An international comparison of serum 25-hydroxyvitamin D measurements.
Lips P, Chapuy MC, Dawson-Hughes B, Pols HA, Holick MF.
Osteoporos Int. 1999;9(5):394-7.
PMID: 10550457
DOI: 10.1007/s001980050162
The results show that 25(OH)D values from different laboratories can not be assumed to be comparable unless a careful cross-calibration has been performed.
"This website is about Vitamin D and MS
Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS), with an uncertain cause. Colleen Hayes and Donald Achaeson have suggested that insufficient sunlight exposure and chronic viral infections might be unrelated environmental risk factors for MS. These risk factors may act synergistically to enable the pathogenic autoimmune response.
The prevalence of MS is highest where environmental supplies of vitamin D are lowest. Sunshine enables the production of vitamin D3 (VD3) in the skin. Epidemiological studies have shown that higher vitamin D blood levels are associated with lower risk, less relapses and a slower progression of multiple sclerosis. Higher vitamin D levels can be achieved in part by increased oral intake of VD3.
Optimal health requires serum 25 hydroxyvitamin D levels higher than 20 ng/ml (50 nmol/L) P Lips, 40 ng/ml (100 nmol/L) P Heaney or at least 40 ng/ml (100 nmol/L) R Vieth. "
Vitamin D status predicts physical performance and its decline in older persons.
Wicherts IS, van Schoor NM, Boeke AJ, Visser M, Deeg DJ, Smit J, Knol DL, Lips P.
J Clin Endocrinol Metab. 2007 Jun;92(6):2058-65. Epub 2007 Mar 6.
PMID: 17341569
doi:10.1210/jc.2006-1525
ONCLUSIONS: Serum 25-OHD concentrations below 20 ng/ml are associated with poorer physical performance and a greater decline in physical performance in older men and women. Because almost 50% of the population had serum 25-OHD below 20 ng/ml, public health strategies should be aimed at this group.
Higher levels of 25-hydroxyvitamin D are associated with a lower incidence of multiple sclerosis only in women.
Kragt J, van Amerongen B, Killestein J, Dijkstra C, Uitdehaag B, Polman Ch, Lips P.
Mult Scler. 2009 Jan;15(1):9-15. Epub 2008 Aug 13.
PMID: 18701572
DOI: 10.1177/1352458508095920
CONCLUSIONS: Our data suggest that higher circulating levels of 25(OH)D are associated with a lower incidence of MS and MS-related disability in women. This may imply clues to the pathogenesis of the sex difference in risk and to the nature of the environmental factors involved in MS.
Global vitamin D status and determinants of hypovitaminosis D.
Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman JA, El-Hajj Fuleihan G, Josse RG, Lips P, Morales-Torres J; on behalf of the IOF Committee of Scientific Advisors (CSA) Nutrition Working Group.
Osteoporos Int. 2009 Jun 19. [Epub ahead of print]
PMID: 19543765
CONCLUSION: Reports from across the world indicate that hypovitaminosis D is widespread and is re-emerging as a major health problem globally.
Wicherts IS, van Schoor NM, Boeke AJ, Visser M, Deeg DJ, Smit J, Knol DL, Lips P.
Vitamin D status predicts physical performance and its decline in older persons.
J Clin Endocrinol Metab. 2007 Jun;92(6):2058-65. Epub 2007 Mar 6.
PMID: 17341569 [PubMed
Depression is associated with decreased 25-hydroxyvitamin D and increased parathyroid hormone levels in older adults.
Hoogendijk WJ, Lips P, Dik MG, Deeg DJ, Beekman AT, Penninx BW.
Arch Gen Psychiatry. 2008 May;65(5):508-12.
PMID: 18458202
Conclusion The results of this large population-based study show an association of depression status and severity with decreased serum 25(OH)D levels and increased serum PTH levels in older individuals.