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These are not questions that can be answered by the development of the technologies. They require new social understandings. "What are the things we want to see happen?" Cascio asked. "What are the things we should and should not do?"

he floated five simple principles: 1. The right to self-knowledge 2. The right to self-modification 3. The right to refuse modification 4. The right to modify/refuse to modify your children 5. The right to know who has been modified

because the mutation is specific to the tumor — and can serve as a sort of beacon to properly designed immune cells — it might actually be this cancer's Achilles' heel.

treatment involves taking patients' T cells, then inserting a new gene that allows the cells to recognize the mutant protein.

the cells can be reinfused and begin their task of zeroing in on and eliminating cells with the mutation.

"It's taking an antibody, which is typically a kind of molecule that's circulating around in the blood," said Maus. "And it's fusing it to proteins that will cross the membrane and that then will signal to T cells to replicate and kill."

They were right about control but wrong about the controllers. Our Internet handlers, not government, are using operant conditioning to modify our behavior today.

we now know how to design cue, activity, and reward systems to more effectively leverage our brain chemistry and program human behavior.

The beauty of the Internet is that by combining big data, behavioral targeting, wearable and mobile devices, and GPS, application developers can design more effective operant conditioning environments and keep us in virtual Skinner boxes as long as we have a smart phone in our pockets.

Operant conditioning techniques will and are currently being used to program the behavior of susceptible Internet users -- young men who play MMORPG (Massively Multiplayer Online Role-Playing Games) for forty hours a week, women who commit hours to social networks, shoppers seeking the thrill of a deal, and poker players.

As smart devices become integrated into our lives, retailers who will know where we are standing in stores and fast food restaurants and bars will find ways to provide us with cues to trigger behaviors.

The real question is how many hundreds of millions of us will become susceptible to what I believe will prove to be history's most potent marketing techniques.

But perhaps the paper by Liao, Sandberg and Roache will turn out to be a prank played on the journal, like the Sokal hoax, named after the physicist whose paper deploying post-modern gobbledegook to show that “quantum gravity is a social and linguistic construct” was published in a cultural studies journal.

It’s easy to imagine academics sitting around swapping the most outrageous solutions to climate change and then daring one another to have them published. I hope this will turn out to be the case. In the meantime I cringe at the thought of what the long-dead giants of Western philosophy would make of their discipline’s response to the climate crisis.

There are plenty of theories, of course, especially regarding why: increasingly complex social networks, a culture built around tool use and collaboration, the challenge of adapting to a mercurial and often harsh climate

Although these possibilities are fascinating, they are extremely difficult to test.

“What kinds of mutations occurred, and what did they do? We’re starting to get answers and a deeper appreciation for just how complicated this process was.”

contrary to long-standing assumptions, larger mammalian brains do not always have more neurons, and the ones they do have are not always distributed in the same way.

The human brain has 86 billion neurons in all: 69 billion in the cerebellum, a dense lump at the back of the brain that helps orchestrate basic bodily functions and movement; 16 billion in the cerebral cortex, the brain’s thick corona and the seat of our most sophisticated mental talents, such as self-awareness, language, problem solving and abstract thought; and 1 billion in the brain stem and its extensions into the core of the brain

In contrast, the elephant brain, which is three times the size of our own, has 251 billion neurons in its cerebellum, which helps manage a giant, versatile trunk, and only 5.6 billion in its cortex

primates evolved a way to pack far more neurons into the cerebral cortex than other mammals did

The great apes are tiny compared to elephants and whales, yet their cortices are far denser: Orangutans and gorillas have 9 billion cortical neurons, and chimps have 6 billion. Of all the great apes, we have the largest brains, so we come out on top with our 16 billion neurons in the cortex.

Although it makes up only 2 percent of body weight, the human brain consumes a whopping 20 percent of the body’s total energy at rest. In contrast, the chimpanzee brain needs only half that.

there was a strong evolutionary pressure to modify the human regulatory regions in a way that sapped energy from muscle and channeled it to the brain.

Accounting for body size and weight, the chimps and macaques were twice as strong as the humans. It’s not entirely clear why, but it is possible that our primate cousins get more power out of their muscles than we get out of ours because they feed their muscles more energy. “Compared to other primates, we lost muscle power in favor of sparing energy for our brains,” Bozek said. “It doesn’t mean that our muscles are inherently weaker. We might just have a different metabolism.

a pioneering experiment. Not only were they going to identify relevant genetic mutations from our brain’s evolutionary past, they were also going to weave those mutations into the genomes of lab mice and observe the consequences.

Silver and Wray introduced the chimpanzee copy of HARE5 into one group of mice and the human edition into a separate group. They then observed how the embryonic mice brains grew.

After nine days of development, mice embryos begin to form a cortex, the outer wrinkly layer of the brain associated with the most sophisticated mental talents. On day 10, the human version of HARE5 was much more active in the budding mice brains than the chimp copy, ultimately producing a brain that was 12 percent larger

“It wasn’t just a couple mutations and—bam!—you get a bigger brain. As we learn more about the changes between human and chimp brains, we realize there will be lots and lots of genes involved, each contributing a piece to that. The door is now open to get in there and really start understanding. The brain is modified in so many subtle and nonobvious ways.”

As recent research on whale and elephant brains makes clear, size is not everything, but it certainly counts for something. The reason we have so many more cortical neurons than our great-ape cousins is not that we have denser brains, but rather that we evolved ways to support brains that are large enough to accommodate all those extra cells.

There’s a danger, though, in becoming too enamored with our own big heads. Yes, a large brain packed with neurons is essential to what we consider high intelligence. But it’s not sufficient

No matter how large the human brain grew, or how much energy we lavished upon it, it would have been useless without the right body. Three particularly crucial adaptations worked in tandem with our burgeoning brain to dramatically increase our overall intelligence: bipedalism, which freed up our hands for tool making, fire building and hunting; manual dexterity surpassing that of any other animal; and a vocal tract that allowed us to speak and sing.

Human intelligence, then, cannot be traced to a single organ, no matter how large; it emerged from a serendipitous confluence of adaptations throughout the body. Despite our ongoing obsession with the size of our noggins, the fact is that our intelligence has always been so much bigger than our brain.

The technique holds the power to repair or enhance any human gene. “It raises the most fundamental of issues about how we are going to view our humanity in the future and whether we are going to take the dramatic step of modifying our own germline and in a sense take control of our genetic destiny, which raises enormous peril for humanity,”

The paper’s authors, however, are concerned about countries that have less regulation in science. They urge that “scientists should avoid even attempting, in lax jurisdictions, germline genome modification for clinical application in humans” until the full implications “are discussed among scientific and governmental organizations.”

Though such a moratorium would not be legally enforceable and might seem unlikely to exert global influence, there is a precedent. In 1975, scientists worldwide were asked to refrain from using a method for manipulating genes, the recombinant DNA technique, until rules had been established.

Though highly efficient, the technique occasionally cuts the genome at unintended sites. The issue of how much mistargeting could be tolerated in a clinical setting is one that Dr. Doudna’s group wants to see thoroughly explored before any human genome is edited.

“We worry about people making changes without the knowledge of what those changes mean in terms of the overall genome,” Dr. Baltimore said. “I personally think we are just not smart enough — and won’t be for a very long time — to feel comfortable about the consequences of changing heredity, even in a single individual.”

Many ethicists have accepted the idea of gene therapy, changes that die with the patient, but draw a clear line at altering the germline, since these will extend to future generations. The British Parliament in February approved the transfer of mitochondria, small DNA-containing organelles, to human eggs whose own mitochondria are defective. But that technique is less far-reaching because no genes are edited.

There are two broad schools of thought on modifying the human germline, said R. Alta Charo, a bioethicist at the University of Wisconsin and a member of the Doudna group. One is pragmatic and seeks to balance benefit and risk. The other “sets up inherent limits on how much humankind should alter nature,” she said. Some Christian doctrines oppose the idea of playing God, whereas in Judaism and Islam there is the notion “that humankind is supposed to improve the world.” She described herself as more of a pragmatist, saying, “I would try to regulate such things rather than shut a new technology down at its beginning.

The Doudna group calls for public discussion, but is also working to develop some more formal process, such as an international meeting convened by the National Academy of Sciences, to establish guidelines for human use of the genome-editing technique.“We need some principled agreement that we want to enhance humans in this way or we don’t,” Dr. Jaenisch said. “You have to have this discussion because people are gearing up to do this.”

A digestible portion of Gary’s thinking on his work and career can be found at 3AM Magazine in this 2012 interview with Richard Marshall. And this quote from that talk is as good as any to return to now, as a reminder of the continual work he saw as necessary for remaining true to both ourselves and to the world around us: “Our fundamental beliefs don’t need intellectual justification, but they do need intellectual maintenance. We need to understand their implications, modify them to eliminate internal contradictions, defend and perhaps modify them in response to objections.”

The researchers note that only a few modifier genes of disease mutations such as Ankrd16 have been identified and a modifier-based mechanism for understanding the underlying pathology of neurodegenerative diseases may be a promising route to understand disease development.

A small percentage of the public believes that vaccines are truly dangerous. People who hold this view — which is incorrect — also believe that they know more than experts about this topic.

the study was also conducted in France and Germany, with similar results.

those with the least understanding of science had the most science-opposed views, but thought they knew the most

Many Americans take supplements, but the reasons are varied and are not linked to any hard evidence

Most of them say they are unaffected by claims from experts contradicting the claims of manufacturers. Only a quarter said they would stop using supplements if experts said they were ineffective. They must think they know better.

the Dunning-Kruger effect, named for the two psychologists who wrote a seminal paper in 1999 entitled “Unskilled and Unaware of It.”

A lack of knowledge leaves some without the contextual information necessary to recognize mistakes, they wrote, and their “incompetence robs them of the ability to realize it.”

communication strategies on G.M.O.s — intended to help the public see that their beliefs did not align with experts — wound up backfiring

attempting to provide corrective information to voters about death panels wound up increasing their belief in them among politically knowledgeable supporters of Sarah Palin.

A 2015 study published in Vaccine showed that giving corrective information about the flu vaccine led patients most concerned about side effects to be less likely to get the vaccine.

“knowledge deficit model,” an idea that the lack of support for good policies, and good science, merely reflects a lack of scientific information.

Scientists need to be formally trained in communication skills, they said, and they also need to realize that the knowledge deficit model makes for easy policy, but not necessarily good results.

It seems important to engage the public more, and earn their trust through continued, more personal interaction, using many different platforms and technologies

Bombarding people with more information about studies isn’t helping. How the information contained in them is disseminated and discussed may be much more important.

This is just one more indication that the Times can’t tell the difference between real news and fake news. Earlier today, the paper had to recant because it reported an obviously fake tweet as news.

The New York Times, overwhelmed by ignorance and bias, may have arrived at that juncture.

Recreating these and other features without LCDM’s titular ingredient, Spergel showed, requires the finest of theoretical needle threading. “We haven’t disproven the existence of all these [modified-gravity theories],” he says. “But any alternative theory has to jump through these hoops.”

Złosnik and Skordis believe they’ve done just that—although in a way that might surprise MOND skeptics and fans alike. They managed to construct a theory of gravity that contains an ingredient that acts exactly like an invisible form of matter on cosmic scales, blurring the line between the dark matter and MOND paradigms.

Their theory, dubbed RelMOND, adds to the equations of general relativity an omnipresent field that behaves differently in different arenas. On the grandest scales, where the universe noticeably stretches as it expands, the field acts like invisible matter. In this mode, which Złosnik calls “dark dust,” the field could have shaped the visible universe just as dark matter would

RelMOND “cannot do worse than LCDM,” says Złosnik, who notes that it very closely mimics that theory for the universe as a whole.

But if we zoom in on a galaxy, where the fabric of space holds rather still, the field acts in a way that’s true to its MOND roots: It entwines itself with the standard gravitational field, beefing it up just enough to hold a galaxy together without extra matter

(The researchers aren’t yet sure how the field acts for larger clusters of galaxies, a perennial MOND sore spot. They suggest that this intermediate scale might be a good place to look for observational clues that could set the theory apart.)

Despite this mathematical achievement by Złosnik and Skordis, dark matter remains the simpler theory. Constructing the new field takes four new moving mathematical parts, while LCDM handles dark matter with just one. Hooper likens the situation to a detective debating whether a person at a murder scene is the murderer or has been framed by the CIA. Even if the available evidence matches both theories, one requires less of a leap.

Moreover, when they attempt to give their expert knowledge for policy decisions, conservatives will choose to ignore the evidence, claiming a liberal bias.

most of the bad news is the potential impact on scientists. Why? Because scientists, he believes -- once perceived by Republicans to be a Democratic interest group -- will lose bipartisan support for federal science funding.

this sort of thinking might well be bad for scientists, but is simply dangerous for the country. As professionals, scientists should not be put into a subservient place by politicians and ideologues. They should never be felt that their advice might well be attached to carrots or sticks.

Political choices can be made after the evidence is presented, but the evidence should stand for what it is. If the evidence itself is rejected by politicians -- as is currently going on -- then the ignorance of the political class should indeed be exposed, and all threats resisted.

This might seem to be a diatribe against conservatives. But really this criticism is aimed at all unscientific thinking.

there are a number on the left who have their own dogmatic beliefs; the most notable are unscientific theories with regard to the dangers of vaccinations, genetically modified produce, or nuclear energy.

What you do is to take the different bits of material which you have gathered and feel them all over, as it were, with the tentacles of the mind. You take one fact, turn it this way and that, look at it in different lights, and feel for the meaning of it. You bring two facts together and see how they fit. What you are seeking now is the relationship, a synthesis where everything will come together in a neat combination, like a jig-saw puzzle.

Then and only then, Young promises, everything will click in the fourth stage of the seemingly serendipitous a-ha! moment: Out of nowhere the Idea will appear. It will come to you when you are least expecting it

In his third stage of the creative process, Young stresses the importance of making absolutely “no effort of a direct nature”: It is important to realize that this is just as definite and just as necessary a stage in the process as the two preceding ones. What you have to do at this time, apparently, is to turn the problem over to your unconscious mind and let it work while you sleep.

[W]hen you reach this third stage in the production of an idea, drop the problem completely and turn to whatever stimulates your imagination and emotions. Listen to music, go to the theater or movies, read poetry or a detective story.

articulates the increasing importance of quality information filters in our modern information diet. This notion of gathering raw material is the first step in his outline of the creative process:

Young calls the last stage “the cold, gray dawn of the morning after,” when your newborn idea has to face reality: It requires a deal of patient working over to make most ideas fit the exact conditions, or the practical exigencies, under which they must work. And here is where many good ideas are lost. The idea man, like the inventor, is often not patient enough or practical enough to go through with this adapting part of the process. But it has to be done if you are to put ideas to work in a work-a-day world. Do not make the mistake of holding your idea close to your chest at this stage. Submit it to the criticism of the judicious. When you do, a surprising thing will happen. You will find that a good idea has, as it were, self-expanding qualities. It stimulates those who see it to add to it. Thus possibilities in it which you have overlooked will come to light.

what’s perhaps most interesting is the following note he made to the postscript of a reprint: From my own further experience in advertising, government, and public affairs I find no essential points which I would modify in the idea-producing process. There is one, however, on which I would put greater emphasis. This is as to the store of general materials in the idea-producer’s reservoir. […] I am convinced, however, that you gather this vicarious experience best, not when you are boning up on it for an immediate purpose, but when you are pursuing it as an end in itself.

Even more than what you think, how you think matters. The stakes for understanding this could not be higher than they are today, because we are not just battling for what it means to be scientists. We are battling for what it means to be citizens.

Just as the loss of a species decreases the richness of an ecosystem, the addition of new animals could achieve the opposite effect.

National Geographic Society hosted a larger conference to debate the scientific and ethical questions raised by the prospect of “de-extinction.

“De-extinction went from concept to potential reality right before our eyes,

“This may be the biggest attraction and possibly the biggest benefit of de-extinction. It would surely be very cool to see a living woolly mammoth.”

less scientific, if more persuasive, argument was advanced by the ethicist Hank Greely and the law professor Jacob Sherkow, both of Stanford. De-extinction should be pursued, they argued in a paper published in Science, because it would be really

They will replace chunks of band-tailed-pigeon DNA with synthesized chunks of passenger-pigeon DNA, until the cell’s genome matches their working passenger-pigeon genome.

Scientists predict that changes made by human beings to the composition of the atmosphere could kill off a quarter of the planet’s mammal species, a fifth of its reptiles and a sixth of its birds by 2050

This cloning method, called somatic cell nuclear transfer, can be used only on species for which we have cellular material.

There is a shortcut. The genome of a closely related species will have a high proportion of identical DNA, so it can serve as a blueprint, or “scaffold.”

By comparing the fragments of passenger-pigeon DNA with the genomes of similar species, researchers can assemble an approximation of an actual passenger-pigeon genome.

“We’ve framed it in terms of conservation,”

the genome will have to be inscribed into a living cell.

As with any translation, there may be errors of grammar, clumsy phrases and perhaps a few missing passages, but the book will be legible. It should, at least, tell a good story.

MAGE (Multiplex Automated Genome Engineering). MAGE is nicknamed the “evolution machine” because it can introduce the equivalent of millions of years of genetic mutations within minutes

Developmental and behavioral biologists would take over, just in time to answer some difficult questions. Chicks imitate their parents’ behavior. How do you raise a passenger pigeon without parents of its own species? And how do you train band-tailed pigeons to nurture the strange spawn that emerge from their eggs; chicks that, to them, might seem monstrous: an avian Rosemary’s Baby?

For endangered species with tiny populations, scientists would introduce genetic diversity to offset inbreeding.

They will try to alter the birds’ diets, migration habits and environment. The behavior of each subsequent generation will more closely resemble that of their genetic cousins.

“There’s always this fear that somehow, if we do it, we’re going to accidentally make something horrible, because only nature can really do it right. But nature is totally random. Nature makes monsters. Nature makes threats. Many of the things that are most threatening to us are a product of nature. Revive & Restore is not going to tip the balance in any way.”

For species threatened by contagion, an effort would be made to fortify their DNA with genes that make them disease-resistant

This optimistic, soft-focus fantasy of de-extinction, while thrilling to Ben Novak, is disturbing to many conservation biologists, who consider it a threat to their entire discipline and even to the environmental movement.

The first question posed by conservationists addresses the logic of bringing back an animal whose native habitat has disappeared. Why go through all the trouble just to have the animal go extinct all over again?

There is also anxiety about disease

“If you recreate a species genetically and release it, and that genotype is based on a bird from a 100-year-old environment, you probably will increase risk.”

The scientific term for this type of genetic intervention is “facilitated adaptation.”

De-extinction also poses a rhetorical threat to conservation biologists. The specter of extinction has been the conservation movement’s most powerful argument. What if extinction begins to be seen as a temporary inconvenience?

De-extinction suggests that we can technofix our way out of environmental issues generally, and that’s very, very bad.

How will we decide which species to resurrect?

Philip Seddon recently published a 10-point checklist to determine the suitability of any species for revival, taking into account causes of its extinction, possible threats it might face upon resurrection and man’s ability to destroy the species “in the event of unacceptable ecological or socioeconomic impacts.”

But the most visceral argument against de-extinction is animal cruelty.

“Is it fair to do this to these animals?” Shapiro asked. “Is ‘because we feel guilty’ a good-enough reason?” Stewart Brand made a utilitarian counterargument: “We’re going to go through some suffering, because you try a lot of times, and you get ones that don’t take. On the other hand, if you can bring bucardos back, then how many would get to live that would not have gotten to live?”

In “How to Permit Your Mammoth,” published in The Stanford Environmental Law Journal, Norman F. Carlin asks whether revived species should be protected by the Endangered Species Act or regulated as a genetically modified organism.

He concludes that revived species, “as products of human ingenuity,” should be eligible for patenting.

The term “de-extinction” is misleading. Passenger pigeons will not rise from the grave

Our understanding of the passenger pigeon’s behavior derives entirely from historical accounts.

There is no authoritative definition of “species.” The most widely accepted definition describes a group of organisms that can procreate with one another and produce fertile offspring, but there are many exceptions.

Theseus’ ship, therefore, “became a standing example among the philosophers . . . one side holding that the ship remained the same, and the other contending that it was not the same.”

What is coming will go well beyond the resurrection of extinct species. For millenniums, we have customized our environment, our vegetables and our animals, through breeding, fertilization and pollination. Synthetic biology offers far more sophisticated tools. The creation of novel organisms, like new animals, plants and bacteria, will transform human medicine, agriculture, energy production and much else.

what exercize and diet and sleep do for the body, thought and practice and sleep do for the brain. And when this kind of practice of something becomes effortless, when it becomes second nature, instinctual, it becomes part of you and you of it. You simply cannot describe the great skill of a craftsman, or a cook, or a priest, or an artist except by observing how he or she has become what she creates and does.

where the idea and the practice and the person simply become one, human activity takes flight. It becomes integral.

"We waited for a full match but it did not come. By the grace of God, we took the decision to have the treatment.

There are currently about 1,600 people in the UK waiting for a bone-marrow transplant and 37,000 worldwide.

Compared with five years ago, both citizens and scientists are less upbeat about the scientific enterprise. Citizens are still broadly positive about the place of U.S. scientific achievements and its impact on society, but slightly more are negative than five years ago. And, while a majority of scientists think it is a good time for science, they are less upbeat than they were five years ago.

While a majority of the public sees U.S. scientific achievements in positive terms, the share saying U.S. scientific achievements are the best in the world or above average is down 11 points to 54% today, compared with 65% in 2009.

The largest differences between the public and the AAAS scientists are found in beliefs about the safety of eating genetically modified (GM) foods.