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Matti Narkia

The inflammatory Th 17 subset in immunity against self and non-self antigens - Autoimmu... - 0 views

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    The inflammatory Th 17 subset in immunity against self and non-self antigens.
    Jin D, Zhang L, Zheng J, Zhao Y.
    Autoimmunity. 2008 Mar;41(2):154-62. Review.
    PMID: 18324485
    DOI: 10.1080/08916930701776605
Matti Narkia

Interleukin 2-mediated conversion of ovarian cancer-associated CD4+ regulatory T cells ... - 0 views

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    Interleukin 2-mediated conversion of ovarian cancer-associated CD4+ regulatory T cells into proinflammatory interleukin 17-producing helper T cells.
    Leveque L, Deknuydt F, Bioley G, Old LJ, Matsuzaki J, Odunsi K, Ayyoub M, Valmori D.
    J Immunother. 2009 Feb-Mar;32(2):101-8.
    PMID: 19238008
    doi: 10.1097/CJI.0b013e318195b59e

    Thus, although the impact of TH17 cells on the evolution of EOC remains to be established, our data suggest that local IL-2 treatment in ovarian cancer may result in the conversion of tumor-associated Treg into TH17 cells, relieve Treg-mediated suppression, and contribute to enhance antitumor immunity.
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