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Spasticity Information Page at National Institute of Neurological Disorders and Stroke NINDS - What is Spasticity -Treatment - Prognosis - Research - Clinical Trials and Organizations

PEDIATRICS artice of study to document the effects of botulinum toxin A injections into the gastrocnemius muscles in children with spastic diplegia. Outcomes are evaluated across all 5 domains of the National Centers for Medical and Rehabilitation Research domains of medical rehabilitation.

Study to develop a comprehensive spasticity management program which will then be developed for the individual. Clinical and outcome assessments at baseline and at follow-up will include measures of range of motion, global spasticity according to a modified Ashworth scale, and the time and number of staff required for the task. In addition, video will be obtained of caregivers performing each participant's care area tasks at baseline and follow-up to allow an independent external reviewer to judge task difficulty

Study to investigate if patients who have had a stroke and suffer from spasticity might benefit from being given BOTOX® in addition to the normal Standard Care. Spasticity is characterized by stiffness or frequent cramps accompanied by pain and abnormal movements and can prevent the carrying out of everyday tasks such as walking and getting dressed. BOTOX® is a neurotoxin, which is used to prevent the contraction of muscle fibre and has been shown to reduce spasticity significantly. Patients will be enrolled in this study at about 33 locations in Europe and Canada

Study will provide information about changes that occur in the motor neurons of the spinal cord (the nerve cells that control the muscles) when the motor cortex (the region of the brain that controls movement) is unable to send messages to the spinal cord and muscles in the normal way. This information will help elucidate how the nervous system adapts after injury or disease of the motor cortex.

CPI Fact Sheets providing information on research being conduct on the Use of Neuromuscular Electrical Stimulation to Increase Muscle Strength and Walking Speed in Children with Spastic Diplegic Cerebral Palsy.

Resources and referrals to help people and their families cope with the problems that occur with TS. Membership includes individuals, families, relatives, and medical and allied professionals working in the field. University of Michigan - Hereditary Spastic Paraplegia - Program development, education and medical programs, government outreach, adherence to TSA's mission, maximizing efforts, minimizing expenses, event management, awareness, media, publications, chapter relations, research grants, scientific and medical conferences, are ongoing efforts of TSA's full-time professional staff.

Study completed and sponsored by Hvidovre University Hospital to investigate if physical therapy with strength training is better at improving muscle and gait function after anti-spastic treatment with Botulinum toxin compared to physical therapy without strength training in children with cerebral palsy.

Clinical trial being conducted by Eunice Kennedy Shriver NationalInstitute of Child Health and Human Development NICHD to examine botulinum toxin (BOTOX, or BTX) for the treatment of muscle twitches and spasticity associated with cerebral palsy in children. Botulinum toxin is a naturally occurring bacterial toxin (botulinum toxin) that inactivates certain parts of muscles.

Hypertonia Information Page at National Institute of Neurological Disorders and Stroke NINDS - What is hypertonia - Treatment - Prognosis - Research - Clinical Trials and Organizations

PubMed Abstract of double-blind study of high cervical spinal cord stimulation conducted in eight moderately disabled, spastic, cerebral palsied children failed to demonstrate any significant improvement over base line function during chronic spinal cord stimulation at either optimal stimulation parameters or random placebo parameters

Information regarding ongoing study being sponsored by University of Southern California assessing the effect of an exercise program using stationary bicycling for children with spastic diplegic cerebral palsy

Theta-burst transcranial magnetic stimulation (TBS) is a type of repetitive transcranial magnetic stimulation (rTMS) method that reduces the excitability of a small region of brain for less than one hour. Since dystonia and spasticity may be associated with increased excitability of motor cortex, we expect that by reducing the excitability of motor cortex with TBS we will temporarily improve these symptoms and hopefully open avenues in the future for the use of TBS as a new, non-invasive therapeutic intervention to aid in physical therapy and symptom amelioration of dystonia and spasticity.

Completed study. Objective of this project was to develop and evaluate two different alternative or complementary medical modalities that have been used in children with cerebral palsy by practitioners in an attempt to decelerate the complications from the neurologic insult and resultant muscle imbalance.

Research team study to asses ways to measure the stiffness in the joints of hypertonic arms.

Vanderbilt study is to determine the safe and effective levels of optical stimulation in peripheral nerves of humans otherwise undergoing nerve lesioning in surgery, namely children undergoing selective rhizotomy for treatment of medically refractory spasticity.

Stanford trial and study to learn about upper extremity hypertonia (stiffness) in children and young adults with cerebral palsy. Specifically, they want to learn about ways to measure the stiffness in the joints of hypertonic arms. The information the research team will collect includes any physical exams or computer generated data about your arm movements.

Stanford University sponsored study of trihexyphenidyl in children with upper extremity dystonia due to cerebral palsy. It is hypothesized that trihexyphenidyl in doses up to 0.75mg/kg/day would be well-tolerated and show significant changes on the Melbourne scale of upper extremity function.

This research is designed to look at any additional benefit that may occur when Botox injections are combined with specific occupational therapy exercises and with a device that uses functional electrical stimulation (FES) to help improve muscle function after stroke.

Baclofen Efficacy and Safety Trials - Pediatric Pharmacokinetic and Pharmacodynamic Study of Oral Baclofen for the Treatment of Spasticity Associated with Cerebral Palsy (BEST-PK/PD)