Best content in WSU BIOL209 Microbiology

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Miracle Baby Who Got Melanoma in Womb Still Living - 0 views

gma.yahoo.com/80514838--abc-news-health.html

shared by Nellie Bogunovic on 09 May 13 - No Cached

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Using 'Bacteria-Eaters' to Prevent Infections On Medical Implant Materials - 0 views

www.sciencedaily.com/...130508123024.htm

shared by Abdirizak Abdi on 09 May 13 - No Cached

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Your Immune System 'Remembers' Microbes It's Never Fought Before, New Study Says - 0 views

www.popsci.com/...ts-never-fought-new-study-says

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New Insights Into Ebola Infection Pave the Way for Much-Needed Therapies - 0 views

www.sciencedaily.com/...130507134547.htm

shared by Abdirizak Abdi on 09 May 13 - No Cached

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Pseudomonas aeruginosa Turns Protein Into a Virulence Factor in One Easy Step - 0 views

www.infectioncontroltoday.com/...e-factor-in-one-easy-step.aspx

shared by Alletia DeMartino on 09 May 13 - No Cached

To infect its host, the respiratory pathogen Pseudomonas aeruginosa takes an ordinary protein usually involved in making other proteins and adds three small molecules to turn it into a key for gaining access to human cells.
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P. aeruginosa, one of the most common causes of hospital-acquired pneumonia.
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P. aeruginosa mostly uses this protein called elongation factor-Tu (EF-Tu) inside the cel
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...10 more annotations...
but she and her collaborators have learned that as a virulence factor, it could represent a vulnerability for the bacterium
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EF-Tu is presumed to be an essential protein, and it's performing these moonlighting functions as well. If we figured out how it was doing that, we could devise strategies to inhibit it," says Goldberg.
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acquired pneumonia and is the leading cause of death among critically ill patients whose airways have been damaged by ventilation, trauma, or other infections.
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P. aeruginosa takes
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the protein EF-Tu, which was generally thought to exist only inside the cell, and decorates the exterior of the cell with it, but in a modified form.
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EF-Tu is modified somehow to mimic ChoP, allowing P. aeruginosa to enjoy the benefits of ChoP.
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, ChoP carries out a crucial step for setting up an infection for a number of different types of respiratory pathogens.
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Using a host of techniques, including mass spectrometry, site directed mutagenesis of key residues in the protein, and genetic loss of function/gain of function studies, they found that P. aeruginosa only makes small changes to EF-Tu to get it to mimic this powerful ligand. P. aeruginosa transfers three methyl groups to a lysine on EF-Tu, giving it a structure similar to ChoP and allowing it to fit in the PAFR receptor in the way ChoP does.
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"It allows [P. aeruginosa] to adhere to the cells and invade,"
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"Its interaction with humans is accidental. It's an opportunist. The fact that it has this novel modification on this protein that is inherent in the bacterium that enables it to attach and persist and cause disease is exciting,"
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Alletia DeMartino on 09 May 13

Interesting!! however, very scary. It just keeps modifying itself and being more virulent. what's next?!

<div class="cArrow"> </div><div class="cContentInner">Interesting!! however, very scary. It just keeps modifying itself and being more virulent. what's next?!</div>

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Genes show one big European family - 0 views

www.sciencedaily.com/...130507195642.htm

shared by Alletia DeMartino on 09 May 13 - No Cached

to a new study of the DNA of people from across the continent.
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This was predicted in theory over a decade ago, and we now have concrete evidence from DNA data,
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But even a pair of individuals who live as far apart as the United Kingdom and Turkey -- a distance of some 2,000 miles -- likely are related to all of one another's ancestors from a thousand years ago.
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Ralph and Coop used ideas about the expected amount of genome shared between relatives of varying degrees of relatedness
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Ralph and Coop looked for shorter blocks of DNA that were shared between cousins separated by many more generations
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But in large samples, rare cases of distant sharing could be detected. With their analysis, Coop and Ralph were able to detect these shared blocks of DNA in individuals spread across Europe, and calculate how long ago they shared an ancestor.
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Alletia DeMartino on 09 May 13

kind of creepy to think about....

<div class="cArrow"> </div><div class="cContentInner">kind of creepy to think about....</div>

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Lucky Bacteria Strike It Rich During Formation of Treatment-Resistant Colonies: Researc... - 1 views

www.sciencedaily.com/...130508131819.htm

shared by Abdirizak Abdi on 08 May 13 - No Cached

Megan Rasmussen on 08 May 13

Researchers are looking at how biofilms form in order to better understand how to battle their ability to be resistant to many antibiotics

<div class="cArrow"> </div><div class="cContentInner">Researchers are looking at how biofilms form in order to better understand how to battle their ability to be resistant to many antibiotics</div>

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Abdirizak Abdi on 09 May 13

Like pioneers in search of a better life, bacteria on a surface wander around and often organize into highly resilient communities, known as biofilms. It turns out that a lucky few bacteria become the elite cells that start the colonies, and they organize in a rich-get-richer pattern similar to the distribution of wealth in the US economy, according to a new study..

<div class="cArrow"> </div><div class="cContentInner">Like pioneers in search of a better life, bacteria on a surface wander around and often organize into highly resilient communities, known as biofilms. It turns out that a lucky few bacteria become the elite cells that start the colonies, and they organize in a rich-get-richer pattern similar to the distribution of wealth in the US economy, according to a new study..</div>

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Construction and evaluation of a novel recombinant T cell epitope-based vaccine against... - 0 views

iai.asm.org/...IAI.00566-12

shared by Amy Jorgenson on 08 May 13 - No Cached

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Environmental variability and coccidiodiomycosis (valley fever) - 0 views

Kolivras, Korine N., Peter S. Johnson, Andrew C. Comrie, and Stephen R. Yool. 2001. "Environmental Variability and Coccidioidomycosis (valley Fever)." Aerobiologia 17 (1): 31-42

shared by Amy Jorgenson on 08 May 13 - No Cached

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Coccidioidomycosis-A Fungal Disease of the Americas - 0 views

www.ncbi.nlm.nih.gov/...PMC545195

shared by Amy Jorgenson on 24 Apr 13 - No Cached

Alison Prodzinski on 24 Apr 13

This paper is an overview of Coccidioidomycosis. The explains the demographics, the life cycle, history, immunology, and treatment. The hope for a vaccine is also prevalent in this paper. The paper summarizes Coccidioidomycosis and gives quick details about it. Excellent paper on learning about the disease without diving in too deeply.

<div class="cArrow"> </div><div class="cContentInner">This paper is an overview of Coccidioidomycosis. The explains the demographics, the life cycle, history, immunology, and treatment. The hope for a vaccine is also prevalent in this paper. The paper summarizes Coccidioidomycosis and gives quick details about it. Excellent paper on learning about the disease without diving in too deeply.</div>

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Amy Jorgenson on 08 May 13

This article discusses the etiology and epidemiology of coccidiodiomycosis as well as the potential for a vaccine to treat the devastating symptoms brought about by this disease.

<div class="cArrow"> </div><div class="cContentInner">This article discusses the etiology and epidemiology of coccidiodiomycosis as well as the potential for a vaccine to treat the devastating symptoms brought about by this disease.</div>

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Signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations a... - 0 views

www.sciencedirect.com/...S0091674913002650

shared by Amy Jorgenson on 24 Apr 13 - No Cached

Alison Prodzinski on 24 Apr 13

This paper does an excellent job researching the correlation of the methylation of the STAT-1 gene and genetic mutations in coccidiodiomycosis and histoplasmosis. The paper shows evidence of the methylation of the STAT-1 by the PIAS1 protein. This gene mutation immunologically challenges the IFN-γ and alters the body's defense mechanisms. Excellent paper on a very scary disease. Hopeful for a vaccine!!!

<div class="cArrow"> </div><div class="cContentInner">This paper does an excellent job researching the correlation of the methylation of the STAT-1 gene and genetic mutations in coccidiodiomycosis and histoplasmosis. The paper shows evidence of the methylation of the STAT-1 by the PIAS1 protein. This gene mutation immunologically challenges the IFN-γ and alters the body's defense mechanisms. Excellent paper on a very scary disease. Hopeful for a vaccine!!! </div>

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Amy Jorgenson on 08 May 13

This article was used as a resource for our presentation. This is the article where we obtained the information regarding the patient case studies.

<div class="cArrow"> </div><div class="cContentInner">This article was used as a resource for our presentation. This is the article where we obtained the information regarding the patient case studies.</div>

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