palsy by connecting researchers with persons with cerebral palsy through a secure, established database.

Study to develop a comprehensive spasticity management program which will then be developed for the individual. Clinical and outcome assessments at baseline and at follow-up will include measures of range of motion, global spasticity according to a modified Ashworth scale, and the time and number of staff required for the task. In addition, video will be obtained of caregivers performing each participant's care area tasks at baseline and follow-up to allow an independent external reviewer to judge task difficulty

Study will provide information about changes that occur in the motor neurons of the spinal cord (the nerve cells that control the muscles) when the motor cortex (the region of the brain that controls movement) is unable to send messages to the spinal cord and muscles in the normal way. This information will help elucidate how the nervous system adapts after injury or disease of the motor cortex.

Study to investigate if patients who have had a stroke and suffer from spasticity might benefit from being given BOTOX® in addition to the normal Standard Care. Spasticity is characterized by stiffness or frequent cramps accompanied by pain and abnormal movements and can prevent the carrying out of everyday tasks such as walking and getting dressed. BOTOX® is a neurotoxin, which is used to prevent the contraction of muscle fibre and has been shown to reduce spasticity significantly. Patients will be enrolled in this study at about 33 locations in Europe and Canada

Stanford University completed study on the relationship between spasticity and strength in children with cerebral palsy and reducing spasticity permits and increase in strength

Vanderbilt study is to determine the safe and effective levels of optical stimulation in peripheral nerves of humans otherwise undergoing nerve lesioning in surgery, namely children undergoing selective rhizotomy for treatment of medically refractory spasticity.

Completed study is to provide further information regarding the risks and benefits of Dysport in marketed indications.

Study completed and sponsored by Hvidovre University Hospital to investigate if physical therapy with strength training is better at improving muscle and gait function after anti-spastic treatment with Botulinum toxin compared to physical therapy without strength training in children with cerebral palsy.

Completed research study of head cooling to determine whether cooling babies' heads can reduce or prevent brain damage that may have resulted from temporarily reduced oxygen supply to the brain

The North American Clinical Trials Network (NACTN) is one more way that the Reeve Foundation is moving promising therapies from the lab to spinal cord injured patients. NACTN is working hard to insure that any clinical trial will be done in a way that maximizes both patient safety and our ability to gather valid, meaningful data. NACTN is an international network of hospitals with highly trained personnel and uniform protocols and data collection that help to ensure safety for all trial subjects and interpretable trial data

Research Study for Children to Test Balance. Researchers at the University of Kentucky College of Health Sciences are conducting a research study to investigate the reliability of a test of balance for typically developing children and children with cerebral palsy

Dr. Christine Houlihan of the University of Virginia is conducting a clinical study to look at how childrens bones grow and mature when they have Cerebral Palsy. This information will be compared to growth in children that do not have Cerebral Palsy

Dr. Michelle Kuperminc of the University of Virginia is conducting a clinical study to determine what the best way is to measure Body Composition in children with Cerebral Palsy. Body composition is the amount of muscle, bone and fat in your body. There are several different ways we can measure body composition and would like to know which one is best for children with CP.