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Planned Parenthood has said some fetal tissue is donated for medical research. Such donations are illegal in Ohio, and a Planned Parenthood state leader has said no donation program exists here.

DeWine's office found no evidence that the group made money from aborted fetuses, but the report instead criticized Planned Parenthood facilities for disposing of fetal remains in landfills.

DeWine told reporters on Friday the disposal practice is callous and violates state rules requiring that fetuses be disposed of in a humane manner. He plans to seek an injunction Monday to prevent Planned Parenthood from disposing of fetal remains in landfills.

Planned Parenthood called the alleged wrongdoing "inflammatory." The organization said it follows Ohio law and uses the same practices as hospitals and ambulatory surgical facilities, which generally contract with outside companies to dispose of all medical waste.

Stephanie Kight, president and CEO of Planned Parenthood of Greater Ohio, said the disposal process is handled safely and respectfully. She said Sunday the tissue is processed and sent to a solid waste facility that's specifically licensed for medical material, not a typical landfill.

In its lawsuit, Planned Parenthood said it's always abided by the directive that fetal tissue be disposed in a "humane" manner and has never been cited by the Ohio Department of Health, which licenses abortion facilities in Ohio, for violating those regulations.

Attorneys for Planned Parenthood accused the state's health director, Richard Hodges, of abandoning his standard process of providing notice of alleged non-compliance and providing an opportunity to correct such issues. Planned Parenthood said it didn't hear from health officials about the alleged violation until the group reached out to them Friday.

"This sudden and targeted treatment is no doubt motivated by his animus to a woman's right to safe and legal abortion and to Planned Parenthood in particular," the attorneys wrote.

Planned Parenthood has asked the court to block the state from any taking action and allow Planned Parenthood to work with the health department to sort out any issues related to the regulations.

Meanwhile, Republican lawmakers in the GOP-controlled Ohio House planned a Monday news conference to announce legislation following the attorney general's investigation.

Abbott said that canceling Medicaid participation for Planned Parenthood in Texas moves the state closer to “providing greater access to safe healthcare for women while protecting our most vulnerable – the unborn.”

Planned Parenthood has long said that its fetal tissue donations are legal, since the organization did not accept payment for the donations beyond the reimbursement of costs. On Oct. 13, Planned Parenthood announced that it will no longer accept reimbursements for expenses related to donated fetal tissue. “Planned Parenthood’s policies on fetal tissue donation already exceed the legal requirements,” Planned Parenthood President Cecile Richards wrote in a letter to the National Institutes of Health. “Now we’re going even further in order to take away any basis for attacking Planned Parenthood to advance an anti-abortion political agenda.”

The record-tampering charges accused Mr. Daleiden and Ms. Merritt of making and presenting fake California driver’s licenses, with the intent to defraud, for their April meeting at Planned Parenthood in Houston.

Abortion opponents claimed that the videos, which were released starting in July, revealed that Planned Parenthood was engaged in the illegal sale of body parts — a charge that the organization has denied and that has not been supported in numerous congressional and state investigations triggered by the release of the videos.

In a statement on Monday night, Mr. Daleiden said: “The Center for Medical Progress uses the same undercover techniques that investigative journalists have used for decades in exercising our First Amendment rights to freedom of speech and of the press, and follows all applicable laws. We respect the processes of the Harris County district attorney, and note that buying fetal tissue requires a seller as well. Planned Parenthood still cannot deny the admissions from their leadership about fetal organ sales captured on video for all the world to see.”

The release of the videos last summer created a furor and gave new strength to the conservative drive to defund Planned Parenthood. The organization was forced to apologize for the casual tone that one of its officials had used to discuss a possible transfer of fetal tissue to what she believed was a legitimate medical company. But Planned Parenthood said the fees being discussed were to cover costs and were legal. Advertisement Continue reading the main story Advertisement Continue reading the main story

Herbert said the extent of the damage is not yet clear. When clinic staff thawed a few eggs affected by the malfunction, they found that the tissue remained viable. Staff have not checked any of the embryos, he said.

For affected patients who are still eager to use their eggs or embryos to try to become pregnant, Herbert said the clinic plans to first thaw them and check for viability. If the tissue is not viable, he said, “we are going to make our patients happy one way or another.”

The emergencies mentioned in the guidance are fires, floods, power failures and terrorist attacks — but do not include instances in which a clinic’s own equipment fails.

“It became apparent just how many hypotheses there were out there,” Dr. Harper said. “Thirty-plus over the past 10 years.”

it’s a mistake to search for a single cause. They propose that a tangled web of factors and feedbacks were responsible for evolution’s big bang.

Long before the Cambrian explosion, Dr. Smith and Dr. Harper argue, one lineage of animals had already evolved the genetic capacity for spectacular diversity. Known as the bilaterians, they probably looked at first like little crawling worms.

It took a global flood to tap that capacity,

They offered evidence that the Cambrian Explosion was preceded by a rise in sea level that submerged vast swaths of land, eroding the drowned rocks.

“There’s a big kick that correlates with the sea level rise,” Dr. Smith said of the fossil record. He and Dr. Harper propose that this kick happened thanks to the new habitats created by the sea level rise. These shallow coastal habitats were bathed in sunlight and nourished with eroding nutrients like phosphates. Animals colonized these new fertile habitats, Dr. Smith and Dr. Harper argue, and evolved to take up new ecological niches.

The erosion of the coastlines released calcium, which can be toxic to cells. In order to survive, animals had to evolve ways to rid themselves of the poison. One solution may have been to pack the calcium into crystals, which eventually evolved into shells, bones, and other hard tissues.

These shells and other hard tissues sped up animal evolution even more. Predators could grow hard claws and jaws for killing prey, and their prey could evolve hard shells and spines to defend themselves. Animals became locked in an evolutionary arms race.

Anand said he has grown organoids that include 98% of cells that exist in a brain of a human fetus at five weeks. 

Preparation is the key to a good plan.

Hopefully, you've been following standard hygiene practices. These are behaviors we should be doing daily, automatically, to protect ourselves from germs, colds and flu:

Avoid touching your eyes, nose and mouth with unwashed hands; cough and sneeze into elbows or tissues that you immediately throw away, and regularly wash, wash, wash those hands with warm water and lots of soapy bubbles.

Parents and guardians should plan well in advance by setting up a structure in which all kids and potential caregivers know their roles and expectations, said pediatrician Dr. Tanya Altmann, Editor-in-Chief of the American Academy of Pediatrics' book "Caring for Your Baby and Young Child: Birth to Age 5 and The Wonder Years."

A working thermometer to monitor fever, which is considered to be 100 degrees Fahrenheit (37.7 degrees Celsius), and a method to clean it, such as Isopropyl alcohol.

Fever reducing medications, such as acetaminophen.

Regular soap and 70% alcohol-based hand sanitizer (antibacterial soap isn't necessary if you wash properly, and that way you won't will contribute to the world's growing antibiotic-resistant superbugs).

Tissues to cover sneezes and coughs. But there's really no need to hoard toilet paper -- this is a respiratory disease.

Regular cleaning supplies, kitchen cleaning gloves and trash can liners.

Disinfectant cleaning supplies -- the CDC suggests picking from a list that meets the virus-fighting standards of the US Environmental Protection Agency, but says you can also make your own version by using 1/3 cup unexpired bleach per gallon of water or 4 teaspoons bleach per quart of water. Never mix bleach with ammonia or any other cleanser -- it produces toxic gases.

If you live alone, that's not difficult. Your challenge is to monitor your symptoms and care for yourself when you're not feeling well. Be sure to have a plan in place to deliver food and medications, and find someone who can be responsible for virtually checking in on you on a regular basis.

The rest of the family should practice isolation as well, Radesky added.

If you are running short on face masks, or don't have any because of hoarding, try to protect the caregiver as best you can, the CDC says.

Altmann stresses maximizing isolation and protective actions.

"You can have a healthy person leave the sick one food and drinks at the door, and then go wash their hands," Altmann explained. "Wear gloves to pick up the empty plates, take them back to the kitchen and wash them in hot water with soap, or preferably with a dishwasher, and wash your hands again."

One last, very important thing: Call 911 immediately if you or your loved ones have any of these symptoms: increased or sudden difficulty breathing or shortness of breath; a persistent pain or pressure in the chest; and any sign of oxygen deprivation, such as new confusion, bluish lips or face, or you can't arouse the sick person.

To be clear: Everyone in the house needs to isolate themselves from the outside world as much as possible.

No clear data is available about vaccine hesitancy among evangelicals of other racial groups. But religious reasoning often spreads beyond white churches.

“If we can’t get a significant number of white evangelicals to come around on this, the pandemic is going to last much longer than it needs to,” said Jamie Aten, founder and executive director of the Humanitarian Disaster Institute at Wheaton College, an evangelical institution in Illinois.

There are about 41 million white evangelical adults in the U.S. About 45 percent said in late February that they would not get vaccinated against Covid-19, making them among the least likely demographic groups to do so, according to the Pew Research Center.

Many high-profile conservative pastors and institutional leaders have endorsed the vaccines. Franklin Graham told his 9.6 million Facebook followers that Jesus would advocate for vaccination.

Dr. Simone Gold, a prominent Covid-19 skeptic who was charged with violent entry and disorderly conduct in the Jan. 6 Capitol siege, told an evangelical congregation in Florida that they were in danger of being “coerced into taking an experimental biological agent.”

Some evangelicals believe that any Covid restrictions — including mask mandates and restrictions on in-person church worship — constitute oppression.

“Fear is the motivating power behind all of this, and fear is the opposite of who God is,” said Teresa Beukers, who travels throughout California in a motor home. “I violently oppose fear.”

“Go ahead and throw us in the lions’ den, go ahead and throw us in the furnace,” she said, referring to two biblical stories in which God’s people miraculously survive persecution after refusing to submit to temporal powers.

The vaccines do not include fetal tissue, and no additional abortions are required to manufacture them. Still, the kernel of a connection has metastasized online into false rumors about human remains or fetal DNA being an ingredient in the vaccines.

White evangelicals who do not plan to get vaccinated sometimes say they see no need, because they do not feel at risk. Rates of Covid-19 death have been about twice as high for Black, Hispanic, and Native Americans as for white Americans.

There has been a “sea change” over the past century in how evangelical Christians see science, a change rooted largely in the debates over evolution and the secularization of the academy, said Elaine Ecklund, professor of sociology and director of the Religion and Public Life Program at Rice University.

The Centers for Disease Control and Prevention and Dr. Anthony Fauci are not going to be able to persuade evangelicals, according to Curtis Chang, a consulting professor at Duke Divinity School who is leading an outreach project to educate evangelicals about the vaccine.

Mr. Rainey helped his own Southern Baptist congregation get ahead of false information by publicly interviewing medical experts — a retired colonel specializing in infectious disease, a church member who is a Walter Reed logistics management analyst, and a church elder who is a nurse for the Department of Veterans Affairs.

“It is necessary for pastors to instruct their people that we don’t always have to be adversaries with the culture around us,” he said. “We believe Jesus died for those people, so why in the world would we see them as adversaries?”

But I do think it’s going to be a while before this virus becomes completely normal. And I’ve never been convinced that this current generation of elderly people will ever get to a place where it is completely normal. If you’re 65 or 75 or even older — it’s really hard to teach an immune system new tricks if you’re that age

And so while we may see excess mortality in the elderly decline somewhat, I don’t think we’ll see it ever disappear for this generation who was already old when the pandemic hit. Many will never develop that robust, long-term immunological memory we would want to see — and which happens naturally to someone who’s been exposed hundreds of times since they were a little baby.

There’s a similar story with measles. There is no routine later-life sequelae, like shingles, for measles. But what we do see is that, in measles outbreaks today, there are some people who were vaccinated who get it anyway. Maybe 5 to 15 percent of cases are not immunologically naïve people, but vaccinated people.

Is it really the case that, as babies, we are fighting off those viruses hundreds of times?The short answer is yeah. We start seeing viruses when we’re 2 months old, when we’re a month old. And a lot of these viruses we’ve seen literally tens, if not hundreds of times for some people by the time we’re adults. People tend to think that immunity is binary — you’re either immune or you’re not. That couldn’t be farther from the truth. It’s a gradient, and your protection gets stronger the more times you see a virus.

We used to think we just had this spectacular immune response when we first encountered the virus at, say, age 6, and that the immune response lasted until we were 70. But actually what we were seeing was the effect of an immune system being retrained every time it came into contact with the virus after the initial infection — at 6, and 7, and 8, and so on. Every time your friend got chickenpox, or your neighbor, you got a massive boost. You were re-upping your immune response and diversifying your immunological tools — potentially multiple times a year, a kind of natural booster.

But now, in America, kids get chickenpox vaccines. So you don’t have kids in America getting chickenpox today, and never will. But that means that older Americans, who did get it as kids, are not being exposed again — certainly not multiple times each year. And it turns out that, in the absence of routine re-exposures, that first exposure alone isn’t nearly as good at driving lifelong immunity and warding off shingles until your immune system begins to fall apart in old age — it can last until you’re in your 30s, for example but not until your 70s.

With Covid, when it infects you, it can land in your upper respiratory tract and it just start replicating right there. Immediately, it’s present and replicating in your lungs and in your nose. And that alone elicits enough of an immune response to cause us to feel really crappy and even cause us to feel disease.

But we could have just set the narrative better at the beginning: Look, you might get sick again, but your risk of landing in the hospital is going to be really low, and if you get a booster, you might still get sick again, but your risk of landing in the hospital is going to be even lower. That’s something I think humans can deal with, and I think the public could have understood it.

But it’s why we don’t see the severe disease as much, with a second exposure or an exposure after vaccination: For most people, it’s not getting into the heart and the liver and stuff nearly as easily.

But it doesn’t have to. It’s still causing symptomatic disease. And maybe mucosal vaccines could stop this, but without them we’re likely to continue seeing infections and even symptomatic infections.

through most of 2020 and into 2021, though. Back then, I think the conventional wisdom was that a single exposure — through infection or vaccination — would be the end of the pandemic for you. If this is basic virology and immunology, how did we get that so wrong?

The short answer is that epidemiologists are not immunologists and immunologists are not virologists and virologists are not epidemiologists. And, in general, physicians don’t know anything about the details.

But this failure had some pretty concrete impacts. When reinfections first began popping up, people were surprised, they were scared, and then, to some degree, they lost trust in vaccines. And the people they were turning to for guidance — not only did they not warn us about that, they were slow to acknowledge it, as well.

It had dramatic impacts and ripple effects that will last for years to limit our ability to get populations properly vaccinated.

the worst thing we can do during a pandemic is set inappropriately high expectations. These vaccines are incredible, they’ve had an enormously positive impact on mortality, but they were never going to end the pandemic.

And now, there’s a huge number of people questioning, do these vaccines even do anything?

For babies born today, though, I really think they’re not going to view Covid as any different than other viruses. By the time they are 20, it will be like any other virus to them. Because their immune systems will have grown up with it.

Instead, we set society up for failure, since people feel like the government failed everyone, that biology failed us, and that this was a crazy virus that has broken all the rules of our immune system, when it’s just doing what we’ve always known it would do.

How do you wish we had messaged things differently? What would it have meant to communicate early and clearly that Covid was a textbook virus, as you say?I think the biggest thing would have been just to say, we understand the enemy.

To say that this is a textbook virus, it doesn’t mean that it’s not killing people. Objectively, it’s still killing more people than any other infectious disease

What it means is that we could’ve taken action based on what we knew, rather than waiting around to prove everything and publish papers in Nature and Science talking about things we already knew.

We could have prepared for November and December of 2020 and then for November and December of 2021. But everyone kept saying, we don’t know if it’s going to come back. We knew it was going to come back and it makes me want to cry to think about it. We did nothing and hundreds of thousands of people died. We didn’t prepare nursing homes because we all got to the summer of 2020 and we said, cross our fingers.

We knew how tests worked. We knew about serial testing and why it was important for a public health approach. We knew that vaccines could have really good impacts once they were around. And if you were looking through the correct lens, we even knew that they weren’t going to stop transmission.

We didn’t have to live in a world where we were flying blind. We could have lived in a world where we’re knowledgeable. But instead, we chose almost across the board to will ourselves into this state of fear and anxiety.

And that really started in the earliest days. Almost the first experience I had was a lot like that movie with Jennifer Lawrence —Don’t Look Up.

none of this was complicated. You just had to ask a simple question: what would happen if you took away all immunity from an adult? Well, once you control for no immunity, adults are going to get very, very sick.

Of course, by and large, babies didn’t get very sick from this disease.Babies are immunologically naïve, but they are also resilient. A virus can tear up a baby, but a baby can repair its tissue so fast. Adults don’t have that. It’s just like a baby getting a cut. They’ll heal really quick

An adult getting a cut — you go by age, and every decade of age that you are, it’s going to take exponentially longer for that wound to heal. Eventually get to 80 or 90 and the wound can’t even heal. In the immunology world, this is called “tolerance.”

why are all these organ systems getting damaged when other viruses don’t seem to do that? It’s natural to think, it’s Covid — this is a weird disease. But it’s much more a story about immunity and how it develops than about the virus or the disease. None of our organ systems had any immune defenses around to help them out. And I think that the majority of post-acute sequelae and multi-organ complications and long Covid — they are not the result of the virus being a crazy different virus, but are a result of this virus replicating in an environment where there were such absent or exceedingly low defenses.

Is it the same whenever we encounter a virus for the first time?Think about travelers. Travelers get way more sick from a local disease than people who grew up with that virus. If you get malaria as a traveler, you’re much more likely to get really sick. You don’t see everyone in Nicaragua taking chloroquine every day. But you definitely see travelers taking it, because malaria can be deadly for adults.

What about, not severity, but post-acute complications — do we have long malaria? Do we have liver complications from dengue?

The really hard part of answering that question is there’s just not enough data on the frequency of long-term effects, because nothing like this has ever happened at such scale. It’s like everyone in Europe and North America suddenly traveled to a country where malaria was endemic.

Or think about H.I.V. It essentially kills your immune system, and once the immune barriers are down, other viruses that used to infect humans would get into tissues that we didn’t like them to get into. If there wasn’t such a clear signal of a loss of CD-4 T cells to explain it, people might still be scratching their heads and going, man, I wonder why all these patients are getting fungal infections. Well, there’s a virus there that’s depleting their immune system.

Covid is absolutely waking the world up to this — to the fact that there are really weird long-term sequelae to viruses when they infect organ systems that would normally be protected. And I think we’re going to find that more and more cancers are being attributed to viral infections.

It wasn’t that long ago that we first learned that most cases of cervical cancer were caused by H.P.V. — I think the 1980s. And now we have a vaccine for H.P.V. and rates of cervical cancer have fallen by two-thirds.

what about incidence? We’ve talked at a few points about how important it is to think about all of these questions in terms of the scale. What is the right scale for thinking about future long Covid, for instance, or other post-acute sequelae?

I think the absolute risk, per infection, is going down and down and down. That’s just true.

he U.K.’s Office of National Statistics, which shows a much lower risk of developing long Covid now, from reinfection, than from an initial infection earlier in the pandemic.

the worst is definitely behind us, which is a good thing, especially for people who worry that the problems will keep building and a lot of people — or even everyone — will get long Covid symptoms. I don’t think there’s a world where we’re looking at the babies of today dealing with long Covid at any meaningful scale.

a lot of the fear right now comes from the worst cases, and there’s a lot of worst cases. Even one of the people that I know well, I know in their mind they’re worried that they’ll never recover, but I think objectively they are recovering slowly. It might not be an eight month course. It might be a year and a half. But they will get better. Most of us will.

that would be on par with what we experience with flu viruses, which scientists estimate hit us about every two to five years, less often in adulthood. It also matches up well with the documented cadence of the four other coronaviruses that seasonally trouble humans, and cause common colds.

For now, every infection, and every subsequent reinfection, remains a toss of the dice. “Really, it’s a gamble,” says Ziyad Al-Aly, a clinical epidemiologist and long-COVID researcher at Washington University in St. Louis. Vaccination and infection-induced immunity may load the dice against landing on severe disease, but that danger will never go away completely, and scientists don’t yet know what happens to people who contract “mild” COVID over and over again

Or maybe not. This virus seems capable of tangling into just about every tissue in the body, affecting organs such as the heart, brain, liver, kidneys, and gut; it has already claimed the lives of millions, while saddling countless others with symptoms that can linger for months or years.

considering our current baseline, “less dangerous” could still be terrible—and it’s not clear exactly where we’re headed. When it comes to reinfection, we “just don’t know enough,”

Perhaps, as several experts have posited since the pandemic’s early days, SARS-CoV-2 will just become the fifth cold-causing coronavirus.

Bodies, wised up to the virus’s quirks, can now react more quickly, clobbering it with sharper and speedier strikes.

Future versions of SARS-CoV-2 could continue to shape-shift out of existing antibodies’ reach, as coronaviruses often do. But the body is flush with other fighters that are much tougher to bamboozle—among them, B cells and T cells that can quash a growing infection before it spirals out of control

Those protections tend to build iteratively, as people see pathogens or vaccines more often. People vaccinated three times over, for instance, seem especially well equipped to duke it out with all sorts of SARS-CoV-2 variants, including Omicron and its offshoots.

promising patterns: Second infections and post-vaccination infections “are significantly less severe,” she told me, sometimes to the point where people don’t notice them at all

A third or fourth bout might be more muted still; the burden of individual diseases may be headed toward an asymptote of mildness that holds for many years

Gordon and Swartz are both hopeful that the slow accumulation of immunity will also slash people’s chances of developing long COVID.

Immunity, though, is neither binary nor permanent. Even if SARS-CoV-2’s assaults are blunted over time, there are no guarantees about the degree to which that happens, or how long it lasts.

A slew of factors could end up weighting the dice toward severe disease—among them, a person’s genetics, age, underlying medical conditions, health-care access, and frequency or magnitude of exposure to the virus.

for everyone else, no amount of viral dampening can totally eliminate the chance, however small it may be, of getting very sick.

Long COVID, too, might remain a possibility with every discrete bout of illness. Or maybe the effects of a slow-but-steady trickle of minor, fast-resolving infections would sum together, and bring about the condition.

Every time the body’s defenses are engaged, it “takes a lot of energy, and causes tissue damage,” Thomas told me. Should that become a near-constant barrage, “that’s probably not great for you.”

Bodies are resilient, especially when they’re offered time to rest, and she doubts that reinfection with a typically ephemeral virus such as SARS-CoV-2 would cause mounting damage. “The cumulative effect is more likely to be protective than detrimental,” she said, because of the immunity that’s laid down each time.

people who have caught the virus twice or thrice may be more likely to become long-haulers than those who have had it just once.

Some other microbes, when they reinvade us, can fire up the immune system in unhelpful ways, driving bad bouts of inflammation that burn through the body, or duping certain defensive molecules into aiding, rather than blocking, the virus’s siege. Researchers don’t think SARS-CoV-2 will do the same. But this pathogen is “much more formidable than even someone working on coronaviruses would have expected,

Seasonal encounters with pathogens other than SARS-CoV-2 don’t often worry us—but perhaps that’s because we’re still working to understand their toll. “Have we been underestimating long-term consequences from other repeat infections?” Thomas said. “The answer is probably, almost certainly, yes.”

the rhythm of reinfection isn’t just about the durability of immunity or the pace of viral evolution. It’s also about our actions and policies, and whether they allow the pathogen to transmit and evolve. Strategies to avoid infection—to make it as infrequent as possible, for as many people as possible—remain options, in the form of vaccination, masking, ventilation, paid sick leave, and more.

“There are still very good reasons” to keep exposures few and far between, Landon, of the University of Chicago, told me. Putting off reinfection creates fewer opportunities for harm: The dice are less likely to land on severe disease (or chronic illness) when they’re rolled less often overall. It also buys us time to enhance our understanding of the virus, and improve our tools to fight it.

The outlooks of the experts I spoke with spanned the range from optimism to pessimism, though all agreed that uncertainty loomed. Until we know more, none were keen to gamble with the virus—or with their own health. Any reinfection will likely still pose a threat, “even if it’s not the worst-case scenario,” Abdool Karim told me. “I wouldn’t want to put myself in that position.”

But Joshua Akey, a geneticist at the University of Washington in Seattle, said he thought the more likely cause of the gene’s spread among East Asians was sexual selection. Thick hair and small breasts are visible sexual signals which, if preferred by men, could quickly become more common as the carriers had more children.

East Asians are sometimes assumed to have evolved in a cold environment because of their narrow nostrils, which conserve heat, and the extra eyelid fat that insulates the eye. But the Broad team calculates that the EDAR variant arose about 35,000 years ago in central China and that the region was then quite warm and humid. Extra sweat glands would have been advantageous to the hunter-gatherers who lived at that time.

The finding that the gene has so many effects raises the question of which one was the dominant trigger for natural selection. Dr. Sabeti said the extra sweat glands could have been the feature favored by natural selection, with all the other effects being dragged along in its train.

each of the effects of the EDAR variant may have been favored by natural selection at a different time. A series of selections on different traits thus made the variant version so common among East Asians. About 93 percent of Han Chinese carry the variant, as do about 70 percent of people in Japan and Thailand, and 60 to 90 percent of American Indians, a population descended from East Asians.

Mr. Hillary has also accused the county prosecutor, Mary Rain, of forsaking justice in the name of keeping a campaign promise: Ms. Rain was elected in 2013, in part on the strength of campaigning with Ms. Cyrus and promising to focus the energies of her small office on Garrett’s murder.

The suspicions and repercussions surrounding the boy’s death have rippled through time and distance. A key defense witness, for instance, suddenly discovered “Justice for Garrett” signs posted near his new workplace and home — each hundreds of miles from Potsdam. Mr. Hillary, now free on bail, found himself rearrested in September for allegedly violating an order of protection by using a drive-through A.T.M. at the bank where Ms. Cyrus worked.

Garrett Phillips was an ebullient child despite an early-life tragedy: When he was a toddler, his father, Robert — an amiable grounds worker at the State University of New York at Potsdam — suffered a brain aneurysm and never recovered. He died before Garrett was 3.Though Garrett never knew his father, the boy emulated him as he grew. Like his father, he hunted and fished; played any sport involving a ball; and balanced his rowdy and respectful sides, rambunctious sometimes in public but polite to family and strangers.

On the afternoon of Oct. 24, 2011, Garrett was playing basketball at the middle school with some friends as rain fell intermittently. A little before 5 p.m., Tandy Cyrus called his cellphone and told him to go home to do schoolwork.

Garrett got on his caster board — something of a cross between a skateboard and a snowboard — and headed home, his progress captured by a series of surveillance cameras and later described in a police timeline.

Combing the apartment for evidence, investigators found a possible clue: The screen of the bedroom window, about 20 feet off the ground, was “bent outward,” according to the incident report. A tile seemed to be broken on the roof of a lower section of the building, about 10 feet below, and there was a gash in the grass

His appeal, as both a coach and a person, is evident: His energy is intense, but his smile is unencumbered. He said he had always loved the North Country region’s rural mountains and summertime greenery — when it was warm it reminded him of Jamaica — though he was aware of the cultural boundaries beyond campus.“You’re a black person,” he said in an interview. “You were viewed as such.”A year after being hired by Clarkson, Mr. Hillary found that his relationship with his longtime girlfriend, Stacia Lee, the mother of his three children, was struggling. At a bar called Ton’s, he became acquainted with a bartender, Tandy Cyrus.

“I go, ‘Listen. Help me understand. Are you and Tandy together?’” Deputy Jones said.Ms. Cyrus, 37, declined to be interviewed for this article, but Mr. Hillary said he had been harassed because of his relationship with her. “It’s not a community with a lot of interracial relationships,” he said, adding that he had “to be mindful” when he was out. “I would go to the local restaurant,” he said, and Deputy Jones’s “friends would come up to me and like, ‘You know you’re not supposed to be dating John’s girl.’”A few months after they met, Mr. Hillary and Ms. Cyrus moved in together, forming a household of five, including his teenage daughter, Shanna-Kay, and Ms. Cyrus’s two sons.

Lieutenant Murray saw Mr. Duff as deeply credible.“I just can’t bring myself to fathom why a collegiate person playing on a Division III soccer team with his entire future ahead of him would lie and perjure himself on a sworn statement for no reason,” he said.On the evening after the murder, Lieutenant Murray went to watch Clarkson’s men’s soccer squad and videotaped Mr. Hillary coaching the penultimate game of a rough season. (The 2011 Clarkson squad had more losses than goals.)According to a search-warrant application, as Mr. Hillary strode along the sideline, he seemed stiff and sedate and had a “significant limp in his right leg,” something the detective inferred would have been caused by jumping from a second-story window. Last year, though, The Watertown Daily Times posted a clip from Lieutenant Murray’s video: In it, Mr. Hillary appears to walk unhindered along the sidelines.

As the men were being questioned, detectives searched for damning evidence. They seized Mr. Hillary’s phone and examined the contents of his pockets and his socks. Nude photographs, fingerprints and palm prints were taken. Mr. Hillary’s car was searched. (The timing of the seizures, and of the subsequent search warrants, has been a focus of Mr. Hillary’s civil suit.) The police also obtained his DNA from a coffee cup and the butt of a cigarette.

It’s the vast imbalance that turns mere force into unforgivable vice, which is why we tend to associate cruelty with tyranny. Cruelty also violates any sense of human dignity and empathy. It tears at our connective, human tissue. And it is almost always imposed out of cowardice rooted in some kind of fear

it is a vice particularly dangerous for any sort of liberal democracy. Its incompatibility with the liberal idea is rooted, quite simply, in the immense inequality that cruelty invariably entails — between, say, an armed adult agent of the law and a helpless, alien, exhausted child

Many evils and vices exist, some arguably worse than cruelty. It is not included in the deadly sins, for example

Except, of course, we haven’t. America was founded in cruelty

Cruelty, in this view, is abuse of power at its most extreme. Which is why, in so many ways, our wanton destruction of this planet’s ecosystem and the subsequent suffering of so many other species may be the cruelest act of humankind in our time.

It spreads, this stuff, which is why we have slowly constructed a liberal civilization over the last few centuries in which this most ordinary and yet most pernicious of the vices has been kept under control

We have progressed immensely over the centuries on this question, but it is always a temptation. Small cruelties easily lead to larger ones. And larger ones require, for most people, the dehumanization of the victims, which makes cruelty more tolerable and therefore more likely

Letting it slip, allowing it to fester, becoming numb to it: this is the danger we face in this authoritarian moment

We simply cannot let these children down. We simply cannot look away until everyone is accounted for.

The challenge is that unlike some of our other organs, like the skin and liver, the heart has a very limited ability to self-heal. Heart muscle cells replicate at a rate of just 0.5% a year, not sufficient to repair any significant damage. Instead, the dead cells are replaced by thick layers of tough, rigid scar tissue, meaning that sections of the heart simply cease to function.

But along with a team of stem cell biologists at the University of Cambridge’s Stem Cell Institute, Sinha is working on a slightly different idea: heart patches.

One of the main challenges with this approach is how to electrically integrate the new patch with the heart to ensure that both beat in synchrony. Any defective electrical connections could stimulate an abnormal heart rhythm.

Nation-states, when they form, imagine a past. That, at least in part, accounts for why modern historical writing arose with the nation-state.

For more than a century, the nation-state was the central object of historical inquiry.

studying American history meant studying the American nation. As the historian John Higham put it, “From the middle of the nineteenth century until the 1960s, the nation was the grand subject of American history.”

“A history in common is fundamental to sustaining the affiliation that constitutes national subjects,” the historian Thomas Bender once observed. “Nations are, among other things, a collective agreement, partly coerced, to affirm a common history as the basis for a shared future.”

in the 1970s, studying the nation fell out of favor in the American historical profession. Most historians started looking at either smaller or bigger things, investigating the experiences and cultures of social groups or taking the broad vantage promised by global history

The endurance of nationalism proves that there’s never any shortage of blackguards willing to prop up people’s sense of themselves and their destiny with a tissue of myths and prophecies, prejudices and hatreds, or to empty out old rubbish bags full of festering resentments and calls to violence.

When historians abandon the study of the nation, when scholars stop trying to write a common history for a people, nationalism doesn’t die. Instead, it eats liberalism. 

is there any option other than to try to craft a new American history—one that could foster a new Americanism? 

o review: a nation is a people with common origins, and a state is a political community governed by laws.

A nation-state is a political community governed by laws that unites a people with a supposedly common ancestry.

These Truths, “Very often, histories of nation-states are little more than myths that hide the seams that stitch the nation to the state.”

Not until the 1840s, when European nations were swept up in what has been called “the age of nationalities,” did Americans come to think of themselves as belonging to a nation, with a destiny

the state-nation, which arises when the state is formed before the development of any sense of national consciousness. The United States might be seen as a, perhaps the only, spectacular example of the latter”

Bancroft’s ten-volume History of the United States, From the Discovery of the American Continent, was published between 1834 and 1874.

An architect of manifest destiny, Bancroft wrote his history in an attempt to make the United States’ founding appear inevitable, its growth inexorable, and its history ancient. De-emphasizing its British inheritance, he celebrated the United States as a pluralistic and cosmopolitan nation, with ancestors all over the world:

Nineteenth-century nationalism was liberal, a product of the Enlightenment. It rested on an analogy between the individual and the collective

“The concept of national self-determination—transferring the ideal of liberty from the individual to the organic collectivity—was raised as the banner of liberalism.” 

Nineteenth-century Americans understood the nation-state within the context of an emerging set of ideas about human rights: namely, that the power of the state guaranteed everyone eligible for citizenship the same set of irrevocable political rights.

The American Civil War was a struggle over two competing ideas of the nation-state. This struggle has never ended; it has just moved around

Southerners were nationalists, too. It’s just that their nationalism was what would now be termed “illiberal” or “ethnic,” as opposed to the Northerners’ liberal or civic nationalism.

much of U.S. history has been a battle between them. 

“Ours is the government of the white man,” the American statesman John C. Calhoun declared in 1848, arguing against admitting Mexicans as citizens of the United States. “This Government was made by our fathers on the white basis,” the American politician Stephen Douglas said in 1858. “It was made by white men for the benefit of white men and their posterity forever.” 

In 1861, the Confederacy’s newly elected vice president, Alexander Stephens, delivered a speech in Savannah in which he explained that the ideas that lay behind the U.S. Constitution “rested upon the assumption of the equality of races”—here ceding Lincoln’s argument—but that “our new government is founded upon exactly the opposite ideas; its foundations are laid, its cornerstone rests, upon the great truth that the negro is not equal to the white man; that slavery is his natural and moral condition.”

the battle between liberal and illiberal nationalism raged on, especially during the debates over the 14th and 15th Amendments, which marked a second founding of the United States on terms set by liberal ideas about the rights of citizens and the powers of nation-states—namely, birthright citizenship, equal rights, universal (male) suffrage, and legal protections for noncitizens

For Douglass, progress could only come in this new form of a nation, the composite nation. “We shall spread the network of our science and civilization over all who seek their shelter, whether from Asia, Africa, or the Isles of the sea,” he said, and “all shall here bow to the same law, speak the same language, support the same Government, enjoy the same liberty, vibrate with the same national enthusiasm, and seek the same national ends.”

that effort had been betrayed by white Northerners and white Southerners who patched the United States back together by inventing a myth that the war was not a fight over slavery at all but merely a struggle between the nation and the states. “We fell under the leadership of those who would compromise with truth in the past in order to make peace in the present,” Du Bois wrote bitterly.

Nationalism was taking a turn, away from liberalism and toward illiberalism, including in Germany

That “placed the question of the ‘nation,’ and the citizen’s feelings towards whatever he regarded as his ‘nation,’ ‘nationality’ or other centre of loyalty, at the top of the political agenda.”

began in the United States in the 1880s, with the rise of Jim Crow laws, and with a regime of immigration restriction, starting with the Chinese Exclusion Act, the first federal law restricting immigration, which was passed in 1882. Both betrayed the promises and constitutional guarantees made by the 14th and 15th Amendments.

the white men who delivered speeches at the annual meetings of the American Historical Association during those years had little interest in discussing racial segregation, the disenfranchisement of black men, or immigration restriction

All offered national histories that left out the origins and endurance of racial inequality.

the uglier and more illiberal nationalism got, the more liberals became convinced of the impossibility of liberal nationalism

The last, best single-volume popular history of the United States written in the twentieth century was Degler’s 1959 book, Out of Our Past: The Forces That Shaped Modern America: a stunning, sweeping account that, greatly influenced by Du Bois, placed race, slavery, segregation, and civil rights at the center of the story, alongside liberty, rights, revolution, freedom, and equality. Astonishingly, it was Degler’s first book.

hatred for nationalism drove American historians away from it in the second half of the twentieth century.

with the coming of the Vietnam War, American historians stopped studying the nation-state in part out of a fear of complicity with atrocities of U.S. foreign policy and regimes of political oppression at home.

Bender observed in Rethinking American History in a Global Age in 2002. “Only recently,” he continued, “and because of the uncertain status of the nation-state has it been recognized that history as a professional discipline is part of its own substantive narrative and not at all sufficiently self-conscious about the implications of that circularity.” Since then, historians have only become more self-conscious, to the point of paralysis

If nationalism was a pathology, the thinking went, the writing of national histories was one of its symptoms, just another form of mythmaking

Beginning in the 1960s, women and people of color entered the historical profession and wrote new, rich, revolutionary histories, asking different questions and drawing different conclusions

a lot of historians in the United States had begun advocating a kind of historical cosmopolitanism, writing global rather than national history

Michael Walzer grimly announced that “the tribes have returned.” They had never left. They’d only become harder for historians to see, because they weren’t really looking anymore. 

Writing national history creates plenty of problems. But not writing national history creates more problems, and these problems are worse.

What would a new Americanism and a new American history look like? They might look rather a lot like the composite nationalism imagined by Douglass and the clear-eyed histories written by Du Bois

A nation born in contradiction will forever fight over the meaning of its history. But that doesn’t mean history is meaningless, or that anyone can afford to sit out the fight.

“The history of the United States at the present time does not seek to answer any significant questions,” Degler told his audience some three decades ago. If American historians don’t start asking and answering those sorts of questions, other people will, he warned

The cost: The participating counties and municipalities are contributing to a $4bn statewide spend, including Miami Beach’s $400m Forever Bond, a $1bn stormwater plan and $250m of improvements to Broward county’s sewage systems to protect against flooding and seawater seepage. In the Keys, many consider the estimated $60m a mile cost of raising roads too expensive.

The threat: Saltwater from sea level rise is seeping further inland through Florida’s porous limestone bedrock and contaminating underground freshwater supplies, notably in the Biscayne aquifer, the 4,000-sq mile shallow limestone basin that provides drinking water to millions in southern Florida. Years of over-pumping and toxic runoff from farming and the sugar industry in central Florida and the Everglades have worsened the situation. The Florida department of environmental protection warned in March that “existing sources of water will not adequately meet the reasonable beneficial needs for the next 20 years”. A rising water table, meanwhile, has exacerbated problems with south Florida’s ageing sewage systems. Since December, millions of gallons of toxic, raw sewage have spilled on to Fort Lauderdale’s streets from a series of pipe failures.

The cost: The Everglades restoration plan was originally priced at $7.8bn, rose to $10.5bn, and has since ballooned to $16.4bn. Donald Trump’s proposed 2021 federal budget includes $250m for Everglades restoration. The estimated $1.8bn cost of the reservoir will be split between federal and state budgets.

Possible solutions

The cost: With homeowners and businesses largely bearing their own costs, the specific amount spent on “hurricane-proofing” in Florida is impossible to know. A 2018 Pew research study documented $1.3bn in hazard mitigation grants from federal and state funding in 2017, along with a further $8bn in post-disaster grants. Florida is spending another $633m from the US Department of Housing and Urban Development on resiliency planning.

Wildlife and habitat loss The threat: Florida’s native flora and fauna are being devastated by climate change, with the Florida Natural Areas Inventory warning that a quarter of the 1,200 species it tracks is set to lose more than half their existing habitat, and the state’s beloved manatees and Key deer are at risk of extinction. Warmer and more acidic seas reduce other species’ food stocks and exacerbate the deadly red-tide algal blooms that have killed incalculable numbers of fish, turtles, dolphins and other marine life. Bleaching and stony coral tissue disease linked to the climate crisis threaten to hasten the demise of the Great Florida Reef, the only living coral reef in the continental US. Encroaching saltwater has turned Big Pine Key, a crucial deer habitat, into a ghost forest.

As for the Key deer, of which fewer than 1,000 remain, volunteers leave clean drinking water to replace salt-contaminated watering holes as herds retreat to higher ground. A longer-term debate is under way on the merits and ethics of relocating the species to other areas of Florida or the US.

Coastal erosion The threat: Tourist brochures showcase miles of golden, sandy beaches in South Florida, but the reality is somewhat different. The Florida department of environmental protection deems the entire coastline from Miami to Cape Canaveral “critically eroded”, the result of sea level rise, historically high tides and especially storm surges from a succession of powerful hurricanes. In south-eastern Florida’s Palm Beach, Broward, Miami-Dade and Monroe counties, authorities are waging a continuous war on sand loss, eager to maintain their picture-perfect image and protect two of their biggest sources of income, tourism dollars and lucrative property taxes from waterfront homes and businesses.

In the devastating hurricane season just one year before, major storms named Harvey, Maria and Irma combined to cause damage estimated at $265bn. Scientists have evidence the climate crisis is causing cyclones to be more powerful, and intensify more quickly, and Florida’s position at the end of the Atlantic Ocean’s “hurricane alley” makes it twice as vulnerable as any other state.

With the other option abandoning beaches to the elements, city and county commissions have little choice but costly replenishment projects with sand replacement and jetty construction. Federal law prohibits the importation of cheaper foreign sand, so the municipalities must source a more expensive alternative from US markets, often creating friction with residents who don’t want to part with their sand. Supplementary to sand replenishment, the Nature Conservancy is a partner in a number of nature-based coastal defense projects from West Palm Beach to Miami.

benefited from 61,000 cubic yards of new sand this year at a cost of $16m. Statewide, Florida spends an average $50m annually on beach erosion.

The threat: “Climate gentrification” is a buzzword around south Florida, a region barely 6ft above sea level where land has become increasingly valuable in elevated areas. Speculators and developers are eyeing historically black, working-class and poorer areas, pushing out long-term residents and replacing affordable housing with upscale developments and luxury accommodations that only the wealthy can afford.

No study has yet calculated the overall cost of affordable housing lost to the climate crisis. Private developers will bear the expense of mitigating the impact on the neighborhood – $31m in Magic City’s case over 15 years to the Little Haiti Revitalization Trust, largely for new “green” affordable housing. The University of Miami’s housing solutions lab has a $300,000 grant from JPMorgan to report on the impact of rising seas to South Florida’s affordable housing stocks and recommend modifications to prevent it from flooding and other climate events. A collaboration of not-for-profit groups is chasing $75m in corporate funding for affordable housing along the 70-mile south Florida rail trail from Miami to West Palm Beach, with the first stage, a $5m project under way to identify, build and renovate 300 units.

Florida has long been plagued by political leadership more in thrall to the interests of big industry than the environment. As governor from 2011 to 2019, Rick Scott, now a US senator, slashed $700m from Florida’s water management budget, rolled back environmental regulations and enforcement, gave a free ride to polluters, and flip-flopped over expanding offshore oil drilling. The politician who came to be known as “Red Tide Rick”, for his perceived inaction over 2018’s toxic algae bloom outbreaks, reportedly banned the words “climate change” and “global warming” from state documents.

Last month, state legislators approved the first dedicated climate bill. It appears a promising start for a new administration, but activists say more needs to be done. In January, the Sierra Club awarded DeSantis failing grades in an environmental report card, saying he failed to protect Florida’s springs and rivers and approved new roads that threatened protected wildlife.

The cost: Florida’s spending on the environment is increasing. The state budget passed last month included $650m for Everglades restoration and water management projects (an instalment of DeSantis’s $2.5bn four-year pledge) and $100m for Florida Forever. A $100m bridge project jointly funded by the state and federal governments will allow the free flow of water under the Tamiami Trail for the first time in decades.

Florida has woken up to the threat of climate change but it is not yet clear how effective the response will be. The challenges are innumerable, the costs immense and the political will to fix or minimize the issues remains questionable, despite recent progress. At stake is the very future of one of the largest and most diverse states in the nation, in terms of both its population and its environment. Action taken now will determine its survival.