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Nellie Bogunovic

Miracle Baby Who Got Melanoma in Womb Still Living - 0 views

gma.yahoo.com/80514838--abc-news-health.html

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  • Nellie Bogunovic on 09 May 13
     
    Didn't even know this could happen!
Abdirizak Abdi

Using 'Bacteria-Eaters' to Prevent Infections On Medical Implant Materials - 0 views

www.sciencedaily.com/...130508123024.htm

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  • Abdirizak Abdi on 09 May 13
     
    They describe attachment of phages to the surfaces of materials like those used in implanted medical devices, and evidence that the phages remain active, killing E. coli and Staphylococcus aureus. Those bacteria cause the most common hospital-acquired infections.
Abdirizak Abdi

Your Immune System 'Remembers' Microbes It's Never Fought Before, New Study Says - 0 views

www.popsci.com/...ts-never-fought-new-study-says

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  • Abdirizak Abdi on 09 May 13
     
    How do naive cells accomplish this microbial memory generation? It's all about the environment. People are constantly exposed to countless bacteria, fungi and viruses, everywhere all of the time. T cells might act like they're reacting to something they've seen before--maybe the bacteria's proteins look similar to that of a harmless bug, and the cell is fooled.
Abdirizak Abdi

New Insights Into Ebola Infection Pave the Way for Much-Needed Therapies - 0 views

www.sciencedaily.com/...130507134547.htm

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  • Abdirizak Abdi on 09 May 13
     
    Little research is available on how the Ebola virus buds from the plasma membrane of human cells, says senior study author Robert Stahelin of Indiana University School of Medicine. "By shedding light on this process, our study will help us to identify potential drug candidates that could interfere with this step in the viral life cycle.
Alletia DeMartino

Pseudomonas aeruginosa Turns Protein Into a Virulence Factor in One Easy Step - 0 views

www.infectioncontroltoday.com/...e-factor-in-one-easy-step.aspx

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  • To infect its host, the respiratory pathogen Pseudomonas aeruginosa takes an ordinary protein usually involved in making other proteins and adds three small molecules to turn it into a key for gaining access to human cells.
  • P. aeruginosa, one of the most common causes of hospital-acquired pneumonia.
  • P. aeruginosa mostly uses this protein called elongation factor-Tu (EF-Tu) inside the cel
  • ...10 more annotations...
  • but she and her collaborators have learned that as a virulence factor, it could represent a vulnerability for the bacterium
  • EF-Tu is presumed to be an essential protein, and it's performing these moonlighting functions as well. If we figured out how it was doing that, we could devise strategies to inhibit it," says Goldberg.
  • acquired pneumonia and is the leading cause of death among critically ill patients whose airways have been damaged by ventilation, trauma, or other infections.
  • P. aeruginosa takes
  • the protein EF-Tu, which was generally thought to exist only inside the cell, and decorates the exterior of the cell with it, but in a modified form.
  • EF-Tu is modified somehow to mimic ChoP, allowing P. aeruginosa to enjoy the benefits of ChoP.
  • , ChoP carries out a crucial step for setting up an infection for a number of different types of respiratory pathogens.
  • Using a host of techniques, including mass spectrometry, site directed mutagenesis of key residues in the protein, and genetic loss of function/gain of function studies, they found that P. aeruginosa only makes small changes to EF-Tu to get it to mimic this powerful ligand. P. aeruginosa transfers three methyl groups to a lysine on EF-Tu, giving it a structure similar to ChoP and allowing it to fit in the PAFR receptor in the way ChoP does.
  • "It allows [P. aeruginosa] to adhere to the cells and invade,"
  • "Its interaction with humans is accidental. It's an opportunist. The fact that it has this novel modification on this protein that is inherent in the bacterium that enables it to attach and persist and cause disease is exciting,"
  • Alletia DeMartino on 09 May 13
     
    Interesting!! however, very scary. It just keeps modifying itself and being more virulent. what's next?!
Alletia DeMartino

Genes show one big European family - 0 views

www.sciencedaily.com/...130507195642.htm

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  • to a new study of the DNA of people from across the continent.
  • This was predicted in theory over a decade ago, and we now have concrete evidence from DNA data,
  • But even a pair of individuals who live as far apart as the United Kingdom and Turkey -- a distance of some 2,000 miles -- likely are related to all of one another's ancestors from a thousand years ago.
  • ...3 more annotations...
  • Ralph and Coop used ideas about the expected amount of genome shared between relatives of varying degrees of relatedness
  • Ralph and Coop looked for shorter blocks of DNA that were shared between cousins separated by many more generations
  • But in large samples, rare cases of distant sharing could be detected. With their analysis, Coop and Ralph were able to detect these shared blocks of DNA in individuals spread across Europe, and calculate how long ago they shared an ancestor.
  • Alletia DeMartino on 09 May 13
     
    kind of creepy to think about....
Abdirizak Abdi

Lucky Bacteria Strike It Rich During Formation of Treatment-Resistant Colonies: Researc... - 1 views

www.sciencedaily.com/...130508131819.htm

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  • Megan Rasmussen on 08 May 13
     
    Researchers are looking at how biofilms form in order to better understand how to battle their ability to be resistant to many antibiotics
  • Abdirizak Abdi on 09 May 13
     
    Like pioneers in search of a better life, bacteria on a surface wander around and often organize into highly resilient communities, known as biofilms. It turns out that a lucky few bacteria become the elite cells that start the colonies, and they organize in a rich-get-richer pattern similar to the distribution of wealth in the US economy, according to a new study..
Amy Jorgenson

Construction and evaluation of a novel recombinant T cell epitope-based vaccine against... - 0 views

iai.asm.org/...IAI.00566-12

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  • Amy Jorgenson on 08 May 13
     
    This article discusses in great detail the complexity of creating a T-cell epitope-based vaccine to treat coccidiodiomycosis. This information was aslo used and discussed in our presentation.
Amy Jorgenson

Environmental variability and coccidiodiomycosis (valley fever) - 0 views

Kolivras, Korine N., Peter S. Johnson, Andrew C. Comrie, and Stephen R. Yool. 2001. "Environmental Variability and Coccidioidomycosis (valley Fever)." Aerobiologia 17 (1): 31-42

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  • Amy Jorgenson on 08 May 13
     
    This was the review article used for our presentation. This article discusses the relationship between temperature and precipitation, and the prevalence of outbreaks of this disease.
Amy Jorgenson

Coccidioidomycosis-A Fungal Disease of the Americas - 0 views

www.ncbi.nlm.nih.gov/...PMC545195

shared by Amy Jorgenson on 24 Apr 13 - No Cached
  • Alison Prodzinski on 24 Apr 13
     
    This paper is an overview of Coccidioidomycosis. The explains the demographics, the life cycle, history, immunology, and treatment. The hope for a vaccine is also prevalent in this paper.  The paper summarizes Coccidioidomycosis and gives quick details about it.  Excellent paper on learning about the disease without diving in too deeply.
  • Amy Jorgenson on 08 May 13
     
    This article discusses the etiology and epidemiology of coccidiodiomycosis as well as the potential for a vaccine to treat the devastating symptoms brought about by this disease.
Amy Jorgenson

Signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations a... - 0 views

www.sciencedirect.com/...S0091674913002650

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  • Alison Prodzinski on 24 Apr 13
     
    This paper does an excellent job researching the correlation of the methylation of the STAT-1 gene and genetic mutations in coccidiodiomycosis and histoplasmosis. The paper shows evidence of the methylation of the STAT-1 by the PIAS1 protein. This gene mutation immunologically challenges the IFN-γ and alters the body's defense mechanisms. Excellent paper on a very scary disease. Hopeful for a vaccine!!! 
  • Amy Jorgenson on 08 May 13
     
    This article was used as a resource for our presentation. This is the article where we obtained the information regarding the patient case studies.
Amy Jorgenson

Pathogen turns protein into a virulence factor in one easy step - 0 views

phys.org/...ein-virulence-factor-easy.html

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  • Amy Jorgenson on 08 May 13
     
    This is more of a blurb (rather than an article) about P. aeruginosa making three small changes to the EF-Tu protein in order to gain entry into human cells. Understanding these changes appears to be a great link to understanding/studying hospital-acquired pneumonia. Not sure how I feel about the comment comparing proteins to a spork in a takeout meal....
Megan Rasmussen

Parents' saliva on pacifier could reduce kids' allergies, asthma Read more: http://www... - 0 views

www.foxnews.com/...d-reduce-kids-allergies-asthma

microbiology

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  • Megan Rasmussen on 08 May 13
     
    First thought: eww, but interesting!
Nate Scheibe

Alga borrows genes to beat the heat, acid and toxic metals | Life | Science News - 0 views

www.sciencenews.org/...the_heat_acid_and_toxic_metals

genes acid metals life

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  • Nate Scheibe on 08 May 13
     
    This is an interesting article about eukaryotes engaging in gene transfer with bacteria and archaea to survive in extreme environments.
Nate Scheibe

Microbes flourish at deepest ocean site | Life | Science News - 0 views

www.sciencenews.org/...flourish_at_deepest_ocean_site

ocean life

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  • Nate Scheibe on 08 May 13
     
    This gives "the ubiquity of bacteria" a whole new meaning. It is very cool that life can exist at the extremes.
Nate Scheibe

Genetic fossils betray hepatitis B's ancient roots | Life | Science News - 0 views

www.sciencenews.org/...ray_hepatitis_Bs_ancient_roots

ancient hepatitis

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  • Nate Scheibe on 08 May 13
     
    I guess I never really gave thought to how old a virus is...interesting.
Abdirizak Abdi

Bacteria Adapt and Evade Nanosilver's Sting - 0 views

www.sciencedaily.com/...130508093058.htm

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  • Abdirizak Abdi on 08 May 13
     
    Although nanosilver has effective antimicrobial properties against certain pathogens, it can cause other potentially harmful organisms to rapidly adapt and flourish, a new study reveal...Hmmm!!
Abdirizak Abdi

MicroRNA Cooperation Mutes Breast Cancer Oncogenes - 0 views

www.sciencedaily.com/...130507134649.htm

shared by Abdirizak Abdi on 08 May 13 - No Cached
  • Abdirizak Abdi on 08 May 13
     
    Study shows enhancing a few microRNAs may offer as much anti-breast-cancer activity as enhancing one, many times over and without the side effect.
Samantha Mishall

New bird flu show signs of direct jump to humans - 0 views

ca.news.yahoo.com/ect-jump-humans-234733728.html

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  • Samantha Mishall on 08 May 13
     
    This is the last thing we need! Another strain of bird-to-human transmitted virus, and researcher believe this could be the worst one yet. While research on this virus is still being conducted in China, there is already strong evidence that this could be the next big flu outbreak.
Samantha Mishall

10 Ways You May Put Yourself at Risk for Flu (Without Realizing It!) - 0 views

www.health.com/...0,,20311978_last,00.html

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  • Samantha Mishall on 08 May 13
     
    Not exactly a scientific article, however the sources are from science journals. This demonstrates how simple things that may be routine (like going to the gym) or that we don't give much thought about (going out for a few drinks with friends) can increase our risk for flu infection.
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