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margogramiak

New Hampshire Woman Gets New Face For Second Time In 10 Years | HuffPost - 1 views

www.huffpost.com/...ant_n_5f2da3d8c5b6e96a22b255ac

shared by margogramiak on 03 Nov 20 - No Cached
  • has a new face.
  • has a new face.
    • margogramiak
      margogramiak on 03 Nov 20
       
      face transplant?
  • The transplant from an anonymous donor took place at Boston’s Brigham and Women’s Hospital in July.
    • margogramiak
      margogramiak on 03 Nov 20
       
      I know a little bit about these surgeries. They are revolutionary!
  • ...14 more annotations...
  • whose face was disfigured in an attack by her ex-husband,
    • margogramiak
      margogramiak on 03 Nov 20
       
      :(
  • More than 40 patients worldwide have received face transplants, including 16 in the United States. None of the American patients had lost their donor faces until Tarleton.
    • margogramiak
      margogramiak on 03 Nov 20
       
      So few people.
  • She really got lucky.”
    • margogramiak
      margogramiak on 03 Nov 20
       
      good for her. She deserved to be lucky.
  • rejected his donor face eight years after his first transplant underwent a second
    • margogramiak
      margogramiak on 03 Nov 20
       
      I don't know anything about this stuff, but that seems like a very delayed rejection.
  • She really wanted to try one more time,” said Pomahac, who led the 20-hour, second surgery. A team of around 45 clinicians removed the failing transplant and then prepared sensory nerves and blood vessels in the neck for the surgical connection. The face was then transplanted and Tarleton will gain sensory and motor function in the coming months.
    • margogramiak
      margogramiak on 03 Nov 20
       
      wow!
  • a much better tissue match.
    • margogramiak
      margogramiak on 03 Nov 20
       
      What constitutes a good match? Blood type? Skin tone? What are important factors?
  • “The pain I had is gone,” she said. “It’s a new chapter in my life. I’ve been waiting for almost a year. I’m really happy. It’s what I needed. I got a great match.”
    • margogramiak
      margogramiak on 03 Nov 20
       
      Awww I'm so happy for her!
  • “When you look at most organ transplants, there is a shelf life,” Gastman said. “We are getting to the point where these face transplantations are hitting against the maximum number of years someone can have one in.”
    • margogramiak
      margogramiak on 03 Nov 20
       
      The transplant surgeries are so new that they are now seeing how long they last.
  • Tarleton was burned on over 80% of her body and blinded in 2007 when her estranged husband, Herbert Rodgers, beat her with a baseball bat and doused her body with lye because he thought she was seeing another man.
    • margogramiak
      margogramiak on 03 Nov 20
       
      Oh my gosh. I'm glad she gets this new opportunity.
  • The first transplant transformed Tarleton’s life.
    • margogramiak
      margogramiak on 03 Nov 20
       
      I'm sure it did. So many people take "normal" appearances for granted.
  • don’t get stared at so easily.”
    • margogramiak
      margogramiak on 03 Nov 20
       
      I can't imagine having to think about that.
  • She was added back on when the state allowed elective surgeries to resume.
    • margogramiak
      margogramiak on 03 Nov 20
       
      Must be very recent!
  • But by last year, the face was failing. She began experiencing scarring, tightness and pain because of a loss of blood flow to her face. Black patches appeared on her face. Her eyelids contracted and her lips began disappearing, making it difficult to eat. She was mostly housebound and resumed taking strong pain medications.
    • margogramiak
      margogramiak on 03 Nov 20
       
      If they didn't do another transplant, what would another remedy be?
  • “It is strange. I am not going to lie,” she added. “I’ll have to get used to it. My sister will have to get used to it. It takes a while for my friends and family to get used to what I look like now.”
    • margogramiak
      margogramiak on 03 Nov 20
       
      I can't imagine my whole appearance changing on a dime.
grayton downing

BBC News - First human trial of new bone-marrow transplant method - 0 views

www.bbc.co.uk/...health-24609025

human trial transplant science

shared by grayton downing on 22 Oct 13 - No Cached
  • Doctors at London's Great Ormond Street Hospital have carried out a pioneering bone-marrow transplant technique.
  • Mohammed Ahmed, who is nearly five years old, was among the first three children in the world to try out the new treatment.
  • Mohammed's doctors then modified these donated immune cells, called "T-cells", in the lab to engineer a safety switch - a self-destruct message that could be activated if Mohammed's body should start to reject them once transplanted.
  • ...2 more annotations...
  • "We waited for a full match but it did not come. By the grace of God, we took the decision to have the treatment.
  • There are currently about 1,600 people in the UK waiting for a bone-marrow transplant and 37,000 worldwide.
aqconces

What it will take for a head transplant to work - The Washington Post - 0 views

www.washingtonpost.com/...-for-a-head-transplant-to-work

shared by aqconces on 08 Mar 15 - No Cached
  • Sergio Canavero, an Italian neurosurgeon at the Turin Advanced Neuromodulation Group who has claimed that advances in medical science now make it possible to carry out head transplants that would allow patients to not only survive, but function normally
  • “I think we are now at a point when the technical aspects are all feasible,” Canavero told New Scientist.
  • While expert opinions on Canavero’s claims vary, the possibility isn’t as far fetched as it sounds. James Harrop, director of Adult Reconstructive Spine at Thomas Jefferson University in Philadelphia and co-editor of Congress of Neurological Surgeons, says that the kind of complications the surgeons faced back in 1970 could easily be fixed using today’s methods.
  • ...1 more annotation...
  • “Technically it’s not any harder than a liver and heart transplant,” he says
grayton downing

Opinion: I Want My Kidney | The Scientist Magazine® - 0 views

www.the-scientist.com/?articles.view/articleNo/38154/title/Opinion--I-Want-My-Kidney/

kidney science research

shared by grayton downing on 11 Nov 13 - No Cached
  • Indeed,10 years ago, one of Atala's young patients, Luke Massella, received an engineered bladder made using similar technology.
  • human kidney, albeit non-functional, takes us a step closer to utilizing the enormous potential of stem cells from different sources.
  • disorders can contribute to end-stage renal disease, which is the main indicator for kidney transplantation. Diabetes alone, which is on the rise the world over, is the major cause, responsible for more than 40 percent of all end-stage renal disease cases in need of kidney transplant
  • ...1 more annotation...
  • Research on differentiated kidney cells, particularly podocytes that can be cultured in the lab, may hold some answers. Although there are a few human- and mouse-derived cell lines that potentially differentiate into functional podocytes, there is a need for better cell lines and systems that mimic the in vivo situation more closely
qkirkpatrick

New test uses a single drop of blood to reveal entire history of viral infections | Sci... - 0 views

www.theguardian.com/...re-history-of-viral-infections

science knowledge technology

shared by qkirkpatrick on 05 Jun 15 - No Cached
  • Researchers have developed a cheap and rapid test that reveals a person’s full history of viral infections from a single drop of blood.
  • The test allows doctors to read out a list of the viruses that have infected, or continue to infect, patients even when they have not caused any obvious symptoms. The technology means that GPs could screen patients for all of the viruses capable of infecting people
  • When a droplet of blood from a patient is mixed with the modified viruses, any antibodies they have latch on to human virus proteins they recognise as invaders. The scientists then pull out the antibodies and identify the human viruses from the protein fragments they have stuck to.
  • ...2 more annotations...
  • In a demonstration of the technology, the team analysed blood from 569 people in the US, South Africa, Thailand and Peru. The test found that, on average, people had been infected with 10 species of viruses, though at least two people in the trial had histories of 84 infections from different kinds of viruses.
  • The test could bring about major benefits for organ transplant patients. One problem that can follow transplant surgery is the unexpected reawakening of viruses that have lurked inactive in the patient or donor for years. These viruses can return in force when the patient’s immune system is suppressed with drugs to prevent them rejecting the organ. Standard tests often fail to pick up latent viruses before surgery, but the VirScan procedure could reveal their presence and alert doctors and patients to the danger.
  • qkirkpatrick on 05 Jun 15
     
    How can new technology revolutionize medicine and curing people of diseases?
Lucy Yeatman

Recent Developments in Health and Science News - NYTimes.com - 0 views

www.nytimes.com/...n-health-and-science-news.html

science knowledge technology

shared by Lucy Yeatman on 31 Jan 13 - No Cached
  • Wednesday in Science
  • as young as 1 ½ can guess what other people are thinking
  • helping people manage their time
  • ...7 more annotations...
  • be making it harde
  • that doesn’t fit the way they think and work
  • swallowing five shops and one building
  • provided financial support to both an aging parent and a child
  • growth rates have slowed dramaticall
  • received a double-arm transplant said he hated living without arms
  • lost for a while
sissij

New Prospects for Growing Human Replacement Organs in Animals - The New York Times - 0 views

www.nytimes.com/...chimera-stemcells-organs.html

new york times science research

shared by sissij on 28 Jan 17 - No Cached
  • For the first time, biologists have succeeded in growing human stem cells in pig embryos, shifting from science fiction to the realm of the possible the idea of developing human organs in animals for later transplant.
  • Since the organ would be made of a patient’s own cells, there would be little risk of immune rejection.
  • They would be generated by implanting human stem cells into an early pig embryo, resulting in an animal composed of mixed pig and human cells.
  • ...5 more annotations...
  • The two reports together establish the feasibility of trying to grow replacement human organs in animals, though such a goal is still far off.
  • Creating chimeras, especially those with human cells, may prove controversial, given the possibility that test animals could be humanized in undesirable ways. One would be if human cells should be incorporated into a pig’s brain, endowing it with human qualities. Almost no one wants a talking pig.
  • The ban is still in place, and it’s unclear whether the Trump administration would continue to consider lifting the moratorium or whether new objections would be raised to using public funds for this line of research.
  • But no one knows exactly what sequence of chemicals is required for the generation of each different tissue or organ. This may be why glassware experiments with stem cells have not yet lived up to their full promise.
  • Concern about human cells’ incorporation into a lower animal’s brain is not without basis. Dr. Steven Goldman of the University of Rochester Medical Center found in 2013 that mice injected with a special type of human brain cell had enhanced learning abilities.
  • sissij on 28 Jan 17
     
    The ethics in biology is always a controversial issue in the research. In biology, we want to get as close to the truth as we possibly can, but that sometimes means that we have to research on things that are considered to be inhumane. This article talks about a new possibility that we can grow human stem cells in animals. That would lead to a potential problem of animals gaining intelligence. If animals start to have human properties, how would we treat them? Will they be a threat to our identity? And also, through the experiment described in the article, we can see that the scientific method in biology is dealing with probabilism and population. It is always gathering data. They are always ready for exceptions. --Sissi (1/28/2017)
Emily Horwitz

News from The Associated Press - 0 views

hosted.ap.org/...US_SCI_STEM_CELLS_DEAFNESS

science ethics AP knowledge research stem cells

shared by Emily Horwitz on 13 Sep 12 - No Cached
  • For the first time, scientists have improved hearing in deaf animals by using human embryonic stem cells, an encouraging step for someday treating people with certain hearing disorders.
  • it will be years before human patients might benefit.
  • Human embryonic stem cells can be manipulated to produce any type of cell. Using them is controversial because they are initially obtained by destroying embryos.
  • ...1 more annotation...
  • Yehoash Raphael of the University of Michigan, who didn't participate in the work, said it's possible the stem cell transplants worked by stimulating the gerbils' own few remaining nerve cells, rather than creating new ones. But either way, "this is a big step forward in use of stem cells for treating deafness," he said.
anonymous

Paying kidney donors would save money, study concludes | CTV News - 1 views

www.ctvnews.ca/...oney-study-concludes-1.1513134

health ethics

shared by anonymous on 28 Oct 13 - No Cached
  • Some say the research raises ethical and legal questions
  • “The buying and selling of organs for transplantation is illegal everywhere, and it should remain illegal,” ethicist Arthur Schafer said in an interview with CTV News
  • And some suggest that moving to a paid donation system would mean the most needy would be the most likely to sell kidneys. “You’re probably going to likely attract the poorest segment of society,” said Dr. Jeff Zaltzman, a scientist at St. Michael’s Hospital in Toronto. “People of more substantial means would not do that for $10,000.”
anonymous

Gene Therapy Creates Replacement Skin to Save a Dying Boy - The New York Times - 1 views

www.nytimes.com/...gene-therapy-skin-graft.html

science research knowledge technology health

shared by anonymous on 09 Nov 17 - No Cached
  • The boy in the Nature article had suffered since birth from blisters all over his body, and in 2015 contracted bacterial infections that caused him to lose two-thirds of his skin. His doctors did not know how to treat him, other than keeping him on morphine for the pain.
  • Doctors in the burn unit tried everything: antibiotics, bandages, special nutritional measures, a skin transplant from the boy’s father. Nothing worked.
  • The doctors removed a sample of the boy’s skin — slightly more than half a square inch — and took it to Modena, where they genetically engineered his cells, using a virus to insert the normal form of his mutated gene into his DNA.Then they grew the engineered cells in the laboratory into sheets of skin and transported them back to Germany, where surgeons grafted them onto the boy’s body.In October 2015, they covered his arms and legs with the new skin, and in November, his back. Ultimately, they replaced 80 percent of the child’s skin.
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  • A major concern with any type of gene therapy is that the inserted genetic material could have dangerous side effects, like turning off an essential gene or turning on one that could lead to cancer.
anonymous

The Perseverance of New York City's Wildflowers - The New York Times - 0 views

www.nytimes.com/...new-york-flowers-spring.html

shared by anonymous on 26 Mar 21 - No Cached
  • The Perseverance of New York City’s Wildflowers
  • A park in Williamsburg awaits the miniature beauty of its spring blossoms.
  • In Williamsburg, on a seven-acre park by the East River, spring will soon unfurl in blue blossoms
  • ...21 more annotations...
  • Cornflowers are always the first to bloom in the pollinator meadow of Marsha P. Johnson State Park, a welcome sign to bees and people that things are beginning to thaw.
  • If New York City has a warm spring, the cornflowers may open up by late April, eventually followed by orange frills of butterfly milkweed, purple spindly bee balm and yolk-yellow, black-eyed Susans that also inhabit the meadow — hardy species that can weather the salty spray that confronts life on the waterfront.
  • Not all of these flowers are native to New York, or even North America, but they have sustained themselves long enough to become naturalized
  • These species pose little threat to native wildlife, unlike more domineering introduced species such as mugwort, an herb with an intrepid rhizome system.
  • A wildflower can refer to any flowering plant that was not cultivated, intentionally planted or given human aid, yet it still managed to grow and bloom.
  • This is one of several definitions offered by the plant ecologist Donald J. Leopold in Andrew Garn’s new photo book “Wildflowers of New York City,” and one that feels particularly suited to the city and its many transplants.
  • Scarlet bee balm.
  • Ms. Lopez, who grew up on the Upper West Side near a sooty smokestack, has always longed for more green spaces in the city.
  • In February of 2020, Gov. Andrew Cuomo renamed the park after the activist Marsha P. Johnson, one of the central figures of the Stonewall riots and a co-founder of Street Transvestite Action Revolutionaries with the activist Sylvia Rivera. Ms. Johnson, who died in 1992 of undetermined causes, would have turned 75 in August 2020.
  • Mr. Garn did not intend for “Wildflowers of New York City” to be a traditional field guide for identifying flowers. Rather, his reverent portraits invite us to delight in the beauty of flowers that we more often encounter in a sidewalk crack than in a bouquet.
  • Marsha P. Johnson, a central figure of the Stonewall riots and a co-founder of Street Transvestite Action Revolutionaries
  • Ms. Johnson was known for wearing crowns of fresh flowers that she would arrange from leftover blooms and discarded daffodils from the flower district in Manhattan, where she often slept.
  • In one photo, Ms. Johnson wears a crown of roses, carnations, chrysanthemums, frilly tulips, statice and baby’s breath.
  • Although cumulous clusters of baby’s breath are now a staple of floral arrangements, the species is a wildflower native to central and Eastern Europe.
  • Ms. Lopez and STARR have criticized a proposal for a new $70 million beach scheduled to be built on Gansevoort Peninsula, near waterfronts where Ms. Rivera once lived and Ms. Johnson died. In its place, she suggests a memorial garden for Ms. Johnson, Ms. Rivera and other transgender people
  • “We will never feed enough people, we will never plant enough flowers, never be good enough to honor Sylvia and Marsha,” Ms. Lopez said. “They cared too much, even when no one cared for them.”
  • “I have candles lit always for Marsha and Sylvia, but I’m praying especially hard now that we get a plan that includes lots of flowers,” said Mariah Lopez, the executive director of Strategic Trans Alliance for Radical Reform, or STARR, an advocacy group.
  • Her dream of the park includes a range of verdant and functional spaces: a paved area where people can vogue and hold rallies, a flower garden in tribute to Ms. Johnson, a greenhouse and an apiary for bees.
  • Tansy.
  • The redesign of the park will add a new fence around the meadow, as well as interpretive signs about the pollinators who depend on its wildflowers. “What would happen if there were no bees in the world?”
  • “We have to protect them. That’s what the function of this sweet little meadow is.”
  • anonymous on 26 Mar 21
     
    Real life story and example of how we treat history- what stories we're telling, who we're trying to save.
anonymous

The Costly, Painful, Lonely Burden of Care - The New York Times - 0 views

www.nytimes.com/...caregiving-burnout.html

shared by anonymous on 27 Mar 21 - No Cached
  • The Costly, Painful, Lonely Burden of Care
  • Health care in the U.S. relies on an “invisible army” of caregivers — mostly women. For many, stunted careers, lost earnings and exhaustion are part of the fallout.
  • “If society wants us to keep caring for others, it’s going to have to show a little more care for us.”
  • ...28 more annotations...
  • Her husband, Brad Buchanan, was late for family dinner. She found him in the bathroom, coughing up blood — a lot of it.
  • Doctors found that a tumor had ruptured in one of his lungs and he urgently needed chemo. As her husband became critically ill, Ms. Washington, a freelance writer, was thrust into the role of nurse.
  • “My hands were shaking,” she said as she remembered apprehensively pushing in the drugs for the first time and feeling the weight of keeping her husband alive.
  • Mr. Buchanan had a stem cell transplant that left him with graft-versus-host disease
  • Depending on the analysis, between 61 and 75 percent of caregivers are women
  • When she explained that she had two children who also had needs, he said, “Well, usually family steps in, and it works out fine.”
  • Ms. Washington felt the burden of responsibility, but also the sting
  • The U.S. health care system relies on and takes for granted the “invisible army” of people — mostly women — who keep the system functioning by performing home care for the many people who are “too well for the hospital” but “too sick for home,” as well as for those on end-of-life care.
  • In 2017, AARP found that about 41 million family caregivers in America perform roughly $470 billion worth of unpaid labor a year.
  • they tend to do more personal care tasks like helping patients bathe and use the toilet than their male counterparts, who are more likely to oversee finances and arrangement of care.
  • The historical roots are complex, but as Evelyn Glenn puts it in “Forced to Care,”
  • emale caregivers put in more hours — 22 to men’s 17
  • they are also more likely to stand by their partner through a serious illness
  • Many people who take on caregiving roles experience negative health impacts, but women are especially at risk of the fallout from caregiver stress.
  • Female caregivers are also 2.5 times more likely to live in poverty as non-caregiver
  • A 2011 study found that women who left their jobs to care for a parent lost an average of $324,000 in wages and benefits over their lifetimes.
  • Ms. Washington was able to dip into savings and a recent inheritance to help pay for supplemental in-home care, but it was still a struggle, causing stress, resentment and lost income.
  • It was hard to have my life put on hold. Everything kind of slipped away.
  • I lost a sense of who I was. I was going to pick up a prescription for myself, the only prescription I had when my husband was sick, and the pharmacist asked for my date of birth, and I gave his date of birth
  • People talk about how it’s the most important job in the world, taking care of our children or taking care of our vulnerable elders, and yet those are some of the worst paid jobs.
  • How much is a quarterback paid versus someone who is doing care for a vulnerable elderly person?
  • How did care work become so undervalued?
  • A doctor told Ms. Washington that her husband would need 24-hour care and “could not be left alone for even a moment.”
  • Western culture has long framed care work done by women as a moral duty or obligation, rather than an economic activity.
  • If your earnings are lower than they would normally be because you’re busy caring for a family member, and you can’t save and pay into social security, it can lock whole families into a cycle of lower wealth and economic instability.
  • And what should someone not do
  • Don’t tell someone to stay positive. For me, there was no staying about it, because I didn’t feel positive to start with. It brought up this feeling
  • My time isn’t my own, but surely my emotions can be
pier-paolo

Modern Science Didn't Appear Until the 17th Century. What Took So Long? - The New York ... - 0 views

www.nytimes.com/...-science-michael-strevens.html

carbon emissions

shared by pier-paolo on 01 Nov 20 - No Cached
  • While modern science is built on the primacy of empirical data — appealing to the objectivity of facts — actual progress requires determined partisans to move it along.
  • Why wasn’t it the ancient Babylonians putting zero-gravity observatories into orbit around the earth,” Strevens asks, “the ancient Greeks engineering flu vaccines and transplanting hearts?”
  • transforming ordinary thinking humans into modern scientists entails “a morally and intellectually violent process.”
  • ...6 more annotations...
  • So much scientific research takes place under conditions of “intellectual confinement” — painstaking, often tedious work that requires attention to minute details, accounting for fractions of an inch and slivers of a degree.
  • This kind of obsessiveness has made modern science enormously productive, but Strevens says there is something fundamentally irrational and even “inhuman” about it.
  • He points out that focusing so narrowly, for so long, on tedious work that may not come to anything is inherently unappealing for most people. Rich and learned cultures across the world pursued all kinds of erudition and scholarly traditions, but didn’t develop this “knowledge machine”
  • The same goes for brilliant, intellectually curious individuals like Aristotle, who generated his own theory about physics but never proposed anything like the scientific method.
  • but in order to communicate with one another, in scientific journals, they have to abide by this rule. The motto of England’s Royal Society, founded in 1660, is “Nullius in verba”: “Take nobody’s word for it.”
  • purged of all nonscientific curiosity by a “program of moralizing and miseducation.” The great scientists were exceptions because they escaped the “deadening effects” of this inculcation; the rest are just “the standard product of this system”: “an empiricist all the way down.”
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