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Lawrence Hrubes

BBC News - A Point of View: The upside of losing one's memory - 0 views

  • Reading the scientific research, I learn that the brain starts deteriorating from the mid-20s onwards. By our 40s and 50s, it's well under way. The changes include a drop in brain volume, loss of myelin integrity, cortical thinning, impaired receptor binding and signalling, and altered concentrations of various brain metabolites. The accumulation of neuro-fibrillary tangles, something we associate with Alzheimer's, also happens in normal ageing.
  • You may be asking what I am worrying about. I'm not yet 50, after all. I don't have Alzheimer's or Parkinson's or any reason to be worried about those diseases. My favourite novelist, Penelope Fitzgerald, was nearly 80 when her last and best book, The Blue Flower, was published. The philosopher Mary Midgley is still sharp as a razor, and she'll be 96 next birthday. She didn't even write a book till she was past 50. The psychoanalyst Hedda Bolgar was still seeing patients at the age of 102.
  • Last week, my colleague listened to his father, behind a drawn hospital curtain, doing an Alzheimer's diagnostic test. He said that the trickiest part was when they read out a list of words but instead of asking you to repeat them they moved on to some numerical questions before asking you to list the words a moment later. He was petrified to find that he couldn't do it himself.
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  • If I was looking for advice about anything other than which smart phone to buy, I'd generally ask someone aged 80- rather than an 18-year-old. It's like when you take a photograph - there's the shutter speed to consider, but there's also the depth of field. Perspective matters.
markfrankel18

What's a Metaphor For? - The Chronicle Review - The Chronicle of Higher Education - 1 views

  • "Metaphorical thinking—our instinct not just for describing but for comprehending one thing in terms of another—shapes our view of the world, and is essential to how we communicate, learn, discover and invent. ... Our understanding of metaphor is in the midst of a metamorphosis. For centuries, metaphor has been seen as a kind of cognitive frill, a pleasant but essentially useless embellishment to 'normal' thought. Now, the frill is gone. New research in the social and cognitive sciences makes it increasingly plain that metaphorical thinking influences our attitudes, beliefs, and actions in surprising, hidden, and often oddball ways." Geary further unpacks metaphor's influence in his foreword: "Metaphor conditions our interpretations of the stock market and, through advertising, it surreptitiously infiltrates our purchasing decisions. In the mouths of politicians, metaphor subtly nudges public opinion; in the minds of businesspeople, it spurs creativity and innovation. In science, metaphor is the preferred nomenclature for new theories and new discoveries; in psychology, it is the natural language of human relationships and emotions."
  • The upshot of the boom in metaphor studies, Geary makes clear, is the overturning of that presumption toward literalism: Nowadays, it's believers in a literalism that goes all the way down (so to speak) who are on the defensive in intellectual life, and explorers of metaphor who are on the ascendant. As a result, Geary hardly feels a need to address literalism, devoting most of his book to how metaphor connects to etymology, money, mind, politics, pleasure, science, children, the brain, the body, and such literary forms as the proverb and aphorism.
markfrankel18

The Knowledge, London's Legendary Taxi-Driver Test, Puts Up a Fight in the Age of GPS - 2 views

  • The examination to become a London cabby is possibly the most difficult test in the world — demanding years of study to memorize the labyrinthine city’s 25,000 streets and any business or landmark on them. As GPS and Uber imperil this tradition, is there an argument for learning as an end in itself?
  • Which is where the Knowledge comes in. It is a weird city’s weird solution to the riddle of itself, a municipal training program whose graduates are both transit workers and Gnostics: chauffeurs taught by the government to know the unknowable.
  • The brains of London taxi drivers have attracted scholarly attention. Eleanor Maguire, a neuroscientist at University College London, has spent 15 years studying cabbies and Knowledge boys. She has discovered that the posterior hippocampus, the area of the brain known to be important for memory, is bigger in London taxi drivers than in most people, and that a successful Knowledge candidate’s posterior hippocampus enlarges as he progresses through the test.
Lawrence Hrubes

My Great-Great-Aunt Discovered Francium. And It Killed Her. - NYTimes.com - 0 views

  • There is a common narrative in science of the tragic genius who suffers for a great reward, and the tale of Curie, who died from exposure to radiation as a result of her pioneering work, is one of the most famous. There is a sense of grandeur in the idea that paying heavily is a means of advancing knowledge. But in truth, you can’t control what it is that you find — whether you’ve sacrificed your health for it, or simply years of your time.
  • How quickly an element decayed and how it did so — meaning which of its component parts it shed — became the focus of researchers in radioactivity. Apart from purely scientific insights, there was a hope that radiation could lead to something marvelous. X-rays, a kind of radiation discovered by Wilhelm Roentgen and produced by accelerated electrons, had already been hailed as a major medical breakthrough and, in addition to showing doctors their patients’ insides, were being investigated as a treatment for skin lesions from tuberculosis and lupus. In her 1904 book “Investigations on Radioactive Substances,” Marie Curie wrote that radium had promise, too — diseased skin exposed to it later regrew in a healthy state. Radium’s curious ability to destroy tissue was being turned against cancer, with doctors sewing capsules of radium into the surgical wounds of cancer patients (including Henrietta Lacks, whose cells are used today in research). This enthusiasm for radioactivity was not confined to the doctor’s office. The element was in face creams, tonics, even candy. According to the Encyclopaedia Britannica article that Curie and her daughter wrote on radium in 1926, preliminary experiments suggested that radium could even improve the quality of soil.
  • Perhaps the most tragic demonstration of this involved workers at the United States Radium Corporation factory in Orange, N.J., which in 1917 began hiring young women to paint watch faces with glow-in-the-dark radium paint. The workers were told that the paint was harmless and were encouraged to lick the paintbrushes to make them pointy enough to inscribe small numbers. In the years that followed, the women began to suffer ghoulish physical deterioration. Their jaws melted and ballooned into masses of tumors larger than fists, and cancers riddled their bodies. They developed anemia and necrosis. The sensational court case started — and won — by the dying Radium Girls, as they were called, is a landmark in the history of occupational health. It was settled in June 1928, four months before Marguerite Perey arrived at the Radium Institute to begin a 30-year career of heavy exposure to radiation.
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  • We know now that alpha and beta particles emitted in radiation attack DNA and that the mutations they cause can lead to cancer. Ingested radioactive elements can concentrate in the bones, where they continue their decay, in effect poisoning someone for as long as that person lives. By the time Perey made her discovery, she was already heavily contaminated. She spent the last 15 years of her life in treatment for a gruesome bone cancer that spread throughout her body, claiming her eyesight, pieces of her hand and most of the years in which she had planned to study francium. As the disease progressed, she warned her students of the horrible consequences of radiation exposure. Francis, my grandfather, says he recalls hearing that when she walked into labs with radiation counters in her later years, they would go off.
  • Over the years, historians have pondered what drove the Curies to throw caution so thoroughly to the wind. Perhaps it was inconceivable to them that the benefits of their research would not outweigh the risks to themselves and their employees. In a field in which groundbreaking discoveries were being made and the competition might arrive there first, speed was put above other concerns, Rona noted. But you almost get the impression that in the Curie lab, dedication to science was demonstrated by a willingness to poison yourself — as if what made a person’s research meaningful were the sacrifices made in the effort to learn something new.
Lawrence Hrubes

Vermont Proposes Official Latin Motto, Wingnuts Tell Vermont To Go Back To Mexico | Won... - 0 views

  • Here’s a sweet little story of Democracy in Action. A bright eighth grader writes to her state legislator with an idea for a law: Vermont doesn’t have an official Latin motto, so why not adopt one? And for that matter, make it a reference to history? Neato! So state Sen. Joe Benning — a Republican who was actually trying to do a good thing, which he has probably learned to never try again — introduced a bill to adopt the motto “Stella quarta decima fulgeat.” — May the fourteenth star shine bright.” Because Vermont was the 14th state, see? Benning noted that when Vermont briefly minted its own currency, it was engraved with “Stella Quarta Deccima,” so the phrase had real historical cachet.ADVERTISEMENTAnd then Burlington TV station WCAX put the story on its Facebook page with the headline, “Should Vermont have an official Latin motto?” and all Stupid broke loose when morons thought that Vermont was knuckling under to a bunch of goddamned illegal immigrants. Charles Topher at “If you Only News” collected some of the worst of the over 600 comments from some of the geniuses worried about protecting ‘Merca from the invading Latin hordes:
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    Note: In addition to the article itself, see the comments from angry citizens.
markfrankel18

Why Do People Persist in Believing Things That Just Aren't True? : The New Yorker - 2 views

  • One thing he learned early on is that not all errors are created equal. Not all false information goes on to become a false belief—that is, a more lasting state of incorrect knowledge—and not all false beliefs are difficult to correct. Take astronomy. If someone asked you to explain the relationship between the Earth and the sun, you might say something wrong: perhaps that the sun rotates around the Earth, rising in the east and setting in the west. A friend who understands astronomy may correct you. It’s no big deal; you simply change your belief. But imagine living in the time of Galileo, when understandings of the Earth-sun relationship were completely different, and when that view was tied closely to ideas of the nature of the world, the self, and religion. What would happen if Galileo tried to correct your belief?
markfrankel18

Why Music Communities Fight to Define Authenticity in Pop - 2 views

  • “Why is pop music the only art form that still inspires such arrantly stupid discussion?,” Frere-Jones asked. “No movie review begins, ‘Meryl Streep, despite not being a Prime Minister, is reasonably convincing in The Iron Lady.’” So the question remains: Why do music fans obsess about authenticity? What’s at stake when a fan argues, with emotions riding high, that Taylor Swift is too pop to be country, or that Green Day isn’t authentic punk rock? As a sociologist who studies music, I’ve spent the last five years trying to understand these authenticity debates—which, incidentally, span just about every style of 20th- and 21st-century music, from electronic dance to South Texas polka. And what I’ve learned is that, if you want to understand why authenticity disputes occur, it’s best to look first at when they do.
markfrankel18

Psychiatry's Mind-Brain Problem - The New York Times - 1 views

  • Recently, a psychiatric study on first episodes of psychosis made front-page news. People seemed quite surprised by the finding: that lower doses of psychotropic drugs, when combined with individual psychotherapy, family education and a focus on social adaptation, resulted in decreased symptoms and increased wellness.
  • Recently, a psychiatric study on first episodes of psychosis made front-page news. People seemed quite surprised by the finding: that lower doses of psychotropic drugs, when combined with individual psychotherapy, family education and a focus on social adaptation, resulted in decreased symptoms and increased wellness. But the real surprise — and disappointment — was that this was considered so surprising.
  • But the real surprise — and disappointment — was that this was considered so surprising.
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  • Unfortunately, Dr. Kane’s study arrives alongside a troubling new reality. His project was made possible by funding from the National Institute of Mental Health before it implemented a controversial requirement: Since 2014, in order to receive the institute’s support, clinical researchers must explicitly focus on a target such as a biomarker or neural circuit. It is hard to imagine how Dr. Kane’s study (or one like it) would get funding today, since it does not do this. In fact, psychiatry at present has yet to adequately identify any specific biomarkers or circuits for its major illnesses.
  • Unfortunately, Dr. Kane’s study arrives alongside a troubling new reality. His project was made possible by funding from the National Institute of Mental Health before it implemented a controversial requirement: Since 2014, in order to receive the institute’s support, clinical researchers must explicitly focus on a target such as a biomarker or neural circuit. It is hard to imagine how Dr. Kane’s study (or one like it) would get funding today, since it does not do this. In fact, psychiatry at present has yet to adequately identify any specific biomarkers or circuits for its major illnesses.
markfrankel18

A Cambridge professor on how to stop being so easily manipulated by misleading statisti... - 0 views

  • Graphs can be as manipulative as words. Using tricks such as cutting axes, rescaling things, changing data from positive to negative, etc. Sometimes putting zero on the y-axis is wrong. So to be sure that you are communicating the right things, you need to evaluate the message that people are taking away. There are no absolute rules. It all depends on what you want to communicate.
  • The bottom line is that humans are very bad at understanding probability. Everyone finds it difficult, even I do. We just have to get better at it. We need to learn to spot when we are being manipulated.
Lawrence Hrubes

The Great A.I. Awakening - The New York Times - 1 views

  • Translation, however, is an example of a field where this approach fails horribly, because words cannot be reduced to their dictionary definitions, and because languages tend to have as many exceptions as they have rules. More often than not, a system like this is liable to translate “minister of agriculture” as “priest of farming.” Still, for math and chess it worked great, and the proponents of symbolic A.I. took it for granted that no activities signaled “general intelligence” better than math and chess.
  • A rarefied department within the company, Google Brain, was founded five years ago on this very principle: that artificial “neural networks” that acquaint themselves with the world via trial and error, as toddlers do, might in turn develop something like human flexibility. This notion is not new — a version of it dates to the earliest stages of modern computing, in the 1940s — but for much of its history most computer scientists saw it as vaguely disreputable, even mystical. Since 2011, though, Google Brain has demonstrated that this approach to artificial intelligence could solve many problems that confounded decades of conventional efforts. Speech recognition didn’t work very well until Brain undertook an effort to revamp it; the application of machine learning made its performance on Google’s mobile platform, Android, almost as good as human transcription. The same was true of image recognition. Less than a year ago, Brain for the first time commenced with the gut renovation of an entire consumer product, and its momentous results were being celebrated tonight.
markfrankel18

Why People Mistake Good Deals for Rip-Offs : The New Yorker - 5 views

  • Last Saturday, an elderly man set up a stall near Central Park and sold eight spray-painted canvases for less than one five-hundredth of their true value. The art works were worth more than two hundred and twenty-five thousand dollars, but the man walked away with just four hundred and twenty dollars. Each canvas was an original by the enigmatic British artist Banksy, who was approaching the midpoint of a monthlong residency in New York City. Banksy had asked the man to sell the works on his behalf. For several hours, hundreds of oblivious locals and tourists ignored the quiet salesman, along with the treasure he was hiding in plain sight. The day ended with thirty paintings left unsold. One Banksy aficionado, certain she could distinguish a fake from the real thing, quietly scolded the man for knocking off the artist’s work.
  • What makes Banksy’s subversive stunt so compelling is that it forces us to acknowledge how incoherently humans derive value. How can a person be willing to pay five hundred times more than another for the same art work born in the same artist’s studio?
  • Some concepts are easy to evaluate without a reference standard. You don’t need a yardstick, for example, when deciding whether you’re well-rested or exhausted, or hot or cold, because those states are “inherently evaluable”—they’re easy to measure in absolute terms because we have sensitive biological mechanisms that respond when our bodies demand rest, or when the temperature rises far above or falls far below seventy-two degrees. Everyone agrees that three days is too long a period without sleep, but art works satisfy far too abstract a need to attract a universal valuation. When you learn that your favorite abstract art work was actually painted by a child, its value declines precipitously (unless the child happens to be your prodigious four-year-old).
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  • We’re swayed by all the wrong cues, and our valuation estimates are correspondingly incoherent. Banksy knew this when he asked an elderly man to sell his works in Central Park. It’s comforting to believe that we get what we pay for, but discerning true value is as difficult as spotting a genuine Banksy canvas in a city brimming with imitations.
Lawrence Hrubes

How Science Saved Me from Pretending to Love Wine | The New Yorker - 2 views

  • was in my late forties when I finally admitted to myself that I would never love wine. As other women fake orgasms, I have faked hundreds of satisfied responses to hundreds of glasses—not a difficult feat, since my father schooled my brother and me in the vocabulary of wine from an early age. Confronted with another Bordeaux or Burgundy, I could toss around the terms I had learned at the dinner table (Pétillant! Phylloxera! Jeroboam!), then painstakingly direct the wine straight down the center of my tongue, a route that limited my palate’s exposure to what it perceived as discomfiting intensity.
Lawrence Hrubes

As the World Melts, an Artist Finds Beauty in Ancient Ice | The New Yorker - 1 views

  • When the artist Peggy Weil first learned about the National Ice Core Laboratory, a few years ago, she was captivated. She contacted Geoffrey Hargreaves, the lab’s curator, and soon found herself inside a giant freezer, bundled in an Arctic-ready parka. (The temperature was minus thirty-eight degrees Fahrenheit.) With the help of lab assistants, she loaded up a cart with cannisters made of thick cardboard, each containing a small segment of a two-mile-long core from the Greenland ice sheet. Weil trundled her specimens to a cylindrical scanner and photographed them in high resolution. Eventually, she strung together eighty-eight scans, top to bottom. Then she animated them and added an accompanying score, creating a four-and-a-half-hour video, designed to be projected onto a wall.
markfrankel18

Thinking in a Foreign Language Makes Decisions More Rational | Wired Science | Wired.com - 5 views

  • To judge a risk more clearly, it may help to consider it in a foreign language. A series of experiments on more than 300 people from the U.S. and Korea found that thinking in a second language reduced deep-seated, misleading biases that unduly influence how risks and benefits are perceived.
  • it’s plausible that the cognitive demands of thinking in a non-native, non-automatic language would leave people with little leftover mental horsepower, ultimately increasing their reliance on quick-and-dirty cogitation. Equally plausible, however, is that communicating in a learned language forces people to be deliberate, reducing the role of potentially unreliable instinct. Research also shows that immediate emotional reactions to emotively charged words are muted in non-native languages, further hinting at deliberation.
  • The researchers believe a second language provides a useful cognitive distance from automatic processes, promoting analytical thought and reducing unthinking, emotional reaction.
Lawrence Hrubes

The Brain That Couldn't Remember - The New York Times - 0 views

  • In that pantheon of illuminatingly broken men and women, Henry stands apart. It is difficult to exaggerate the impact he has had on our understanding of ourselves. Before Brenda Milner collaborated on that first paper about Henry, the prevailing theory of memory held that its functions could not be localized to a single cortical area, that learning was distributed across the brain as a whole. By that theory — built upon the experimental lesioning of the brains of rats — a person’s memory would be affected only in proportion to the amount of brain tissue removed, regardless of which brain structures the tissue was removed from. Milner’s first paper about Henry, along with her previous work, upended this view.
  • Five years after Milner’s first paper about Henry, she published a second that was almost as revelatory. That paper documented Henry’s gradual improvement over a three-day period on a difficult hand-eye coordination task. His improvement came despite his inability to ever remember his previous attempts at the task, indicating that there are at least two different memory systems in the brain — one responsible for our conscious, episodic memories, the second responsible for task-or-skill related “procedural” memories — and that these two systems seem to rely on entirely distinct parts of the brain. This was another fundamental step forward in our understanding of how memory works. Together, Milner’s two Henry-­related revelations can be viewed as the cornerstones of modern memory science.
  • Corkin: Yeah, but it’s not peer-­reviewed, for one thing. That’s important. The stuff that’s published is good stuff. Peer-­reviewed. You can believe it. Things that, you know, experiments that might not have been good experiments, there might have been inadequate control groups. ... There are all sorts of things that can go wrong with experiments. Not every experiment is publishable.
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  • Me: But they can still be interpreted by other people. ... Maybe as we continue to understand how the brain works, and how memory works, some of this existing data of H.M.’s could be reilluminated by new theories, by new ideas, by new — it just seems a shame to destroy it. And it also seems — and this would be the darker interpretation of it — it locks in stone your own telling of H.M.’s story.
markfrankel18

More Virtuous Than We Think : Democracy Journal - 0 views

  • Homo Economicus is a fundamentally selfish man. But what if he’s been vastly overhyped?
  • policymakers have over-learned Adam Smith’s lesson that people achieve collective good when they pursue private interest. Smith noted that pursuit of self interest often produces societal benefit. But Smith hedged his bets. Bowles charges that economists, jurists, and policymakers often don’t hedge theirs, and they have come to rely excessively on incentives based on the proposition that people’s behavior is entirely self-interested and amoral.
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