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sdahlseng10

In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector - 0 views

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    Supplemental Article to Lesch et al. (2011); Journal club 1: This article provides interesting support to the effectiveness of lentivirus vectors for gene therapy treatment. Not only is HIV or lentivirus efficient at transduction to rapidly dividing cells, it is also capable of transduction to nondividing cells; making it an exciting vector for gene therapy treatment. The range of diseases that could be treatable with a gene therapy vector that can target other cell types than hematopoietic cells could transform the science of gene therapy.
sdahlseng10

Possible applications for replicating HIV 1 vectors - 0 views

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    Review Article; Journal club 1: This is a basic review article about HIV virus vectors and their potential uses in clinical science.
sdahlseng10

Replication-competent Lentivirus Analysis of Clinical Grade Vector Products - 0 views

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    Supplementary Article to Lesch et al. (2011); journal club 1: This article helps us understand the dangers of attenuated lentiviruses used for gene therapy and other clinical applications. It also details a method for screening newly synthesized lentiviruses for replication competency.
Casey Finnerty

Using a Pan-Viral Microarray Assay (Virochip) to Screen Clinical Samples for Viral Path... - 1 views

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    A video-based publication from the peer-reviewed "Journal of Visualized Experiments". Nice introduction to the virochip method of virus screening.
Casey Finnerty

Ebola virus entry requires the host-programmed recognition of an intracellular receptor... - 0 views

  • NPC1 is the first known viral receptor that recognizes its ligand within an intracellular compartment and not at the plasma membrane.
Casey Finnerty

American Society for Microbiology:Norovirus Disinfection: How Much is Enough? - 0 views

  • wipe with a wet cloth, and then disinfect with chlorine.
  • Household bleach, says Duizer, is an average about 5 percent chlorine when new (concentration declines with age), or 50,000 PPM, and thus, can be diluted 50-fold to achieve the 1,000 ppm.
  • Norovirus is apparently no more resistant to cleaning and disinfection than other pathogens, says Duizer. The virus’ efficiency in causing outbreaks “is more likely due to their extremely low infectious dose
Matthew Marshall

Dengue: a continuing global threat : Article : Nature Reviews Microbiology - 0 views

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    Follow up research subsequent to viewing Dr. Eva Harris's Lecture, Dengue Fever: Breaking Epidemic Cycles. Research focused on mechanisms behind severe dengue forms DHF and DSS. Figure 1 in paper is from this article.
Casey Finnerty

Flu shot time? Google Flu Trends predicts worst season on record. - Slate Magazine - 0 views

  • The CDC’s current estimates aren’t all that current.
  • That’s where Google comes in.
  • the numbers can tell us only how many people were suffering from the flu a couple weeks ago.
  • ...2 more annotations...
  • According to a study published in Nature in February 2009, the system can detect outbreaks nearly two weeks before they show up in the official CDC reports.
  • won’t know until the end of the season.”
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