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Matti Narkia

Lack of Association between Serum Levels of 25-Hydroxyvitamin D and the Subsequent Risk... - 0 views

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    Lack of association between serum levels of 25-hydroxyvitamin D and the subsequent risk of prostate cancer in Finnish men.
    Faupel-Badger JM, Diaw L, Albanes D, Virtamo J, Woodson K, Tangrea JA.
    Cancer Epidemiol Biomarkers Prev. 2007 Dec;16(12):2784-6.
    PMID: 18086789
    doi: 10.1158/1055-9965.EPI-07-0672
Matti Narkia

Serum 25(OH)-Vitamin D Concentration and Risk of Esophageal Squamous Dysplasia - Cancer... - 0 views

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    Serum 25(OH)-vitamin D concentration and risk of esophageal squamous dysplasia.
    Abnet CC, Chen W, Dawsey SM, Wei WQ, Roth MJ, Liu B, Lu N, Taylor PR, Qiao YL.
    Cancer Epidemiol Biomarkers Prev. 2007 Sep;16(9):1889-93.
    PMID: 17855710
    doi: 10.1158/1055-9965.EPI-07-0461

    Background: Squamous dysplasia is the precursor lesion for esophageal squamous cell carcinoma, and nutritional factors play an important role in the etiology of this cancer. Previous studies using a variety of measures for vitamin D exposure have reached different conclusions about the association between vitamin D and the risk of developing esophageal cancer.

    Conclusions: Higher serum 25(OH)D concentrations were associated with significantly increased risk of squamous dysplasia. No obvious source of measured or unmeasured confounding explains this finding.

    In conclusion, we found that a higher serum 25(OH)D concentration was associated with an increased risk of esophageal squamous dysplasia, the precursor lesion for ESCC. This finding concurs with our previous prospective study which found that higher vitamin D status was associated with increased risk of incident ESCC in this same population. These unexpected findings suggest that further studies of the association of vitamin D and digestive tract cancers are needed before the effect of vitamin D in different populations can be elucidated.
Matti Narkia

Incident Invasive Breast Cancer, Geographic Location of Residence, and Reported Average... - 0 views

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    ncident invasive breast cancer, geographic location of residence, and reported average time spent outside.
    Millen AE, Pettinger M, Freudenheim JL, Langer RD, Rosenberg CA,
    Mossavar-Rahmani Y, Duffy CM, Lane DS, McTiernan A, Kuller LH, Lopez AM, Wactawski-Wende J.
    Cancer Epidemiol Biomarkers Prev. 2009 Feb;18(2):495-507. Epub 2009 Feb 3.
    PMID: 19190147
    doi: 10.1158/1055-9965.EPI-08-0652

    In conclusion, region of residence and geographic solar irradiance are not consistently related to risk of breast cancer and may not be sufficient proxy measures for sunlight/vitamin D exposure. The observed association between time spent outside and breast cancer risk support the hypothesis that vitamin D may protect against breast cancer.
Matti Narkia

Serum Levels of Vitamin D Metabolites and Breast Cancer Risk in the Prostate, Lung, Col... - 0 views

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    Serum levels of vitamin D metabolites and breast cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trial.

    Freedman DM, Chang SC, Falk RT, Purdue MP, Huang WY, McCarty CA, Hollis BW, Graubard BI, Berg CD, Ziegler RG.
    Cancer Epidemiol Biomarkers Prev. 2008 Apr;17(4):889-94. Epub 2008 Apr 1.
    PMID: 18381472
    doi: 10.1158/1055-9965.EPI-07-2594

    In this prospective study of postmenopausal women, we did not observe an inverse association between circulating 25(OH)D or 1,25(OH)2D and breast cancer risk, although we cannot exclude an association in younger women or with long-term or earlier exposure
Matti Narkia

Plasma 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D and Risk of Incident Ovarian Can... - 0 views

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    Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D and risk of incident ovarian cancer.
    Tworoger SS, Lee IM, Buring JE, Rosner B, Hollis BW, Hankinson SE.
    Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):783-8.
    PMID: 17416771
    doi: 10.1158/1055-9965.EPI-06-0981

    Overall, our results do not suggest that plasma vitamin D levels are associated with risk of ovarian cancer. However, we observed significant associations in some subgroups, which should be evaluated further in other studies because increasing vitamin D intake is an easy preventive measure to adopt.
Matti Narkia

Vitamin D Receptor Expression in Normal, Premalignant, and Malignant Human Lung Tissue ... - 0 views

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    Vitamin D receptor expression in normal, premalignant, and malignant human lung tissue.
    Menezes RJ, Cheney RT, Husain A, Tretiakova M, Loewen G, Johnson CS, Jayaprakash V, Moysich KB, Salgia R, Reid ME.
    Cancer Epidemiol Biomarkers Prev. 2008 May;17(5):1104-10.
    PMID: 18483332
    doi: 10.1158/1055-9965.EPI-07-2713

    onclusions: VDR expression spanned the lung carcinogenesis spectrum. Nuclear expression was similar across various histologies, whereas cytoplasmic expression decreased with increasing histologic grade. These results indicate that there is potential for the use of calcitriol as a chemopreventive agent against the development of lung cancer. (Cancer Epidemiol Biomarkers Prev 2008;17(5):1104-10)
Matti Narkia

Calcium, Dairy Foods, Vitamin D, and Colorectal Cancer Risk: The Fukuoka Colorectal Can... - 0 views

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    Calcium, dairy foods, vitamin D, and colorectal cancer risk: the Fukuoka Colorectal Cancer Study.
    Mizoue T, Kimura Y, Toyomura K, Nagano J, Kono S, Mibu R, Tanaka M, Kakeji Y, Maehara Y, Okamura T, Ikejiri K, Futami K, Yasunami Y, Maekawa T, Takenaka K, Ichimiya H, Imaizumi N.
    Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2800-7.
    PMID: 18843026
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