Group items tagged

A group of leading biologists on Thursday called for a worldwide moratorium on use of a new genome-editing technique that would alter human DNA in a way that can be inherited.

The biologists fear that the new technique is so effective and easy to use that some physicians may push ahead before its safety can be assessed. They also want the public to understand the ethical issues surrounding the technique, which could be used to cure genetic diseases, but also to enhance qualities like beauty or intelligence. The latter is a path that many ethicists believe should never be taken.

a technique invented in 2012 makes it possible to edit the genome precisely and with much greater ease. The technique has already been used to edit the genomes of mice, rats and monkeys, and few doubt that it would work the same way in people.

In 2001, President George W. Bush issued an executive order banning federal funding for new sources of stem cells developed from preimplantation human embryos. The action stalled research and discouraged scientists.

re-energized the field by devising a technique to “reprogram” any adult cell, such as a skin cell, and coax it back to its earliest “pluripotent” stage. From there it can become any type of cell, from a heart muscle cell to a neuron.

But it’s a double-edged sword. After multiple cell cycles, the chances of mutations increases.

she cried, “They took my f***ing phone!” Attempting to engage Kelly in conversation, I asked her what she liked about her phone and social media. “They make me happy,” she replied.

Even though they were loving and involved parents, Kelly’s mom couldn’t help feeling that they’d failed their daughter and must have done something terribly wrong that led to her problems.

My practice as a child and adolescent psychologist is filled with families like Kelly’s. These parents say their kids’ extreme overuse of phones, video games, and social media is the most difficult parenting issue they face — and, in many cases, is tearing the family apart.

the social psychologist Sheena Iyengar asked 100 American and Japanese college students to take a piece of paper. On one side, she had them write down the decisions in life they would like to make for themselves. On the other, they wrote the decisions they would like to pass on to others.

The Americans desired choice in four times more domains than the Japanese.

Americans now have more choices over more things than any other culture in human history. We can choose between a broader array of foods, media sources, lifestyles and identities. We have more freedom to live out our own sexual identities and more religious and nonreligious options to express our spiritual natures.

Rosenstein belongs to a small but growing band of Silicon Valley heretics who complain about the rise of the so-called “attention economy”: an internet shaped around the demands of an advertising economy.

“It is very common,” Rosenstein says, “for humans to develop things with the best of intentions and for them to have unintended, negative consequences.”

most concerned about the psychological effects on people who, research shows, touch, swipe or tap their phone 2,617 times a day.

A Bachelor’s degree taught me how to learn to ace exams. But it didn’t teach me how to learn to remember.

65% to 80% of students answered “no” to the question “Do you study the way you do because somebody taught you to study that way?”

the most-popular Coursera course of all time: Dr. Barabara Oakley’s free course on “Learning how to Learn.” So did I. And while this course taught me about chunking, recalling, and interleaving

A couple of years ago I was told a rumor about a notable artist who would break up everything she did, from making films in the day to running her studio in the afternoon to reading books in the evening, into intervals of 25 minutes, with five-minute breaks in between — 25 minutes on, five minutes off, over and over again.

the Pomodoro technique. Invented by Francesco Cirillo, a student at Rome’s Luiss Business School in the late 1980s, it’s a time-management method that takes its name from the tomato-shaped kitchen timer he used to regulate its core process, breaking the day into brief intervals

A pomodoro, once started, must not be interrupted, otherwise it has to be abandoned

In learning any art the important things to learn are, first, Principles, and second, Method. This is true of the art of producing ideas. Particular bits of knowledge are nothing, because they are made up [of] so called rapidly aging facts. Principles and method are everything.

So with the art of producing ideas. What is most valuable to know is not where to look for a particular idea, but how to train the mind in the method by which all ideas are produced and how to grasp the principles which are at the source of all ideas.

Every really good creative person…whom I have ever known has always had two noticeable characteristics. First, there was no subject under the sun in which he could not easily get interested — from, say, Egyptian burial customs to modern art. Every facet of life had fascination for him. Second, he was an extensive browser in all sorts of fields of information.

the age of Skinnerian Marketing. Future applications making use of big data, location, maps, tracking of a browser's interests, and data streams coming from mobile and wearable devices, promise to usher in the era of unprecedented power in the hands of marketers, who are no longer merely appealing to our innate desires, but programming our behaviors.

In the 1930's, B. F. Skinner developed the concept of operant conditioning. He put pigeons and rats in Skinner boxes to study how he could modify their behavior using rewards and punishments.

Skinner's techniques of operant conditioning and his notorious theory of behavior modification were denounced by his critics 70 years ago as fascist, manipulative vehicles that could be used for government control.

What the Bay Area-based cartoonist recognizes, he says, is the careful art behind Trump’s rhetorical techniques.

Adams believes Trump will win because he’s “a master persuader.”

His stated credentials in this arena, says Adams — who holds an MBA from UC Berkeley — largely involve being a certified hypnotist and, as a writer and business author, an eternal student in the techniques of persuasive rhetoric.

Now scientists have found a more noble purpose for the technique in a study that suggests deep-rooted biases about race and gender could be “unlearnt” during a short nap. The findings appear to confirm the idea that sleeping provides a unique window for accessing and altering fundamental beliefs – even prejudices that we don’t know we have.

Simply playing auditory cues while people slept partially undid racial and gender bias, the study found, and the effects were still evident at least a week later.

“These biases are well-learned,” said Hu. “They can operate efficiently even when we have the good intention to avoid such biases. Moreover, we are often not aware of their influences on our behaviour.”

A University of Otago researcher is part of an international collaboration that has developed an exciting and expansive new set of tools to probe cell types in the brain

involves using techniques that manipulate the genes of a small subset of cells so that the cells glow under fluorescent microscopes. By manipulating unique gene markers for each cell type into fluorescent labels or probes, the structure and function of various types of neurons can be visualized and studied

making certain cell types fluorescently glow, is the ability to use light to make the cells actually fire a signal, using a technique called optogenetics

A variety of methods have been developed over the past few decades to allow mapping of the functioning human brain. Two basic classes of mapping technique have evolved: those that map (or localise) the underlying electrical activity of the brain; and those that map local physiological or metabolic consequences of altered brain electrical activity. Among the former are the non-invasive neural electromagnetic techniques of electroencephalography (EEG) and magnetoencephalography (MEG). These methods allow exquisite temporal resolution of neural processes (typically over a 10–100 ms time scale), but suffer from poor spatial resolution (between 1 and several centimetres). Functional MRI (fMRI) methods are in the second category. They can be made sensitive to the changes in regional blood perfusion, blood volume (for example, using injected magnetic resonance contrast agents), or blood oxygenation that accompany neuronal activity. Blood oxygenation level dependent (BOLD) fMRI, which is sensitive primarily to the last of these variables, allows an image spatial resolution that is of the order of a few millimetres, with a temporal resolution of a few seconds (limited by the haemodynamic response itself). An accessible and more detailed introduction to the technique than is possible in this brief review is found in a recent book.1

Methods such as positron emission tomography (PET) provide an absolute measure of tissue metabolism. In contrast, BOLD fMRI can at present be used only for determining relative signal intensity changes associated with different cognitive states during a single imaging session. The most time efficient approach for comparing brain responses in different states during the imaging experiment is the “block” design19 (fig 3). This design uses relatively long alternating periods (for example, 30 seconds), during each of which a discrete cognitive state is maintained. In the simplest form, there may only be two such states, which are alternated throughout the experiment in order to ensure that variations arising from fluctuations in scanner sensitivity, patient movement, or changes in attention have a similar impact on the signal responses associated with both states.

Brain surgeons are bringing artificial intelligence and new imaging techniques into the operating room, to diagnose tumors as accurately as pathologists, and much faster, according to a report in the journal Nature Medicine.

The traditional method, which requires sending the tissue to a lab, freezing and staining it, then peering at it through a microscope, takes 20 to 30 minutes or longer. The new technique takes two and a half minutes.

In addition to speeding up the process, the new technique can also detect some details that traditional methods may miss, like the spread of a tumor along nerve fibers

He is, on the contrary, seized by the conviction that science is beset by sloppy statistical maneuvering and, in some cases, outright fraud. He has therefore been moonlighting as a fraud-buster, developing techniques to help detect doctored data in other people’s research. Already, in the space of less than a year, he has blown up two colleagues’ careers.

In a paper called “False-Positive Psychology,” published in the prestigious journal Psychological Science, he and two colleagues—Leif Nelson, a professor at the University of California at Berkeley, and Wharton’s Joseph Simmons—showed that psychologists could all but guarantee an interesting research finding if they were creative enough with their statistics and procedures.

By going on what amounted to a fishing expedition (that is, by recording many, many variables but reporting only the results that came out to their liking); by failing to establish in advance the number of human subjects in an experiment; and by analyzing the data as they went, so they could end the experiment when the results suited them, they produced a howler of a result, a truly absurd finding. They then ran a series of computer simulations using other experimental data to show that these methods could increase the odds of a false-positive result—a statistical fluke, basically—to nearly two-thirds.

As the car hummed along and we relived his spiritual journey, I asked Lynch what he really believed. Did he see Transcendental Meditation as simply a technique for relaxation, perfect for young Hollywood actresses, or rather as an all-encompassing way of life, as Maharishi had encouraged — one with peace palaces and an army of meditators fomenting world peace? Lynch paused, and then spoke for more than five minutes, explaining that T.M. was the answer for all seeking true inner happiness. He ended with this thought: “Things like traumatic stress and anxiety and tension and sorrow and depression and hate and bitter, selfish anger and fear start to lift away. And that’s a huge sense of freedom when that heavy weight of negativity begins to lift. So it’s like gold flowing in from within and garbage going out. The things in life that used to almost kill you, stress you, depress you, make you sad, make you afraid — they have less and less power. It’s like you’re building up a flak jacket of protection. You’re starting to glow with this from within.”

I still meditate. For 20 minutes or more, twice a day, I’m able to step back from the news scroll of thoughts and be truly quiet. I use T.M. to deal with anxiety and fatigue and to stave off occasional despair. But that’s because, in my head, I’ve managed to excise the weird flotsam of spirituality that engulfed T.M. for the first part of my life. Now, for me, it is something very simple, like doing yoga or avoiding dairy. Objectively speaking, meditation has been shown to decrease the incidence of heart attacks and strokes and increase longevity. The Department of Veterans Affairs and the Department of Defense commissioned studies to determine whether T.M. can help veterans alleviate post-traumatic stress disorder. Thanks to the David Lynch foundation, low-performing public schools have instituted “Quiet Time,” an elective 10 minutes, twice a day, during which students meditate, with some encouraging results.

The office of the David Lynch Foundation for Consciousness-Based Education and World Peace in New York is filled with young adults, many of whom grew up practicing Transcendental Meditation. Since Lynch started spreading the good news about T.M., the number of people learning the technique has increased tenfold. Close to Lynch’s heart are those suffering from PTSD, it seems, but it is in his own industry that he has made a more visible impact. Roth, who runs the foundation, spends much of his time flying around the world as well as initiating a long list of public figures: Gwyneth Paltrow, Ellen DeGeneres, Russell Simmons, Katy Perry, Susan Sarandon, Candy Crowley, Soledad O’Brien, George Stephanopoulos and Paul McCartney’s grandchildren.

The Supreme Court of Canada ruled Thursday that evidence obtained through hypnosis should not be used in criminal cases because testimony based on such evidence is not "sufficiently reliable" in a court of law.

evidence obtained through hypnosis has been used byCanadian courtsfor nearly 30 years.

the technique of hypnosis and its impact on human memory are not understood well enough for post-hypnosis testimony to be sufficiently reliable in a court of law

The technique is being hailed as a breakthrough in understanding how the trillions of complex cells in a body are descended from a single egg.

The human body has around 40 trillion cells, each with a highly specialised function. Yet each can trace its history back to the same starting point - a fertilised egg.

The molecular tape recorder developed by Prof Shendure's team at the University of Washington in Seattle, US, is a length of DNA inserted into the genome that contains a series of edit points which can be changed throughout an organism's life.

According to paratroopers, stunt professionals, physical therapists and martial arts instructors, there is indeed a “right way” to fall — and it can save you a lot of grief if you know how to do it.

The Agency for Healthcare Research and Quality estimates that falls cause more than a third of injury-related emergency room visits, around 7.9 million a year.

Moreover, falling straight forward or backward raises the risk of damaging your spine and vital organs.