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Matti Narkia

The High Prevalence of Vitamin D Insufficiency across Australian Populations Is Only Pa... - 1 views

    The high prevalence of vitamin D insufficiency across Australian populations is only partly explained by season and latitude.
    van der Mei IA, Ponsonby AL, Engelsen O, Pasco JA, McGrath JJ, Eyles DW, Blizzard L, Dwyer T, Lucas R, Jones G.
    Environ Health Perspect. 2007 Aug;115(8):1132-9.
    PMID: 17687438
    doi: 10.1289/ehp.9937.

    Vitamin D insufficiency is common over a wide latitude range in Australia. Season appears to be more important than latitude, but both accounted for less than one-fifth of the variation in serum 25(OH)D levels, highlighting the importance of behavioral factors. Current sun exposure guidelines do not seem to fully prevent vitamin D insufficiency, and consideration should be given to their modification or to pursuing other means to achieve vitamin D adequacy.
Matti Narkia

Vitamin-D supplements benefit diabetic Indian women - 0 views

    "Women from India, Pakistan and Sri Lanka with insulin resistance showed marked improvement after taking vitamin D supplements, says a study.

    Von Hurst, nutrition lecturer at the Institute of Food, Nutrition and Human Health at Albany, conducted the study for her doctoral thesis.

    Insulin resistance is largely symptom-free and sufferers are unaware of their condition. 'Once it has fully developed into type-2 diabetes, it can be treated, but not cured,' says Von Hurst.

    Von Hurst says that while diet and exercise play a major part in the onset of type-2 diabetes, her findings reinforce the importance of vitamin D from the sun and supplements to prevent type-2 diabetes. She also found evidence of vitamin D increasing bone strength in older women.
Matti Narkia

Hypovitaminosis D in an Italian population of healthy subjects and hospitalized patient... - 0 views

    Hypovitaminosis D in an Italian population of healthy subjects and hospitalized patients.
    Romagnoli E, Caravella P, Scarnecchia L, Martinez P, Minisola S.
    Br J Nutr. 1999 Feb;81(2):133-7.
    PMID: 10450331

    The results of the present study emphasize the importance of 25-hydroxyvitamin D measurement, and the need to increase vitamin D intake in Italy; foodstuff fortification and supplement use must be considered in order to prevent negative effects of vitamin D deficiency on skeletal integrity.

    All hospitalized patients, both in summer and in winter,
    are characterized by the highest prevalence of hypovitaminosis
    D, especially the older patients. Medical
    inpatients may be at risk for vitamin D deficiency,
Matti Narkia

Low Vitamin D Status, High Bone Turnover, and Bone Fractures in Centenarians -- Passeri... - 0 views

    Low vitamin D status, high bone turnover, and bone fractures in centenarians.
    Passeri G, Pini G, Troiano L, Vescovini R, Sansoni P, Passeri M, Gueresi P, Delsignore R, Pedrazzoni M, Franceschi C.
    J Clin Endocrinol Metab. 2003 Nov;88(11):5109-15.
    PMID: 14602735

    We conclude that the extreme decades of life are characterized by a pathophysiological sequence of events linking vitamin D deficiency, low serum calcium, and secondary hyperparathyroidism with an increase in bone resorption and severe osteopenia. These data offer a rationale for the possible prevention of elevated bone turnover, bone loss, and consequently the reduction of osteoporotic fractures and fracture-induced disability in the oldest olds through the supplementation with calcium and vitamin D.
Matti Narkia

Benefits of Vitamin D Supplementation - Journal of American Physicians and Surgeons Vol... - 1 views

    Benefits of Vitamin D Supplementation
    Joel M. Kauffman, Ph.D.
    Journal of American Physicians and Surgeons
    Volume 14 Number 2 - Summer 2009

    Clinical trials show that vitamin D supplementation at higher
    levels than previously recommended is beneficial for many
    conditions. It decreases the frequency of falls and fractures, helps
    prevent cardiovascular disease, and reduces symptoms of colds or
    influenza. Benefits are also seen in diabetes mellitus, multiple
    sclerosis, Crohn disease, pain, depression, and possibly autism.
    Sunlight does not cause an overdose of vitamin D production,
    and toxicity from supplementation is rare. Dose recommendations
    are increasing, but appear to be lagging the favorable trial results. A
    number of common drugs deplete vitamin D levels, and others may
    limit its biosynthesis from sunlight.
    People with adequate levels from sun exposure will not benefit
    from supplementation. While dietary intake is helpful,
    supplementation is better able to raise serum 25-hydroxyvitamin D ,
    the major circulating metabolite, to the level now thought adequate,
    30-50 ng/mL.
    Where there is inadequate daily sun exposure, oral doses of
    1,000-2,000 IU/d are now considered routine, with much higher
    doses (up to 50,000 IU) for rapid repletion now considered safe.
Matti Narkia

Vitamin D Deficiency Lead to Disease - Dr. Weil's Weekly Bulletin - 0 views

    "If you're running low on vitamin D - as an estimated 70 percent of the U.S. population is - your immune system may not be functioning as well as it should. As a result, you may be more vulnerable to infectious diseases than you would if your vitamin D levels were optimal. Worse, you could be at higher than normal risk of a long list of diseases including heart disease and several kinds of cancer. A report recently published journal, Future Microbiology, highlighted research at the Linus Pauling Institute at Oregon State University, which has shown that vitamin D induces expression of an antimicrobial peptide gene called cathelicidin that is the "first line of defense" in the immune system's response to minor wounds, cuts and bacterial and viral infections. The regulation of cathelicidin by vitamin D could help explain its vital role in immune function. The report noted that vitamin D is a key cofactor in reducing inflammation, in blood pressure control and helping to protect against heart disease. Author Adrian Gombart explains that there is still much to explore about D's mechanisms of action, the potential use of synthetic analogs of it in new treatments, and its duty in fighting infection."
Matti Narkia

Serum 25-Hydroxyvitamin D Levels Among US Children Aged 1 to 11 Years: Do Children Need... - 0 views

    Serum 25-Hydroxyvitamin D Levels Among US Children Aged 1 to 11 Years: Do Children Need More Vitamin D?
    Mansbach JM, Ginde AA, Camargo CA Jr.
    Pediatrics. 2009 Nov;124(5):1404-1410.
    PMID: 19951983

    CONCLUSIONS: On the basis of a nationally representative sample of US children aged 1 to 11 years, millions of children may have suboptimal levels of 25(OH)D, especially non-Hispanic black and Hispanic children. More data in children are needed not only to understand better the health implications of specific serum levels of 25(OH)D but also to determine the appropriate vitamin D supplement requirements for children.
Matti Narkia

Urgent action needed to improve vitamin D status among older people in England! - [Age ... - 0 views

    Urgent action needed to improve vitamin D status among older people in England!
    Hirani V, Tull K, Ali A, Mindell J.
    Age Ageing. 2009 Nov 23. [Epub ahead of print]
    PMID: 19934073

    CONCLUSIONS: poor vitamin D status of older people continues to be a public health problem in England. Hypovitaminosis D is associated with many risk factors and poor health outcomes. There is now an urgent need for a uniform policy on assessment and dietary supplementation of vitamin D in older people to prevent poor vitamin D status and its negative consequences
Matti Narkia

Vitamin D Shows Heart Benefits in Study - Well Blog - - 0 views

    "A new study suggests many Americans aren't getting anywhere nearly enough of the vitamin, and it may be affecting their heart health.

    In the study, researchers looked at tens of thousands of healthy adults 50 and older whose vitamin D levels had been measured during routine checkups. A majority, they found, were deficient in the vitamin. About two-thirds had less vitamin D in their bloodstreams than the authors considered healthy, and many were extremely deficient.

    Less than two years later, the researchers found, those who had extremely low levels of the vitamin were almost twice as likely to have died or suffered a stroke than those with adequate amounts. They also had more coronary artery disease and were twice as likely to have developed heart failure.

    The findings, which are being presented today at an American Heart Association conference in Orlando, don't prove that lack of vitamin D causes heart disease; they only suggest a link between the two. "
Matti Narkia

Prevalence of low serum vitamin D concentration in an urban population of elderly women... - 0 views

    Prevalence of low serum vitamin D concentration in an urban population of elderly women in Poland.
    Napiórkowska L, Budlewski T, Jakubas-Kwiatkowska W, Hamzy V, Gozdowski D, Franek E.
    Pol Arch Med Wewn. 2009 Nov;119(11):699-703.
    PMID: 19920793

    CONCLUSIONS: The prevalence of low vitamin D concentrations in an urban population of elderly women in Poland is very high. Lower vitamin D levels are associated with a higher PTH concentration
Matti Narkia

Plasma calcidiol, season, and serum parathyroid hormone concentrations in healthy elder... - 0 views

    Plasma calcidiol, season, and serum parathyroid hormone concentrations in healthy elderly men and women.
    Dawson-Hughes B, Harris SS, Dallal GE.
    Am J Clin Nutr. 1997 Jan;65(1):67-71.
    PMID: 8988915

    Plasma calcidiol and serum PTH concentrations were inversely related, with PTH rising slowly as calcidiol concentrations declined below 110 nmol/L (95 CI: 60, 168 nmol/L). More than 90% of the men and women had calcidiol concentrations below this value in the wintertime. The high prevalence of lower wintertime calcidiol values may increase risk of bone loss in elderly men and women.
Matti Narkia

Vitamin D Deficiency and Seasonal Variation in an Adult South Florida Population -- Lev... - 0 views

    Vitamin d deficiency and seasonal variation in an adult South Florida population.
    Levis S, Gomez A, Jimenez C, Veras L, Ma F, Lai S, Hollis B, Roos BA.
    J Clin Endocrinol Metab. 2005 Mar;90(3):1557-62. Epub 2005 Jan 5.
    PMID: 15634725

    The prevalence of hypovitaminosis D is considerable even in southern latitudes and should be taken into account in the evaluation of postmenopausal and male osteoporosis.
Matti Narkia

Demographic Differences and Trends of Vitamin D Insufficiency in the US Population, 198... - 0 views

    Demographic differences and trends of vitamin D insufficiency in the US population, 1988-2004.
    Ginde AA, Liu MC, Camargo CA Jr.
    Arch Intern Med. 2009 Mar 23;169(6):626-32.
    PMID: 19307527

    Conclusions National data demonstrate a marked decrease in serum 25(OH)D levels from the 1988-1994 to the 2001-2004 NHANES data collections. Racial/ethnic differences have persisted and may have important implications for known health disparities. Current recommendations for vitamin D supplementation are inadequate to address the growing epidemic of vitamin D insufficiency.
Matti Narkia

Explaining multiple sclerosis prevalence by ultraviolet exposure: a geospatial analysis... - 0 views

    Explaining multiple sclerosis prevalence by ultraviolet exposure: a geospatial analysis.
    Beretich B, Beretich T.
    Mult Scler. 2009 Aug;15(8):891-8.
    PMID: 19667017
    DOI: 10.1177/1352458509105579


    This analysis suggests a strong association between UV radiation and MS distribution, and an increase in risk for MS in those areas with a low UVI.
Matti Narkia

The Role of Vitamin D in Cancer Prevention -- Garland et al. 96 (2): 252 -- American Jo... - 0 views

    The role of vitamin D in cancer prevention.
    Garland CF, Garland FC, Gorham ED, Lipkin M, Newmark H, Mohr SB, Holick MF.
    Am J Public Health. 2006 Feb;96(2):252-61. Epub 2005 Dec 27. Review.
    PMID: 16380576
    DOI: 10.2105/AJPH.2004.045260

    Vitamin D status differs by latitude and race, with residents of the northeastern United States and individuals with more skin pigmentation being at increased risk of deficiency. A PubMed database search yielded 63 observational studies of vitamin D status in relation to cancer risk, including 30 of colon, 13 of breast, 26 of prostate, and 7 of ovarian cancer, and several that assessed the association of vitamin D receptor genotype with cancer risk.

    The majority of studies found a protective relationship between sufficient vitamin D status and lower risk of cancer. The evidence suggests that efforts to improve vitamin D status, for example by vitamin D supplementation, could reduce cancer incidence and mortality at low cost, with few or no adverse effects
Matti Narkia

Prevalence and Associations of 25-Hydroxyvitamin D Deficiency in US Children: NHANES 20... - 0 views

    Prevalence and Associations of 25-Hydroxyvitamin D Deficiency in US Children: NHANES 2001-2004.
    Kumar J, Muntner P, Kaskel FJ, Hailpern SM, Melamed ML.
    Pediatrics. 2009 Aug 3. [Epub ahead of print]
    PMID: 19661054

    CONCLUSIONS: 25(OH)D deficiency is common in the general US pediatric population and is associated with adverse cardiovascular risks.
Matti Narkia

Association of low 25-hydroxyvitamin D concentrations with elevated parathyroid hormone... - 0 views

    Association of low 25-hydroxyvitamin D concentrations with elevated parathyroid hormone concentrations and low cortical bone density in early pubertal and prepubertal Finnish girls.
    Cheng S, Tylavsky F, Kröger H, Kärkkäinen M, Lyytikäinen A, Koistinen A, Mahonen A, Alen M, Halleen J, Väänänen K, Lamberg-Allardt C.
    Am J Clin Nutr. 2003 Sep;78(3):485-92. Erratum in: Am J Clin Nutr. 2006 Jan;83(1):174.
    PMID: 12936933

    CONCLUSIONS: Vitamin D-deficient girls have low cortical BMD and high iPTH concentrations, which are consistent with secondary hyperparathyroidism. A low vitamin D concentration accompanied by high bone resorption (TRAP 5b) may limit the accretion of bone mass in young girls.
Matti Narkia

Teenage girls and elderly women living in northern Europe have low winter vitamin D sta... - 0 views

    Teenage girls and elderly women living in northern Europe have low winter vitamin D status.
    Andersen R, Mølgaard C, Skovgaard LT, Brot C, Cashman KD, Chabros E, Charzewska J, Flynn A, Jakobsen J, Kärkkäinen M, Kiely M, Lamberg-Allardt C, Moreiras O, Natri AM, O'brien M, Rogalska-Niedzwiedz M, Ovesen L.
    Eur J Clin Nutr. 2005 Apr;59(4):533-41.
    PMID: 15714215

    CONCLUSION: Vitamin D status is low in northern Europe during winter. More than one-third of the adolescent girls have vitamin D status below 25 nmol/l and almost all are below 50 nmol/l. Two-thirds of the elderly community-dwelling women have vitamin D status below 50 nmol/l. Use of vitamin D supplements is a significant positive determinant for S-25OHD for both girls and women (P = 0.001). SPONSORSHIP: The European Fifth Framework Programme (Contract No. QLK1-CT-2000-00623)
Matti Narkia

Low serum 25-hydroxyvitamin D concentrations and secondary hyperparathyroidism in middl... - 0 views

    Low serum 25-hydroxyvitamin D concentrations and secondary hyperparathyroidism in middle-aged white strict vegetarians.
    Lamberg-Allardt C, Kärkkäinen M, Seppänen R, Biström H.
    Am J Clin Nutr. 1993 Nov;58(5):684-9.
    PMID: 8237875

    In conclusion, white strict vegetarians are at risk of vitamin D deficiency, at least in the winter, primarily because of a low dietary vitamin D intake, despite a normal sunlight exposure in summer. Low serum 25(OH)D concentrations are accompanied by high S-iPTH concentrations, which also are affected by a low calcium intake. The effect of these changes on bone health remains to be evaluated.
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