The inflammatory Th 17 subset in immunity against self and non-self antigens.
Jin D, Zhang L, Zheng J, Zhao Y.
Autoimmunity. 2008 Mar;41(2):154-62. Review.
PMID: 18324485
DOI: 10.1080/08916930701776605
Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease.
Kidd P.
Altern Med Rev. 2003 Aug;8(3):223-46. Review.
PMID: 12946237
Th1 pathways typically produce activation
of cytotoxic T lymphocytes (Tc), NK cells,
macrophages, and monocytes, all of which can
attack cancer cells and generally defend against
tumors.55 IFN-gamma and other Th1 cytokines are
typically lower in advanced cancer patients, while
the Th2 marker IL-4 can be higher or unchanged
Multi-targeted therapy of cancer by omega-3 fatty acids.
Berquin IM, Edwards IJ, Chen YQ.
Cancer Lett. 2008 Oct 8;269(2):363-77. Epub 2008 May 13. Review.
PMID: 18479809
doi:10.1016/j.canlet.2008.03.044
The application of probiotics in cancer.
de Moreno de LeBlanc A, Matar C, Perdigón G.
Br J Nutr. 2007 Oct;98 Suppl 1:S105-10. Review.
PMID: 17922945
doi:10.1017/S0007114507839602
Not enough vitamin D: health consequences for Canadians.
Schwalfenberg G.
Can Fam Physician. 2007 May;53(5):841-54. Review
PMID: 17872747
Conclusion
Low levels of VTD are considered a major public health problem in Canada, especially during the winter. Those with risk factors should be screened for low 25(OH)D levels and repletion therapy instituted if needed. Researchers have estimated that the oral dose of vitamin D3 to attain and maintain 25(OH)D levels >80 nmol/L is 2200 IU/d if baseline levels are 20 to 40 nmol/L, 1800 IU/d if levels are 40 to 60 nmol/L, and 1160 IU/d if levels are between 60 and 80 nmol/L.64
We need to ensure that patients have healthy blood levels of 25(OH)D to prevent levels of parathyroid hormone from rising and to maximize absorption of calcium, magnesium, and phosphate. Positive effects on bone are marginal at best unless patients consume at least 800 IU/d of VTD. The emerging and exciting role of the VTD receptor and the actions of VTD in maintaining health in other cell types have become more apparent during the last decade.
Arginine deprivation as a targeted therapy for cancer.
Feun L, You M, Wu CJ, Kuo MT, Wangpaichitr M, Spector S, Savaraj N.
Curr Pharm Des. 2008;14(11):1049-57. Review.
PMID: 18473854
Vitamin d and its role in cancer and immunity: a prescription for sunlight.
Mullin GE, Dobs A.
Nutr Clin Pract. 2007 Jun;22(3):305-22. Review.
PMID: 17507731
DOI: 10.1177/0115426507022003305
The role of vitamin D in cancer prevention.
Garland CF, Garland FC, Gorham ED, Lipkin M, Newmark H, Mohr SB, Holick MF.
Am J Public Health. 2006 Feb;96(2):252-61. Epub 2005 Dec 27. Review.
PMID: 16380576
DOI: 10.2105/AJPH.2004.045260
Vitamin D status differs by latitude and race, with residents of the northeastern United States and individuals with more skin pigmentation being at increased risk of deficiency. A PubMed database search yielded 63 observational studies of vitamin D status in relation to cancer risk, including 30 of colon, 13 of breast, 26 of prostate, and 7 of ovarian cancer, and several that assessed the association of vitamin D receptor genotype with cancer risk.
The majority of studies found a protective relationship between sufficient vitamin D status and lower risk of cancer. The evidence suggests that efforts to improve vitamin D status, for example by vitamin D supplementation, could reduce cancer incidence and mortality at low cost, with few or no adverse effects.
The role of vitamin D in cancer prevention.
Garland CF, Garland FC, Gorham ED, Lipkin M, Newmark H, Mohr SB, Holick MF.
Am J Public Health. 2006 Feb;96(2):252-61. Epub 2005 Dec 27. Review.
PMID: 16380576
DOI: 10.2105/AJPH.2004.045260
Vitamin D status differs by latitude and race, with residents of the northeastern United States and individuals with more skin pigmentation being at increased risk of deficiency. A PubMed database search yielded 63 observational studies of vitamin D status in relation to cancer risk, including 30 of colon, 13 of breast, 26 of prostate, and 7 of ovarian cancer, and several that assessed the association of vitamin D receptor genotype with cancer risk.
The majority of studies found a protective relationship between sufficient vitamin D status and lower risk of cancer. The evidence suggests that efforts to improve vitamin D status, for example by vitamin D supplementation, could reduce cancer incidence and mortality at low cost, with few or no adverse effects
Vitamin D and the epidemiology of prostate cancer.
Schwartz GG.
Semin Dial. 2005 Jul-Aug;18(4):276-89. Review.
PMID: 16076349
DOI: 10.1111/j.1525-139X.2005.18403.x
An estimate of cancer mortality rate reductions in Europe and the US with 1,000 IU of oral vitamin D per day.
Grant WB, Garland CF, Gorham ED.
Recent Results Cancer Res. 2007;174:225-34. Review.
PMID: 17302200
Epidemiology of vitamin D insufficiency and cancer mortality.
Pilz S, Tomaschitz A, Obermayer-Pietsch B, Dobnig H, Pieber TR.
Anticancer Res. 2009 Sep;29(9):3699-704. Review.
PMID: 19667167
In conclusion, we still need further studies to evaluate the association of vitamin D insufficiency and cancer incidence and mortality, but the multiple health benefits of vitamin D and the easy, safe and inexpensive way by which vitamin D can be supplemented should already guide current public health strategies to achieve 25(OH)D levels of at least 75 nmol/l (30 ng/ml) in the general population.
How to optimize vitamin D supplementation to prevent cancer, based on cellular adaptation and hydroxylase enzymology.
Vieth R.
Anticancer Res. 2009 Sep;29(9):3675-84. Review.
PMID: 19667164